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公开(公告)号:US08334311B2
公开(公告)日:2012-12-18
申请号:US13190324
申请日:2011-07-25
申请人: Gunnar James Hanson , Qi Wei , Charles Caldwell , Ming Zhou , Lai Wang , Susan Harran
发明人: Gunnar James Hanson , Qi Wei , Charles Caldwell , Ming Zhou , Lai Wang , Susan Harran
IPC分类号: C07D291/00 , A61K31/42
CPC分类号: A61K31/42 , C07D498/22
摘要: Indoline compounds having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders are provided.
摘要翻译: 提供了具有抗有丝分裂活性的二氢吲哚化合物,其可用于治疗癌症和其它增殖性疾病。
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公开(公告)号:US20100035946A1
公开(公告)日:2010-02-11
申请号:US12432615
申请日:2009-04-29
申请人: Gunnar James Hanson , Qi Wei , Charles Caldwell , Ming Zhou , Lai Wang , Susan Harran
发明人: Gunnar James Hanson , Qi Wei , Charles Caldwell , Ming Zhou , Lai Wang , Susan Harran
IPC分类号: A61K31/424 , C07D498/22 , A61P35/00
CPC分类号: A61K31/42 , C07D498/22
摘要: Indoline compounds having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders are provided.
摘要翻译: 提供了具有抗有丝分裂活性的二氢吲哚化合物,其可用于治疗癌症和其它增殖性疾病。
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公开(公告)号:US20120264763A1
公开(公告)日:2012-10-18
申请号:US13190324
申请日:2011-07-25
申请人: Gunnar James Hanson , Qi Wei , Charles Caldwell , Ming Zhou , Lai Wang , Susan Harran
发明人: Gunnar James Hanson , Qi Wei , Charles Caldwell , Ming Zhou , Lai Wang , Susan Harran
IPC分类号: A61K31/424 , A61P35/00 , A61K31/496 , A61K31/4245 , C07D498/22 , C07K16/00
CPC分类号: A61K31/42 , C07D498/22
摘要: Indoline compounds having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders are provided.
摘要翻译: 提供了具有抗有丝分裂活性的二氢吲哚化合物,其可用于治疗癌症和其它增殖性疾病。
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公开(公告)号:US07989482B2
公开(公告)日:2011-08-02
申请号:US12432615
申请日:2009-04-29
申请人: Gunnar James Hanson , Qi Wei , Charles Caldwell , Ming Zhou , Lai Wang , Susan Harran
发明人: Gunnar James Hanson , Qi Wei , Charles Caldwell , Ming Zhou , Lai Wang , Susan Harran
IPC分类号: A61K31/42 , C07D291/00
CPC分类号: A61K31/42 , C07D498/22
摘要: Indoline compounds having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders are provided.
摘要翻译: 提供了具有抗有丝分裂活性的二氢吲哚化合物,其可用于治疗癌症和其它增殖性疾病。
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公开(公告)号:US20120270841A1
公开(公告)日:2012-10-25
申请号:US13447259
申请日:2012-04-15
申请人: Qi Wei , Ming Zhou , Xiaoming Xu , Charles Caldwell , Susan Harran , Lai Wang
发明人: Qi Wei , Ming Zhou , Xiaoming Xu , Charles Caldwell , Susan Harran , Lai Wang
IPC分类号: A61K31/424 , A61K31/4245 , C07D519/00 , A61K31/437 , C07D498/04 , C07D498/20 , C07F9/6561 , A61K31/675 , A61P35/00 , C07D498/22 , A61K31/427
CPC分类号: C07D498/06 , C07D491/04 , C07D498/08 , C07D498/20 , C07D498/22 , C07D519/00 , C07F9/6561
摘要: Diazonamide analogs having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders, and related pharmaceutical compositions are provided.
摘要翻译: 提供了具有抗有丝分裂活性的二氮嗪类似物,其可用于治疗癌症和其它增殖性疾病,以及相关的药物组合物。
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公开(公告)号:US08592469B2
公开(公告)日:2013-11-26
申请号:US13447259
申请日:2012-04-15
申请人: Qi Wei , Ming Zhou , Xiaoming Xu , Charles Caldwell , Susan Harran , Lai Wang
发明人: Qi Wei , Ming Zhou , Xiaoming Xu , Charles Caldwell , Susan Harran , Lai Wang
CPC分类号: C07D498/06 , C07D491/04 , C07D498/08 , C07D498/20 , C07D498/22 , C07D519/00 , C07F9/6561
摘要: Diazonamide analogs having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders, and related pharmaceutical compositions are provided.
摘要翻译: 提供了具有抗有丝分裂活性的二氮嗪类似物,其可用于治疗癌症和其它增殖性疾病,以及相关的药物组合物。
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公开(公告)号:US08551955B2
公开(公告)日:2013-10-08
申请号:US12914840
申请日:2010-10-28
申请人: Haizhou Sun , Xiaoming Xu , Ming Zhou , Susan Harran , Gunnar James Hanson , Lai Wang
发明人: Haizhou Sun , Xiaoming Xu , Ming Zhou , Susan Harran , Gunnar James Hanson , Lai Wang
CPC分类号: A61K38/08 , A61K38/00 , A61K38/06 , A61K38/191 , C07D207/16 , C07D401/14 , C07D403/14 , C07D413/14 , C07K5/06026 , C07K5/0806 , C07K7/02 , C07K14/4747 , Y02A50/401 , Y02A50/411 , Y02A50/414
摘要: The invention provides small molecule mimics of the Smac peptide that are dimers or dimer-like compounds having two binding domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.
摘要翻译: 本发明提供Smac肽的小分子模拟物,其是具有通过连接体连接的两个结合结构域的二聚体或二聚体样化合物。 这些化合物可用于促进凋亡。 本发明包括包含这些化合物的药物组合物和使用它们来治疗包括癌症和自身免疫疾病的病症的方法。
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公开(公告)号:US20110195043A1
公开(公告)日:2011-08-11
申请号:US12914840
申请日:2010-10-28
申请人: Haizhou Sun , Xiaoming Xu , Ming Zhou , Susan Harran , Gunnar James Hanson , Lai Wang
发明人: Haizhou Sun , Xiaoming Xu , Ming Zhou , Susan Harran , Gunnar James Hanson , Lai Wang
CPC分类号: A61K38/08 , A61K38/00 , A61K38/06 , A61K38/191 , C07D207/16 , C07D401/14 , C07D403/14 , C07D413/14 , C07K5/06026 , C07K5/0806 , C07K7/02 , C07K14/4747 , Y02A50/401 , Y02A50/411 , Y02A50/414
摘要: The invention provides small molecule mimics of the Smac peptide that are dimers or dimer-like compounds having two binding domains connected by a linker These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.
摘要翻译: 本发明提供了Smac肽的小分子模拟物,其是具有通过连接物连接的两个结合结构域的二聚体或二聚体样化合物。这些化合物可用于促进细胞凋亡。 本发明包括包含这些化合物的药物组合物和使用它们来治疗包括癌症和自身免疫疾病的病症的方法。
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公开(公告)号:US20130344026A1
公开(公告)日:2013-12-26
申请号:US13973979
申请日:2013-08-22
申请人: Haizhou Sun , Xiaoming Xu , Ming Zhou , Susan Harran , Gunnar James Hanson , Lai Wang
发明人: Haizhou Sun , Xiaoming Xu , Ming Zhou , Susan Harran , Gunnar James Hanson , Lai Wang
CPC分类号: A61K38/08 , A61K38/00 , A61K38/06 , A61K38/191 , C07D207/16 , C07D401/14 , C07D403/14 , C07D413/14 , C07K5/06026 , C07K5/0806 , C07K7/02 , C07K14/4747 , Y02A50/401 , Y02A50/411 , Y02A50/414
摘要: The invention provides small molecule mimics of the Smac peptide that are dimers or dimer-like compounds having two binding domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.
摘要翻译: 本发明提供Smac肽的小分子模拟物,其是具有通过连接体连接的两个结合结构域的二聚体或二聚体样化合物。 这些化合物可用于促进凋亡。 本发明包括包含这些化合物的药物组合物和使用它们来治疗包括癌症和自身免疫疾病的病症的方法。
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公开(公告)号:US09019240B2
公开(公告)日:2015-04-28
申请号:US13307353
申请日:2011-11-30
申请人: Russell Wayne Gruhlke , Ye Yin , Lai Wang , David William Burns
发明人: Russell Wayne Gruhlke , Ye Yin , Lai Wang , David William Burns
IPC分类号: G06F3/042 , G02F1/1333 , G02B26/00 , G02B26/08 , F21V8/00
CPC分类号: G06F3/0421 , G02B6/0011 , G02B6/0053 , G02B26/001 , G02B26/08 , G02F1/13338 , G06F3/0428
摘要: This disclosure provides systems, methods and apparatus for a touch screens configured to determine a position of a touch event by selectively redirecting light to correlated locations on a light sensor. In one aspect, the touch screen apparatus can include a light guide forming a touch interface, a light source for injecting light into the light guide, a light sensor for detecting the injected light, and a pixilated light-turning layer. The pixilated light-turning layer can include a plurality of light-turning features forming pixels. The pixels can receive incident light corresponding to the emitted light scattered by an object contacting the light guide. The pixels can redirect the incident scattered light towards the light sensor such that light selectively propagates to one or more correlated light receiving locations. A processor can map the light receiving location to an area contacted by the object, thereby determining a position of a touch event.
摘要翻译: 本公开提供了用于触摸屏的系统,方法和装置,其被配置为通过选择性地将光重定向到光传感器上的相关位置来确定触摸事件的位置。 一方面,触摸屏装置可以包括形成触摸界面的光导,用于将光注入到光导中的光源,用于检测注入的光的光传感器和像素化的光转向层。 像素化的光转向层可以包括形成像素的多个光转向特征。 像素可以接收对应于由与光导相接触的物体散射的发射光的入射光。 像素可以将入射的散射光重定向到光传感器,使得光选择性地传播到一个或多个相关的光接收位置。 处理器可以将光接收位置映射到由对象接触的区域,从而确定触摸事件的位置。
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