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公开(公告)号：US06861518B2
公开(公告)日：2005-03-01
申请号：US10253981
申请日：2002-09-24
申请人： George Just , Zhili Xin , Eric Marsault , Yi Jin , Jianchao Wang
发明人： George Just , Zhili Xin , Eric Marsault , Yi Jin , Jianchao Wang
IPC分类号： C07H21/04 , B01J31/02 , C07F9/141 , C07F9/6584 , C07H9/04 , C07H9/06 , C07H19/10 , C07H21/00 , C12N15/09 , C12Q1/68
CPC分类号： C07H9/04 , C07F9/1411 , C07F9/65846 , C07H9/06 , C07H19/10 , C07H21/00
摘要： Methods and Intermediates for the Preparation of Oligomers Containing Diastereomerically Enriched Phosphorothioate Linkages are Disclosed.
摘要翻译： 公开了用于制备含有非对映异构的富含硫代磷酸酯连接的低聚物的方法和中间体。
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公开(公告)号：US06476216B1
公开(公告)日：2002-11-05
申请号：US09051610
申请日：1998-12-03
申请人： George Just , Zhili Xin , Eric Marsault , Yi Jin , Jianchao Wang
发明人： George Just , Zhili Xin , Eric Marsault , Yi Jin , Jianchao Wang
IPC分类号： C07H2100
CPC分类号： C07H9/04 , C07F9/1411 , C07F9/65846 , C07H9/06 , C07H19/10 , C07H21/00
摘要： The present invention is directed to methods for solid phase nucleotide synthesis utilizing substituted imidazole catalysts.
摘要翻译： 本发明涉及使用取代的咪唑催化剂的固相核苷酸合成方法。
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公开(公告)号：US6160109A
公开(公告)日：2000-12-12
申请号：US109215
申请日：1998-06-30
申请人： George Just , Zhili Xin , Eric Marsault , Yi Jin , Jianchao Wang , Muthiah Manoharan
发明人： George Just , Zhili Xin , Eric Marsault , Yi Jin , Jianchao Wang , Muthiah Manoharan
IPC分类号： C07H21/04 , B01J31/02 , C07F9/141 , C07F9/6584 , C07H9/04 , C07H9/06 , C07H19/10 , C07H21/00 , C12N15/09 , C12Q1/68
CPC分类号： C07H21/00 , C07F9/1411 , C07F9/65846 , C07H9/04 , C07H9/06 , C07H19/10
摘要： Methods and intermediates for the preparation of oligomers containing diastereomerically enriched phosphorothioate and boranophosphate linkages are disclosed.
摘要翻译： 公开了用于制备含有非对映体富集的硫代磷酸酯和硼磷酸酯键的低聚物的方法和中间体。
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公开(公告)号：US06596857B1
公开(公告)日：2003-07-22
申请号：US09452604
申请日：1999-12-01
申请人： George Just , Zhili Xin , Eric Marsault , Yi Jin
发明人： George Just , Zhili Xin , Eric Marsault , Yi Jin
IPC分类号： C07H2100
CPC分类号： C07H9/04 , C07F9/1411 , C07F9/65846 , C07H9/06 , C07H19/10 , C07H21/00
摘要： Methods and intermediates for the preparation of oligomers containing diastereomerically enriched phosphorothioate linkages are disclosed.
摘要翻译： 公开了制备含有非对映体富集的硫代磷酸酯键的低聚物的方法和中间体。
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公开(公告)号：US6031092A
公开(公告)日：2000-02-29
申请号：US951132
申请日：1997-10-15
申请人： George Just , Zhili Xin , Eric Marsault , Yi Jin
发明人： George Just , Zhili Xin , Eric Marsault , Yi Jin
IPC分类号： C07H21/04 , B01J31/02 , C07F9/141 , C07F9/6584 , C07H9/04 , C07H9/06 , C07H19/10 , C07H21/00 , C12N15/09 , C12Q1/68 , C07H21/02
CPC分类号： C07H9/04 , C07F9/1411 , C07F9/65846 , C07H19/10 , C07H21/00 , C07H9/06
摘要： Methods and intermediates for the preparation of oligomers containing diastereomerically enriched phosphorothioate linkages are disclosed.
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公开(公告)号：US5945521A
公开(公告)日：1999-08-31
申请号：US948152
申请日：1997-10-09
申请人： George Just , Zhili Xin , Eric Marsault , Yi Jin
发明人： George Just , Zhili Xin , Eric Marsault , Yi Jin
IPC分类号： C07H21/04 , B01J31/02 , C07F9/141 , C07F9/6584 , C07H9/04 , C07H9/06 , C07H19/10 , C07H21/00 , C12N15/09 , C12Q1/68 , C07H1/02
CPC分类号： C07H9/04 , C07F9/1411 , C07F9/65846 , C07H19/10 , C07H21/00 , C07H9/06
摘要： Methods and intermediates for the preparation of oligomers containing diastereomerically enriched phosphorothioate linkages are disclosed.
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公开(公告)号：US5734041A
公开(公告)日：1998-03-31
申请号：US546198
申请日：1995-10-20
申请人： George Just , Zhili Xin , Eric Marsault , Yi Jin
发明人： George Just , Zhili Xin , Eric Marsault , Yi Jin
IPC分类号： C07H21/04 , B01J31/02 , C07F9/141 , C07F9/6584 , C07H9/04 , C07H9/06 , C07H19/10 , C07H21/00 , C12N15/09 , C12Q1/68 , C07H1/02
CPC分类号： C07H9/04 , C07F9/1411 , C07F9/65846 , C07H19/10 , C07H21/00 , C07H9/06
摘要： Methods and intermediates for the preparation of oligomers containing diastereomerically enriched phosphorothioate linkages are disclosed.
摘要翻译： 公开了制备含有非对映体富集的硫代磷酸酯键的低聚物的方法和中间体。
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公开(公告)号：US07049432B2
公开(公告)日：2006-05-23
申请号：US10163439
申请日：2002-06-04
申请人： Muthiah Manoharan , George Just , Andrei Guzaev , Arlène Roland , Jianchao Wang , Michael E. Jung
发明人： Muthiah Manoharan , George Just , Andrei Guzaev , Arlène Roland , Jianchao Wang , Michael E. Jung
摘要： The present invention provides alkylphosphonate dimers and oligonucleotides prepared therefrom. The invention further provides novel methods for the preparation of these alkylphosphonate dimers. Methods for the preparation of substantially diastereomerically pure alkylphosphonate dimers are also provided.
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9.发明授权Oligonucleotides having alkylphosphonate linkages and methods for their preparation 失效具有烷基膦酸酯键的寡核苷酸及其制备方法公开(公告)号：US06486313B1
公开(公告)日：2002-11-26
申请号：US09252521
申请日：1999-02-18
申请人： Muthiah Manoharan , George Just , Andrei Guzaev , Arlène Roland , Jianchao Wang , Michael E. Jung
发明人： Muthiah Manoharan , George Just , Andrei Guzaev , Arlène Roland , Jianchao Wang , Michael E. Jung
IPC分类号： C07H2102
摘要： The present invention provides alkylphosphonate dimers and oligonucleotides prepared therefrom. The invention further provides novel methods for the preparation of these alkylphosphonate dimers. Methods for the preparation of substantially diastereomerically pure alkylphosphonate dimers are also provided.
摘要翻译： 本发明提供烷基膦酸二聚体和由其制备的寡核苷酸。 本发明还提供了制备这些烷基膦酸二聚体的新方法。 还提供了制备基本上非对映体纯的烷基膦酸二聚体的方法。
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公开(公告)号：US20060101621A1
公开(公告)日：2006-05-18
申请号：US11323923
申请日：2006-01-03
申请人： George Just
发明人： George Just
IPC分类号： B42F1/00
CPC分类号： B42F1/06 , A45C2001/062 , A45F5/02 , Y10T24/1394 , Y10T24/20 , Y10T24/32
摘要： A magnetic clip comprising a combined magnetic member/firm plate unit (34) lever, an opposing ferric armature member (22) lever, and attachment means (26) which hingedly connect said opposing levers. The lower proximal edge of said magnetic member serves as a fulcrum (44) about which said two levers can be pivoted by the operator's fingers of only one hand which can raise or lower portions (52), (56), (54), and (58) thereby causing the leading edges of said clip to open or close as needed to secure or release said bookmark to or from a sheet (30).
摘要翻译： 包括组合的磁性构件/牢固板单元（34）杆，相对的铁电枢构件（22）杆以及铰接地连接所述相对杆的附接装置（26）的磁夹。 所述磁性构件的下近侧边缘用作支点（44），所述两个杠杆可围绕所述支点枢转，所述操作者的手指只能一只手可以升高或降低部分（52），（56），（54）和 （58），从而使得所述夹子的前边缘根据需要打开或关闭以将所述书签固定或释放到片材（30）上或从片材（30）释放。
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