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公开(公告)号:US20110287079A1
公开(公告)日:2011-11-24
申请号:US13022124
申请日:2011-02-07
申请人: Gonzalo Serafica , Constance Ace , Jessica Donlin , Junping Wang
发明人: Gonzalo Serafica , Constance Ace , Jessica Donlin , Junping Wang
CPC分类号: A61K9/70 , A61K35/12 , A61L27/20 , A61L27/3813 , A61L27/3817 , A61L27/3852 , A61L2430/06 , A61L2430/10 , A61L2430/16 , A61L2430/20 , A61L2430/24 , C12N5/0068 , C12N2533/78 , C08L1/02
摘要: Provided in one embodiment is an implantable support material for culturing cells, wherein at least some of the cells substantially maintain at least one of (i) phenotype and (ii) genotype thereof after being cultured on the support material.
摘要翻译: 在一个实施方案中提供了用于培养细胞的可植入支持材料,其中至少一些细胞在载体材料上培养后基本上保持(i)表型和(ii)基因型中的至少一种。
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公开(公告)号:US20100310623A1
公开(公告)日:2010-12-09
申请号:US12455778
申请日:2009-06-05
CPC分类号: A61F2/28 , A61F2002/30062 , A61F2002/30235 , A61F2002/30293 , A61F2002/3084 , A61F2210/0004 , A61F2230/0069 , A61F2230/0091 , A61F2310/00179 , A61L27/18 , A61L27/306 , A61L27/32 , A61L27/34 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2400/12 , A61L2430/02 , C08L67/04
摘要: An integrated scaffold for bone tissue engineering has a tubular outer shell and a spiral scaffold made of a porous sheet. The spiral scaffold is formed such that the porous sheet defines a series of spiral coils with gaps of controlled width between the coils to provide an open geometry for enhanced cell growth. The spiral scaffold resides within the bore of the shell and is integrated with the shell to fix the geometry of the spiral scaffold. Nanofibers may be deposited on the porous sheet to enhance cell penetration into the spiral scaffold. The spiral scaffold may have alternating layers of polymer and ceramic on the porous sheet that have been built up using a layer-by-layer method. The spiral scaffold may be seeded with cells by growing a cell sheet and placing the cell sheet on the porous sheet before it is rolled.
摘要翻译: 用于骨组织工程的综合支架具有管状外壳和由多孔片构成的螺旋支架。 形成螺旋支架,使得多孔片材限定一系列在线圈之间具有受控宽度间隙的螺旋线圈,以提供用于增强细胞生长的开放几何形状。 螺旋支架位于壳体的孔内,并与壳体整合以固定螺旋支架的几何形状。 纳米纤维可以沉积在多孔片上以增强细胞穿入螺旋支架。 螺旋支架可以在多孔片上具有聚合物和陶瓷的交替层,其已经使用逐层方法建立。 螺旋支架可以通过生长细胞片并将细胞片放置在多孔片材上之前将细胞接种在细胞上。
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