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1.发明授权Small peptides for the treatment of Alzheimer's disease and other beta-amyloid protein fibrillogenesis disorders 有权用于治疗阿尔茨海默病和其他β-淀粉样蛋白原纤维发生障碍的小肽公开(公告)号：US07384910B2
公开(公告)日：2008-06-10
申请号：US11016706
申请日：2004-12-16
IPC分类号： A61K38/08
CPC分类号： A61K38/08 , A61K38/10 , C07K7/08 , G01N33/6896 , G01N2800/2821
摘要： A pharmaceutical composition comprising peptide Leu-Ala-Phe-Val-Leu-Arg-Lys-amide having at least one D-amino acid.
摘要翻译： 包含具有至少一个D-氨基酸的肽Leu-Ala-Phe-Val-Leu-Arg-Lys-酰胺的药物组合物。
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2.发明授权Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as alzheimer's disease, type 2 diabetes, and parkinson's disease 失效用于治疗淀粉样蛋白病和突触核蛋白病如阿尔茨海默病，2型糖尿病和帕金森病的化合物，组合物和方法公开(公告)号：US07763747B2
公开(公告)日：2010-07-27
申请号：US12264858
申请日：2008-11-04
申请人： Alan D. Snow , Beth P. Nguyen , Gerardo M. Castillo , Virginia J. Sanders , Thomas P. Lake , Lesley Larsen , Rex T. Weavers , Stephen D. Lorimer , David S. Larsen , David L. Coffen , Charlotte Coffen, legal representative
发明人： Alan D. Snow , Beth P. Nguyen , Gerardo M. Castillo , Virginia J. Sanders , Thomas P. Lake , Lesley Larsen , Rex T. Weavers , Stephen D. Lorimer , David S. Larsen , David L. Coffen
IPC分类号： C07C69/035 , C07C69/21 , A61K31/222 , A61K31/225
CPC分类号： C07C49/248 , A61K31/047 , C07C39/15 , C07C39/16 , C07C39/17 , C07C45/62 , C07C45/64 , C07C49/83 , C07C49/835 , C07C69/017 , C07C215/50 , C07C231/02 , C07C235/34 , C07C235/38 , C07C235/48 , C07C235/54 , C07C235/56 , C07C237/22 , C07C275/34 , C07D207/16 , C07D211/74 , C07D213/30 , C07D213/69 , C07D213/85 , C07D221/08 , C07D221/18 , C07D231/06 , C07D241/08 , C07D263/38 , C07D265/38 , C07D295/096 , C07D295/192 , C07D311/60 , C07D317/50 , C07D317/54 , C07D317/58 , C07D317/60 , C07D317/66 , C07D317/68 , C07D333/16 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D451/06 , C07D471/04 , C07D487/08 , C07D491/08
摘要： Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
摘要翻译： 双 - 和三 - 二羟基芳基化合物及其亚甲二氧基类似物和药学上可接受的酯，它们的合成，含有它们的药物组合物及其在治疗淀粉样蛋白病，尤其是A＆ 诸如在阿尔茨海默病中观察到的淀粉样变性，诸如在2型糖尿病中观察到的IAPP淀粉样变性和诸如在帕金森病中观察到的突触核蛋白病，以及用于这种治疗的药物的制造。
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3.发明授权Compounds, compositions and methods for the treatment of amyloid diseases such as systemic AA amyloidosis 有权用于治疗淀粉样变性疾病如全身性AA淀粉样变性的化合物，组合物和方法公开(公告)号：US07601876B2
公开(公告)日：2009-10-13
申请号：US11714894
申请日：2007-03-05
申请人： Alan D. Snow , Beth P. Nguyen , Gerardo M. Castillo , Virginia J. Sanders , Thomas P. Lake , Lesley Larsen , Rex T. Weavers , Stephen D. Lorimer , David S. Larsen , David L. Coffen , Charlotte Coffen, legal representative
发明人： Alan D. Snow , Beth P. Nguyen , Gerardo M. Castillo , Virginia J. Sanders , Thomas P. Lake , Lesley Larsen , Rex T. Weavers , Stephen D. Lorimer , David S. Larsen , David L. Coffen
IPC分类号： C07C33/00 , C07C49/00 , C07C209/00 , C07C211/00 , C07C233/00 , C07C239/00 , C07C275/00 , A61K31/00
CPC分类号： C07C39/15 , C07C39/16 , C07C39/17 , C07C69/017 , C07D207/16 , C07D211/74 , C07D213/30 , C07D213/69 , C07D213/85 , C07D221/08 , C07D221/18 , C07D231/06 , C07D241/08 , C07D263/38 , C07D265/38 , C07D295/096 , C07D295/192 , C07D311/60 , C07D317/50 , C07D317/54 , C07D317/58 , C07D317/60 , C07D317/66 , C07D317/68 , C07D333/16 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D451/06 , C07D471/04 , C07D487/08 , C07D491/08
摘要： Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, AA/SAA amyloidosis, such as observed in systemic AA amyloidosis and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
摘要翻译： 双 - 和三 - 二羟基芳基化合物及其亚甲二氧基类似物和药学上可接受的酯，其合成，含有它们的药物组合物及其在治疗淀粉样蛋白病，尤其是Aβ淀粉样变性中的用途，例如在阿尔茨海默病，IAPP淀粉样变性 在2型糖尿病中观察到，AA / SAA淀粉样变性，例如在全身性AA淀粉样变性和突触核蛋白病中观察到的，例如在帕金森病中观察到的，以及制备用于这种治疗的药物。
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公开(公告)号：US20090197965A1
公开(公告)日：2009-08-06
申请号：US12269017
申请日：2008-11-11
申请人： Alan D. Snow , Beth P. Nguyen , Gerardo M. Castillo , Virginia J. Sanders , Thomas P. Lake , Lesley Larsen , Rex T. Weavers , David S. Lorimer , David S. Larsen , David L. Coffen , Charlotte Coffen , Stephen D. Lorimer
发明人： Alan D. Snow , Beth P. Nguyen , Gerardo M. Castillo , Virginia J. Sanders , Thomas P. Lake , Lesley Larsen , Rex T. Weavers , David S. Lorimer , David S. Larsen , David L. Coffen , Charlotte Coffen , Stephen D. Lorimer
IPC分类号： A61K31/17 , C07C233/56 , A61K31/167 , C07C275/34 , A61P25/28
CPC分类号： C07C49/248 , A61K31/047 , C07C39/15 , C07C39/16 , C07C39/17 , C07C45/62 , C07C45/64 , C07C49/83 , C07C49/835 , C07C69/017 , C07C215/50 , C07C231/02 , C07C235/34 , C07C235/38 , C07C235/48 , C07C235/54 , C07C235/56 , C07C237/22 , C07C275/34 , C07D207/16 , C07D211/74 , C07D213/30 , C07D213/69 , C07D213/85 , C07D221/08 , C07D221/18 , C07D231/06 , C07D241/08 , C07D263/38 , C07D265/38 , C07D295/096 , C07D295/192 , C07D311/60 , C07D317/50 , C07D317/54 , C07D317/58 , C07D317/60 , C07D317/66 , C07D317/68 , C07D333/16 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D451/06 , C07D471/04 , C07D487/08 , C07D491/08
摘要： Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
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5.发明申请COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES SUCH AS ALZHEIMER'S DISEASE, TYPE 2 DIABETES, AND PARKINSON'S DISEASE 失效用于治疗阿尔茨海默病，类型2糖尿病和帕金森病的淀粉样变性和合并症的化合物，组合物和方法公开(公告)号：US20090069432A1
公开(公告)日：2009-03-12
申请号：US12264858
申请日：2008-11-04
申请人： Alan D. Snow , Beth P. Nguyen , Gerardo M. Castillo , Virginia J. Sanders , Thomas P. Lake , Lesley Larsen , Rex T. Weavers , Stephen D. Lorimer , David S. Larsen , David L. Coffen , Chrlotte Coffen
发明人： Alan D. Snow , Beth P. Nguyen , Gerardo M. Castillo , Virginia J. Sanders , Thomas P. Lake , Lesley Larsen , Rex T. Weavers , Stephen D. Lorimer , David S. Larsen , David L. Coffen , Chrlotte Coffen
IPC分类号： A61K31/167 , C07C233/75
CPC分类号： C07C49/248 , A61K31/047 , C07C39/15 , C07C39/16 , C07C39/17 , C07C45/62 , C07C45/64 , C07C49/83 , C07C49/835 , C07C69/017 , C07C215/50 , C07C231/02 , C07C235/34 , C07C235/38 , C07C235/48 , C07C235/54 , C07C235/56 , C07C237/22 , C07C275/34 , C07D207/16 , C07D211/74 , C07D213/30 , C07D213/69 , C07D213/85 , C07D221/08 , C07D221/18 , C07D231/06 , C07D241/08 , C07D263/38 , C07D265/38 , C07D295/096 , C07D295/192 , C07D311/60 , C07D317/50 , C07D317/54 , C07D317/58 , C07D317/60 , C07D317/66 , C07D317/68 , C07D333/16 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D451/06 , C07D471/04 , C07D487/08 , C07D491/08
摘要： Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
摘要翻译： 双 - 和三 - 二羟基芳基化合物及其亚甲二氧基类似物和药学上可接受的酯，其合成，含有它们的药物组合物及其在治疗淀粉样蛋白病，尤其是Aβ淀粉样变性中的用途，例如在阿尔茨海默病，IAPP淀粉样变性 在2型糖尿病中观察到，以及突触核蛋白病，例如在帕金森病中观察到的，以及用于这种治疗的药物的制造。
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6.发明授权Small peptides for the treatment of Alzheimer's disease and other beta-amyloid protein fibrillogenesis disorders 有权用于治疗阿尔茨海默病和其他β-淀粉样蛋白原纤维发生障碍的小肽公开(公告)号：US07276483B1
公开(公告)日：2007-10-02
申请号：US10821250
申请日：2004-04-08
CPC分类号： A61K38/10
摘要： A pharmaceutical composition, or pharmaceutical agent for treating Aβ amyloidosis in a patient that has at least one laminin-derived peptide or fragment thereof from the group D-A13, D-HA3G76, D-A4G82, D-A5G81, D-A5G101, D-HA3G47, D-HA3G58, D-HA3G74, D-HA3G83, D-A5G82, D-R-AG73, D-R-A13, D-R-HA3G76, D-R-A4G82, and D-R-A5G81.
摘要翻译： 在D-A13，D-HA3G76，D-A4G82，D-A5G81，D-A5G101，D组中具有至少一种层粘连蛋白衍生肽或其片段的患者中用于治疗Aβ淀粉样变性的药物组合物或药剂 -HA3G47，D-HA3G58，D-HA3G74，D-HA3G83，D-A5G82，DR-AG73，DR-A13，DR-HA3G76，DR-A4G82和DR-A5G81。
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7.发明授权Substituted N-aryl benzamides and related compounds for treatment of amyloid diseases and synucleinopathies 有权取代的N-芳基苯甲酰胺和相关化合物用于治疗淀粉样蛋白病和突触核蛋白病公开(公告)号：US07745490B2
公开(公告)日：2010-06-29
申请号：US11328748
申请日：2006-01-09
IPC分类号： C07C303/00 , A01N41/06
CPC分类号： C07C311/08
摘要： Substituted n-aryl benzamides, related compounds and their pharmaceutically acceptable derivatives, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, including Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment are provided.
摘要翻译： 取代的正芳基苯甲酰胺，相关化合物及其药学上可接受的衍生物，其合成，含有它们的药物组合物及其在治疗淀粉样蛋白疾病中的用途，包括A＆bgr; 提供淀粉样变性，例如在阿尔茨海默病中观察到的，IAPP淀粉样变性，例如在2型糖尿病中观察到的，以及突触核蛋白病，例如在帕金森病中观察到的，并且制备用于这种治疗的药物。
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