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    Method for forming a medical device with polymer coated inner lumen
    1.
    发明授权
    Method for forming a medical device with polymer coated inner lumen 有权
    用聚合物涂覆的内腔形成医疗装置的方法

    公开(公告)号：US07112298B2

    公开(公告)日：2006-09-26

    申请号：US10264794

    申请日：2002-10-03

    申请人： Greg J. Kampa ,  Pu Zhou

    发明人： Greg J. Kampa ,  Pu Zhou

    IPC分类号： B29C41/10 ,  B29C41/14

    CPC分类号： A61L29/085 ,  A61L29/12

    摘要： A medical device, such as a catheter shaft, having an inner lumen defined by a layer of polymer coating, and a method for forming such a medical device. In some embodiments, the method generally includes the steps of applying a polymer coating to an elongated mandrel, and constructing the remainder of the catheter shaft body around the polymer coated mandrel. In some embodiments, the polymer coating layer is made from water dispersible polymer or water soluble polymer.

    摘要翻译： 具有由聚合物涂层层限定的内腔的医疗装置，例如导管轴，以及用于形成这种医疗装置的方法。 在一些实施方案中，该方法通常包括以下步骤：将聚合物涂层施加到细长心轴上，并且围绕聚合物涂覆的心轴构建导管轴体的其余部分。 在一些实施方案中，聚合物涂层由水分散性聚合物或水溶性聚合物制成。

    Catheter having increased curve performance through heat treatment
    2.
    发明授权
    Catheter having increased curve performance through heat treatment 有权
    导管通过热处理增加曲线性能

    公开(公告)号：US08197453B2

    公开(公告)日：2012-06-12

    申请号：US12955561

    申请日：2010-11-29

    申请人： Pu Zhou

    发明人： Pu Zhou

    IPC分类号： A61M5/00

    CPC分类号： B29C53/84 ,  A61M25/0009 ,  A61M25/0041 ,  A61M25/0045 ,  B29C53/083 ,  B29C71/02 ,  B29C2071/022 ,  B29L2031/7542

    摘要： The present invention includes catheters and catheter shafts having a curved portion, for example, a curved distal portion. The curved distal portion may be formed by subjecting the distal portion, which might include one or more polymeric segments or layers, to heat at or above the melt temperature thereof. Heating at or above the melt temperature may reduce residual stress and eliminate heat history.

    摘要翻译： 本发明包括具有弯曲部分的导管和导管轴，例如弯曲的远端部分。 弯曲的远端部分可以通过将可能包括一个或多个聚合物段或多个层的远端部分经受其熔融温度或其上的熔化温度而加热而形成。 在熔融温度以上加热可能会降低残余应力并消除热历史。

    Crossing guidewire
    6.
    发明授权
    Crossing guidewire 有权
    穿越导丝

    公开(公告)号：US08551020B2

    公开(公告)日：2013-10-08

    申请号：US11854954

    申请日：2007-09-13

    申请人： Hancun Chen ,  Horng-Ban Lin ,  Pu Zhou

    发明人： Hancun Chen ,  Horng-Ban Lin ,  Pu Zhou

    IPC分类号： A61M25/09

    CPC分类号： A61M25/09 ,  A61M2025/09091 ,  A61M2025/09141 ,  A61M2025/0915

    摘要： Medical devices and methods for manufacturing and using medical devices. An example medical device includes a core member, a tubular member coupled to the core member, and a tip member coupled to the tubular member. The tubular member may have a plurality of slots formed therein. The tip member may include a polymeric material. An intermediate member may be disposed between the tubular member and the core member that aids the bonding of the tip member thereto.

    摘要翻译： 用于制造和使用医疗器械的医疗设备和方法。 一个示例性的医疗装置包括芯构件，联接到芯构件的管状构件和联接到管状构件的尖端构件。 管状构件可以具有形成在其中的多个槽。 尖端构件可以包括聚合物材料。 中间构件可以设置在管状构件和芯构件之间，其有助于尖端构件与其接合。

    Unbalanced reinforcement members for medical device
    7.
    发明授权
    Unbalanced reinforcement members for medical device 有权
    医疗器械不平衡加强件

    公开(公告)号：US08377035B2

    公开(公告)日：2013-02-19

    申请号：US10346697

    申请日：2003-01-17

    申请人： Pu Zhou ,  Ling Wang

    发明人： Pu Zhou ,  Ling Wang

    IPC分类号： A61M25/00

    CPC分类号： A61M25/0043 ,  A61M25/0053

    摘要： A medical device shaft including an unbalanced braid reinforcement layer. The reinforcement layer may be an unbalanced braid by having a first set of strands and a second set of strands, the sets wound in opposing directions on a mandrel or on the device shaft. The first set and second set may have different numbers of strands, sizes of strands, or pitch, or combinations thereof. In some embodiments, the unbalanced braid increases contact area between the inner layer and the outer layer of the shaft without compromising the function of the braid. In other embodiments, the variations in strand size and number between the first set and the second set allows improved kink and torque performance in a reduced thickness braid layer. The improved shaft of the present invention may be incorporated into a wide variety of medical devices such as guide catheters, diagnostic catheters, balloon catheters, etc.

    摘要翻译： 一种包括不平衡编织层加强层的医疗装置轴。 加强层可以是不平衡的编织物，通过具有第一组股线和第二组股线，该组在心轴或装置轴上以相反的方向缠绕。 第一组和第二组可以具有不同数量的股线，股线的大小或间距，或其组合。 在一些实施例中，不平衡编织物增加轴的内层和外层之间的接触面积，而不损害编织物的功能。 在其他实施例中，第一组和第二组之间的股线尺寸和数量的变化允许在减小的厚度编织层中改善扭结和转矩性能。 本发明的改进的轴可以结合到各种医疗装置中，例如导向导管，诊断导管，球囊导管等。

    Guide-in-guide catheter system
    8.
    发明授权
    Guide-in-guide catheter system 有权
    导向导管系统

    公开(公告)号：US07569046B2

    公开(公告)日：2009-08-04

    申请号：US10026517

    申请日：2001-12-27

    申请人： Pu Zhou

    发明人： Pu Zhou

    IPC分类号： A61M25/00

    CPC分类号： A61M25/0054 ,  A61M25/0017

    摘要： A multiple catheter system is described. In one embodiment a medical catheter system includes a first catheter having an entrance orifice, an exit orifice, a channel connecting the entrance orifice and the exit orifice, and a wall surrounding the channel. In this embodiment the hardness of the wall surrounding the channel decreases in in hardness, increases in hardness and then decreases in hardness again, when considered from an initial reference point at the entrance orifice and traveling towards the exit orifice. Another medical catheter system includes a first catheter having an entrance orifice, an exit orifice, a channel linking the entrance orifice and the exit orifice, and a first wall surrounding the channel wherein the first wall has a bendable curve memory portion.

    摘要翻译： 描述多导管系统。 在一个实施例中，医疗导管系统包括具有入口孔，出口孔，连接入口孔和出口孔的通道以及围绕通道的壁的第一导管。 在该实施例中，当从入口孔处的初始参考点考虑并且朝向出口孔行进时，围绕通道的壁的硬度在硬度方面降低，硬度增加然后再次降低。 另一种医用导管系统包括具有入口孔，出口孔，连接入口孔和出口孔的通道的第一导管和围绕通道的第一壁，其中第一壁具有可弯曲曲线存储部分。

    Non-sticky coatings with therapeutic agents for medical devices
    9.
    发明申请
    Non-sticky coatings with therapeutic agents for medical devices 审中-公开
    用于医疗器械治疗剂的非粘性涂层

    公开(公告)号：US20070254003A1

    公开(公告)日：2007-11-01

    申请号：US11416488

    申请日：2006-05-01

    申请人： Pu Zhou

    发明人： Pu Zhou

    IPC分类号： A61K31/4745 ,  A61K31/337 ,  A61F2/02

    CPC分类号： A61L31/10 ,  A61L31/022 ,  A61L31/16 ,  A61L2300/608

    摘要： A stent for delivering a therapeutic agent to body tissue of a patient and a method of making such a medical device are disclosed. The invention relates generally to a medical device such as an intravascular stent that is useful for delivering a therapeutic agent to the body tissue of a patient, and the method for making such a device. More particularly, in one embodiment the invention is directed to a stent having a tubular sidewall comprising a plurality of struts, in which the inner and outer surfaces of the struts are coated with different coating compositions. In another embodiment, a first coating composition comprising a therapeutic agent and a first polymer is disposed on the outer surface of the strut, while the inner surface is free of any coating composition.

    摘要翻译： 公开了一种用于将治疗剂递送到患者的身体组织的支架和制造这种医疗装置的方法。 本发明一般涉及可用于将治疗剂递送到患者的身体组织的医疗装置，例如血管内支架，以及制造这种装置的方法。 更具体地，在一个实施例中，本发明涉及具有包括多个支柱的管状侧壁的支架，其中支柱的内表面和外表面涂覆有不同的涂层组合物。 在另一个实施方案中，包含治疗剂和第一聚合物的第一涂料组合物设置在支柱的外表面上，而内表面没有任何涂料组合物。

    Multi-layer and multi-section coils for guide wire
    10.
    发明授权
    Multi-layer and multi-section coils for guide wire 有权
    用于导丝的多层和多段线圈

    公开(公告)号：US07097624B2

    公开(公告)日：2006-08-29

    申请号：US10614473

    申请日：2003-07-07

    申请人： Jon T. Campion ,  Todd D. Eungard ,  Pu Zhou

    发明人： Jon T. Campion ,  Todd D. Eungard ,  Pu Zhou

    IPC分类号： A61B5/00 ,  A61M25/00

    CPC分类号： A61M25/09 ,  A61M2025/09083

    摘要： A guide wire having a coil disposed over the guide wire, wherein the coil is integrally formed of a single wire and has regions of differing properties over its length. Some wire embodiments have longitudinally alternating layer segments having differing properties including radiopacity, lubricity, hydrophilicity, hemo-compatibility, flexibility, malleability, stiffness, and shape memory properties. A coil may have numerous distinct property segments, while being formed from only a single wire and requiring only two points for affixation to the guide wire.

    摘要翻译： 一种具有设置在引导线上方的线圈的导丝，其中线圈由单根线整体形成，并且在其长度上具有不同性质的区域。 一些线实施例具有不同性质的纵向交替层段，包括不透射线性，润滑性，亲水性，血红素相容性，柔韧性，延展性，硬度和形状记忆性质。 线圈可以具有许多不同的属性段，而仅由单个线形成，并且仅需要两个点用于附着于导丝。