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公开(公告)号：US20110009960A1
公开(公告)日：2011-01-13
申请号：US12814037
申请日：2010-06-11
IPC分类号： A61F2/12
CPC分类号： A61F2/0063 , A61F2/0059 , A61F2/12 , A61F2210/0004 , A61F2220/0008 , A61L27/227 , A61L27/3604 , A61L27/3843 , A61L27/48 , A61L27/54 , A61L2300/25 , A61L2300/414 , A61L2430/04 , D01F4/02 , C08L89/00
摘要： Disclosed herein is an implantable prosthesis for breast augmentation or reconstruction procedures. The prosthesis comprises a biocompatible and biodegradable fabric structure comprising one or more individual yarns comprised of sericin-extracted native fibroin fibers, wherein the yarns are intertwined to produce the fabric structure. The fabric structure extends in at least a first dimension and has at least a first surface that is adapted to engage and support natural breast tissue and/or a prosthetic breast implant in a patient. Also disclosed are methods of supporting breast tissue or a breast implant in a patient by inserting the prosthesis between the skin of the patient and the breast tissue and/or implant within the patient.
摘要翻译： 本文公开了一种用于隆胸或重建手术的可植入假体。 假体包括生物相容性和可生物降解的织物结构，其包括由丝胶提取的天然丝心蛋白纤维组成的一个或多个单独纱线，其中纱线缠结以产生织物结构。 织物结构在至少第一维度上延伸并且具有至少第一表面，其适于接合和支撑患者中的天然乳房组织和/或假体乳房植入物。 还公开了通过将假体插入患者的皮肤和患者体内的乳房组织和/或植入物之间来支持患者的乳房组织或乳房植入物的方法。
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2.发明授权Knitted biodegradable silk fabric comprising yarn promoting ingrowth of cells and methods of making 有权针织生物降解丝织物，包括促进细胞向内生长的纱线和制造方法公开(公告)号：US08633027B2
公开(公告)日：2014-01-21
申请号：US13071380
申请日：2011-03-24
CPC分类号： A61K9/70 , A61F2/00 , A61F2/08 , A61K35/12 , A61K35/28 , A61K38/17 , A61L27/227 , A61L27/3608 , A61L27/3662 , A61L27/3804 , A61L27/3821 , A61L27/3834 , A61L27/386 , A61L27/3895 , A61L27/48 , A61L2430/10 , C07K14/43518 , C12N5/066 , C12N5/0663 , C12N2533/50 , Y10T428/249921 , Y10T428/298 , Y10T442/2566 , C08L89/00
摘要： Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.
摘要翻译： 丝被纯化以消除免疫原性成分（特别是丝胶蛋白），并且用于形成用于形成用于植入的组织支撑假体装置的织物。 织物可以携带官能团，药物和其他生物试剂。 应用包括疝修补，组织壁重建和器官支撑，如膀胱吊带。 丝纤维平行布置，并且任选地缠结（例如扭曲）以形成构造体; 可以在织物形成期间的任何点提取丝胶蛋白，留下具有优异拉伸强度和其它机械性能的丝素蛋白纤维构建体。
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3.发明授权Helically organized silk fibroin fiber bundles for matrices in tissue engineering 有权螺旋组织丝素蛋白纤维束用于组织工程中的基质公开(公告)号：US06902932B2
公开(公告)日：2005-06-07
申请号：US10008924
申请日：2001-11-16
IPC分类号： C12M1/00 , A61F2/08 , A61K35/12 , A61K38/17 , A61L27/00 , A61L27/22 , A61L27/38 , B32B27/04 , C12M3/00 , C12N5/00 , C12N5/02 , C12N5/071 , C12N5/10 , C12N5/06 , C12N5/08 , C12N11/08 , C12N11/04 , A61F2/00
CPC分类号： A61K9/70 , A61F2/00 , A61F2/08 , A61K35/12 , A61K35/28 , A61K38/17 , A61L27/227 , A61L27/3608 , A61L27/3662 , A61L27/3804 , A61L27/3821 , A61L27/3834 , A61L27/386 , A61L27/3895 , A61L27/48 , A61L2430/10 , C07K14/43518 , C12N5/066 , C12N5/0663 , C12N2533/50 , Y10T428/249921 , Y10T428/298 , Y10T442/2566 , C08L89/00
摘要： The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for implantation into a recipient in need thereof. The invention further provides the novel silk-fiber-based matrix which is seeded with pluripotent cells that proliferate and differentiate on the matrix to form a ligament or tendon ex vivo. Also disclosed is a bioengineered ligament comprising the silk-fiber-based matrix seeded with pluripotent cells that proliferate and differentiate on the matrix to form the ligament or tendon. A method for producing a ligament or tendon ex vivo comprising the novel silk-fiber-based matrix is also disclosed.
摘要翻译： 本发明提供了一种新颖的基于丝纤维的基质，其具有用于产生韧带或腱，特别是前交叉韧带的钢丝绳几何形状，用于植入有需要的受体中。 本发明进一步提供了新颖的丝纤维基质，该基质用多能细胞接种，其在基质上增殖和分化以离体形成韧带或肌腱。 还公开了一种生物工程化韧带，其包含用多能细胞接种的基于丝纤维的基质，其在基质上增殖和分化以形成韧带或腱。 还公开了一种用于生产包含新型丝纤维基质的离体的韧带或肌腱的方法。
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4.发明授权Methods for making biocompatible, implantable, substantially sericin free silk fabric 有权制造生物相容的，可植入的，基本上无丝蛋白的丝织物的方法公开(公告)号：US08685426B2
公开(公告)日：2014-04-01
申请号：US13456860
申请日：2012-04-26
CPC分类号： A61K9/70 , A61F2/00 , A61F2/08 , A61K35/12 , A61K35/28 , A61K38/17 , A61L27/227 , A61L27/3608 , A61L27/3662 , A61L27/3804 , A61L27/3821 , A61L27/3834 , A61L27/386 , A61L27/3895 , A61L27/48 , A61L2430/10 , C07K14/43518 , C12N5/066 , C12N5/0663 , C12N2533/50 , Y10T428/249921 , Y10T428/298 , Y10T442/2566 , C08L89/00
摘要： Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.
摘要翻译： 丝被纯化以消除免疫原性成分（特别是丝胶蛋白），并且用于形成用于形成用于植入的组织支撑假体装置的织物。 织物可以携带官能团，药物和其他生物试剂。 应用包括疝修补，组织壁重建和器官支撑，如膀胱吊带。 丝纤维平行布置，并且任选地缠结（例如扭曲）以形成构造体; 可以在织物形成期间的任何点提取丝胶蛋白，留下具有优异拉伸强度和其它机械性能的丝素蛋白纤维构建体。
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5.发明授权Method of forming an implantable knitted fabric comprising silk fibroin fibers 有权形成包含丝素蛋白纤维的可植入针织物的方法公开(公告)号：US08628791B2
公开(公告)日：2014-01-14
申请号：US13071396
申请日：2011-03-24
CPC分类号： A61K9/70 , A61F2/00 , A61F2/08 , A61K35/12 , A61K35/28 , A61K38/17 , A61L27/227 , A61L27/3608 , A61L27/3662 , A61L27/3804 , A61L27/3821 , A61L27/3834 , A61L27/386 , A61L27/3895 , A61L27/48 , A61L2430/10 , C07K14/43518 , C12N5/066 , C12N5/0663 , C12N2533/50 , Y10T428/249921 , Y10T428/298 , Y10T442/2566 , C08L89/00
摘要： Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.
摘要翻译： 丝被纯化以消除免疫原性成分（特别是丝胶蛋白），并且用于形成用于形成用于植入的组织支撑假体装置的织物。 织物可以携带官能团，药物和其他生物试剂。 应用包括疝修补，组织壁重建和器官支撑，如膀胱吊带。 丝纤维平行布置，并且任选地缠结（例如扭曲）以形成构造体; 可以在织物形成期间的任何点提取丝胶蛋白，留下具有优异拉伸强度和其它机械性能的丝素蛋白纤维构建体。
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公开(公告)号：US20110189773A1
公开(公告)日：2011-08-04
申请号：US13074282
申请日：2011-03-29
CPC分类号： A61K9/70 , A61F2/00 , A61F2/08 , A61K35/12 , A61K35/28 , A61K38/17 , A61L27/227 , A61L27/3608 , A61L27/3662 , A61L27/3804 , A61L27/3821 , A61L27/3834 , A61L27/386 , A61L27/3895 , A61L27/48 , A61L2430/10 , C07K14/43518 , C12N5/066 , C12N5/0663 , C12N2533/50 , Y10T428/249921 , Y10T428/298 , Y10T442/2566 , C08L89/00
摘要： The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for implantation into a recipient in need thereof. The invention further provides the novel silk-fiber-based matrix which is seeded with pluripotent cells that proliferate and differentiate on the matrix to form a ligament or tendon ex vivo. Also disclosed is a bioengineered ligament comprising the silk-fiber-based matrix seeded with pluripotent cells that proliferate and differentiate on the matrix to form the ligament or tendon. A method for producing a ligament or tendon ex vivo comprising the novel silk-fiber-based matrix is also disclosed.
摘要翻译： 本发明提供了一种新颖的基于丝纤维的基质，其具有用于产生韧带或腱，特别是前交叉韧带的钢丝绳几何形状，用于植入有需要的受体中。 本发明进一步提供了新颖的丝纤维基质，该基质用多能细胞接种，其在基质上增殖和分化以离体形成韧带或肌腱。 还公开了一种生物工程化韧带，其包含用多能细胞接种的基于丝纤维的基质，其在基质上增殖和分化以形成韧带或腱。 还公开了一种用于生产包含新型丝纤维基质的离体的韧带或肌腱的方法。
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公开(公告)号：US20120289981A1
公开(公告)日：2012-11-15
申请号：US13561911
申请日：2012-07-30
IPC分类号： A61B17/03
CPC分类号： A61K9/70 , A61F2/00 , A61F2/08 , A61K35/12 , A61K35/28 , A61K38/17 , A61L27/227 , A61L27/3608 , A61L27/3662 , A61L27/3804 , A61L27/3821 , A61L27/3834 , A61L27/386 , A61L27/3895 , A61L27/48 , A61L2430/10 , C07K14/43518 , C12N5/066 , C12N5/0663 , C12N2533/50 , Y10T428/249921 , Y10T428/298 , Y10T442/2566 , C08L89/00
摘要： Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.
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公开(公告)号：US20110171453A1
公开(公告)日：2011-07-14
申请号：US13071380
申请日：2011-03-24
CPC分类号： A61K9/70 , A61F2/00 , A61F2/08 , A61K35/12 , A61K35/28 , A61K38/17 , A61L27/227 , A61L27/3608 , A61L27/3662 , A61L27/3804 , A61L27/3821 , A61L27/3834 , A61L27/386 , A61L27/3895 , A61L27/48 , A61L2430/10 , C07K14/43518 , C12N5/066 , C12N5/0663 , C12N2533/50 , Y10T428/249921 , Y10T428/298 , Y10T442/2566 , C08L89/00
摘要： Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.
摘要翻译： 丝被纯化以消除免疫原性成分（特别是丝胶蛋白），并且用于形成用于形成用于植入的组织支撑假体装置的织物。 织物可以携带官能团，药物和其他生物试剂。 应用包括疝修补，组织壁重建和器官支撑，如膀胱吊带。 丝纤维平行布置，并且任选地缠结（例如扭曲）以形成构造体; 可以在织物形成期间的任何点提取丝胶蛋白，留下具有优异拉伸强度和其它机械性能的丝素蛋白纤维构建体。
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公开(公告)号：US09066884B2
公开(公告)日：2015-06-30
申请号：US13561949
申请日：2012-07-30
IPC分类号： A61F2/00 , A61F2/08 , A61K9/70 , A61K38/17 , A61L27/22 , A61L27/36 , A61L27/38 , A61L27/48 , C12N5/077 , C07K14/435 , A61K35/12
CPC分类号： A61K9/70 , A61F2/00 , A61F2/08 , A61K35/12 , A61K35/28 , A61K38/17 , A61L27/227 , A61L27/3608 , A61L27/3662 , A61L27/3804 , A61L27/3821 , A61L27/3834 , A61L27/386 , A61L27/3895 , A61L27/48 , A61L2430/10 , C07K14/43518 , C12N5/066 , C12N5/0663 , C12N2533/50 , Y10T428/249921 , Y10T428/298 , Y10T442/2566 , C08L89/00
摘要： Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.
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公开(公告)号：US20120296443A1
公开(公告)日：2012-11-22
申请号：US13561949
申请日：2012-07-30
IPC分类号： A61F2/02
CPC分类号： A61K9/70 , A61F2/00 , A61F2/08 , A61K35/12 , A61K35/28 , A61K38/17 , A61L27/227 , A61L27/3608 , A61L27/3662 , A61L27/3804 , A61L27/3821 , A61L27/3834 , A61L27/386 , A61L27/3895 , A61L27/48 , A61L2430/10 , C07K14/43518 , C12N5/066 , C12N5/0663 , C12N2533/50 , Y10T428/249921 , Y10T428/298 , Y10T442/2566 , C08L89/00
摘要： Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.
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