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1.发明申请Dual Drug Formulations For Implantable Medical Devices For Treatment of Vascular Diseases 审中-公开用于治疗血管疾病的可植入医疗器械的双重药物制剂公开(公告)号：US20090104240A1
公开(公告)日：2009-04-23
申请号：US11875723
申请日：2007-10-19
申请人： Gordon Stewart , Syed F.A. Hossainy , Benjamyn Serna , Mikael Trollsas , Jessica R. Desnoyer , Leslie Coleman , Gina Zhang , Maricela Kezis
发明人： Gordon Stewart , Syed F.A. Hossainy , Benjamyn Serna , Mikael Trollsas , Jessica R. Desnoyer , Leslie Coleman , Gina Zhang , Maricela Kezis
CPC分类号： A61K31/573 , A61F2250/0068 , A61K31/436 , A61K31/56 , A61L31/10 , A61L31/16 , A61L2300/222 , A61L2300/416 , A61L2300/45
摘要： The present invention relates to implantable medical devices coated with the polymer containing at least an olimus and a corticosteroid for the treatment of vascular diseases.
摘要翻译： 本发明涉及涂覆有至少含有极性的聚合物和用于治疗血管疾病的皮质类固醇的可植入医疗装置。
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2.发明申请POLY(ESTER AMIDES) FOR THE CONTROL OF AGENT-RELEASE FROM POLYMERIC COMPOSITIONS 有权POLY（ESTER AMIDES）用于控制聚合物组合物的发行公开(公告)号：US20090297583A1
公开(公告)日：2009-12-03
申请号：US12478693
申请日：2009-06-04
申请人： JESSICA R. DesNoyer , Stephen D. Pacetti , Lothar W. Kleiner , Syed F.A. Hossainy , Yung-Ming Chen , Gordon Stewart , Gina Zhang
发明人： JESSICA R. DesNoyer , Stephen D. Pacetti , Lothar W. Kleiner , Syed F.A. Hossainy , Yung-Ming Chen , Gordon Stewart , Gina Zhang
IPC分类号： A61K9/00 , A61K31/765 , A61P9/10
CPC分类号： A61L31/10 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/16 , A61L2300/416 , A61L2300/604 , C08L77/12
摘要： The present invention generally encompasses a medical article, such as a medical device or coating comprising an agent or combination of agents, wherein the agent is distributed throughout a polymeric matrix. The polymeric matrix comprises an agent and a poly(ester amide) having a design that was preselected to provide a predetermined release rate of the combination of agents from the medical article.
摘要翻译： 本发明通常包括医疗制品，例如包含试剂或试剂组合的医疗装置或涂层，其中所述试剂分布在整个聚合物基质中。 聚合物基质包含试剂和聚（酯酰胺），该聚（酯酰胺）具有预设以提供来自医药制品的试剂组合的预定释放速率的设计。
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公开(公告)号：US20120231049A1
公开(公告)日：2012-09-13
申请号：US13481515
申请日：2012-05-25
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L31/16 , A61L2300/608 , A61L2420/02
摘要： Methods are disclosed for controlling the morphology and the release-rate of active agent from a coating layer for medical devices comprising a polymer matrix and one or more active agents. The methods comprise exposing a wet or dry coating to a freeze-thaw cycle. The coating layer can be used for controlled delivery of an active agent or a combination of active agents.
摘要翻译： 公开了用于控制活性剂从包含聚合物基质和一种或多种活性剂的医疗装置的涂层的形态和释放速率的方法。 所述方法包括将湿或干涂层暴露于冻融循环。 涂层可用于控制递送活性剂或活性剂的组合。
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公开(公告)号：US20100055295A1
公开(公告)日：2010-03-04
申请号：US12616651
申请日：2009-11-11
申请人： Syed F.A. Hossainy , Gordon Stewart , Srinivasan Sridharan , Arkady Kokish , Klaus Kleine , Benjamyn Serna , Bjorn G. Svensson
发明人： Syed F.A. Hossainy , Gordon Stewart , Srinivasan Sridharan , Arkady Kokish , Klaus Kleine , Benjamyn Serna , Bjorn G. Svensson
CPC分类号： B05D1/32 , B05B12/20 , B05B13/0442 , B05D1/02 , Y10T428/13
摘要： A mask for masking a stent during a coating procedure may include a mask body that has a negative pattern or an approximate negative pattern of a stent pattern being masked by the mask body. An apparatus for selectively coating a predetermined portion of a medical article may include a dispenser of a coating composition, a mask, a device for creating a relative movement between the mask and the medical article.
摘要翻译： 用于在涂覆过程中遮蔽支架的掩模可以包括掩模体，其具有由掩模体遮蔽的支架图案的负图案或近似负图案。 用于选择性地涂覆医疗用品的预定部分的设备可以包括涂料组合物的分配器，掩模，用于在面罩和医疗制品之间产生相对运动的装置。
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5.发明申请公开(公告)号：US20090286761A1
公开(公告)日：2009-11-19
申请号：US12191209
申请日：2008-08-13
申请人： Jin Cheng , Stephen Dugan , Gordon Stewart , Gina Zhang , Nancy Kirsten , Paul Consigny , Christopher Feezor , Gene Park , Wouter Roorda , Syed F.A. Hossainy
发明人： Jin Cheng , Stephen Dugan , Gordon Stewart , Gina Zhang , Nancy Kirsten , Paul Consigny , Christopher Feezor , Gene Park , Wouter Roorda , Syed F.A. Hossainy
CPC分类号： A61L31/16 , A61F2/91 , A61F2250/0067 , A61F2250/0068 , A61K31/4745 , A61K31/56 , A61K31/573 , A61L31/10 , A61L31/148 , A61L2300/222 , A61L2300/416 , A61L2300/45 , A61K2300/00
摘要： A drug-delivery system is provided including at least 100 μg of everolimus and clobetasol, such that the ratio of everolimus to clobetasol is at least 10:1 (w/w) or the amount of everolimus by weight is at least 10 times more than clobetasol. The system can be a stent. Also provided a method of treating restenosis or vulnerable plaque of a blood vessel, the method includes locally administering to a patient a first drug selected from a group consisting of rapamycin (sirolimus), Biolimus A9, deforolimus, AP23572, tacrolimus, temsirolimus, pimecrolimus, zotarolimus (ABT-578), 40-O-(2-hydroxy)ethylrapamycin (everolimus), 40-O-(3-hydroxy)propylrapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethylrapamycin, 40-O-tetrazolylrapamycin and 40-epi-(N1-tetrazolyl)rapamycin, and locally administering to a patient a second drug consisting of clobetasol, wherein the minimum amount of the first drug that is locally administered is 100 μg, and wherein the ratio of the first drug to the second drug is, for example, 10:1 to 100:1 (w/w).
摘要翻译： 提供了一种药物递送系统，其包括至少100杯依维莫司和氯倍他索，使得依维莫司与氯倍他索的比例至少为10：1（w / w），依维莫司的重量比为至少10倍 氯倍他索 该系统可以是支架。 还提供了治疗血管的再狭窄或易损斑块的方法，所述方法包括向患者局部施用选自雷帕霉素（西罗莫司），Biolimus A9，deforolimus，AP23572，他克莫司，替西罗莫司，吡美莫司， 40-（2-羟基）乙基雷帕霉素（依维莫司），40-O-（3-羟基）丙基雷帕霉素，40-O- [2-（2-羟基）乙氧基]乙基雷帕霉素，40- O-四唑基雷帕霉素和40-表 - （N1-四唑基）雷帕霉素，并且对患者局部施用由氯倍他索组成的第二药物，其中局部施用的第一药物的最小量为100杯，其中 第二种药物的第一种药物例如为10：1〜100：1（w / w）。
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6.发明申请POLYMERS CONTAINING POLY(ESTER AMIDES) AND AGENTS FOR USE WITH MEDICAL ARTICLES AND METHODS OF FABRICATING THE SAME 有权含有多种（酯类）的聚合物和与医药品一起使用的药剂及其制备方法公开(公告)号：US20090274741A1
公开(公告)日：2009-11-05
申请号：US12504542
申请日：2009-07-16
申请人： Stephen D. Pacetti , Charles D. Claude , Thierry Glauser , Jessica R. DesNoyer , Syed F.A. Hossainy
发明人： Stephen D. Pacetti , Charles D. Claude , Thierry Glauser , Jessica R. DesNoyer , Syed F.A. Hossainy
IPC分类号： A61K31/56 , A61K31/727 , A61P41/00
摘要： Polymers containing poly(ester amides) and agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable substrate having a coating, and the coating contains a polymer comprising a polymeric product of a reaction comprising a polyol, a polycarboxylic acid, an amino acid and an agent.
摘要翻译： 公开了含有聚（酯酰胺）的聚合物和用于医疗制品的试剂及其制造方法。 医疗制品通常包括具有涂层的可植入基底，并且该涂层含有包含包含多元醇，多元羧酸，氨基酸和试剂的反应的聚合产物的聚合物。
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7.发明申请Coating Comprising A Poly(Ethylene Glycol)-Poly(Lactide-Glycolide-Caprolactone) Interpenetrating Network 审中-公开包含聚（乙二醇） - 聚（丙交酯 - 乙交酯 - 己内酯）互穿网络的涂料公开(公告)号：US20120121684A1
公开(公告)日：2012-05-17
申请号：US13356457
申请日：2012-01-23
IPC分类号： A61F2/82 , A61K31/337 , A61K31/565 , A61K38/44 , A61K31/4468 , A61P9/00 , A61K31/573 , A61K31/506 , A61K31/553 , A61P9/10 , A61P7/02 , A61P7/04 , A61K9/00 , A61K31/436
CPC分类号： A61L31/10 , Y10S623/926 , C08L71/02 , C08L67/04
摘要： Implantable medical devices are disclosed. The devices comprise a coating comprising an interpenetrating network or semi-interpenetrating network. The interpenetrating network or semi-interpenetrating network comprises poly(ethylene glycol) and an aliphatic polyester copolymer. A method of using the implantable device is also provided.
摘要翻译： 公开了可植入的医疗装置。 这些装置包括包含互穿网络或半互穿网络的涂层。 互穿网络或半互穿网络包括聚（乙二醇）和脂族聚酯共聚物。 还提供了一种使用可植入装置的方法。
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公开(公告)号：US20090041845A1
公开(公告)日：2009-02-12
申请号：US11891131
申请日：2007-08-08
申请人： Lothar Walter Kleiner , Jessica Renee DesNoyer , Bozena Zofia Maslanka , Mikael Trollsas , Syed F.A. Hossainy , Yiwen Tang , Thierry Glauser , Michael Ngo
发明人： Lothar Walter Kleiner , Jessica Renee DesNoyer , Bozena Zofia Maslanka , Mikael Trollsas , Syed F.A. Hossainy , Yiwen Tang , Thierry Glauser , Michael Ngo
IPC分类号： A61K9/00 , A61K31/436
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2420/06
摘要： Disclosed herein is a coating having a layer that includes a matrix phase and a dispersed phase substantially immiscible in the matrix phase and methods of using the same.
摘要翻译： 本文公开了一种涂层，其具有包括基质相和在基质相中基本上不混溶的分散相的层及其使用方法。
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公开(公告)号：US20110244017A1
公开(公告)日：2011-10-06
申请号：US12751989
申请日：2010-03-31
IPC分类号： A61F2/00 , A61K31/337 , A61K31/565 , A61K38/44 , A61K31/436 , A61K31/573 , A61K31/57 , A61K31/506 , A61K31/553 , A61K31/216 , A61P7/02 , A61P9/10 , A61K38/16 , B05D7/00
CPC分类号： A61L31/148 , A61L31/10 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2420/02 , A61L2420/08 , C08L67/04
摘要： The present invention provides an absorbable coating for an implantable device and the methods of making and using the same.
摘要翻译： 本发明提供了一种用于可植入装置的可吸收涂层及其制造和使用方法。
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10.发明申请Bioabsorbable Stent With Time Dependent Structure And Properties And Regio-Selective Degradation 有权生物可吸收支架与时间依赖的结构和性质和选择性降解公开(公告)号：US20110066225A1
公开(公告)日：2011-03-17
申请号：US12561971
申请日：2009-09-17
申请人： Mikael Trollsas , Dariush Davalian , Michael Huy Ngo , Hao-Ming Hsiao , Boris Anukhin , Syed F.A. Hossainy , David C. Gale
发明人： Mikael Trollsas , Dariush Davalian , Michael Huy Ngo , Hao-Ming Hsiao , Boris Anukhin , Syed F.A. Hossainy , David C. Gale
CPC分类号： A61F2/89 , A61F2/91 , A61F2/915 , A61F2002/828 , A61F2210/0004 , A61F2230/0054 , A61F2250/0036 , A61L31/06 , A61L31/10 , A61L31/148 , C08L67/04
摘要： A bioabsorbable polymeric stent with time dependent structure and properties and methods of treating a diseased blood vessel with the bioabsorable polymeric stent are disclosed. The structure and properties of the stent change with time and allow the vessel to be restored to a natural unstented state. The bioabsorbable stent loses mechanical integrity in a controlled manner due to modification of selected structural elements.
摘要翻译： 公开了具有时间依赖性结构的生物可吸收聚合物支架，以及用生物可吸收聚合物支架治疗患病血管的特性和方法。 支架的结构和性质随时间而变化，并允许血管恢复到自然不稳定状态。 由于选择的结构元件的修饰，生物可吸收的支架以受控的方式失去机械完整性。
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