公开(公告)号：US06573039B1

公开(公告)日：2003-06-03

申请号：US09650937

申请日：2000-08-29

申请人： R. Terry Dunlay ,  D. Lansing Taylor

发明人： R. Terry Dunlay ,  D. Lansing Taylor

IPC分类号： G01N3353

CPC分类号： B82Y30/00 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00707 ,  B01J2219/00743 ,  B01L3/5085 ,  C12Q1/68 ,  C12Q1/6813 ,  C40B60/14 ,  G01N15/1475 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6458 ,  G01N33/5005 ,  G01N33/5035 ,  G01N33/582 ,  G01N2015/1486 ,  G01N2015/1497 ,  G01N2021/6419 ,  G01N2021/6482 ,  G02B21/16 ,  G02B21/365 ,  Y10S436/80 ,  Y10S436/807 ,  Y10S436/809 ,  Y10S977/795 ,  Y10S977/881 ,  Y10S977/92 ,  Y10S977/941 ,  Y10S977/942 ,  C12Q2525/179

摘要： The invention relates to an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for specific biological activity. The invention involves providing cells containing fluorescent reporter molecules in an array of locations and scanning numerous cells in each location with a fluorescent microscope, converting the optical information into digital data, and utilizing the digital data to determine the distribution, environment or activity of the fluorescently labeled reporter molecules in the cells. The array of locations may be an industry standard 96 well or 384 well microtiter plate or a microplate which is a microplate having a cells in a micropaterned array of locations. The invention includes apparatus and computerized method for processing, displaying and storing the data.

公开(公告)号：US5989835A

公开(公告)日：1999-11-23

申请号：US810983

申请日：1997-02-27

申请人： R. Terry Dunlay ,  D. Lansing Taylor

发明人： R. Terry Dunlay ,  D. Lansing Taylor

IPC分类号： B01L3/00 ,  C12Q1/68 ,  C40B60/14 ,  G01N15/14 ,  G01N33/50 ,  G01N33/58 ,  G01N33/533

CPC分类号： B82Y30/00 ,  C12Q1/68 ,  C12Q1/6813 ,  G01N15/1475 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6458 ,  G01N33/5005 ,  G01N33/5035 ,  G01N33/582 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00707 ,  B01J2219/00743 ,  B01L3/5085 ,  C40B60/14 ,  G01N2015/1486 ,  G01N2015/1497 ,  G01N2021/6419 ,  G01N2021/6482 ,  Y10S436/80 ,  Y10S436/807 ,  Y10S436/809 ,  Y10S977/795 ,  Y10S977/881 ,  Y10S977/92 ,  Y10S977/941 ,  Y10S977/942

摘要： The invention relates to an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for specific biological activity. The invention involves providing cells containing fluorescent reporter molecules in an array of locations and scanning numerous cells in each location with a fluorescent microscope, converting the optical information into digital data, and utilizing the digital data to determine the distribution, environment or activity of the fluorescently labeled reporter molecules in the cells. The array of locations may be an industry standard 96 well or 384 well microtiter plate or a microplate which is a microplate having a cells in a micropaterned array of locations. The invention includes apparatus and computerized method for processing, displaying and storing the data.

公开(公告)号：US20170203520A1

公开(公告)日：2017-07-20

申请号：US15411780

申请日：2017-01-20

申请人： Genia Technologies, Inc.

发明人： Roger J.A. Chen ,  Randy Davis

IPC分类号： B29C67/20 ,  G01N33/487 ,  C12Q1/68

CPC分类号： B29C67/20 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y40/00 ,  C12Q1/6869 ,  G01N33/48721 ,  Y10S977/797 ,  Y10S977/90 ,  Y10S977/942 ,  C12Q2565/631

摘要： Techniques for forming a nanopore in a lipid bilayer are described herein. In one example, an agitation stimulus level such as an electrical agitation stimulus is applied to a lipid bilayer wherein the agitation stimulus level tends to facilitate the formation of nanopores in the lipid bilayer. In some embodiments, a change in an electrical property of the lipid bilayer resulting from the formation of the nanopore in the lipid bilayer is detected, and a nanopore has formed in the lipid bilayer is determined based on the detected change in the lipid bilayer electrical property.

公开(公告)号：US20140374252A1

公开(公告)日：2014-12-25

申请号：US14335616

申请日：2014-07-18

申请人： Genia Technologies, Inc.

发明人： Roger J.A. Chen ,  Randy Davis

IPC分类号： C12Q1/68 ,  G01N33/487

CPC分类号： B29C67/20 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y40/00 ,  C12Q1/6869 ,  G01N33/48721 ,  Y10S977/797 ,  Y10S977/90 ,  Y10S977/942 ,  C12Q2565/631

摘要： Techniques for forming a nanopore in a lipid bilayer are described herein. In one example, an agitation stimulus level such as an electrical agitation stimulus is applied to a lipid bilayer wherein the agitation stimulus level tends to facilitate the formation of nanopores in the lipid bilayer. In some embodiments, a change in an electrical property of the lipid bilayer resulting from the formation of the nanopore in the lipid bilayer is detected, and a nanopore has formed in the lipid bilayer is determined based on the detected change in the lipid bilayer electrical property.

摘要翻译： 本文描述了在脂质双层中形成纳米孔的技术。 在一个实例中，将搅动刺激水平（例如电刺激刺激）施加到脂质双层，其中搅动刺激水平倾向于促进脂质双层中的纳米孔的形成。 在一些实施方案中，检测由在脂质双层中形成纳米孔而导致的脂质双层的电性质的变化，并且基于检测到的脂质双层电性能的变化来确定在脂质双层中形成的纳米孔 。

公开(公告)号：US20080040044A1

公开(公告)日：2008-02-14

申请号：US11809937

申请日：2007-06-04

申请人： R. Dunlay ,  D. Taylor

发明人： R. Dunlay ,  D. Taylor

IPC分类号： G06F19/00 ,  G01J1/10 ,  G01J1/58 ,  G01J3/28

CPC分类号： B82Y30/00 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00707 ,  B01J2219/00743 ,  B01L3/5085 ,  C12Q1/68 ,  C12Q1/6813 ,  C40B60/14 ,  G01N15/1475 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6458 ,  G01N33/5005 ,  G01N33/5035 ,  G01N33/582 ,  G01N2015/1486 ,  G01N2015/1497 ,  G01N2021/6419 ,  G01N2021/6482 ,  G02B21/16 ,  G02B21/365 ,  Y10S436/80 ,  Y10S436/807 ,  Y10S436/809 ,  Y10S977/795 ,  Y10S977/881 ,  Y10S977/92 ,  Y10S977/941 ,  Y10S977/942 ,  C12Q2525/179

摘要： The invention relates to an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for specific biological activity. The invention involves providing cells containing fluorescent reporter molecules in an array of locations and scanning numerous cells in each location with a fluorescent microscope, converting the optical information into digital data, and utilizing the digital data to determine the distribution, environment or activity of the fluorescently labeled reporter molecules in the cells. The array of locations may be an industry standard 96 well or 384 well microtiter plate or a microplate which is a microplate having a cells in a micropatterned array of locations. The invention includes apparatus and computerized method for processing, displaying and storing the data.

摘要翻译： 本发明涉及用于确定荧光标记的报道分子在细胞中的分布，环境或活性的光学系统，以筛选大量用于特定生物活性的化合物。 本发明涉及在荧光显微镜的阵列中提供含有荧光报告分子的细胞，并用荧光显微镜扫描各个位置的多个细胞，将光学信息转换为数字数据，并利用数字数据确定荧光的分布，环境或活性 标记的细胞中的报告分子。 位置阵列可以是工业标准96孔或384孔微量滴定板或微板，其是具有位于微图案阵列中的细胞的微孔板。 本发明包括用于处理，显示和存储数据的装置和计算机化方法。

公开(公告)号：US20050063210A1

公开(公告)日：2005-03-24

申请号：US10964150

申请日：2004-10-13

申请人： Brent Segal ,  Darren Brock ,  Thomas Rueckes

发明人： Brent Segal ,  Darren Brock ,  Thomas Rueckes

IPC分类号： B81B3/00 ,  G11C13/02 ,  G11C23/00 ,  H01L21/768 ,  H01L27/108 ,  H01L29/76

CPC分类号： G11C23/00 ,  B82Y10/00 ,  G11C13/025 ,  G11C2213/16 ,  G11C2213/77 ,  G11C2213/81 ,  Y10S977/724 ,  Y10S977/734 ,  Y10S977/742 ,  Y10S977/942 ,  Y10S977/943

摘要： A hybrid memory system having electromechanical memory cells is disclosed. A memory cell core circuit has an array of electromechanical memory cells, in which each cell is a crossbar junction at least one element of which is a nanotube or a nanotube ribbon. An access circuit provides array addresses to the memory cell core circuit to select at least one corresponding cell. The access circuit is constructed of semiconductor circuit elements.

摘要翻译： 公开了一种具有机电存储器单元的混合存储器系统。 存储单元核心电路具有机电存储器单元的阵列，其中每个单元是横截面结，其中至少一个元件是纳米管或纳米管带。 访问电路向存储器单元核心电路提供阵列地址以选择至少一个对应的单元。 存取电路由半导体电路元件构成。

公开(公告)号：US06574130B2

公开(公告)日：2003-06-03

申请号：US09915095

申请日：2001-07-25

申请人： Brent M. Segal ,  Darren K. Brock ,  Thomas Rueckes

发明人： Brent M. Segal ,  Darren K. Brock ,  Thomas Rueckes

IPC分类号： G11C1100

CPC分类号： G11C23/00 ,  B82Y10/00 ,  G11C13/025 ,  G11C2213/16 ,  G11C2213/77 ,  G11C2213/81 ,  Y10S977/724 ,  Y10S977/734 ,  Y10S977/742 ,  Y10S977/942 ,  Y10S977/943

摘要： A hybrid memory system having electromechanical memory cells is disclosed. A memory cell core circuit has an array of electromechanical memory cells, in which each cell is a crossbar junction at least one element of which is a nanotube or a nanotube ribbon. An access circuit provides array addresses to the memory cell core circuit to select at least one corresponding cell. The access circuit is constructed of semiconductor circuit elements.

摘要翻译： 公开了一种具有机电存储器单元的混合存储器系统。 存储单元核心电路具有机电存储器单元的阵列，其中每个单元是横截面结，其中至少一个元件是纳米管或纳米管带。 访问电路向存储器单元核心电路提供阵列地址以选择至少一个对应的单元。 存取电路由半导体电路元件构成。

公开(公告)号：US11884024B2

公开(公告)日：2024-01-30

申请号：US17303024

申请日：2021-05-18

申请人： Roche Sequencing Solutions, Inc.

发明人： Roger J. A. Chen ,  Randy Davis

IPC分类号： B29C67/20 ,  B82Y5/00 ,  C12Q1/6869 ,  G01N33/487 ,  B82Y10/00 ,  B82Y40/00

CPC分类号： B29C67/20 ,  B82Y5/00 ,  C12Q1/6869 ,  G01N33/48721 ,  B82Y10/00 ,  B82Y40/00 ,  Y10S977/797 ,  Y10S977/90 ,  Y10S977/942 ,  C12Q1/6869 ,  C12Q2565/631

摘要： Techniques for forming a nanopore in a lipid bilayer are described herein. In one example, an agitation stimulus level such as an electrical agitation stimulus is applied to a lipid bilayer wherein the agitation stimulus level tends to facilitate the formation of nanopores in the lipid bilayer. In some embodiments, a change in an electrical property of the lipid bilayer resulting from the formation of the nanopore in the lipid bilayer is detected, and a nanopore has formed in the lipid bilayer is determined based on the detected change in the lipid bilayer electrical property.

公开(公告)号：US09737885B2

公开(公告)日：2017-08-22

申请号：US14209354

申请日：2014-03-13

申请人： FUJIKURA LTD.

发明人： Masayasu Inaguma

IPC分类号： B32B3/24 ,  B01J35/00 ,  C01B31/02 ,  B82Y30/00 ,  B82Y40/00 ,  H01G9/042 ,  B82Y99/00 ,  C23C16/26 ,  D01F9/127 ,  H01G9/20 ,  H01M4/583 ,  H01M4/90

CPC分类号： B01J35/002 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/158 ,  C01B32/162 ,  C01B2202/08 ,  C01B2202/34 ,  C01B2202/36 ,  C01B2203/1041 ,  C01B2203/1047 ,  C01B2203/1064 ,  C01B2203/1082 ,  D01F9/127 ,  H01G9/042 ,  H01G9/2045 ,  H01M4/583 ,  H01M4/9075 ,  Y10S977/742 ,  Y10S977/843 ,  Y10S977/932 ,  Y10S977/942 ,  Y10T428/12611 ,  Y10T428/1266 ,  Y10T428/12667 ,  Y10T428/24322 ,  Y10T428/24331 ,  Y10T428/24612 ,  Y10T428/249921 ,  Y10T428/249924 ,  Y10T428/25 ,  Y10T428/265 ,  Y10T428/30

摘要： Provided is a structure for forming carbon nanofiber, including a base material containing an oxygen ion-conductive oxide, and a metal catalyst that is provided on one surface side of the base material.

公开(公告)号：US20110193249A1

公开(公告)日：2011-08-11

申请号：US12658591

申请日：2010-02-08

申请人： Roger Chen ,  Randy Davis

发明人： Roger Chen ,  Randy Davis

IPC分类号： B29C67/24

CPC分类号： B29C67/20 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y40/00 ,  C12Q1/6869 ,  G01N33/48721 ,  Y10S977/797 ,  Y10S977/90 ,  Y10S977/942 ,  C12Q2565/631

摘要： Techniques for forming a nanopore in a lipid bilayer are described herein. In one example, an agitation stimulus level such as an electrical agitation stimulus is applied to a lipid bilayer wherein the agitation stimulus level tends to facilitate the formation of nanopores in the lipid bilayer. In some embodiments, a change in an electrical property of the lipid bilayer resulting from the formation of the nanopore in the lipid bilayer is detected, and a nanopore has formed in the lipid bilayer is determined based on the detected change in the lipid bilayer electrical property.

摘要翻译： 本文描述了在脂质双层中形成纳米孔的技术。 在一个实例中，将搅动刺激水平（例如电刺激刺激）施加到脂质双层，其中搅动刺激水平倾向于促进脂质双层中的纳米孔的形成。 在一些实施方案中，检测由在脂质双层中形成纳米孔而导致的脂质双层的电性质的变化，并且基于检测到的脂质双层电性能的变化来确定在脂质双层中形成的纳米孔 。