-
1.发明授权公开(公告)号：US10968252B2
公开(公告)日：2021-04-06
申请号：US15677888
申请日：2017-08-15
申请人： Genzyme Corporation
摘要： Provided herein are methods of processing a fluid that include the use of one or both of a circuit system including a tangential flow filtration (TFF) unit and a circuit system including a tangential flow virus filtration (TFVF) unit. Also provided are integrated and continuous processes for manufacturing a therapeutic protein drug substance that include a step of processing a fluid including the recombinant therapeutic protein using any of the methods provided herein.
-
公开(公告)号：US20200377850A1
公开(公告)日：2020-12-03
申请号：US16799592
申请日：2020-02-24
申请人： Genzyme Corporation
摘要： Provided herein are seed train processes and methods of producing a recombinant protein that include the use of these seed train processes.
-
公开(公告)号：US10087214B2
公开(公告)日：2018-10-02
申请号：US14598450
申请日：2015-01-16
申请人： Genzyme Corporation
发明人： Rahul Godawat , Veena Warikoo , Rohan Patil , Konstantin Konstantinov , Venkat Kishore Ryakala , Mahsa Rohani
IPC分类号： A61L2/08 , B01D15/18 , B01D15/20 , B01D15/36 , B01D15/38 , B01D15/42 , C07K1/16 , C07K1/22 , C12N9/40
摘要： Provided herein are methods of performing chromatography with gamma-irradiated chromatography resin that include providing a chromatography column including a gamma-irradiated chromatography resin; performing a first cycle of chromatography through the column, where the cycle includes exposing the chromatography resin to a denaturing buffer; and performing at least one additional cycle of chromatography through the column. Also provided are integrated, closed or substantially closed, and continuous processes for manufacturing of a recombinant protein that include the use of at least one chromatography column including gamma-irradiated chromatography resin, where the gamma-irradiated chromatography resin is exposed to denaturing buffer during each cycle in the process, and reduced bioburden buffer is used in the process.
-
公开(公告)号：US20170218012A1
公开(公告)日：2017-08-03
申请号：US15493523
申请日：2017-04-21
申请人： Genzyme Corporation
IPC分类号： C07K1/16 , C07K1/18 , C07K16/00 , C12N9/40 , C12N9/24 , B01D15/42 , C07K1/36 , C12M1/00 , B01D15/18 , B01D15/36 , B01D15/34 , B01D15/38 , C07K1/22 , C12P21/00
摘要： Provided herein are integrated continuous biomanufacturing processes for producing a therapeutic protein drug substance. Also provided are systems that are capable of continuously producing a therapeutic protein drug substance.
-
公开(公告)号：US20150158907A1
公开(公告)日：2015-06-11
申请号：US14627674
申请日：2015-02-20
申请人： Genzyme Corporation
发明人： Hang Zhou , Benjamin Wright , Marcella Yu , Jin Yin , Konstantin Konstantinov
CPC分类号： C07K1/34 , C07K14/475 , C07K14/52 , C07K16/00 , C12M29/00 , C12M29/04 , C12M29/10 , C12M29/18 , C12M33/14 , C12M41/00 , C12M47/10 , C12M47/12 , C12N9/00
摘要： Provided herein are methods of processing a cell culture and open circuit filtration systems.
摘要翻译： 本文提供了处理细胞培养和开路过滤系统的方法。
-
公开(公告)号：US12110312B2
公开(公告)日：2024-10-08
申请号：US16908401
申请日：2020-06-22
申请人： Genzyme Corporation
IPC分类号： B01D15/18 , B01D15/32 , B01D15/34 , B01D15/36 , B01D15/38 , B01D15/42 , C07K1/16 , C07K1/18 , C07K1/22 , C07K1/36 , C07K16/00 , C12M1/00 , C12N9/00 , C12N9/24 , C12N9/40 , C12P21/00
CPC分类号： C07K1/22 , B01D15/1807 , B01D15/1864 , B01D15/1871 , B01D15/327 , B01D15/34 , B01D15/362 , B01D15/363 , B01D15/3809 , B01D15/3814 , B01D15/422 , C07K1/16 , C07K1/18 , C07K1/36 , C07K16/00 , C12M23/52 , C12M47/10 , C12M47/12 , C12N9/00 , C12N9/2402 , C12N9/2465 , C12P21/00 , C12P21/005 , C12Y302/01022 , C12Y302/01045 , C07K2317/14
摘要： Provided herein are integrated continuous biomanufacturing processes for producing a therapeutic protein drug substance. Also provided are systems that are capable of continuously producing a therapeutic protein drug substance.
-
7.发明授权公开(公告)号：US11884703B2
公开(公告)日：2024-01-30
申请号：US17180272
申请日：2021-02-19
申请人： Genzyme Corporation
CPC分类号： C07K1/34 , B01D15/1864 , B01D61/145 , B01D61/146 , C07K16/00 , B01D2315/06 , C07K2317/21 , C07K2317/31
摘要： Provided herein are methods of processing a fluid that include the use of one or both of a circuit system including a tangential flow filtration (TFF) unit and a circuit system including a tangential flow virus filtration (TFVF) unit. Also provided are integrated and continuous processes for manufacturing a therapeutic protein drug substance that include a step of processing a fluid including the recombinant therapeutic protein using any of the methods provided herein.
-
公开(公告)号：US10711034B2
公开(公告)日：2020-07-14
申请号：US15493523
申请日：2017-04-21
申请人： Genzyme Corporation
IPC分类号： B01D15/18 , B01D15/32 , B01D15/34 , B01D15/36 , B01D15/38 , B01D15/42 , C07K1/16 , C07K1/18 , C07K1/36 , C12M1/00 , C12N9/00 , C12N9/24 , C12N9/40 , C12P21/00 , C07K1/22 , C07K16/00
摘要： Provided herein are integrated continuous biomanufacturing processes for producing a therapeutic protein drug substance. Also provided are systems that are capable of continuously producing a therapeutic protein drug substance.
-
公开(公告)号：US20180354986A1
公开(公告)日：2018-12-13
申请号：US16107203
申请日：2018-08-21
申请人： Genzyme Corporation
发明人： Rahul Godawat , Veena Warikoo , Rohan Patil , Konstantin Konstantinov , Venkat Kishore Ryakala , Mahsa Rohani
IPC分类号： C07K1/16 , B01D15/38 , B01D15/18 , C12N9/40 , C07K1/22 , B01D15/42 , A61L2/08 , B01D15/36 , B01D15/20
CPC分类号： C07K1/16 , A61L2/081 , B01D15/1807 , B01D15/1864 , B01D15/20 , B01D15/363 , B01D15/3809 , B01D15/426 , C07K1/165 , C07K1/22 , C12N9/2465 , C12Y302/01022
摘要： Provided herein are methods of performing chromatography with gamma-irradiated chromatography resin that include providing a chromatography column including a gamma-irradiated chromatography resin; performing a first cycle of chromatography through the column, where the cycle includes exposing the chromatography resin to a denaturing buffer; and performing at least one additional cycle of chromatography through the column. Also provided are integrated, closed or substantially closed, and continuous processes for manufacturing of a recombinant protein that include the use of at least one chromatography column including gamma-irradiated chromatography resin, where the gamma-irradiated chromatography resin is exposed to denaturing buffer during each cycle in the process, and reduced bioburden buffer is used in the process.
-
10.发明申请公开(公告)号：US20150232505A1
公开(公告)日：2015-08-20
申请号：US14627559
申请日：2015-02-20
申请人： Genzyme Corporation
CPC分类号： C07K1/16 , B01D15/1807 , B01D15/1864 , B01D15/1871 , B01D15/327 , B01D15/34 , B01D15/362 , B01D15/363 , B01D15/3809 , B01D15/3814 , B01D15/422 , C07K1/18 , C07K1/22 , C07K1/36 , C07K16/00 , C07K2317/14 , C12M23/52 , C12M47/10 , C12M47/12 , C12N9/00 , C12N9/2402 , C12N9/2465 , C12P21/00 , C12P21/005 , C12Y302/01022 , C12Y302/01045
摘要： Provided herein are integrated continuous biomanufacturing processes for producing a therapeutic protein drug substance. Also provided are systems that are capable of continuously producing a therapeutic protein drug substance.
摘要翻译： 本文提供了用于生产治疗性蛋白质药物物质的一体化连续生物制造方法。 还提供能够连续生产治疗性蛋白质药物物质的系统。
-
-
-
-
-
-
-
-
-
搜索结果
33 条记录 (耗时 0.025 秒)
