公开(公告)号：US20240376110A1

公开(公告)日：2024-11-14

申请号：US18663952

申请日：2024-05-14

Applicant: Gilead Sciences, Inc.

Inventor： Megan K. Armstrong ,  Elbert Chin ,  Chienhung Chou ,  Laurent P. Debien ,  Yifan Deng ,  Joshua D. Farr ,  Pancham Lal Gupta ,  Chao-I Hung ,  Benjamin J. June ,  Prasenjit K. Mukherjee ,  Shaina V. Nguyen ,  Gregory T. Notte ,  Daniel Roa ,  Adam J. Schrier ,  Katie A. Spence ,  Zheng-Yu Yang

IPC: C07D487/04 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/5383 ,  A61K31/5386 ,  A61K31/55 ,  A61K45/06 ,  A61P35/00 ,  C07D487/14 ,  C07D519/00

Abstract: The present disclosure relates generally to compounds that inhibit PRMT5. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through inhibiting PRMT5. The disclosure further relates to the use of the compounds for the treatment of a disease or condition associated with chromosome 9p21 deletion, MTAP null, or any other MTAP deficiency. The disclosure further relates to the use of the compounds for the treatment of cancers.

公开(公告)号：US20240417411A1

公开(公告)日：2024-12-19

申请号：US18645671

申请日：2024-04-25

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Jennifer L. Cosman Ellis ,  Yifan Deng ,  Richard L. Mackman ,  Xianhuang Zeng

IPC: C07D519/00 ,  A61K31/53 ,  A61K45/06

Abstract: The present disclosure provides compounds of Formula I: Also provided are pharmaceutical compositions comprising the compounds of Formula I, as well as uses thereof.

公开(公告)号：US11780844B2

公开(公告)日：2023-10-10

申请号：US18117858

申请日：2023-03-06

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Daniel H. Byun ,  Yifan Deng ,  Jennifer L. Cosman Ellis ,  Rao V. Kalla ,  Richard L. Mackman ,  Dustin S. Siegel ,  Xianhuang Zeng

IPC: C07D487/04 ,  A61P31/14

CPC classification number: C07D487/04 ,  A61P31/14

Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and salts or pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

公开(公告)号：US20230279013A1

公开(公告)日：2023-09-07

申请号：US18117858

申请日：2023-03-06

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Daniel H. Byun ,  Yifan Deng ,  Jennifer L. Cosman Ellis ,  Rao V. Kalla ,  Richard L. Mackman ,  Dustin S. Siegel ,  Xianhuang Zeng

IPC: C07D487/04 ,  A61P31/14

CPC classification number: C07D487/04 ,  A61P31/14

Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and salts or pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

公开(公告)号：US20240246986A1

公开(公告)日：2024-07-25

申请号：US18601528

申请日：2024-03-11

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Daniel H. Byun ,  Yifan Deng ,  Jennifer L. Cosman Ellis ,  Rao V. Kalla ,  Richard L. Mackman ,  Dustin S. Siegel ,  Xianhuang Zeng

IPC: C07D487/04 ,  A61K9/00 ,  A61K45/06 ,  A61P31/14 ,  C07D519/00 ,  C07F9/6561

CPC classification number: C07D487/04 ,  A61K9/0053 ,  A61K45/06 ,  A61P31/14 ,  C07D519/00 ,  C07F9/6561

Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and salts or pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

公开(公告)号：US11851438B2

公开(公告)日：2023-12-26

申请号：US18117878

申请日：2023-03-06

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Daniel H. Byun ,  Yifan Deng ,  Jennifer L. Cosman Ellis ,  Rao V. Kalla ,  Richard L. Mackman ,  Dustin S. Siegel ,  Xianhuang Zeng

IPC: A61K31/341 ,  C07D307/20 ,  C07D487/04 ,  A61P31/14

CPC classification number: C07D487/04 ,  A61P31/14

Abstract: 1′-Cyano nucleoside analogs of Formula I and methods of using said compounds, singly or in combination with additional agents, and salts or pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

公开(公告)号：US20230295172A1

公开(公告)日：2023-09-21

申请号：US18115955

申请日：2023-03-01

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Daniel H. Byun ,  Yifan Deng ,  Jennifer L. Cosman Ellis ,  Rao V. Kalla ,  Richard L. Mackman ,  Dustin S. Siegel ,  Xianhuang Zeng

IPC: C07D487/04 ,  C07D519/00 ,  C07F9/6561 ,  A61P31/14

CPC classification number: C07D487/04 ,  C07D519/00 ,  C07F9/6561 ,  A61P31/14

Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and salts or pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

公开(公告)号：US20250154172A1

公开(公告)日：2025-05-15

申请号：US18932042

申请日：2024-10-30

Applicant: Gilead Sciences, Inc.

Inventor： Megan K. Armstrong ,  Elbert Chin ,  Chienhung Chou ,  Laurent P. Debien ,  Yifan Deng ,  Joshua D. Farr ,  Chao-I Hung ,  Benjamin J. June ,  Shaina V. Nguyen ,  Daniel Roa ,  Katie A. Spence ,  Zheng-Yu Yang

IPC: C07D519/00 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/439 ,  A61K31/473 ,  A61K31/4745 ,  A61K31/538 ,  A61P35/00 ,  C07D471/04 ,  C07D471/14 ,  C07D491/147

Abstract: The present disclosure relates generally to compounds that inhibit PRMT5. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through inhibiting PRMT5. The disclosure further relates to the use of the compounds for the treatment of a disease or condition associated with chromosome 9p21 deletion or MTAP null. The disclosure further relates to the use of the compounds for the treatment of cancers.

公开(公告)号：US12180217B2

公开(公告)日：2024-12-31

申请号：US18601528

申请日：2024-03-11

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Daniel H. Byun ,  Yifan Deng ,  Jennifer L. Cosman Ellis ,  Rao V. Kalla ,  Richard L Mackman ,  Dustin S. Siegel ,  Xianhuang Zeng

IPC: C07D487/04 ,  A61K9/00 ,  A61K45/06 ,  A61P31/14 ,  C07D519/00 ,  C07F9/6561

Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and salts or pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

公开(公告)号：US20240150359A1

公开(公告)日：2024-05-09

申请号：US18237152

申请日：2023-08-23

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Daniel H. Byun ,  Yifan Deng ,  Jennifer L. Cosman Ellis ,  Rao V. Kalla ,  Richard L. Mackman ,  Dustin S. Siegel ,  Xianhuang Zeng

IPC: C07D487/04 ,  A61K9/00 ,  A61K45/06 ,  A61P31/14 ,  C07D519/00 ,  C07F9/6561

CPC classification number: C07D487/04 ,  A61K9/0053 ,  A61K45/06 ,  A61P31/14 ,  C07D519/00 ,  C07F9/6561

Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and salts or pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.