公开(公告)号：US20170008878A1

公开(公告)日：2017-01-12

申请号：US15271581

申请日：2016-09-21

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Deepak BANDYOPADHYAY ,  Patrick M. EIDAM ,  Peter J. GOUGH ,  Philip Anthony HARRIS ,  Jae U. JEONG ,  Jianxing KANG ,  Bryan Wayne KING ,  Ami LAKDAWALA SHAH ,  Lara Kathryn LEISTER ,  Robert W. MARQUIS, JR. ,  Attiq RAHMAN ,  Joshi M. RAMANJULU ,  Clark A. SEHON ,  Robert SINGHAUS, JR. ,  Daohua ZHANG

IPC: C07D403/12

CPC classification number: A61K31/553 ,  A61K31/55 ,  C07D223/08 ,  C07D267/14 ,  C07D281/10 ,  C07D403/12 ,  C07D403/14 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D487/04 ,  C07D498/04

Abstract: Disclosed are compounds having the formula: wherein X, Y, Z1, Z2, Z3, Z4, R5, RA, m, A. L, and B are as defined herein, and methods of making and using the same.

Abstract translation: 其中X，Y，Z 1，Z 2，Z 3，Z 4，R 5，RA，m，A L和B如本文所定义，以及制备和使用它们的方法。

公开(公告)号：US20200165205A1

公开(公告)日：2020-05-28

申请号：US16778206

申请日：2020-01-31

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Niall Andrew ANDERSON ,  Deepak BANDYOPADHYAY ,  Alain Claude-Marie DAUGAN ,  Frederic G. DONCHE ,  Patrick M. EIDAM ,  Nicolas Eric FAUCHER ,  Nicolas S. GEORGE ,  Philip Anthony HARRIS ,  Jae U. JEONG ,  Bryan W. KING ,  Clark A. SEHON ,  Gemma Victoria WHITE ,  David Duff WISNOSKI

IPC: C07D231/06 ,  C07D413/04 ,  C07D409/06 ,  C07D403/06 ,  A61K31/5377 ,  A61K31/506 ,  A61K31/4545 ,  A61K31/454 ,  A61K31/422 ,  A61K31/415 ,  A61P21/00 ,  C07D417/14 ,  C07D409/14 ,  C07D405/06 ,  C07D405/04 ,  C07D401/06 ,  C07D401/04 ,  C07D413/14 ,  C07D405/14 ,  C07D401/14 ,  C07D487/04 ,  C07D403/04

Abstract: Disclosed are compounds having the formula: wherein R1, R2, and R3 are as defined herein, and methods of making and using the same.

公开(公告)号：US20180134665A1

公开(公告)日：2018-05-17

申请号：US15575235

申请日：2016-05-19

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Niall Andrew ANDERSON ,  Deepak BANDYOPADHYAY ,  Alain Claude-Marie DAUGAN ,  Frederic G. DONCHE ,  Patrick M. EIDAM ,  Nicolas Eric FAUCHER ,  Nicolas S. GEORGE ,  Philip Anthony HARRIS ,  Jae U. JEONG ,  Bryan W. KING ,  Clark A. SEHON ,  Gemma Victoria WHITE ,  David Duff WISNOSKI

IPC: C07D231/06 ,  C07D401/14 ,  A61K31/506 ,  A61K31/4545 ,  C07D405/14 ,  A61K31/454 ,  A61K31/415 ,  C07D401/04 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D413/04 ,  A61K31/422 ,  C07D405/04 ,  C07D413/14 ,  A61K31/5377 ,  C07D417/14 ,  C07D409/14 ,  C07D409/06 ,  A61P21/00

CPC classification number: C07D231/06 ,  A61K31/415 ,  A61K31/422 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/5377 ,  A61P21/00 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04

Abstract: Disclosed are compounds having the formula (I): wherein R1, R2, and R3 are as defined herein, and methods of making and using the same.

公开(公告)号：US20170152233A1

公开(公告)日：2017-06-01

申请号：US15431942

申请日：2017-02-14

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Michael Jonathan BURY ,  Linda N. CASILLAS ,  Adam K. CHARNLEY ,  Michael P. DEMARTINO ,  Xiaoyang DONG ,  Patrick M. EIDAM ,  Pamela A. HAILE ,  Robert W. MARQUIS, JR. ,  Joshi M. RAMANJULU ,  Joseph J. ROMANO ,  Ami Lakdawala SHAH ,  Robert R. SINGHAUS, JR. ,  Gren WANG

IPC: C07D239/94 ,  C07D403/12 ,  C07D417/14 ,  C07D417/12

CPC classification number: C07D239/94 ,  C07D403/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3, and Z are as defined herein, and methods of making and using the same.

公开(公告)号：US20150353533A1

公开(公告)日：2015-12-10

申请号：US14763183

申请日：2014-02-14

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Deepak BANDYOPADHYAY ,  Patrick M. EIDAM ,  Peter J. GOUGH ,  Philip Anthony HARRIS ,  Jae U. JEONG ,  Jianxing KANG ,  Bryan Wayne KING ,  Ami LAKDAWALA SHAH ,  Lara Kathryn LEISTER ,  Robert W. MARQUIS, JR. ,  Attiq RAHMAN ,  Joshi M. RAMANJULU ,  Clark A. SEHON ,  Robert SINGHAUS, JR. ,  Daohua ZHANG

IPC: C07D413/12 ,  C07D403/12

CPC classification number: A61K31/553 ,  A61K31/55 ,  C07D223/08 ,  C07D267/14 ,  C07D281/10 ,  C07D403/12 ,  C07D403/14 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D487/04 ,  C07D498/04

Abstract: Disclosed are compounds having the formula: wherein X, Y, Z1, Z2, Z3, Z4, R5, RA, m, A, L, and B are as defined herein, and methods of making and using the same.

Abstract translation: 公开了具有下式的化合物：其中X，Y，Z1，Z2，Z3，Z4，R5，RA，m，A，L和B如本文所定义，以及制备和使用它们的方法。