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公开(公告)号：US5714755A
公开(公告)日：1998-02-03
申请号：US609364
申请日：1996-03-01
CPC分类号： H01J49/424 , H01J49/429
摘要： An improved method of using an ion trap mass spectrometer is disclosed. According to the method an asymmetrical trapping field is applied to the trap. Preferably, the asymmetrical trapping field comprises a quadrupole field and a dipole field having the same frequency. In addition, higher order trapping field components, such as hexapole or octopole fields, may also be included, and the electrodes of the ion trap can be shaped to introduce such higher order field components. The effect of the asymmetrical trapping field of the present invention is to cause the center of the trapping field to be displaced from the mechanical center of the ion trap. A supplemental quadrupole field is then applied to the ion trap, the center of the supplemental quadrupole field being located at the mechanical center of the trap, i.e., it is displaced from the center of the trapping field. The supplement quadrupole field and the trapping field may be viewed as forming one combined field which acts upon the ions in the trap. The combined field is then scanned to cause ions of differing masses to be resonantly ejected from the ion trap in sequential mass order. Preferably, the combined field is scanned by scanning the voltage of the trapping field. Preferably, the supplemental field is set to have a frequency which is two-thirds of the trapping field frequency and is phase locked with the trapping field frequency.
摘要翻译： 公开了使用离子阱质谱仪的改进方法。 根据该方法，将不对称捕获场应用于陷阱。 优选地，不对称捕获场包括具有相同频率的四极场和偶极场。 此外，还可以包括诸如六极或八极场的较高阶捕获场分量，并且离子阱的电极可被成形为引入这种较高阶场分量。 本发明的不对称捕获场的作用是使捕集场的中心从离子阱的机械中心位移。 然后将补充的四极场施加到离子阱，补充四极场的中心位于阱的机械中心，即其从俘获场的中心位移。 补充四极场和俘获场可以被视为形成一个组合场，其作用在阱中的离子上。 然后扫描组合场，使不同质量的离子以顺序的质量顺序从离子阱共振地喷出。 优选地，通过扫描捕获场的电压来扫描组合场。 优选地，补充场被设置为具有捕获场频率的三分之二的频率并且与捕获场频率锁相。
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公开(公告)号：US07701123B2
公开(公告)日：2010-04-20
申请号：US11301588
申请日：2005-12-13
IPC分类号： H01J9/02
摘要： An electron source includes a first electrode, a second electrode, a thermionic element interposed between and electrically isolated from the first electrode and the second electrode, and a guard electrode interposed between and electrically isolated from the first electrode and the second electrode. The thermionic element and the guard electrode may be at substantially the same voltage. Another electron source includes a first electrode, a second electrode, a thermionic element interposed between and electrically isolated from the first electrode and the second electrode, and a thermal expansion component interposed between and electrically isolated from the first electrode and the second electrode. The thermal expansion component may be heated to cause expansion. The heating may be cycled to cause alternating expansion and contraction.
摘要翻译： 电子源包括插入在第一电极和第二电极之间并且与第一电极和第二电极电绝缘的第一电极，第二电极和热电离元件，以及插入在第一电极和第二电极之间并与之电隔离的保护电极。 热电离元件和保护电极可以处于基本上相同的电压。 另一电子源包括介于第一电极和第二电极之间并与之电隔离的第一电极，第二电极和热电离元件，以及介于第一电极和第二电极之间并与之电隔离的热膨胀组件。 热膨胀部件可能被加热以引起膨胀。 可以循环加热以引起交替的膨胀和收缩。
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3.发明授权
公开(公告)号：US5397894A
公开(公告)日：1995-03-14
申请号：US68453
申请日：1993-05-28
CPC分类号： H01J49/0009 , H01J49/4275
摘要： A method of using a quadrupole ion trap mass spectrometer for high resolution mass spectroscopy is disclosed. High resolution of a mass spectrum of a desired species is achieved by first using a slow scanning rate and by first ridding the trap of unwanted ions. Accurate mass calibration is achieved by using a reference compound of known mass and using a second supplemental AC dipole voltage to eject the reference ions at nearly the same time as the sample ions of interest are ejected from the trap. This eliminates the need to scan the trap between the masses of the sample and reference ions. Space charge in the trap is held constant, thereby eliminating a major source of mass axis instability, by using the results of one scan to control the ionization time during the next scan. Preferably, during ionization a broadband supplemental dipole voltage is applied to the ion trap to rid it of unwanted ions. During a portion of the ionization time the broadband signal is constructed to retain only sample ions in the ion trap, and during the remainder of the ionization time the broadband signal is constructed to retain both sample and reference ions in the ion trap. By adjusting the relative lengths of the two portions of the ionization time the total space charge in the ion trap can be held constant notwithstanding variations in sample ion concentration.
摘要翻译： 公开了一种使用四极离子阱质谱仪进行高分辨率质谱的方法。 通过首先使用慢扫描速率和首先清除不需要的离子的阱来实现所需物质的质谱的高分辨率。 通过使用已知质量的参考化合物和使用第二补充AC偶极子电压在与感兴趣的样品离子从捕集器中排出的几乎相同的时间喷射参考离子来实现精确的质量校准。 这消除了在样品质量和参比离子之间扫描陷阱的需要。 通过使用一次扫描的结果来控制下次扫描期间的电离时间，陷阱中的空间电荷保持恒定，从而消除了质量轴不稳定的主要来源。 优选地，在电离期间，将宽带补充偶极子电压施加到离子阱以将其除去不想要的离子。 在电离时间的一部分期间，构造宽带信号以仅将样品离子保留在离子阱中，并且在电离时间的剩余时间期间，构建宽带信号以将样品和参考离子保留在离子阱中。 通过调整电离时间的两个部分的相对长度，离子阱中的总空间电荷可以保持恒定，尽管样品离子浓度的变化。
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公开(公告)号：US07501623B2
公开(公告)日：2009-03-10
申请号：US11342485
申请日：2006-01-30
申请人： Roger Tong , Mingda Wang , Gregory J. Wells
发明人： Roger Tong , Mingda Wang , Gregory J. Wells
IPC分类号： H01J49/42
CPC分类号： H01J49/423 , H01J49/4225
摘要： An electrode for use in a device such as an ion trap has an axial length extending generally in the direction of a central axis from a first axial end to a second axial end, and an inside surface. The inside surface includes a surface profile that is uniform from the first axial end to the second axial end, or at least is uniform for a uniform section length along the axial direction. The electrode may include an elongated surface feature such as a groove that extends for at least the uniform section length. An aperture may communicate with the groove. The electrode may be axially segmented into regions. Gaps between the regions may be oriented at an angle relative to a plane orthogonal to the central axis. The electrode may be one of several electrodes arranged as an electrode structure coaxially disposed about an elongated interior space.
摘要翻译： 用于诸如离子阱的装置的电极具有从第一轴向端部到第二轴向端部以及内表面大致沿中心轴线的方向延伸的轴向长度。 内表面包括从第一轴向端到第二轴向端均匀的表面轮廓，或者至少沿着轴向方向具有均匀的截面长度是均匀的。 电极可以包括细长的表面特征，例如延伸至少均匀的截面长度的凹槽。 孔可以与凹槽连通。 电极可以轴向分段成区域。 区域之间的间隙可以相对于与中心轴线正交的平面成一定角度。 电极可以是布置成围绕细长内部空间同轴设置的电极结构的多个电极之一。
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5.发明授权
公开(公告)号：US5457315A
公开(公告)日：1995-10-10
申请号：US179844
申请日：1994-01-11
申请人： Gregory J. Wells , Mingda Wang
发明人： Gregory J. Wells , Mingda Wang
CPC分类号： H01J49/427 , H01J49/424
摘要： A power efficient selective mass range trap filling process in which the RF trapping voltage connected to the ring electrode is slowly modulated simultaneously with: (1) e-beam ionization bombardment and (2) application of a broadband supplemental waveform containing selected secular frequencies to the QIT end caps. The modulation permits the reduction of the number of frequency components required in the broadband supplemental waveform and permits elimination of absorption by ions of energy from more than one supplemental frequency component at any one time.
摘要翻译： 一种功率有效的选择性质量范围陷阱填充过程，其中连接到环形电极的RF捕获电压被同时缓慢调制：（1）电子束电离轰击和（2）将包含选定的长期频率的宽带补充波形应用于 QIT终端。 调制允许减少宽带补充波形中所需的频率分量的数量，并允许在任何一个时间消除来自多于一个补充频率分量的能量的离子的吸收。
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公开(公告)号：US5404011A
公开(公告)日：1995-04-04
申请号：US121844
申请日：1993-09-15
申请人： Gregory J. Wells , Mingda Wang
发明人： Gregory J. Wells , Mingda Wang
CPC分类号： H01J49/0081 , H01J49/0063 , H01J49/424
摘要： A method for using a QIT and for performing collisionally induced disassociation MS.sup.n experiments by scanning the trap potential sequentially so that the field first experiences a secular frequency of a selected parent ion and then the secular frequency of a CID produced daughter ion and then the secular frequency of a granddaughter ion and so on for each secular frequency of each progeny ion in descending mass order.
摘要翻译： 一种使用QIT并用于通过依次扫描陷阱电位来执行碰撞诱导的分离MSn实验的方法，使得场首先经历所选母体离子的长期频率，然后经历CID产生的子离子的长期频率，然后是长期频率 的孙女离子等等，对于每个子代的每个世代频率按降序排列。
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公开(公告)号：US20110059959A1
公开(公告)日：2011-03-10
申请号：US12949254
申请日：2010-11-18
申请人： Sankar Chatterjee , James L. Diebold , Derek Dunn , Robert L. Hudkins , Reddeppareddy Dandu , Gregory J. Wells , Allison L. Zulli
发明人： Sankar Chatterjee , James L. Diebold , Derek Dunn , Robert L. Hudkins , Reddeppareddy Dandu , Gregory J. Wells , Allison L. Zulli
IPC分类号： A61K31/5377 , C07D471/14 , A61K31/437 , C07D487/04 , A61K31/407 , C07D413/14 , C07D249/08 , A61K31/4196 , C07D401/12 , A61K31/454 , C07D403/14 , A61K31/496 , A61P25/00 , A61P25/16 , A61P25/28 , A61P9/10 , A61P3/00 , A61P19/02 , A61P17/06 , A61P35/00 , C12N5/02
CPC分类号： C07D491/14 , C07D471/14 , C07D487/04 , C07D491/04 , C07D495/04 , C07D519/00
摘要： The present invention is directed to novel multicyclic molecules that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of PARP, VEGFR2, and MLK3 enzymes, including, for example, neurodegenerative diseases, inflammation, ischemia, and cancer.
摘要翻译： 本发明涉及介导酶活性的新型多环分子。 特别地，所述化合物可有效治疗与PARP，VEGFR2和MLK3酶的活性相关的疾病或疾病状态，包括例如神经变性疾病，炎症，局部缺血和癌症。
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公开(公告)号：US07470900B2
公开(公告)日：2008-12-30
申请号：US11342895
申请日：2006-01-30
申请人： Gregory J. Wells
发明人： Gregory J. Wells
IPC分类号： H01J49/42
CPC分类号： H01J49/423 , H01J49/4255
摘要： An electrode structure for manipulating ions includes a main electrode and a compensation electrode. An outer surface of the main electrode includes a curved section that includes an apex. An aperture is generally disposed at the apex and extends along a radial center line from the outer surface through a thickness of the main electrode. The compensation electrode is disposed at the radial center line and at a tangent line tangent to the apex. Another electrode structure includes a plurality of main electrodes defining an interior space, and one or more compensation electrodes disposed in the interior space. RF signals may be applied to the main electrodes and to the compensation electrode.
摘要翻译： 用于操作离子的电极结构包括主电极和补偿电极。 主电极的外表面包括包括顶点的弯曲部分。 孔通常设置在顶点处并且沿着径向中心线从外表面延伸通过主电极的厚度。 补偿电极设置在径向中心线和与顶点相切的切线处。 另一电极结构包括限定内部空间的多个主电极和设置在内部空间中的一个或多个补偿电极。 RF信号可以施加到主电极和补偿电极。
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公开(公告)号：US5086254A
公开(公告)日：1992-02-04
申请号：US26934
申请日：1987-03-17
申请人： Gregory J. Wells
发明人： Gregory J. Wells
CPC分类号： G01N30/64 , G01N27/66 , G01N2030/642
摘要： A photoionization detector for detecting effluents from a gas chromatographic column has a microwave induced helium plasma as the photon source. Since the source plasma may be at atmospheric pressure and need not be sealed, energy loss due to transmission of photons through a window can be eliminated. Use of alternating electromagnetic fields instead of a direct current discharge obviates the problems of anode sputtering.
摘要翻译： 用于检测来自气相色谱柱的流出物的光电离检测器具有微波诱导的氦等离子体作为光子源。 由于源极等离子体可能处于大气压并且不需要密封，所以可以消除由于通过窗口传输光子而导致的能量损失。 使用交变电磁场代替直流放电消除了阳极溅射的问题。
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公开(公告)号：US4999162A
公开(公告)日：1991-03-12
申请号：US237266
申请日：1988-08-26
申请人： Gregory J. Wells , John R. Berg
发明人： Gregory J. Wells , John R. Berg
摘要： A flame detector comprising a ceramic flame jet for use in a high temperature gas chromatography system is disclosed. The interior volume of the flame jet is fabricated of a highly inert ceramic material so that sample eluting from the end of a gas chromatography column located within the interior volume of the flame jet does not contact any metallic surface en route to the flame. By avoiding sample contact with metallic surfaces, interferences which are prone to occur at high temperature, such as peak tailing, are avoided. In a further aspect the flame detector is treated with a silylating reagent to further passivate the surfaces which may affect the sample.
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