公开(公告)号：US07366376B2

公开(公告)日：2008-04-29

申请号：US11241907

申请日：2005-09-29

申请人： Milen Shishkov ,  Brett Eugene Bouma ,  Guillermo J. Tearney

发明人： Milen Shishkov ,  Brett Eugene Bouma ,  Guillermo J. Tearney

IPC分类号： G02B6/32 ,  G02B6/12 ,  G02B6/26 ,  G02B6/42 ,  G02B6/44 ,  G02B6/02 ,  G02B6/028 ,  G02B6/032 ,  G02B6/036

CPC分类号： H04J14/0267 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/6852 ,  G02B6/2552 ,  G02B6/262 ,  G02B6/2856

摘要： Apparatus and method are provided for transmitting at least one electro-magnetic radiation is provided. In particular, at least one optical fiber having at least one end extending along a first axis may be provided. Further, a light transmissive optical arrangement may be provided in optical cooperation with the optical fiber. The optical arrangement may have a first surface having a portion that is perpendicular to a second axis, and a second surface which includes a curved portion. The first axis can be provided at a particular angle that is more than 0° and less than 90° with respect to the second axis.

摘要翻译： 提供了用于传送至少一个电磁辐射的装置和方法。 特别地，可以提供至少一个具有沿着第一轴线延伸的至少一个端部的光纤。 此外，可以与光纤光学协作地提供透光的光学装置。 光学装置可以具有第一表面，其具有垂直于第二轴线的部分，以及包括弯曲部分的第二表面。 第一轴可以相对于第二轴线以大于0°且小于90°的特定角度设置。

公开(公告)号：US09646377B2

公开(公告)日：2017-05-09

申请号：US14243508

申请日：2014-04-02

申请人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma ,  Benjamin J. Vakoc ,  Norman S. Nishioka

发明人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma ,  Benjamin J. Vakoc ,  Norman S. Nishioka

IPC分类号： A61B5/00 ,  G06T7/00

CPC分类号： A61B5/0084 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/6852 ,  A61B5/7271 ,  G06T7/0012 ,  G06T2207/10056 ,  G06T2207/10101

摘要： Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and/or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through. Another arrangement can be provided which is configured to measure a pressure within the at least one portion. The data may include a position and/or an orientation of the first arrangement with respect to the luminal or hollow sample.

公开(公告)号：USRE43875E1

公开(公告)日：2012-12-25

申请号：US12323228

申请日：2008-11-25

申请人： Milen Shishkov ,  Brett Eugene Bouma ,  Guillermo J. Tearney

发明人： Milen Shishkov ,  Brett Eugene Bouma ,  Guillermo J. Tearney

IPC分类号： G02B6/32 ,  G02B6/12 ,  G02B6/26 ,  G02B6/42 ,  G02B6/44 ,  G02B6/02 ,  G02B6/028 ,  G02B6/032 ,  G02B6/036

CPC分类号： H04J14/0267 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/6852 ,  G02B6/2552 ,  G02B6/262 ,  G02B6/2856

摘要： Apparatus and method are provided for transmitting at least one electro-magnetic radiation is provided. In particular, at least one optical fiber having at least one end extending along a first axis may be provided. Further, a light transmissive optical arrangement may be provided in optical cooperation with the optical fiber. The optical arrangement may have a first surface having a portion that is perpendicular to a second axis, and a second surface which includes a curved portion. The first axis can be provided at a particular angle that is more than 0° and less than 90° with respect to the second axis.

摘要翻译： 提供了用于传送至少一个电磁辐射的装置和方法。 特别地，可以提供至少一个具有沿着第一轴线延伸的至少一个端部的光纤。 此外，可以与光纤光学协作地提供透光的光学装置。 光学装置可以具有第一表面，其具有垂直于第二轴线的部分，以及包括弯曲部分的第二表面。 第一轴可以相对于第二轴线以大于0°且小于90°的特定角度设置。

公开(公告)号：US20120101374A1

公开(公告)日：2012-04-26

申请号：US13114845

申请日：2011-05-24

申请人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Hongki Yoo ,  Milen Shishkov ,  Joseph Gardecki ,  Roman Shubochkin ,  Theodore Morse ,  Farouc Amin Jaffer

发明人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Hongki Yoo ,  Milen Shishkov ,  Joseph Gardecki ,  Roman Shubochkin ,  Theodore Morse ,  Farouc Amin Jaffer

IPC分类号： A61B6/00

CPC分类号： A61B5/0084 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/6852 ,  G01B9/02029 ,  G01B9/0205 ,  G01B9/02091 ,  G01N21/4795 ,  G01N21/64 ,  G01N21/6456 ,  G01N21/65 ,  G01N2201/0866

摘要： Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.

摘要翻译： 描述了用于提供和/或利用光学频域成像（OFDI）和结构荧光以及例如使用OFDI技术和荧光成像技术的多模态成像的示例性系统，装置，方法，装置和计算机可访问介质。 例如，一种布置可以向解剖结构提供至少一个电磁辐射。 这种示例性布置可以包括至少一个光学芯和至少部分围绕光纤的至少一个包层。 光纤芯和包层之间的区域可以具有与光纤芯和包层的折射率不同的折射率。 该装置还可以包括至少一个被配置成经由光学核和包层传播辐射到解剖结构的装置。

公开(公告)号：US20110178398A1

公开(公告)日：2011-07-21

申请号：US12946725

申请日：2010-11-15

申请人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma

发明人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma

IPC分类号： A61B6/00

CPC分类号： A61B5/6852 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/02007

摘要： An apparatus, method and software arrangement for imaging a surface of a structure that is in contact with an opaque fluid is provided. The apparatus includes an article of manufacture (e.g., a housing), a fluid delivery arrangement and an imaging arrangement. The housing includes an aperture formed in the article of manufacture. The fluid delivery arrangement is configured to deliver a volume of substantially transparent fluid to the aperture formed in the housing. The imaging arrangement is configured to image the surface of the structure using an imaging modality after the volume of the transparent fluid is delivered to the aperture, wherein the imaging arrangement and/or the article of manufacture is translated along the surface of the structure while imaging the surface of the structure.

摘要翻译： 提供了一种用于对与不透明流体接触的结构的表面进行成像的装置，方法和软件装置。 该装置包括制品（例如，壳体），流体输送装置和成像装置。 壳体包括形成在制品中的孔。 流体输送装置构造成将一定体积的基本上透明的流体输送到形成在壳体中的孔。 成像装置被配置为在将透明流体的体积传送到孔之后使用成像模态来对结构的表面进行成像，其中成像装置和/或制品在结构的表面上被平移，而成像 结构的表面。

公开(公告)号：US10426548B2

公开(公告)日：2019-10-01

申请号：US11670043

申请日：2007-02-01

申请人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma ,  Benjamin J. Vakoc

发明人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma ,  Benjamin J. Vakoc

IPC分类号： A61B5/00 ,  A61B18/22 ,  A61B18/24 ,  A61B17/00 ,  A61B17/22

摘要： According one exemplary embodiment of the present invention, method and system can be provided for applying a laser radiation to at least one portion of a biological structure. For example, a beam of the laser radiation can be provided to the portion, whereas a cross-sectional area of the beam is at most about 1/10th of an entire area of the at least one portion. The beam can be applied to the portion (a) based on a predetermined pattern, (b) while modulating a wavelength of the laser radiation, and/or (c) while monitoring a depth of the application of the laser radiation.

公开(公告)号：US09254102B2

公开(公告)日：2016-02-09

申请号：US13226274

申请日：2011-09-06

申请人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma

发明人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma

IPC分类号： A61B6/00 ,  A61B5/00 ,  A61B5/02

CPC分类号： A61B5/6852 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/02007

摘要： An apparatus, method and software arrangement for imaging a surface of a structure that is in contact with an opaque fluid is provided. The apparatus includes an article of manufacture (e.g., a housing), a fluid delivery arrangement and an imaging arrangement. The housing includes an aperture formed in the article of manufacture. The fluid delivery arrangement is configured to deliver a volume of substantially transparent fluid to the aperture formed in the housing. The imaging arrangement is configured to image the surface of the structure using an imaging modality after the volume of the transparent fluid is delivered to the aperture, wherein the imaging arrangement and/or the article of manufacture is translated along the surface of the structure while imaging the surface of the structure.

公开(公告)号：US07382949B2

公开(公告)日：2008-06-03

申请号：US11266779

申请日：2005-11-02

申请人： Brett Eugene Bouma ,  Guillermo J. Tearney ,  Milen Shishkov

发明人： Brett Eugene Bouma ,  Guillermo J. Tearney ,  Milen Shishkov

IPC分类号： G02B6/26 ,  G02B6/42

CPC分类号： A61B1/3137 ,  A61B1/00183 ,  A61B1/042 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/6852 ,  A61B18/22 ,  A61B2017/00477 ,  G02B6/32 ,  G02B6/3604

摘要： A device, system and method for transmitting electro-magnetic radiation between at least two separate fibers (as well as for imaging a sample) are provided. For example, a first optical fiber and a second optical fiber may be provided, such that the first and/or second fibers is/are rotatable. At least one first optical arrangement may also be included which communicates with at least one end of the first optical fiber and/or the second optical fiber. Further, at least one second arrangement may be included which is configured to control a position of the optical arrangement to align longitudinal axes of the first and the second optical fibers at least at the ends thereof. In addition, at least one third arrangement can be provided which is adapted to rotate the first and/or second optical fibers at a rate that is greater than 40 revolutions per second. It is also possible to include at least one fourth arrangement which can be adapted for connecting the first optical fiber and/or the second optical fiber to a catheter arrangement, such that the fourth arrangement includes a protector provided at least at one end thereof, and wherein the protector is automatically removed upon a connection of the first and/or second optical fiber to the catheter arrangement via the fourth arrangement.

摘要翻译： 提供了用于在至少两个分离的光纤之间传送电磁辐射的装置，系统和方法（以及用于成像样品）。 例如，可以提供第一光纤和第二光纤，使得第一和/或第二光纤是可旋转的。 还可以包括与第一光纤和/或第二光纤的至少一端通信的至少一个第一光学布置。 此外，可以包括至少一个第二布置，其被配置成至少在其端部处控制光学装置的位置以对准第一和第二光纤的纵向轴线。 另外，可以提供至少一个第三布置，其适于以大于40转/秒的速率旋转第一和/或第二光纤。 还可以包括至少一个第四布置，其可以适于将第一光纤和/或第二光纤连接到导管装置，使得第四布置包括至少在其一端提供的保护器，以及 其中所述保护器在经由所述第四布置将所述第一和/或第二光纤连接到所述导管装置时自动移除。

公开(公告)号：US08208995B2

公开(公告)日：2012-06-26

申请号：US11211483

申请日：2005-08-24

申请人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma

发明人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma

IPC分类号： A61B6/00

CPC分类号： A61B5/6852 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/02007

摘要： An apparatus, method and software arrangement for imaging a surface of a structure that is in contact with an opaque fluid is provided. The apparatus includes an article of manufacture (e.g., a housing), a fluid delivery arrangement and an imaging arrangement. The housing includes an aperture formed in the article of manufacture. The fluid delivery arrangement is configured to deliver a volume of substantially transparent fluid to the aperture formed in the housing. The imaging arrangement is configured to image the surface of the structure using an imaging modality after the volume of the transparent fluid is delivered to the aperture, wherein the imaging arrangement and/or the article of manufacture is translated along the surface of the structure while imaging the surface of the structure.

摘要翻译： 提供了一种用于对与不透明流体接触的结构的表面进行成像的装置，方法和软件装置。 该装置包括制品（例如，壳体），流体输送装置和成像装置。 壳体包括形成在制品中的孔。 流体输送装置构造成将一定体积的基本上透明的流体输送到形成在壳体中的孔。 成像装置被配置为在将透明流体的体积传送到孔之后使用成像模态来对结构的表面进行成像，其中成像装置和/或制品在结构的表面上被平移，而成像 结构的表面。

公开(公告)号：US07538859B2

公开(公告)日：2009-05-26

申请号：US11670058

申请日：2007-02-01

申请人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma ,  Benjamin J. Vakoc

发明人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma ,  Benjamin J. Vakoc

IPC分类号： G01L1/24

CPC分类号： A61B5/0084 ,  A61B5/0066 ,  A61B5/6852 ,  A61B18/24 ,  A61B2017/00057 ,  A61B2017/22051 ,  A61B2018/207 ,  A61B2090/306 ,  A61B2090/3614

摘要： In one exemplary embodiment of the present invention, method and system can be provided for obtaining information associated with at least one portion of a sample. For example, a temperature change can be caused in the portion of the sample. At least one first electro-magnetic radiation can be forwarded to a section near or in the portion of the sample. A deformation of the section can be identified at a plurality of depths as a function of (i) a phase of at least one second electro-magnetic radiation provided from the section, and/or (ii) a rate of change of the phase and/or an amplitude of the second electro-magnetic radiation. In another exemplary embodiment of the present invention, method and system can be provided for controlling a temperature distribution in a sample. For example, an electro-magnetic radiation can be provided to the section in the sample at a particular wavelength. The temperature distribution can be controlled by modifying the particular wavelength of the electro-magnetic radiation when the electro-magnetic radiation is provided to the section.

摘要翻译： 在本发明的一个示例性实施例中，可以提供方法和系统来获得与样本的至少一部分相关联的信息。 例如，可以在样品的部分中引起温度变化。 至少一个第一电磁辐射可以转发到样品附近或部分的部分。 可以在多个深度处识别该部分的变形作为（i）从该部分提供的至少一个第二电磁辐射的相位和/或（ii）相的变化率和 /或第二电磁辐射的振幅。 在本发明的另一示例性实施例中，可以提供方法和系统来控制样品中的温度分布。 例如，可以以特定波长向样品中的部分提供电磁辐射。 当电磁辐射提供给该部分时，可以通过修改电磁辐射的特定波长来控制温度分布。