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177 条记录 (耗时 0.057 秒)

    5-amino-4-hydroxyhexanoic acid derivatives
    1.
    发明授权
    5-amino-4-hydroxyhexanoic acid derivatives 失效
    5-氨基-4-羟基己酸衍生物

    公开(公告)号：US5643878A

    公开(公告)日：1997-07-01

    申请号：US207646

    申请日：1994-03-08

    申请人： Guido Bold ,  Marc Lang ,  Alexander Fassler ,  Hans-Georg Capraro ,  Shripad Bhagwat ,  Peter Schneider ,  Peter van Hoogevest

    发明人： Guido Bold ,  Marc Lang ,  Alexander Fassler ,  Hans-Georg Capraro ,  Shripad Bhagwat ,  Peter Schneider ,  Peter van Hoogevest

    IPC分类号： A61K38/00 ,  C07K5/02 ,  C07K7/02 ,  A61K31/535 ,  C07P265/06

    CPC分类号： C07K5/0207 ,  C07K7/02 ,  A61K38/00

    摘要： Compounds of formula I ##STR1## or their hydroxy-protected derivatives, and compounds of formula I' ##STR2## wherein T is an acyl radical of formula Z ##STR3## wherein R.sup.z is unsubstituted or substituted hydrocarbyl wherein at least one carbon atom has been replaced by a hetero atom with the proviso that a hetero atom is not bonded directly to the carbonyl to which the radical R.sup.z is bonded, alkyl having two or more carbon atoms, lower alkenyl, lower alkynyl, aryl or unsubstituted or substituted amino, and wherein the radicals R.sub.1, B.sub.1, R.sub.2, R.sub.3, A.sub.1, A.sub.2 and NR.sub.4 R.sub.5 are as defined in the description, and precursors thereof, are described. The compounds have pharmaceutical activity, for example in the treatment of retroviral diseases, such as AIDS.

    摘要翻译： 式I化合物（I）或其羟基保护的衍生物和式I'化合物（I'）其中T是式Z的酰基（Z），其中R z是未取代的或 取代的烃基，其中至少一个碳原子已经被杂原子替代，条件是杂原子不直接键合到与基团Rz键合的羰基上，具有两个或更多个碳原子的烷基，低级链烯基，低级炔基 ，芳基或未取代或取代的氨基，并且其中基团R 1，B 1，R 2，R 3，A 1，A 2和NR 4 R 5如说明书中所定义，及其前体。 该化合物具有药物活性，例如用于治疗逆转录病毒疾病，例如艾滋病。

    Morpholin- and thiomorpholin-4-ylamides
    3.
    发明授权
    Morpholin- and thiomorpholin-4-ylamides 失效
    吗啉和硫代吗啉-4-基酰胺

    公开(公告)号：US5409927A

    公开(公告)日：1995-04-25

    申请号：US36748

    申请日：1993-03-25

    申请人： Guido Bold ,  Alexander Fassler ,  Marc Lang ,  Peter Schneider

    发明人： Guido Bold ,  Alexander Fassler ,  Marc Lang ,  Peter Schneider

    IPC分类号： A61K38/00 ,  A61P31/12 ,  A61P31/18 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K14/81 ,  A61K31/535 ,  C07D265/30

    CPC分类号： C07K5/0207 ,  A61K38/00

    摘要： There are described compounds of formula I ##STR1## wherein R.sub.1 is hydrogen or lower alkyl,R.sub.2 is hydrogen, lower alkyl, lower alkoxycarbonyl, phenyl- or naphthyl-lower alkoxycarbonyl, heterocyclylcarbonyl wherein heterocyclyl contains 5 or 6 ring atoms, is saturated and is bonded to the carbonyl group via a ring nitrogen atom and, in addition to the bonding nitrogen atom, contains as ring member one or more further hetero atoms selected from unsubstituted or C.sub.1 -C.sub.4 alkyl-substituted NH, O, S, S.dbd.O and SO.sub.2, or is lower alkanoyl, phenyl- or naphthyl-lower alkanoyl or lower alkanesulfonyl,R.sub.3 is morpholino, thiomorpholino, S-oxothiomorpholino or S,S-dioxothiomorpholino, the heterocyclyl radical in heterocyclylcarbonyl R.sub.2 having the same definition as R.sub.3 or having a definition other than R.sub.3, andR.sub.4 is hydrogen, hydroxy, C.sub.1 -C.sub.4 alkoxy, cyano, trifluoromethyl or fluorine, and salts of those compounds where salt-forming groups are present. These compounds are inhibitors of HIV-protease and are used in the treatment of ADS.

    摘要翻译： 描述了式I的化合物其中R 1是氢或低级烷基，R 2是氢，低级烷基，低级烷氧基羰基，苯基或萘基 - 低级烷氧基羰基，其中杂环基含有5或6个环原子的杂环基羰基是 并且通过环氮原子与羰基键合，并且除了键合氮原子外，还含有一个或多个选自未取代的或C 1 -C 4烷基取代的NH，O，S，S = O和SO 2，或者是低级烷酰基，苯基或萘基 - 低级烷酰基或低级链烷磺酰基，R3是吗啉代，硫代吗啉代，S-氧硫代吗啉代或S，S-二氧代硫代吗啉代，杂环基羰基R2中的杂环基与R3具有相同的定义或具有 除R3以外的定义，R4为氢，羟基，C1-C4烷氧基，氰基，三氟甲基或氟，以及存在成盐基团的那些化合物的盐。 这些化合物是HIV-蛋白酶的抑制剂，用于治疗ADS。

    Endovascular implant
    7.
    发明授权
    Endovascular implant 有权
    血管内植入

    公开(公告)号：US09375327B2

    公开(公告)日：2016-06-28

    申请号：US13153257

    申请日：2011-06-03

    申请人： Robert Giasolli ,  Peter Schneider

    发明人： Robert Giasolli ,  Peter Schneider

    IPC分类号： A61F2/848 ,  A61F2/88 ,  A61F2/89 ,  A61F2/91 ,  A61F2/958 ,  A61F2/82 ,  A61F2/966

    CPC分类号： A61F2/848 ,  A61F2/844 ,  A61F2/88 ,  A61F2/89 ,  A61F2/91 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/823 ,  A61F2002/825 ,  A61F2002/826 ,  A61F2002/8483 ,  A61F2002/8486 ,  A61F2002/91508 ,  A61F2002/91575 ,  A61F2002/91583 ,  A61F2002/9665 ,  A61F2220/0016 ,  A61F2220/0066

    摘要： A plaque tack can be used for holding plaque against blood vessel walls such as in treating atherosclerotic occlusive disease. The plaque tack can be formed as a thin, annular band for holding loose plaque under a spring or other expansion force against a blood vessel wall. Focal elevating elements and/or other features, such as anchors, can be used to exert a holding force on a plaque position while minimizing the amount of material surface area in contact with the plaque or blood vessel wall and reducing the potential of friction with the endoluminal surface. This approach offers clinicians the ability to perform a minimally invasive post-angioplasty treatment and produce a stent-like result without using a stent.

    摘要翻译： 斑块粘性可用于保持血管壁的斑块，例如治疗动脉粥样硬化闭塞性疾病。 斑块粘性可以形成为薄的环形带，用于在弹簧或其他膨胀力下抵靠血管壁保持松弛的斑块。 可以使用焦点升降元件和/或其他特征（例如锚固件）来在斑块位置施加保持力，同时最小化与斑块或血管壁接触的材料表面积的量，并减少与 腔内表面。 这种方法为临床医生提供了进行微创后血管成形术治疗的能力，并且在不使用支架的情况下产生支架样结果。

    Client-side statement cache
    8.
    发明授权
    Client-side statement cache 有权
    客户端语句缓存

    公开(公告)号：US08832143B2

    公开(公告)日：2014-09-09

    申请号：US12970243

    申请日：2010-12-16

    申请人： Ghazi Nourdine Benadjaoud ,  Peter Schneider

    发明人： Ghazi Nourdine Benadjaoud ,  Peter Schneider

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30864 ,  G06F17/30457 ,  G06Q30/02

    摘要： Embodiments include a method, apparatus and computer program product for providing instructions from a database client to a database server. The method includes the steps of receiving from a database a representation of a first instruction and an associated identifier. The representation of the first instruction and the associated identifier are stored in a cache. A second instruction, from an application, is matched with the representation of the first instruction stored in the cache. The associated identifier is retrieved from the cache based on the matching and the associated identifier is sent to the database server. Upon receipt of the associated identifier, the database server executes the first instruction.

    摘要翻译： 实施例包括用于从数据库客户机向数据库服务器提供指令的方法，装置和计算机程序产品。 该方法包括以下步骤：从数据库接收第一指令和相关标识符的表示。 第一指令和相关联的标识符的表示被存储在高速缓存中。 来自应用的第二条指令与存储在高速缓存中的第一条指令的表示相匹配。 基于匹配从高速缓存检索相关联的标识符，并将相关联的标识符发送到数据库服务器。 在接收到相关联的标识符之后，数据库服务器执行第一条指令。

    Method for wireless data transmission between a base station and a passive transponder, as well as a passive transponder
    9.
    发明授权
    Method for wireless data transmission between a base station and a passive transponder, as well as a passive transponder 有权
    基站与被动应答器之间的无线数据传输方法以及无源应答器

    公开(公告)号：US08699560B2

    公开(公告)日：2014-04-15

    申请号：US13434591

    申请日：2012-03-29

    申请人： Martin Berhorst ,  Alexander Kurz ,  Peter Schneider

    发明人： Martin Berhorst ,  Alexander Kurz ,  Peter Schneider

    IPC分类号： H03K9/06

    CPC分类号： H04B5/02 ,  H04B5/0068 ,  H04B5/0075

    摘要： A method for wireless data transmission, in, for example, RFID systems, between a base station and a passive transponder, as well as a passive transponder is provided by inductive coupling, as well as a passive transponder. It is possible to transmit data from the base station to the transponder by a first data transmission protocol type and by at least one second data transmission protocol type, whereby the first or the at least second data transmission protocol type is selected by writing a configuration register in the transponder.

    摘要翻译： 通过电感耦合以及无源应答器提供了在基站和无源应答器之间的无线数据传输方法，例如RFID系统以及无源应答器。 可以通过第一数据传输协议类型和至少一个第二数据传输协议类型从基站向应答器发送数据，由此通过写配置寄存器来选择第一或至少第二数据传输协议类型 在转发器中。