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    Alpha-helical mimetics
    2.
    发明授权
    Alpha-helical mimetics 有权
    α-螺旋模拟物

    公开(公告)号：US07956216B2

    公开(公告)日：2011-06-07

    申请号：US11642591

    申请日：2006-12-21

    申请人： Guillaume Laurent Lessene ,  Jonathan Baell

    发明人： Guillaume Laurent Lessene ,  Jonathan Baell

    IPC分类号： C07C229/00 ,  A61K31/195

    CPC分类号： C07C275/54 ,  C07C323/44 ,  C07C323/59 ,  C07C323/60 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/14 ,  C07D209/26 ,  C07D213/40 ,  C07D213/56 ,  C07D223/16 ,  C07D333/60

    摘要： Benzoyl urea derivatives that are alpha helical peptides mimetics that mimic BH3-only proteins, compositions containing them, their conjugation to cell-targeting-moieties, and their use in the regulation of cell death are disclosed. The benzoyl urea derivatives are capable of binding to and neutralizing pro-survival Bcl-2 proteins. Use of benzoyl urea derivatives in the treatment and/or prophylaxis of diseases or conditions associated with deregulation of cell death are also described.

    摘要翻译： 公开了作为模拟仅含BH3蛋白质的α螺旋肽模拟物，含有它们的组合物，其与细胞靶向部分的缀合及其在调节细胞死亡中的用途的苯甲酰脲衍生物。 苯甲酰脲衍生物能够结合并中和原始存活的Bcl-2蛋白。 还描述了苯甲酰脲衍生物在治疗和/或预防与细胞死亡调节相关的疾病或病症中的用途。

    Conjugates And Therapeutic Uses Thereof
    3.
    发明申请
    Conjugates And Therapeutic Uses Thereof 审中-公开
    共轭及其治疗用途

    公开(公告)号：US20070197430A1

    公开(公告)日：2007-08-23

    申请号：US11571160

    申请日：2005-06-24

    申请人： Jonathan Baell ,  Andrew Wei ,  Denis Scanlon

    发明人： Jonathan Baell ,  Andrew Wei ,  Denis Scanlon

    IPC分类号： A61K38/12 ,  C07K7/64

    CPC分类号： C07K16/2803 ,  A61K38/00 ,  A61K47/6811 ,  A61K47/6849 ,  A61K2039/505 ,  C07K1/02 ,  C07K1/04 ,  C07K7/06 ,  C07K7/08 ,  C07K7/54 ,  C07K7/56 ,  C07K7/60 ,  C07K14/4747 ,  C07K16/00 ,  C07K2319/00

    摘要： Conformationally constrained peptides that mimic BH3-only proteins and their conjugation to antibodies and other cell targeting compounds, compositions containing the conjugates and their use in the regulation of cell death are disclosed. The conformationally constrained peptides are capable of binding to and neutralising pro-survival Bcl-2 proteins. Processes for preparing the conformationally constrained peptides conjugated to antibodies and other cell targeting compounds and use of the conjugates in the treatment and/or prophylaxis of diseases or conditions associated with deregulation of cell death are also disclosed.

    摘要翻译： 公开了模拟仅含有BH3的蛋白质及其与抗体和其他细胞靶向化合物的缀合的构象约束肽，其含有缀合物的组合物及其在调节细胞死亡中的用途。 构象约束的肽能够结合和中和原始存活的Bcl-2蛋白。 还公开了制备与抗体和其它细胞靶向化合物缀合的构象约束肽的方法和缀合物用于治疗和/或预防与细胞死亡调节相关的疾病或病症的用途。

    Peptides and therapeutic uses thereof
    7.
    发明申请
    Peptides and therapeutic uses thereof 审中-公开
    肽及其治疗用途

    公开(公告)号：US20070032417A1

    公开(公告)日：2007-02-08

    申请号：US10540390

    申请日：2003-12-24

    申请人： Jonathan Baell

    发明人： Jonathan Baell

    IPC分类号： A61K38/17 ,  C07K14/47 ,  C07K7/08

    CPC分类号： C07K7/02 ,  A61K38/00 ,  C07K14/4747

    摘要： Conformationally constrained peptides that mimic BH3-only proteins, compositions containing them and their use in the regulation of cell death are disclosed. The conformationally constrained peptides are capable of binding to and neutralising pro-survival Bcl-2 proteins. Processes for preparing the conformationally constrained peptides and their use in the treatment and/or prophylaxis of diseases or conditions associated with deregulation of cell death are also disclosed.

    摘要翻译： 公开了模拟仅含有BH3的蛋白质的构象约束肽，含有它们的组合物及其在调节细胞死亡中的用途。 构象约束的肽能够结合和中和原始存活的Bcl-2蛋白。 还公开了制备构象约束肽及其在治疗和/或预防与细胞死亡调节相关的疾病或病症中的用途的方法。