公开(公告)号：US20150344472A1

公开(公告)日：2015-12-03

申请号：US14662156

申请日：2015-03-18

申请人： Global Blood Therapeutics, Inc. ,  Cytokinetics, Inc. ,  The Regents of the University of California

发明人： Brian Metcalf ,  Chihyuan Chuang ,  Jeffrey Warrington ,  Kumar Paulvannan ,  Matthew P. Jacobson ,  Lan Hua ,  Bradley Morgan

IPC分类号： C07D471/04 ,  C07D215/14 ,  C07D257/04 ,  C07D213/80 ,  C07D211/62 ,  C07D231/56 ,  C07D401/04

CPC分类号： A61K31/4985 ,  A61K31/192 ,  A61K31/235 ,  A61K31/41 ,  A61K31/416 ,  A61K31/437 ,  A61K31/4406 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/47 ,  C07C65/30 ,  C07C69/76 ,  C07D211/62 ,  C07D213/30 ,  C07D213/80 ,  C07D215/14 ,  C07D231/56 ,  C07D257/04 ,  C07D401/04 ,  C07D471/04 ,  C07D487/04

摘要： Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.

摘要翻译： 提供作为血红蛋白的变构调节剂的取代的苯甲醛及其衍生物，其制备方法和中间体，包含调节剂的药物组合物，及其用于治疗血红蛋白介导的疾病的方法以及将受益于组织氧合增加的病症。

公开(公告)号：US09012450B2

公开(公告)日：2015-04-21

申请号：US13730730

申请日：2012-12-28

申请人： Global Blood Therapeutics, Inc. ,  Cytokinetics, Inc. ,  The Regents of the University of California

发明人： Brian Metcalf ,  Chihyuan Chuang ,  Jeffrey Warrington ,  Kumar Paulvannan ,  Matthew P. Jacobson ,  Lan Hua ,  Bradley Morgan

IPC分类号： C07D487/04 ,  C07D471/04 ,  C07D213/80 ,  C07D401/14 ,  C07D401/12 ,  C07D213/69

CPC分类号： C07D401/12 ,  C07D213/65 ,  C07D213/68 ,  C07D213/69 ,  C07D213/80 ,  C07D401/14 ,  C07D405/14 ,  C07D413/12 ,  C07D471/04 ,  C07D487/04

摘要： Provided are substituted heteroaryl aldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.

摘要翻译： 提供作为血红蛋白的变构调节剂的取代的杂芳基醛及其衍生物，其制备方法和中间体，包含调节剂的药物组合物，及其用于治疗血红蛋白介导的疾病的方法以及将受益于组织氧合增加的病症。

公开(公告)号：US20130190315A1

公开(公告)日：2013-07-25

申请号：US13730674

申请日：2012-12-28

申请人： Global Blood Therapeutics, Inc. ,  Cytokinetics, Inc. ,  The Regents of the University of California

发明人： Brian Metcalf ,  Chihyuan Chuang ,  Jeffrey Warrington ,  Kumar Paulvannan ,  Matthew P. Jacobson ,  Lan Hua ,  Bradley Morgan

IPC分类号： C07D487/04 ,  C07D215/14 ,  C07D471/04

CPC分类号： A61K31/4985 ,  A61K31/192 ,  A61K31/235 ,  A61K31/41 ,  A61K31/416 ,  A61K31/437 ,  A61K31/4406 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/47 ,  C07C65/30 ,  C07C69/76 ,  C07D211/62 ,  C07D213/30 ,  C07D213/80 ,  C07D215/14 ,  C07D231/56 ,  C07D257/04 ,  C07D401/04 ,  C07D471/04 ,  C07D487/04

摘要： Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.

公开(公告)号：US20130190316A1

公开(公告)日：2013-07-25

申请号：US13730730

申请日：2012-12-28

申请人： Global Blood Therapeutics, Inc. ,  Cytokinetics, Inc. ,  The Regents of the University of California

发明人： Brian Metcalf ,  Chihyuan Chuang ,  Jeffrey Warrington ,  Kumar Paulvannan ,  Matthew P. Jacobson ,  Lan Hua ,  Bradley Morgan

IPC分类号： C07D487/04 ,  C07D471/04 ,  C07D213/80

CPC分类号： C07D401/12 ,  C07D213/65 ,  C07D213/68 ,  C07D213/69 ,  C07D213/80 ,  C07D401/14 ,  C07D405/14 ,  C07D413/12 ,  C07D471/04 ,  C07D487/04

摘要： Provided are substituted heteroaryl aldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.

公开(公告)号：US20210290619A1

公开(公告)日：2021-09-23

申请号：US17334213

申请日：2021-05-28

申请人： Global Blood Therapeutics, Inc. ,  The Regents of the University of California

发明人： Brian Metcalf ,  Chihyuan Chuang ,  Jeffrey Warrington ,  Matthew P. Jacobson

IPC分类号： A61K31/4985 ,  C07D213/80 ,  C07D231/56 ,  C07D401/04 ,  C07D257/04 ,  C07D211/62 ,  C07D213/30 ,  C07C69/76 ,  C07C65/30 ,  C07D215/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/192 ,  A61K31/235 ,  A61K31/41 ,  A61K31/416 ,  A61K31/437 ,  A61K31/4406 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/47

摘要： Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.

公开(公告)号：US20220125786A1

公开(公告)日：2022-04-28

申请号：US17571183

申请日：2022-01-07

申请人： Global Blood Therapeutics, Inc. ,  The Regents of the University of California

发明人： Brian Metcalf ,  Chihyuan Chuang ,  Jeffrey Warrington ,  Matthew P. Jacobson

IPC分类号： A61K31/4985 ,  C07D213/80 ,  C07D231/56 ,  C07D401/04 ,  C07D257/04 ,  C07D211/62 ,  C07D213/30 ,  C07C69/76 ,  C07C65/30 ,  C07D215/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/192 ,  A61K31/235 ,  A61K31/41 ,  A61K31/416 ,  A61K31/437 ,  A61K31/4406 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/47

摘要： Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.

公开(公告)号：US20230255963A1

公开(公告)日：2023-08-17

申请号：US18137210

申请日：2023-04-20

申请人： Global Blood Therapeutics, Inc. ,  The Regents of the University of California

发明人： Brian Metcalf ,  Chihyuan Chuang ,  Jeffrey Warrington ,  Matthew P. Jacobson

IPC分类号： A61K31/4985 ,  C07D213/80 ,  C07D231/56 ,  C07D401/04 ,  C07D257/04 ,  C07D211/62 ,  C07D213/30 ,  C07C69/76 ,  C07C65/30 ,  C07D215/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/192 ,  A61K31/235 ,  A61K31/41 ,  A61K31/416 ,  A61K31/437 ,  A61K31/4406 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/47

CPC分类号： A61K31/4985 ,  C07D213/80 ,  C07D231/56 ,  C07D401/04 ,  C07D257/04 ,  C07D211/62 ,  C07D213/30 ,  C07C69/76 ,  C07C65/30 ,  C07D215/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/192 ,  A61K31/235 ,  A61K31/41 ,  A61K31/416 ,  A61K31/437 ,  A61K31/4406 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/47

摘要： Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.

公开(公告)号：US20150344483A1

公开(公告)日：2015-12-03

申请号：US14662145

申请日：2015-03-18

申请人： Global Blood Therapeutics, Inc. ,  Cytokinetics, Inc. ,  The Regents of the University of Califorina

发明人： Brian Metcalf ,  Chihyuan Chuang ,  Jeffrey Warrington ,  Kumar Paulvannan ,  Matthew P. Jacobson ,  Lan Hua ,  Bradley Morgan

IPC分类号： C07D487/04 ,  C07D471/04 ,  C07D213/69 ,  C07D213/65 ,  C07D401/12 ,  C07D401/14 ,  C07D213/80 ,  C07D405/14 ,  C07D213/68 ,  C07D413/12

CPC分类号： C07D401/12 ,  C07D213/65 ,  C07D213/68 ,  C07D213/69 ,  C07D213/80 ,  C07D401/14 ,  C07D405/14 ,  C07D413/12 ,  C07D471/04 ,  C07D487/04

摘要： Provided are substituted heteroaryl aldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.

摘要翻译： 提供作为血红蛋白的变构调节剂的取代的杂芳基醛及其衍生物，其制备方法和中间体，包含调节剂的药物组合物，及其用于治疗血红蛋白介导的疾病的方法以及将受益于组织氧合增加的病症。

公开(公告)号：US20230063230A1

公开(公告)日：2023-03-02

申请号：US17431111

申请日：2020-02-19

申请人： The Regents of the University of California ,  ShangPharma Innovation Inc.

发明人： Pamela M. England ,  Matthew P. Jacobson ,  Richard Beresis

IPC分类号： C07D249/04 ,  C07D231/12 ,  C07D403/12 ,  C07F9/165 ,  C07D413/12 ,  C07D257/04 ,  C07C233/22 ,  C07C233/11 ,  C07D265/32 ,  C07C311/06 ,  C07C309/70 ,  C07C321/20 ,  C07C231/02 ,  C07D401/04 ,  C07D403/04 ,  C07F5/02 ,  C07D217/02 ,  C07C67/03 ,  C07C303/38 ,  C07C231/12 ,  C07D413/06 ,  C07D209/30 ,  C07C303/22 ,  C07C247/06 ,  C07C303/28 ,  C07F7/08 ,  C07D409/04

摘要： Described herein, inter alia, are Nurr1 receptor modulators and uses thereof. In an aspect is provided a method for treating a disease associated with dysregulation and/or degeneration of dopaminergic neurons in the central nervous system of a subject in need thereof, the method including administering to the subject in need thereof a therapeutically effective amount of a compound described herein.

公开(公告)号：US20230255934A1

公开(公告)日：2023-08-17

申请号：US17919376

申请日：2021-04-23

申请人： The Regents of the University of California

发明人： Pamela M. England ,  Matthew P. Jacobson

IPC分类号： A61K31/404

CPC分类号： A61K31/404

摘要： Described herein, inter alia, are Nurr1 receptor modulators and uses thereof.