公开(公告)号：US5866559A

公开(公告)日：1999-02-02

申请号：US771805

申请日：1996-12-20

申请人： Gerhard Teichmuller ,  Gerd Muller ,  Sigfrid Schwarz ,  Bernd Undeutsch ,  Harry Henkel ,  Ronald Gebuhr ,  Gunter Kaufmann ,  Doris Hubler ,  Michael Oettel

发明人： Gerhard Teichmuller ,  Gerd Muller ,  Sigfrid Schwarz ,  Bernd Undeutsch ,  Harry Henkel ,  Ronald Gebuhr ,  Gunter Kaufmann ,  Doris Hubler ,  Michael Oettel

IPC分类号： A61K31/565 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  A61P43/00 ,  C07J41/00 ,  C07J75/00 ,  A61K31/57 ,  C07J7/00

CPC分类号： C07J41/0016 ,  C07J41/0094

摘要： The 17.alpha.-cyanomethylestra-4,9-diene derivative compounds are of formula I: ##STR1## wherein R.sub.1 is an alkyl group having from 1 to 2 carbon atoms; R.sub.2 is an alkyl group with 1 to 10 carbon atoms, an acyl group with 1 to 10 carbon atoms or a trialkylsilyl group; and R.sub.3 is an oxygen atom or a R--O--N group, wherein R is a hydrogen atom, an acyl group with 1 to 10 carbon atoms, an alkyl group with 1 to 10 carbon atoms, a sulfamoyl group, an alkylsilyl group or a trialkylsilyl group. These compounds, particularly in combination with at least one suitable estrogen, are suitable for treatment of endometrioses or gestagen-dependent tumors and for hormonal contraception and climacteric hormone replacement therapy (HRT). Processes for making the new steroids are described as well as methods of making the pharmaceutical compositions containing them.

摘要翻译： 17α-氰基甲基雌甾-4,9-二烯衍生物化合物具有式I：其中R 1是具有1至2个碳原子的烷基; R2是碳原子数为1〜10的烷基，碳原子数1〜10的酰基或三烷基甲硅烷基; R3为氧原子或R-O-N基，其中R为氢原子，具有1-10个碳原子的酰基，具有1-10个碳原子的烷基，氨磺酰基，烷基甲硅烷基或三烷基甲硅烷基。 这些化合物，特别是与至少一种合适的雌激素组合，适用于治疗子宫内膜异位症或孕激素依赖性肿瘤以及激素避孕和更年期激素替代疗法（HRT）。 描述了制备新类固醇的方法以及制备含有它们的药物组合物的方法。

公开(公告)号：US5438134A

公开(公告)日：1995-08-01

申请号：US927633

申请日：1993-06-01

申请人： Gerhard Teichmuller ,  Gerd Muller

发明人： Gerhard Teichmuller ,  Gerd Muller

IPC分类号： A61K31/565 ,  A61P13/02 ,  A61P15/00 ,  C07J1/00 ,  C07J41/00

CPC分类号： C07J41/0094

摘要： The unsaturated 17.alpha.-cyanomethyl-17.beta.-hydroxy steroids of the formula I, ##STR1## in which R.sub.1 =Me, Eth; R.sub.2 =H, Me; R.sub.3 =H, OH, an acetoxy or alkoxy group; R.sub.4 =H, R.sub.5 =OH, an acetoxy, alkoxy group of R.sub.4 and R.sub.5 together represent a keto- or ketal group and double bonds are contained in the basic structure of the steroid, particularly between the 15 and 16 position in the steroid ring, from unsaturated 17-ketosteroids of the general formula II as described herein with the aforementioned meanings of R.sub.1 to R.sub.5 by reacting the unsaturated 17-ketosteroids with LiCH.sub.2 CN and subsequently hydrolyzing.The compounds of formula I are pharmacologically interesting steroid compounds or also intermediate products for the synthesis of highly-effective steroid products which can be used in human and veterinary medicine for the treatment of endocrine disorders and for reproductive control based on their specific hormonal/anti-hormonal actions.The compounds are suitable for the treatment of endometriosis and also in combination with preparations with ethinylestradiol for fertility control.

摘要翻译： PCT No.PCT / DE91 / 00562 Sec。 371日期：1993年6月1日 102（e）日期1993年6月1日PCT 1991年7月5日PCT公布。 出版物WO92 / 00991 日期：1992年1月23日。式I的不饱和17α-氰基甲基-17β-羟基类固醇，其中R1 = Me，Eth; R2 = H，Me; R3 = H，OH，乙酰氧基或烷氧基; R4 = H，R5 = OH，R4和R5的乙酰氧基，烷氧基一起表示酮基或缩酮基团，并且类固醇的基本结构中包含双键，特别是类固醇环中15-16位之间， 通过使不饱和的17-酮类固醇与LiCH 2 CN反应并随后水解，从本文所述的通式II的不饱和17-酮类和具有上述R 1至R 5的含义。 式I的化合物是药理学上有趣的类固醇化合物或用于合成高效类固醇产物的中间产物，其可用于人和兽医学用于治疗内分泌紊乱和基于其特异性激素/抗 - 荷尔蒙行动。 该化合物适用于子宫内膜异位症的治疗，也适用于与炔雌醇用于生育控制的制剂。

公开(公告)号：US06855836B2

公开(公告)日：2005-02-15

申请号：US09963680

申请日：2001-09-27

申请人： Bernd Menzenbach ,  Peter Droescher ,  Walter Elger ,  Alexander Hillisch ,  Gunter Kaufmann ,  Hans-Udo Schweikert ,  Gerd Muller

发明人： Bernd Menzenbach ,  Peter Droescher ,  Walter Elger ,  Alexander Hillisch ,  Gunter Kaufmann ,  Hans-Udo Schweikert ,  Gerd Muller

IPC分类号： A61K31/56 ,  C07J13/00

CPC分类号： C07J13/00

摘要： The invention relates to 17-methylene steroids, process for their production and pharmaceutical compositions that contain these compounds.The compounds according to the invention have a hybrid-type profile of action in the sense that they act as inhibitors of 5α-reductase and simultaneously as gestagens. They are therefore suitable for treating diseases that are the result of elevated androgen levels in certain organs and tissues in men and women. Together with other hormonal substances, such as an estrogen, testosterone or a strong androgen, the compounds according to the invention are suitable as contraceptive agents for women and for men.

摘要翻译： 本发明涉及17-亚甲基类固醇，其生产方法和含有这些化合物的药物组合物。根据本发明的化合物具有混合型的作用特征，其意义在于它们作为5α-还原酶的抑制剂，同时作为 gestagens。 因此，它们适用于治疗男性和女性某些器官和组织中雄激素水平升高的疾病。 与其他激素物质如雌激素，睾酮或强雄激素一起，本发明的化合物适合作为妇女和男性的避孕药。

公开(公告)号：US06143440A

公开(公告)日：2000-11-07

申请号：US359120

申请日：1999-07-23

申请人： Andreas Volz ,  Joachim Baumann ,  Klaus Bodganowitz ,  Hans Leysieffer ,  Dieter Muller ,  Gerd Muller

发明人： Andreas Volz ,  Joachim Baumann ,  Klaus Bodganowitz ,  Hans Leysieffer ,  Dieter Muller ,  Gerd Muller

IPC分类号： H01M2/10 ,  H01M2/34 ,  H01M6/50 ,  H04R25/00 ,  H01M10/48

CPC分类号： H01M2/345 ,  H01M2/1044 ,  H01M2/34 ,  H01M2200/20

摘要： A protective device for a repeatedly rechargeable electrochemical battery (10) with a battery housing (12), the protective device having at least one switching element (86) which can be activated by a detector element (62) and which is designed or adjusted to prevent recharging and/or discharging of the battery (10) in an impermissible operating state thereof. The protective device has a hermetically sealed protective housing (54) which holds the battery housing (12). An impermissible operating state of the battery (10) causes a change in shape (deflection) to be impressed on the detector element (62). Preferably, the at least one switching element (86) is made as a make contact which electrically short circuits a recharging circuit supplied by a charging device when a predetermined expansion in the volume of the battery housing (12) and/or gas escape therefrom occurs. The protective device is part of an implantable device, such as a hearing aid.

摘要翻译： 一种用于具有电池壳体（12）的反复可再充电电化学电池（10）的保护装置，所述保护装置具有至少一个开关元件（86），所述至少一个开关元件可被检测器元件（62）激活，并且被设计或调整为 防止电池（10）在不允许的运行状态下的再充电和/或放电。 保护装置具有保持电池壳体（12）的气密密封的保护壳体（54）。 电池（10）的不允许的操作状态导致形成（偏转）的变化被施加到检测器元件（62）上。 优选地，当电池壳体（12）的体积和/或气体逸出时的预定膨胀发生时，所述至少一个开关元件（86）被制成为使接触器电气短路由充电装置供应的再充电电路 。 保护装置是可植入装置的一部分，例如助听器。

公开(公告)号：US5814095A

公开(公告)日：1998-09-29

申请号：US816633

申请日：1997-03-13

申请人： Gerd Muller ,  Hans Leysieffer

发明人： Gerd Muller ,  Hans Leysieffer

IPC分类号： A61N1/36 ,  H04R1/08 ,  H04R25/00 ,  A61F11/04 ,  A61B1/375

CPC分类号： H04R25/606 ,  A61N1/36032 ,  H04R1/08

摘要： Implantable microphone for implantable hearing aids, which is used for excitation of hearing, such as cochlear implants or hearing aids with mechanical stimulation of the middle or inner ear, with a microphone capsule which is accommodated in a hermetically sealed housing, and with an electrical lead-in wire connector for connecting an implant line to the microphone module. The housing has at least two legs which are oriented at an angle relative to one another, one leg holding the microphone capsule and being provided with a sound inlet membrane, and the other leg containing the electrical lead-in wire connector. As a result of the two-legged geometry of the microphone housing, the microphone can be implanted after a mastoidectomy in the mastoid cavity such that the leg which has the sound inlet membrane lies in a hole in the posterior wall of the auditory canal so that, by mechanical contact of the membrane with the closed skin of the auditory canal wall, an acoustic signal incident in the external auditory canal is acoustically received, while the leg of the microphone housing containing the electrical lead-in wire connector is in the area of the mastoid tip. Completely implantable hearing aids for electrical excitation of hearing using the implantable microphone, can have, on the implant side, a battery arrangement for power supply which can be recharged transcutaneously via an external charging device. The audiological implant functions can, likewise, be transcutaneously controlled via a remote control.

摘要翻译： 用于可植入式助听器的植入式麦克风，其用于激发听觉，例如耳蜗植入物或具有机械刺激中耳或内耳的助听器，其具有容纳在气密密封的壳体中的麦克风胶囊，以及电引线 - 用于将植入线连接到麦克风模块的线连接器。 壳体具有相对于彼此成一定角度定向的至少两个腿部，一个腿部保持麦克风胶囊并且设置有声音入口膜，而另一个腿部包含电引入线连接器。 由于麦克风壳体的双腿几何结构，可以在乳突腔中的乳突切除术之后植入麦克风，使得具有声音入口膜的腿位于耳道后壁的孔中，使得 通过膜与耳道壁的闭合皮肤的机械接触，入射在外耳道中的声信号被声学地接收，而包含电引入线连接器的麦克风外壳的腿部处于 乳突尖。 在植入侧可以具有用于电源的电池装置的完全植入式助听器，用于使用可植入麦克风的电激励听力，其可以经由外部充电装置经皮再充电。 听觉植入功能同样可以通过遥控器进行经皮控制。

公开(公告)号：US5788711A

公开(公告)日：1998-08-04

申请号：US726495

申请日：1996-10-07

申请人： Rolf Lehner ,  Gerd Muller ,  Hans Leysieffer

发明人： Rolf Lehner ,  Gerd Muller ,  Hans Leysieffer

IPC分类号： A61B17/00 ,  A61B90/11 ,  A61F11/00 ,  H04R25/00 ,  A61B19/00

CPC分类号： H04R25/606 ,  A61B90/11 ,  A61B2017/00787 ,  A61B90/50

摘要： A permanently implantable, fixable positioning system (1) for stationary attachment to a human body, without play, preferably to the human skull. It has ball-and-socket joint (3), linear axle (4) fixed stationary to it, and a carriage (5) which is guided on the linear axle for accommodating an implantable actuator or sensor device (6). The combination of the axial degree of freedom of the linear axle (4) with three degrees of rotational freedom of the ball-and-socket joint (3) allows a surgeon four-axis, in-situ positioning of the implantable means especially in the middle ear and mastoid cavities. By using the positioning system, precise positioning of a free active end (16) of the implantable device (6) relative to sensitive anatomical structures of the human body is enabled while avoiding risky relative movements between the implantable device and the body of the patient. The positioning system is thus used more or less as a "tremor-free artificial hand" of the surgeon. According to one preferred embodiment, the implantable device is an implantable piezoelectric hearing aid transducer of a partially or completely implantable hearing aid.

摘要翻译： 一种永久可植入的可固定的定位系统（1），用于固定地附接到人体上，而不用玩，最好是人类的头骨。 它具有球窝接头（3），固定在其上的直线轴（4）和一个在直线轴上引导以容纳植入式致动器或传感器装置（6）的托架（5）。 直线轴（4）的轴向自由度与球窝接头（3）的三个旋转自由度的组合允许外科医生四轴，可植入装置的原位定位，特别是在 中耳和乳突腔。 通过使用定位系统，能够相对于人体的敏感解剖结构精确地定位可植入装置（6）的自由主动端（16），同时避免可植入装置与患者身体之间的危险相对运动。 因此，定位系统或多或少地被用作外科医生的“无震动的人造手”。 根据一个优选实施例，可植入装置是部分或完全可植入助听器的可植入式压电助听器换能器。

公开(公告)号：USD385837S

公开(公告)日：1997-11-04

申请号：US25476

申请日：1994-05-20

申请人： Gerd Muller

设计人： Gerd Muller

公开(公告)号：US4133690A

公开(公告)日：1979-01-09

申请号：US678445

申请日：1976-04-19

申请人： Gerd Muller

发明人： Gerd Muller

IPC分类号： C03C3/07 ,  C03C8/24 ,  C03C14/00 ,  H01B3/08 ,  H01L21/316 ,  H01L23/29 ,  H01L23/31 ,  C03C3/04

CPC分类号： C03C14/004 ,  H01L23/291 ,  H01L23/3171 ,  C03C2214/04 ,  H01L2924/0002 ,  Y10T428/252

摘要： Glass compositions useful for passivating silicon semiconductor elements or bodies and to semiconductor elements or bodies coated by such glass compositions. The glass compositions are applied onto the surface of the semiconductor in the form of a finely ground powder and thereafter fused on at least a portion of the semiconductor element. The compositions comprise: (A) glass and (B) powdered cordierite in an amount effective to provide a coefficient of thermal expansion of up to 40 .times. 10.sup.-7 /.degree. C for said composition within the temperature range of 20.degree.-300.degree. C. The compositions are compatible with the thermal expansion of the silicon semiconductor and capable of adhering to the silicon in layers greater than 10 .mu.m without the formation of cracks.

摘要翻译： 可用于钝化硅半导体元件或本体以及由这种玻璃组合物涂覆的半导体元件或物体的玻璃组合物。 将玻璃组合物以细磨粉末的形式施加到半导体的表面上，然后熔合在半导体元件的至少一部分上。 组合物包括：（A）玻璃和（B）粉末状堇青石，其量可以在20℃-300℃的温度范围内为所述组合物提供高达40×10-7 /℃的热膨胀系数 该组合物与硅半导体的热膨胀相容，并且能够以大于10μm的层粘附到硅上而不形成裂纹。

公开(公告)号：US06393868B1

公开(公告)日：2002-05-28

申请号：US09420560

申请日：1999-10-19

申请人： Manfred Krauss ,  Hans-Georg Krolla ,  Eckart Hussmann ,  Bernhard R. Durschang ,  Gerd Muller

发明人： Manfred Krauss ,  Hans-Georg Krolla ,  Eckart Hussmann ,  Bernhard R. Durschang ,  Gerd Muller

IPC分类号： C03B1310

CPC分类号： C03B23/037

摘要： The present invention relates to a novel process for the production of sequences of interference layers composed of layers i of prescribed thicknesses d(i) and refractive indices n(i). In this process a stack of at least two layers i of glasses having refractive indices n(i) and thicknesses d0(i), which are each larger than the predetermined thicknesses d(i) by the same multiplying factor, is provided. The stack is heated to a temperature above the transformation temperature of the glasses and during or after heating, the stack is drawn in such a manner that the individual layers obtain the prescribed thicknesses d(i). After this the drawn stack is cooled.

摘要翻译： 本发明涉及一种用于制作由规定厚度d（i）和折射率n（i）的层i构成的干涉层序列的新方法。 在该过程中，提供了具有折射率n（i）和厚度d0（i）的至少两层i的叠层，其厚度大于预定厚度d（i）乘以相同的倍率。 将叠层加热到高于玻璃的转变温度的温度，并且在加热期间或加热之后，以使得各个层获得规定厚度d（i）的方式被拉伸。 之后，拉制的叠层被冷却。

公开(公告)号：US5760148A

公开(公告)日：1998-06-02

申请号：US455391

申请日：1995-05-31

申请人： Gerd Muller ,  Thomas Schottle

发明人： Gerd Muller ,  Thomas Schottle

IPC分类号： C08F2/00 ,  B01J2/10 ,  B01J19/18 ,  C08F2/16 ,  C08F14/00 ,  C08F14/26

CPC分类号： B01J19/18 ,  B01J2/10 ,  C08F14/26 ,  B01J2219/00162

摘要： The polymerization of tetrafluoroethylene in aqueous suspension can be carried out with high conversion if the medium is thoroughly mixed using an axially conveying stirrer element in such a manner that a cone forms at least as far as the vicinity of the stirrer element. In the region of this stirrer element there are expediently arranged baffles which extend only over a part of the filling height of the reactor.

摘要翻译： 四氟乙烯在水性悬浮液中的聚合可以以高转化率进行，如果使用轴向传送的搅拌器元件充分混合介质，使得锥体形成至少与搅拌器元件附近相同的方式。 在该搅拌器元件的区域中，有便利地设置的挡板仅在反应器的填充高度的一部分上延伸。