公开(公告)号：US20180085365A1

公开(公告)日：2018-03-29

申请号：US15811712

申请日：2017-11-14

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Michael Jonathan BURY ,  Linda N. CASILLAS ,  Adam Kenneth CHARNLEY ,  Pamela A. HAILE ,  Robert W. MARQUIS, JR. ,  John F. MEHLMANN ,  Joseph J. ROMANO ,  Robert R. SINGHAUS, JR. ,  Gren Z. WANG

IPC: A61K31/4709 ,  A61K31/4706

CPC classification number: A61K31/4709 ,  A61K31/4706 ,  C07D215/44 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3 and Z are as defined herein, and methods of making and using the same.

公开(公告)号：US20170128437A1

公开(公告)日：2017-05-11

申请号：US15413792

申请日：2017-01-24

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Michael Jonathan BURY ,  Linda N. CASILLAS ,  Adam Kenneth CHARNLEY ,  Pamela A. HAILE ,  Robert W. MARQUIS, JR. ,  John F. MEHLMANN ,  Joseph J. ROMANO ,  Robert R. SINGHAUS, JR. ,  Gren Z. WANG

IPC: A61K31/4709 ,  A61K31/4706

CPC classification number: A61K31/4709 ,  A61K31/4706 ,  C07D215/44 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3 and Z are as defined herein, and methods of making and using the same.

公开(公告)号：US20170152233A1

公开(公告)日：2017-06-01

申请号：US15431942

申请日：2017-02-14

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Michael Jonathan BURY ,  Linda N. CASILLAS ,  Adam K. CHARNLEY ,  Michael P. DEMARTINO ,  Xiaoyang DONG ,  Patrick M. EIDAM ,  Pamela A. HAILE ,  Robert W. MARQUIS, JR. ,  Joshi M. RAMANJULU ,  Joseph J. ROMANO ,  Ami Lakdawala SHAH ,  Robert R. SINGHAUS, JR. ,  Gren WANG

IPC: C07D239/94 ,  C07D403/12 ,  C07D417/14 ,  C07D417/12

CPC classification number: C07D239/94 ,  C07D403/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3, and Z are as defined herein, and methods of making and using the same.

公开(公告)号：US20160060222A1

公开(公告)日：2016-03-03

申请号：US14934395

申请日：2015-11-06

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Michael Jonathan BURY ,  Linda N. CASILLAS ,  Adam Kenneth CHARNLEY ,  Michael P. DeMARTINO ,  Xiaoyang DONG ,  Patrick EIDAM ,  Pamela A. HAILE ,  Philip Anthony HARRIS ,  Ami Lakdawala SHAH ,  Bryan W. KING ,  Robert W. MARQUIS, JR. ,  John F. MEHLMANN ,  Joseph J. ROMANO ,  Clark A. SEHON

IPC: C07D215/42 ,  C07D215/44 ,  C07D401/12 ,  C07D405/12 ,  C07D411/12 ,  C07D215/48 ,  C07D471/04 ,  C07D417/14 ,  C07D513/04 ,  C07D405/14 ,  C07D401/14 ,  C07D417/12 ,  C07D413/12

CPC classification number: C07D215/42 ,  A61K31/47 ,  C07D215/44 ,  C07D215/48 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D411/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D513/04

Abstract: Disclosed are quinoline compounds having the formula: wherein R1, R2 and A are as defined herein, and methods of making and using the same.