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    Apparatus and method for controlled removal of stenotic material from stents
    1.
    发明授权
    Apparatus and method for controlled removal of stenotic material from stents 失效
    从支架中控制切除狭窄材料的装置和方法

    公开(公告)号：US06319242B1

    公开(公告)日：2001-11-20

    申请号：US09260935

    申请日：1999-03-02

    申请人： Greg R. Patterson ,  Ronald G. Williams ,  James J. Leary

    发明人： Greg R. Patterson ,  Ronald G. Williams ,  James J. Leary

    IPC分类号： A61M3100

    CPC分类号： A61B17/3207 ,  A61B17/221 ,  A61B17/320725 ,  A61B2017/00026 ,  A61B2017/00119 ,  A61B2017/2212 ,  A61B2090/378 ,  A61B2217/005 ,  A61F2/82

    摘要： Apparatus and methods for treating in-stent restenosis are described for removing stenotic material from within previously stented regions of a patient's vasculature. The apparatus includes a catheter system having a stenotic material removal mechanism mounted on a distal portion of an elongated inner catheter. A sensing means, such as one or more sensing electrodes, are positioned on an outer surface of the apparatus. In addition, the apparatus optionally includes control means for diametrically expanding the stenotic material removal mechanism for effective recanalization of the stent. A coaxial outer catheter is provided for aspirating stenotic material which is removed from within the stent. In addition, embolic filter apparatus are described for collecting the stenotic material removed from within the stent. The methods comprise operating the stenotic material removal mechanism within a body vessel, typically a coronary artery or other artery, which has become restenosed or otherwise occluded following the initial stent placement, and sensing the proximity or contact between the stenotic material removal mechanism and the stent within the arterial wall so that the stenosis can be effectively recanalized without damaging the stent. The sensing means may be used to indicate an unsafe condition that might lead to stent damage, in response to which, the stenotic material removal mechanism may be manually or automatically deactivated. Alternatively or additionally, the sensing means may be used to indicate an appropriate endpoint for the stenotic material removal process.

    摘要翻译： 描述了用于治疗支架内再狭窄的装置和方法，用于从患者脉管系统的先前支架区域内移除狭窄材料。 该装置包括具有安装在细长内导管的远端部分上的狭窄材料去除机构的导管系统。 诸如一个或多个感测电极的感测装置位于装置的外表面上。 此外，该装置还可选择地包括用于直径地扩张狭窄材料去除机构以控制支架有效再通的控制装置。 提供同轴的外导管用于吸入从支架内移除的狭窄材料。 此外，描述了用于收集从支架内移除的狭窄材料的栓塞过滤装置。 所述方法包括在主体容器（通常是冠状动脉或其他动脉）中操作狭窄材料去除机构，所述冠状动脉或其它动脉在初始支架放置之后已经被再次闭合或者被封闭，并且感测狭窄材料移除机构和支架之间的接近或接触 在动脉壁内，使得狭窄可以有效再通，而不会损伤支架。 感测装置可以用于指示可能导致支架损伤的不安全状态，响应于此，可以手动或自动停用狭窄材料去除机构。 或者或另外，感测装置可以用于指示用于狭窄材料去除过程的适当端点。

    Vascular stent for reduction of restenosis
    2.
    发明授权
    Vascular stent for reduction of restenosis 失效
    用于减少再狭窄的血管支架

    公开(公告)号：US6165209A

    公开(公告)日：2000-12-26

    申请号：US209233

    申请日：1998-12-10

    申请人： Greg R. Patterson ,  David J. Kupiecki ,  Kathy M. Mah ,  Ronald G. Williams ,  James J. Leary

    发明人： Greg R. Patterson ,  David J. Kupiecki ,  Kathy M. Mah ,  Ronald G. Williams ,  James J. Leary

    IPC分类号： A61F2/90 ,  A61F2/06

    CPC分类号： A61F2/915 ,  A61F2/90 ,  A61F2/91 ,  A61F2/95 ,  A61F2002/91541 ,  A61F2002/9155 ,  A61F2002/91558 ,  A61F2210/0076 ,  A61F2220/005

    摘要： Apparatus and methods are provided for restoring and maintaining an open passage or lumen in a body conduit, such as a blood vessel, which has become stenosed or occluded. The apparatus includes a stent which is specially adapted for inhibiting restenosis within the stent after implantation in a body passage. In various embodiments, the apparatus also includes a catheter or other device for operating the stent to inhibit restenosis within the stented region of the body passage. The methods presented include implanting the stent within a body passage, typically a blood vessel such as a coronary artery, which has become stenosed or occluded, and operating the stent to inhibit ingrowth of stenotic material which would result in restenosis of the stented region. The stent may be operated manually to inhibit or remove ingrowth of stenotic material, for example by introducing a catheter which acts on the stent, or the stent may operate automatically to inhibit or remove ingrowth of stenotic material without manual intervention.

    摘要翻译： 提供了用于恢复和维持已经变得狭窄或闭塞的体导管（例如血管）中的开放通道或内腔的装置和方法。 该装置包括一种支架，其特别适用于在植入人体通道之后抑制支架内的再狭窄。 在各种实施例中，该装置还包括用于操作支架的导管或其他装置，以抑制身体通道的支架区域内的再狭窄。 所提出的方法包括将支架植入人体通道内，通常是已经变得狭窄或闭塞的冠状动脉血管如冠状动脉，以及操作支架以抑制狭窄材料的向内生长，这将导致支架区域的再狭窄。 可以手动操作支架以抑制或消除狭窄材料的向内生长，例如通过引入作用在支架上的导管，或者支架可以自动操作以抑制或消除狭窄材料的向内生长而无需手动干预。

    Apparatus and method for controlled removal of stenotic material from stents
    3.
    发明授权
    Apparatus and method for controlled removal of stenotic material from stents 失效
    从支架中控制切除狭窄材料的装置和方法

    公开(公告)号：US5941869A

    公开(公告)日：1999-08-24

    申请号：US857659

    申请日：1997-05-16

    申请人： Greg R. Patterson ,  G. Ronald Williams ,  James J. Leary

    发明人： Greg R. Patterson ,  G. Ronald Williams ,  James J. Leary

    IPC分类号： A61B17/00 ,  A61B17/22 ,  A61B17/32 ,  A61B19/00 ,  A61F2/82 ,  A61M1/00 ,  A61M31/00

    CPC分类号： A61B17/3207 ,  A61B17/320758 ,  A61B17/221 ,  A61B17/320725 ,  A61B2017/00026 ,  A61B2017/00119 ,  A61B2017/320012 ,  A61B2090/378 ,  A61B2217/005 ,  A61F2/82

    摘要： Apparatus and methods for treating in-stent restenosis are described for removing stenotic material from within previously stented regions of a patient's vasculature. The apparatus includes a catheter system having a stenotic material removal mechanism mounted on a distal portion of an elongated inner catheter. A sensing means, such as one or more sensing electrodes, are positioned on an outer surface of the apparatus. In addition, the apparatus optionally includes control means for diametrically expanding the stenotic material removal mechanism for effective recanalization of the stent. A coaxial outer catheter is provided for aspirating stenotic material which is removed from within the stent. In addition, embolic filter apparatus are described for collecting the stenotic material removed from within the stent. The methods comprise operating the stenotic material removal mechanism within a body vessel, typically a coronary artery or other artery, which has become restenosed or otherwise occluded following the initial stent placement, and sensing the proximity or contact between the stenotic material removal mechanism and the stent within the arterial wall so that the stenosis can be effectively recanalized without damaging the stent. The sensing means may be used to indicate an unsafe condition that might lead to stent damage, in response to which, the stenotic material removal mechanism may be manually or automatically deactivated.

    摘要翻译： 描述了用于治疗支架内再狭窄的装置和方法，用于从患者脉管系统的先前支架区域内移除狭窄材料。 该装置包括具有安装在细长内导管的远端部分上的狭窄材料去除机构的导管系统。 诸如一个或多个感测电极的感测装置位于装置的外表面上。 此外，该装置还可选择地包括用于直径地扩张狭窄材料去除机构以控制支架有效再通的控制装置。 提供同轴的外导管用于吸入从支架内移除的狭窄材料。 此外，描述了用于收集从支架内移除的狭窄材料的栓塞过滤装置。 所述方法包括在主体容器（通常是冠状动脉或其他动脉）中操作狭窄材料去除机构，所述冠状动脉或其它动脉在初始支架放置之后已经被再次闭合或者被封闭，并且感测狭窄材料移除机构和支架之间的接近或接触 在动脉壁内，使得狭窄可以有效再通，而不会损伤支架。 感测装置可以用于指示可能导致支架损伤的不安全状态，响应于此，可以手动或自动停用狭窄材料去除机构。

    Ultrasonic imaging catheter with guidewire channel
    7.
    发明授权
    Ultrasonic imaging catheter with guidewire channel 失效
    超声波成像导管带导丝通道

    公开(公告)号：US5024234A

    公开(公告)日：1991-06-18

    申请号：US422935

    申请日：1989-10-17

    申请人： James J. Leary ,  John R. McKenzie

    发明人： James J. Leary ,  John R. McKenzie

    IPC分类号： A61B8/12 ,  A61B17/22

    CPC分类号： A61B8/12 ,  A61B8/445 ,  A61B8/4461 ,  A61M25/09 ,  A61B2017/22078 ,  A61M2025/0183

    摘要： Intravascular catheters including both a flexible catheter body and a less flexible housing mounted at a distal end of the catheter body are provided with a flexible distal tip, preferably having a conical geometry. Guidewire channel or lumen is formed within the tip, and optionally additional guidewire lumens are formed in the housing or the distal end of the catheter body, or both. The catheters may thus be inserted and withdrawn over a guidewire without the need for the entire length of the catheter to pass over the guidewire.

    摘要翻译： 包括柔性导管主体和安装在导管主体的远端处的较小柔性壳体的血管内导管设置有柔性远侧末端，优选具有圆锥形几何形状。 导丝通道或管腔形成在尖端内，并且可选地在导管主体的外壳或远端形成额外的导丝管腔，或两者。 因此，导管可以在导线上插入和取出，而不需要导管的整个长度通过导线。