公开(公告)号：US20180085365A1

公开(公告)日：2018-03-29

申请号：US15811712

申请日：2017-11-14

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Michael Jonathan BURY ,  Linda N. CASILLAS ,  Adam Kenneth CHARNLEY ,  Pamela A. HAILE ,  Robert W. MARQUIS, JR. ,  John F. MEHLMANN ,  Joseph J. ROMANO ,  Robert R. SINGHAUS, JR. ,  Gren Z. WANG

IPC: A61K31/4709 ,  A61K31/4706

CPC classification number: A61K31/4709 ,  A61K31/4706 ,  C07D215/44 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3 and Z are as defined herein, and methods of making and using the same.

公开(公告)号：US20160060222A1

公开(公告)日：2016-03-03

申请号：US14934395

申请日：2015-11-06

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Michael Jonathan BURY ,  Linda N. CASILLAS ,  Adam Kenneth CHARNLEY ,  Michael P. DeMARTINO ,  Xiaoyang DONG ,  Patrick EIDAM ,  Pamela A. HAILE ,  Philip Anthony HARRIS ,  Ami Lakdawala SHAH ,  Bryan W. KING ,  Robert W. MARQUIS, JR. ,  John F. MEHLMANN ,  Joseph J. ROMANO ,  Clark A. SEHON

IPC: C07D215/42 ,  C07D215/44 ,  C07D401/12 ,  C07D405/12 ,  C07D411/12 ,  C07D215/48 ,  C07D471/04 ,  C07D417/14 ,  C07D513/04 ,  C07D405/14 ,  C07D401/14 ,  C07D417/12 ,  C07D413/12

CPC classification number: C07D215/42 ,  A61K31/47 ,  C07D215/44 ,  C07D215/48 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D411/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D513/04

Abstract: Disclosed are quinoline compounds having the formula: wherein R1, R2 and A are as defined herein, and methods of making and using the same.

公开(公告)号：US20210238172A1

公开(公告)日：2021-08-05

申请号：US16652780

申请日：2018-10-04

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Adam Kenneth CHARNLEY ,  Michael Gerard DARCY ,  Jason W. DODSON ,  Xiaoyang DONG ,  David FAVRE ,  Terry Vincent HUGHES ,  Jianxing KANG ,  Lara Kathryn LEISTER ,  Yuehu LI ,  Yiqian LIAN ,  John F. MEHLMANN ,  Neysa NEVINS ,  Joshi M. RAMANJULU ,  Joseph J. ROMANO ,  Gren Z. WANG ,  Guosen YE ,  Daohua ZHANG

IPC: C07D413/14

Abstract: The invention relates to combinations comprising a compound of the formula: or a salt thereof; and one or more additional pharmaceutically agents active against HIV, and methods of using the same.

公开(公告)号：US20170128437A1

公开(公告)日：2017-05-11

申请号：US15413792

申请日：2017-01-24

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Michael Jonathan BURY ,  Linda N. CASILLAS ,  Adam Kenneth CHARNLEY ,  Pamela A. HAILE ,  Robert W. MARQUIS, JR. ,  John F. MEHLMANN ,  Joseph J. ROMANO ,  Robert R. SINGHAUS, JR. ,  Gren Z. WANG

IPC: A61K31/4709 ,  A61K31/4706

CPC classification number: A61K31/4709 ,  A61K31/4706 ,  C07D215/44 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3 and Z are as defined herein, and methods of making and using the same.

公开(公告)号：US20230071675A1

公开(公告)日：2023-03-09

申请号：US17663749

申请日：2022-05-17

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Adam Kenneth CHARNLEY ,  Michael G DARCY ,  Jason W. DODSON ,  Xiaoyang DONG ,  Terry V. HUGHES ,  Jianxing KANG ,  Lara LEISTER ,  Yiqian LIAN ,  Yue LI ,  John F. MEHLMANN ,  Neysa NEVINS ,  Joshi M. RAMANJULU ,  Joseph J. ROMANO ,  Gren Z. WANG ,  Guosen YE ,  Daohua ZHANG

IPC: C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/22 ,  C07D493/10 ,  C07D498/18 ,  C07F9/6558

Abstract: Disclosed are compounds having the formula: wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.

公开(公告)号：US20180105514A1

公开(公告)日：2018-04-19

申请号：US15730664

申请日：2018-01-03

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： John F. MEHLMANN ,  Joseph J. ROMANO

IPC: C07D403/14

CPC classification number: C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/22 ,  C07D493/10 ,  C07D498/18 ,  C07F9/65583

Abstract: Disclosed are compounds having the formula: wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.

公开(公告)号：US20150361069A1

公开(公告)日：2015-12-17

申请号：US14762905

申请日：2014-02-19

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Linda N. CASILLAS ,  Adam Kenneth CHARNLEY ,  Xiaoyang DONG ,  Pamela A. HAILE ,  Michael P. DEMARTINO ,  John F. MEHLMANN

IPC: C07D403/12 ,  C07D405/14

CPC classification number: C07D403/12 ,  A61K9/2054 ,  A61K9/4866 ,  C07D405/14

Abstract: Disclosed are compounds that are inhibitors of RIP2 kinase and methods of making and using the same.

Abstract translation: 公开了作为RIP2激酶抑制剂的化合物及其制备和使用方法。