-
1.发明授权Dipyrrole compounds, compositions, and methods for treating cancer or viral diseases 有权二吡咯化合物，组合物和治疗癌症或病毒性疾病的方法公开(公告)号：US08420693B2
公开(公告)日：2013-04-16
申请号：US11794488
申请日：2005-12-22
IPC分类号： A61K31/40
CPC分类号： C07D207/44 , A61K31/4025 , A61K31/4439 , A61K31/4709 , A61K31/506 , A61K31/5377 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention relates to novel Dipyrrole Compounds, compositions comprising a Dipyrrole Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Dipyrrole Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, treating or preventing a viral infection, or inhibiting the replication and/or infectivity of a virus. The invention also provides screening assays for compounds that can be used in combination with Dipyrrole Compounds for the treatment of cancer or neoplastic disease, inhibition of cancer cell growth, or treatment of viral infections.
摘要翻译： 本发明涉及新颖的二吡咯化合物，包含二吡咯化合物的组合物，以及可用于治疗或预防癌症或肿瘤性疾病的方法，包括施用二吡咯化合物。 本发明的化合物，组合物和方法也可用于抑制癌细胞或肿瘤细胞的生长，治疗或预防病毒感染，或抑制病毒的复制和/或感染性。 本发明还提供了可以与二吡咯化合物组合用于治疗癌症或肿瘤性疾病，抑制癌细胞生长或治疗病毒感染的化合物的筛选测定。
-
2.发明申请Dipyrrole Compounds, Compositions, and Methods For Treating Cancer or Viral Diseases 有权二吡咯化合物，组合物和治疗癌症或病毒疾病的方法公开(公告)号：US20080280896A1
公开(公告)日：2008-11-13
申请号：US11794488
申请日：2005-12-22
IPC分类号： A61K31/538 , C07D403/06 , A61K31/4025 , A61P35/00 , C12N5/06 , C07D413/14
CPC分类号： C07D207/44 , A61K31/4025 , A61K31/4439 , A61K31/4709 , A61K31/506 , A61K31/5377 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention relates to novel Dipyrrole Compounds, compositions comprising a Dipyrrole Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Dipyrrole Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, treating or preventing a viral infection, or inhibiting the replication and/or infectivity of a virus. The invention also provides screening assays for compounds that can be used in combination with Dipyrrole Compounds for the treatment of cancer or neoplastic disease, inhibition of cancer cell growth, or treatment of viral infections.
摘要翻译： 本发明涉及新颖的二吡咯化合物，包含二吡咯化合物的组合物，以及可用于治疗或预防癌症或肿瘤性疾病的方法，包括施用二吡咯化合物。 本发明的化合物，组合物和方法也可用于抑制癌细胞或肿瘤细胞的生长，治疗或预防病毒感染，或抑制病毒的复制和/或感染性。 本发明还提供了可以与二吡咯化合物组合用于治疗癌症或肿瘤性疾病，抑制癌细胞生长或治疗病毒感染的化合物的筛选测定。
-
公开(公告)号：US20080318903A1
公开(公告)日：2008-12-25
申请号：US12176161
申请日：2008-07-18
申请人： Giorgio Attardo , Kenza Dairi , Jean-Francois Lavallee , Elise Rioux , Sasmita Tripathy , Terrence W. Doyle , Xavuer Billot
发明人： Giorgio Attardo , Kenza Dairi , Jean-Francois Lavallee , Elise Rioux , Sasmita Tripathy , Terrence W. Doyle , Xavuer Billot
IPC分类号： A61K31/675 , A61P35/00 , A61K31/404
CPC分类号： C07D403/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D491/04 , C07F9/65583
摘要： The present invention relates to novel Triheterocyclic Compounds, compositions comprising a Triheterocyclic Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Triheterocyclic Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, treating or preventing a viral infection, or inhibiting the replication and/or infectivity of a virus.
摘要翻译： 本发明涉及新颖的三杂环化合物，包含三杂环化合物的组合物，以及可用于治疗或预防癌症或肿瘤性疾病的方法，包括给予三环杂环化合物。 本发明的化合物，组合物和方法也可用于抑制癌细胞或肿瘤细胞的生长，治疗或预防病毒感染，或抑制病毒的复制和/或感染性。
-
公开(公告)号：US07709477B2
公开(公告)日：2010-05-04
申请号：US12176161
申请日：2008-07-18
IPC分类号： A61K31/497 , A61K31/40 , A61K31/42 , A61K31/44 , A61K31/535 , C07D209/14
CPC分类号： C07D403/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D491/04 , C07F9/65583
摘要： The present invention relates to novel Triheterocyclic Compounds, compositions comprising a Triheterocyclic Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Triheterocyclic Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, treating or preventing a viral infection, or inhibiting the replication and/or infectivity of a virus.
摘要翻译： 本发明涉及新型三杂环化合物，包含三杂环化合物的组合物，以及可用于治疗或预防癌症或肿瘤疾病的方法，其包括施用三环杂环化合物。 本发明的化合物，组合物和方法也可用于抑制癌细胞或肿瘤细胞的生长，治疗或预防病毒感染，或抑制病毒的复制和/或感染性。
-
5.发明申请公开(公告)号：US20050014802A1
公开(公告)日：2005-01-20
申请号：US10857458
申请日：2004-05-28
申请人： Giorgio Attardo , Kenza Dairi , Jean-Francois Lavallee , Elise Rioux , Sasmita Tripathy , Terrence Doyle , Xavier Billot
发明人： Giorgio Attardo , Kenza Dairi , Jean-Francois Lavallee , Elise Rioux , Sasmita Tripathy , Terrence Doyle , Xavier Billot
IPC分类号： C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D491/04 , C07F9/6558 , A61K31/433 , A61K31/4196 , A61K31/4245 , C07D417/14
CPC分类号： C07D403/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D491/04 , C07F9/65583
摘要： The present invention relates to novel Triheterocyclic Compounds, compositions comprising a Triheterocyclic Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Triheterocyclic Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, treating or preventing a viral infection, or inhibiting the replication and/or infectivity of a virus.
-
公开(公告)号：US20080318902A1
公开(公告)日：2008-12-25
申请号：US12176123
申请日：2008-07-18
IPC分类号： C07D401/14 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61K31/404 , C07D413/14 , C07F9/572 , A61K31/675
CPC分类号： C07D403/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D491/04 , C07F9/65583
摘要： The present invention relates to novel Triheterocyclic Compounds, compositions comprising a Triheterocyclic Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Triheterocyclic Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, treating or preventing a viral infection, or inhibiting the replication and/or infectivity of a virus.
摘要翻译： 本发明涉及新颖的三杂环化合物，包含三杂环化合物的组合物，以及可用于治疗或预防癌症或肿瘤性疾病的方法，包括给予三环杂环化合物。 本发明的化合物，组合物和方法也可用于抑制癌细胞或肿瘤细胞的生长，治疗或预防病毒感染，或抑制病毒的复制和/或感染性。
-
公开(公告)号：US07745435B2
公开(公告)日：2010-06-29
申请号：US12176123
申请日：2008-07-18
IPC分类号： A61K31/535 , A61K31/44 , A61K31/42 , A61K31/40 , A61K31/497 , C07D209/14
摘要： The present invention relates to novel Triheterocyclic Compounds, compositions comprising a Triheterocyclic Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Triheterocyclic Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, treating or preventing a viral infection, or inhibiting the replication and/or infectivity of a virus.
-
8.发明授权Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases 有权三联环化合物，组合物和治疗癌症或病毒性疾病的方法公开(公告)号：US07425553B2
公开(公告)日：2008-09-16
申请号：US10857458
申请日：2004-05-28
IPC分类号： A61K31/535 , A61K31/44 , A61K31/42 , A61K31/40 , A61K31/497 , C07D209/14
CPC分类号： C07D403/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D491/04 , C07F9/65583
摘要： The present invention relates to novel Triheterocyclic Compounds, compositions comprising a Triheterocyclic Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Triheterocyclic Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, treating or preventing a viral infection, or inhibiting the replication and/or infectivity of a virus.
摘要翻译： 本发明涉及新颖的三杂环化合物，包含三杂环化合物的组合物，以及可用于治疗或预防癌症或肿瘤性疾病的方法，包括给予三环杂环化合物。 本发明的化合物，组合物和方法也可用于抑制癌细胞或肿瘤细胞的生长，治疗或预防病毒感染，或抑制病毒的复制和/或感染性。
-
9.发明授权7,8-fused 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof 有权7,8-稠合的4H-色烯和类似物作为胱天蛋白酶的激活剂和凋亡诱导剂及其用途公开(公告)号：US06858607B1
公开(公告)日：2005-02-22
申请号：US10146139
申请日：2002-05-16
申请人： Sui Xiong Cai , Lifen Xu , Richard Storer , Giorgio Attardo
发明人： Sui Xiong Cai , Lifen Xu , Richard Storer , Giorgio Attardo
IPC分类号： A61K31/4188 , A61K31/4196 , A61K31/424 , A61K31/429 , A61K31/436 , A61K31/4365 , A61K31/4375 , A61K31/4985 , A61K31/5365 , A61K33/24 , A61K45/06 , C07D491/04 , C07D498/04 , A61K31/437 , C07D471/04
CPC分类号： C07D491/04 , A61K31/4188 , A61K31/4196 , A61K31/424 , A61K31/429 , A61K31/436 , A61K31/4365 , A61K31/4375 , A61K31/4985 , A61K31/5365 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： The present invention is directed to substituted 4H-chromene and analogs thereof, represented by the general Formula I: or pharmaceutically acceptable salts or prodrugs thereof, wherein: wherein A, R1, R2, R5, X, Y, and Z, are defined herein and B is a fused thiazole, oxazole, 2-imino-imidazole, 2,1,3-thiadiazo-2-one, thiazol-2-one, oxazol-2-one, imidazol-2-thione, thiazol-2-thione, oxazol-2-thione, imidazoline, oxazoline, thiazoline, triazole, oxazine, oxazine-2,3-dione, or piperazine ring. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译： 本发明涉及由通式I或其药学上可接受的盐或前药代表的取代的4H-色烯及其类似物，其中：其中A，R 1，R 2，R 5，X，Y和Z在本文中定义 B为稠合噻唑，恶唑，2-亚氨基咪唑，2,1,3-噻二唑-2-酮，噻唑-2-酮，恶唑-2-酮，咪唑-2-硫酮，噻唑-2-硫酮 ，恶唑-2-硫酮，咪唑啉，恶唑啉，噻唑啉，三唑，恶嗪，恶嗪-2,3-二酮或哌嗪环。 本发明还涉及发现具有式I的化合物是胱天蛋白酶的活化剂和凋亡诱导剂。 因此，本发明的胱天蛋白酶和细胞凋亡诱导剂的激活剂可用于诱导异常细胞发生不受控制的生长和扩散的各种临床病症中的细胞死亡。
-
公开(公告)号：US08420638B2
公开(公告)日：2013-04-16
申请号：US13171891
申请日：2011-06-29
IPC分类号： A61K31/535 , A61K31/44 , A61K31/42 , A61K31/40 , A61K31/49 , C07D209/14
CPC分类号： C07D403/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D491/04 , C07F9/65583
摘要： The present invention relates to novel Triheterocyclic Compounds, compositions comprising a Triheterocyclic Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Triheterocyclic Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, treating or preventing a viral infection, or inhibiting the replication and/or infectivity of a virus.
摘要翻译： 本发明涉及新颖的三杂环化合物，包含三杂环化合物的组合物，以及可用于治疗或预防癌症或肿瘤性疾病的方法，包括给予三环杂环化合物。 本发明的化合物，组合物和方法也可用于抑制癌细胞或肿瘤细胞的生长，治疗或预防病毒感染，或抑制病毒的复制和/或感染性。
-
-
-
-
-
-
-
-
-
搜索结果
34 条记录 (耗时 0.027 秒)
