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公开(公告)号：US06566494B1
公开(公告)日：2003-05-20
申请号：US09309828
申请日：1999-05-11
申请人： Knud J. Jensen , George Barany , Micheal F. Songster , Fernando Albericio , Jordi Alsina , Josef Vágner
发明人： Knud J. Jensen , George Barany , Micheal F. Songster , Fernando Albericio , Jordi Alsina , Josef Vágner
IPC分类号： C07K104
CPC分类号： G01N33/54353 , A61K38/2026 , B01J2219/00497
摘要： A support material for solid phase synthesis is provided having an amine-containing organic group attached to it through a linker. The support material is of the following general formula (Formula I):
摘要翻译： 提供用于固相合成的载体材料，其具有通过连接体连接到其上的含胺有机基团。 载体材料具有以下通式（式I）：
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公开(公告)号：US5917015A
公开(公告)日：1999-06-29
申请号：US665509
申请日：1996-06-18
申请人： Knud J. Jensen , George Barany , Micheal F. Songster , Fernando Albericio , Jordi Alsina , Josef Vagner
发明人： Knud J. Jensen , George Barany , Micheal F. Songster , Fernando Albericio , Jordi Alsina , Josef Vagner
IPC分类号： A61K38/20 , G01N33/543 , A61K38/00
CPC分类号： G01N33/54353 , A61K38/2026 , B01J2219/00497
摘要： A support material for solid phase synthesis is provided having an amine-containing organic group attached to it through a linker. The support material is of the following general formula (Formula I): ##STR1##
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公开(公告)号：US5545698A
公开(公告)日：1996-08-13
申请号：US150414
申请日：1993-11-10
摘要： The present invention pertains to polyethylene glycol (PEG) derivatized graft supports, to methods for making these supports and to methods of using the supports to synthesize peptides by solid-phase synthesis techniques. The PEG-graft supports of this invention comprise functionalized PEG derivatives which are covalently attached to solid supports, such as polystyrene.
摘要翻译： 本发明涉及聚乙二醇（PEG）衍生化的接枝载体，制备这些载体的方法以及使用载体通过固相合成技术合成肽的方法。 本发明的PEG-接枝载体包括共价连接到固体载体如聚苯乙烯的官能化PEG衍生物。
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公开(公告)号：US5235028A
公开(公告)日：1993-08-10
申请号：US760768
申请日：1991-09-16
摘要： The present invention pertains to polyethylene glycol (PEG) derivatized graft supports, to methods for making these supports and to methods of using the supports to synthesize peptides by solid-phase synthesis techniques. The PEG-graft supports of this invention comprise functionalized PEG derivatives which are covalently attached to solid supports, such as polystyrene.
摘要翻译： 本发明涉及聚乙二醇（PEG）衍生化的接枝载体，制备这些载体的方法以及使用载体通过固相合成技术合成肽的方法。 本发明的PEG-接枝载体包括共价连接到固体载体如聚苯乙烯的官能化PEG衍生物。
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公开(公告)号：US5196566A
公开(公告)日：1993-03-23
申请号：US576233
申请日：1990-08-31
申请人： George Barany , Fernando Albericio
发明人： George Barany , Fernando Albericio
IPC分类号： C07C69/712
CPC分类号： C07C69/712
摘要： Novel acid-labile tris(alkoxy)benzyl ester handles for use in linking protected amino acid or peptides to a support during peptide synthesis are disclosed. Methods for producing the handles, for linking them to solid support resins and for using the resin-linked handles in peptide synthesis are disclosed.
摘要翻译： 公开了用于将保护的氨基酸或肽与肽合成期间的支持物连接的新的酸不稳定的三（烷氧基）苄酯处理剂。 公开了用于生产手柄的方法，用于将它们连接到固体支持树脂上，以及在肽合成中使用树脂连接的手柄。
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6.发明授权公开(公告)号：US08431720B2
公开(公告)日：2013-04-30
申请号：US12990934
申请日：2009-05-05
IPC分类号： C07D209/30
CPC分类号： C07D209/30 , Y02P20/55
摘要： The invention relates to indolesulfonyl halogenides which are useful for the protection of organic compounds comprising at least one guanidino moiety and/or at least one amino group. The invention further relates to a process for their preparation and their use as protecting reagents. The invention also relates to the process for the protecting reaction and to the protected compounds thereof.
摘要翻译： 本发明涉及可用于保护包含至少一个胍基部分和/或至少一个氨基的有机化合物的吲哚磺酰卤化物。 本发明还涉及其制备方法及其作为保护试剂的用途。 本发明还涉及保护反应的方法及其受保护的化合物。
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公开(公告)号：US20100249370A1
公开(公告)日：2010-09-30
申请号：US12665844
申请日：2008-06-30
申请人： Andreas Brunner , Oleg Werbitzky , Stephane Varray , Francesca Quattrini , Holger Hermann , Andrew Strong , Fernando Albericio , Judit Tulla-Puche , Yesica Garcia Ramos
发明人： Andreas Brunner , Oleg Werbitzky , Stephane Varray , Francesca Quattrini , Holger Hermann , Andrew Strong , Fernando Albericio , Judit Tulla-Puche , Yesica Garcia Ramos
CPC分类号： C07K14/575
摘要： Pramlintide, a peptide having the 37 amino acid sequence KCNTATCATQRLANFLVHSSNNFGPILPPT-NVGSNTY-NH2 is prepared via a convergent three-fragment synthesis strategy from the fragments comprising the amino acid residues 1-12, 13-24 and 25-37, respectively.
摘要翻译： 通过来自包含氨基酸残基1-12,13-24和25-37的片段的收敛三片段合成策略制备具有37个氨基酸序列KCNTATCATQRLANFLVHSSNNFGPILPPT-NVGSNTY-NH2的肽的普兰林肽。
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公开(公告)号：US08524898B2
公开(公告)日：2013-09-03
申请号：US12451496
申请日：2008-05-15
IPC分类号： C07D295/00
CPC分类号： C07D295/13 , C07D207/46 , C07D209/34 , C07D213/57 , C07D213/89 , C07D235/18 , C07D239/92 , C07D249/18 , C07D295/205 , C07D403/06 , C07D471/04
摘要： Novel iminium-type coupling agents containing proton acceptors in their iminium moiety, which can be used beneficially as coupling agents in various chemical polypeptide and/or polynucleotide syntheses, and are particularly useful as yield enhancing and racemization suppressing coupling agents for use in peptide syntheses, are disclosed. Further disclosed are a process of preparing such iminium-type coupling agents and their use in the preparation of polypeptides and/or polynucleotides.
摘要翻译： 在其亚胺部分含有质子受体的新型亚胺型偶联剂，其可有利地用于各种化学多肽和/或多核苷酸合成中的偶联剂，并且特别可用作用于肽合成的产率增强和外消旋化抑制偶联剂， 被披露。 进一步公开的是制备这种亚胺型偶联剂的方法及其在制备多肽和/或多核苷酸中的用途。
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公开(公告)号：US20100292163A1
公开(公告)日：2010-11-18
申请号：US12746957
申请日：2008-12-10
申请人： Judit Tulla-Puche , Eleonora Marcucci , Núria Bayo-Puxan , Fernando Albericio , Maria Del Carmen Cuevas Marchante
发明人： Judit Tulla-Puche , Eleonora Marcucci , Núria Bayo-Puxan , Fernando Albericio , Maria Del Carmen Cuevas Marchante
摘要： Antitumoral compounds of Formula I, and pharmaceutically acceptable salts, derivatives, tautomers, prodrugs or stereoisomers thereof useful as antitumour agents.
摘要翻译： 式I的抗肿瘤化合物及其可用作抗肿瘤剂的药学上可接受的盐，衍生物，互变异构体，前药或立体异构体。
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10.发明申请Mammalian Expression Vector Comprising the MCMV Promoter and First Intron of HCMV Major Immediate Early Gene 审中-公开包含MCMV启动子和HCMV第一内含子的哺乳动物表达载体主要即时早期基因公开(公告)号：US20090181424A1
公开(公告)日：2009-07-16
申请号：US11887652
申请日：2006-04-20
CPC分类号： C12N15/85 , C12N2800/108 , C12N2830/42 , C12N2840/20
摘要： A mammalian expression vector that is a murine CMV promoter and the first intron of the major immediate early gene of the human cytomegalovirus. There are mammalian host cells containing the expression vector. There is also a process for the production of recombinant protein by using the expression vector.
摘要翻译： 哺乳动物表达载体，其是鼠CMV启动子和人巨细胞病毒的主要即时早期基因的第一内含子。 存在含有表达载体的哺乳动物宿主细胞。 还有通过使用表达载体生产重组蛋白的方法。
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