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公开(公告)号：US07754878B2
公开(公告)日：2010-07-13
申请号：US10506619
申请日：2003-03-20
申请人： Giangiacomo Torri , Angelo Alberti , Sabrina Bertini , Gianluca Ciardelli , Giuseppe Gastaldi , Solitario Nesti , Elena Vismara
发明人： Giangiacomo Torri , Angelo Alberti , Sabrina Bertini , Gianluca Ciardelli , Giuseppe Gastaldi , Solitario Nesti , Elena Vismara
摘要： Polysaccharides are functionalized using a source of free radicals which forms stable radicals on the polysaccharides structure and wherein the formed radicals reacts with a functionalized unsaturated compound. The method comprises two steps: a first step, wherein the free radical on the polysaccharides chain is formed, and a second step, wherein said radical reacts with the unsaturated compound in the absence of the radical source.
摘要翻译： 多糖使用自由基源进行功能化，自由基源在多糖结构上形成稳定的基团，其中形成的基团与官能化的不饱和化合物反应。 该方法包括两个步骤：第一步，其中形成多糖链上的自由基，第二步，其中所述自由基在不存在自由基源的情况下与不饱和化合物反应。
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公开(公告)号：US20120232263A1
公开(公告)日：2012-09-13
申请号：US13056085
申请日：2009-07-09
IPC分类号： C07H5/10
摘要： The present invention is directed to sulfated oligosaccharides having 4, 5 or 6 saccharidic units and wherein a glycosidic bond between two saccharide units is substituted by a C—C bond, and wherein the sulfation degree expressed as percentage of OH groups substituted by a OSO3− group is comprised between 50 and 100%. The sulfated oligosaccharides according to the invention are useful as a drug, in particular in the treatment of angiogenesis, metastasis, and inflammation.
摘要翻译： 本发明涉及具有4,5或6个糖苷单元的硫酸化低聚糖，并且其中两个糖单元之间的糖苷键被C-C键取代，并且其中所述硫酸化度表示为被OSO 3 - 组为50〜100％。 根据本发明的硫酸化寡糖可用作药物，特别是用于治疗血管生成，转移和炎症。
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3.发明申请MULTISTEP PROCESS FOR THE PHYSICAL DEPOLYMERIZATION OF HEPARIN AND PRODUCTS OBTAINED THEREFROM 有权HEPARIN及其获得的产品的物理多元化的多重方法公开(公告)号：US20070082869A1
公开(公告)日：2007-04-12
申请号：US11279699
申请日：2006-04-13
申请人： Luigi De Ambrosi , Sergio Gonella , Donata Bensi , Giangiacomo Torri , Antonella Bisio , Elena Vismara
发明人： Luigi De Ambrosi , Sergio Gonella , Donata Bensi , Giangiacomo Torri , Antonella Bisio , Elena Vismara
IPC分类号： A61K31/727 , C08B37/10
CPC分类号： C08B37/0078
摘要： The present invention is directed to a multistep process for the physical depolymerization of heparin wherein heparin is subjected to at least two γ-ray irradiations and wherein between two irradiation steps the depolymerised heparin is subjected to a separation step and only a fraction of the depolymerised heparin obtained from the first irradiation is subjected to the second irradiation step. It is also directed to heparin-derived oligosaccharide fractions obtainable by the process of the invention.
摘要翻译： 本发明涉及用于肝素物理解聚的多步法，其中肝素经受至少两次伽马射线照射，并且其中在两个照射步骤之间进行解聚的肝素进行分离步骤，并且仅将解聚的肝素的一部分 从第一次照射得到的第二照射工序。 还涉及通过本发明的方法获得的肝素衍生的寡糖级分。
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公开(公告)号：US08853387B2
公开(公告)日：2014-10-07
申请号：US13056085
申请日：2009-07-09
摘要： The present invention is directed to sulfated oligosaccharides having 4, 5 or 6 saccharidic units and wherein a glycosidic bond between two saccharide units is substituted by a C—C bond, and wherein the sulfation degree expressed as percentage of OH groups substituted by a OSO3− group is comprised between 50 and 100%. The sulfated oligosaccharides according to the invention are useful as a drug, in particular in the treatment of angiogenesis, metastasis, and inflammation.
摘要翻译： 本发明涉及具有4,5或6个糖苷单元的硫酸化低聚糖，并且其中两个糖单元之间的糖苷键被C-C键取代，并且其中所述硫酸化度表示为被OSO 3 - 组为50〜100％。 根据本发明的硫酸化寡糖可用作药物，特别是用于治疗血管生成，转移和炎症。
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公开(公告)号：US20050108832A1
公开(公告)日：2005-05-26
申请号：US10506619
申请日：2003-03-20
申请人： Giangiacomo Torri , Elena Vismara , Alberti Angelo , Bertini Sabrina , Ciardelli Gianluca , Gastaldi Giuseppe , Nesti Solitario
发明人： Giangiacomo Torri , Elena Vismara , Alberti Angelo , Bertini Sabrina , Ciardelli Gianluca , Gastaldi Giuseppe , Nesti Solitario
摘要： The invention concerns a method for functionalizing polysaccharides using a source or free radicals which forms stable radicals on the polysaccharides structure and wherein the formed radicals reacts with a functionalized unsaturated compound, characterized in that the method comprises two steps: a first step, wherein the free radical on the polysaccharide chain is formed, and a second step, wherein said radical reacts with the unsaturated compound in the absence of the radical source. The invention also relates to the functionalized polysaccharide obtained by this process.
摘要翻译： 本发明涉及使用在多糖结构上形成稳定自由基的源或自由基官能化多糖的方法，其中形成的基团与官能化的不饱和化合物反应，其特征在于该方法包括两个步骤：第一步，其中游离 形成多糖链上的自由基，第二步，其中所述自由基在不存在自由基源的情况下与不饱和化合物反应。 本发明还涉及通过该方法获得的官能化多糖。
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6.发明授权Multistep process for the physical depolymerization of heparin and products obtained therefrom 有权用于肝素物理解聚和由其获得的产物的多步法公开(公告)号：US07939512B2
公开(公告)日：2011-05-10
申请号：US11279699
申请日：2006-04-13
申请人： Luigi De Ambrosi , Sergio Gonella , Donata Bensi , Giangiacomo Torri , Antonella Bisio , Elena Vismara
发明人： Luigi De Ambrosi , Sergio Gonella , Donata Bensi , Giangiacomo Torri , Antonella Bisio , Elena Vismara
IPC分类号： A61K31/727 , C08B37/10
CPC分类号： C08B37/0078
摘要： The present invention is directed to a multistep process for the physical depolymerization of heparin wherein heparin is subjected to at least two γ-ray irradiations and wherein between two irradiation steps the depolymerised heparin is subjected to a separation step and only a fraction of the depolymerised heparin obtained from the first irradiation is subjected to the second irradiation step. It is also directed to heparin-derived oligosaccharide fractions obtainable by the process of the invention.
摘要翻译： 本发明涉及用于肝素物理解聚的多步骤方法，其中肝素进行至少两次γ射线照射，并且其中在两个照射步骤之间进行解聚的肝素进行分离步骤，并且仅将解聚的肝素的一部分 从第一次照射得到的第二照射工序。 还涉及通过本发明的方法获得的肝素衍生的寡糖级分。
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公开(公告)号：US08018231B2
公开(公告)日：2011-09-13
申请号：US12774335
申请日：2010-05-05
申请人： Ram Sasisekharan , Ganesh Venkataraman , Rahul Raman , Benito Casu , Giangiacomo Torri , Marco Guerrini
发明人： Ram Sasisekharan , Ganesh Venkataraman , Rahul Raman , Benito Casu , Giangiacomo Torri , Marco Guerrini
IPC分类号： G01V3/00
CPC分类号： G01N24/08 , Y10T436/143333
摘要： The invention relates to methods for analyzing polysaccharides. In particular, compositional and sequence information about the polysaccharides are derived. Some methods use NMR in conjunction with another experimental method, such as, capillary electrophoretic techniques for the analysis.
摘要翻译： 本发明涉及多糖分析方法。 特别地，衍生出关于多糖的组成和序列信息。 一些方法使用NMR结合另一种实验方法，例如用于分析的毛细管电泳技术。
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公开(公告)号：US20100216176A1
公开(公告)日：2010-08-26
申请号：US12774335
申请日：2010-05-05
申请人： RAM SASISEKHARAN , Ganesh Venkataraman , Rahul Raman , Benito Casu , Giangiacomo Torri , Marco Guerrini
发明人： RAM SASISEKHARAN , Ganesh Venkataraman , Rahul Raman , Benito Casu , Giangiacomo Torri , Marco Guerrini
CPC分类号： G01N24/08 , Y10T436/143333
摘要： The invention relates to methods for analyzing polysaccharides. In particular, compositional and sequence information about the polysaccharides are derived. Some methods use NMR in conjunction with another experimental method, such as, capillary electrophoretic techniques for the analysis.
摘要翻译： 本发明涉及多糖分析方法。 特别地，衍生出关于多糖的组成和序列信息。 一些方法使用NMR结合另一种实验方法，例如用于分析的毛细管电泳技术。
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9.发明授权Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect 有权部分脱硫的糖胺聚糖衍生物作为乙酰肝素酶抑制剂，具有抗血管生成活性，无抗凝作用公开(公告)号：US07781416B2
公开(公告)日：2010-08-24
申请号：US11314736
申请日：2005-12-22
申请人： Benito Casu , Giangiacomo Torri , Anna Maria Naggi , Giuseppe Giannini , Claudio Pisano , Sergio Penco
发明人： Benito Casu , Giangiacomo Torri , Anna Maria Naggi , Giuseppe Giannini , Claudio Pisano , Sergio Penco
IPC分类号： A61K31/727 , A61K31/737
CPC分类号： A61K31/727 , A61K31/737 , C07H5/04 , C08B37/0063
摘要： Partially desulphated glycosaminoglycan derivatives are described, particularly heparin, and more particularly a compound of formula (I) where the U, R and R1 groups have the meanings indicated in the description. These glycosaminoglycan derivatives have antiangiogenic and heparanase-inhibiting activity and are devoid of anticoagulant activity.
摘要翻译： 描述了部分脱硫的糖胺聚糖衍生物，特别是肝素，更具体地，其中U，R和R 1基团具有说明书中所示含义的式（I）化合物。 这些糖胺聚糖衍生物具有抗血管生成和乙酰肝素酶抑制活性，并且没有抗凝血活性。
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10.发明申请Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect 有权部分脱硫的糖胺聚糖衍生物作为乙酰肝素酶抑制剂，具有抗血管生成活性，无抗凝作用公开(公告)号：US20080051567A1
公开(公告)日：2008-02-28
申请号：US11882978
申请日：2007-08-08
申请人： Benito Casu , Giangiacomo Torri , Anna Naggi , Giuseppe Giannini , Claudio Pisano , Sergio Penco
发明人： Benito Casu , Giangiacomo Torri , Anna Naggi , Giuseppe Giannini , Claudio Pisano , Sergio Penco
CPC分类号： A61K31/727 , A61K31/737 , C07H5/04 , C08B37/0063
摘要： Partially desulphated glycosaminoglycan derivatives are described, particularly heparin, and more particularly a compound of formula (I) where the U, R and R1 groups have the meanings indicated in the description. These glycosaminoglycan derivatives have antiangiogenic and heparanase-inhibiting activity and are devoid of anticoagulant activity.
摘要翻译： 描述了部分脱硫的糖胺聚糖衍生物，特别是肝素，更具体地，其中U，R和R 1个基团具有说明书中指出的含义的式（I）化合物。 这些糖胺聚糖衍生物具有抗血管生成和乙酰肝素酶抑制活性，并且没有抗凝血活性。
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