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公开(公告)号:US08551955B2
公开(公告)日:2013-10-08
申请号:US12914840
申请日:2010-10-28
申请人: Haizhou Sun , Xiaoming Xu , Ming Zhou , Susan Harran , Gunnar James Hanson , Lai Wang
发明人: Haizhou Sun , Xiaoming Xu , Ming Zhou , Susan Harran , Gunnar James Hanson , Lai Wang
CPC分类号: A61K38/08 , A61K38/00 , A61K38/06 , A61K38/191 , C07D207/16 , C07D401/14 , C07D403/14 , C07D413/14 , C07K5/06026 , C07K5/0806 , C07K7/02 , C07K14/4747 , Y02A50/401 , Y02A50/411 , Y02A50/414
摘要: The invention provides small molecule mimics of the Smac peptide that are dimers or dimer-like compounds having two binding domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.
摘要翻译: 本发明提供Smac肽的小分子模拟物,其是具有通过连接体连接的两个结合结构域的二聚体或二聚体样化合物。 这些化合物可用于促进凋亡。 本发明包括包含这些化合物的药物组合物和使用它们来治疗包括癌症和自身免疫疾病的病症的方法。
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公开(公告)号:US20110195043A1
公开(公告)日:2011-08-11
申请号:US12914840
申请日:2010-10-28
申请人: Haizhou Sun , Xiaoming Xu , Ming Zhou , Susan Harran , Gunnar James Hanson , Lai Wang
发明人: Haizhou Sun , Xiaoming Xu , Ming Zhou , Susan Harran , Gunnar James Hanson , Lai Wang
CPC分类号: A61K38/08 , A61K38/00 , A61K38/06 , A61K38/191 , C07D207/16 , C07D401/14 , C07D403/14 , C07D413/14 , C07K5/06026 , C07K5/0806 , C07K7/02 , C07K14/4747 , Y02A50/401 , Y02A50/411 , Y02A50/414
摘要: The invention provides small molecule mimics of the Smac peptide that are dimers or dimer-like compounds having two binding domains connected by a linker These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.
摘要翻译: 本发明提供了Smac肽的小分子模拟物,其是具有通过连接物连接的两个结合结构域的二聚体或二聚体样化合物。这些化合物可用于促进细胞凋亡。 本发明包括包含这些化合物的药物组合物和使用它们来治疗包括癌症和自身免疫疾病的病症的方法。
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公开(公告)号:US20130344026A1
公开(公告)日:2013-12-26
申请号:US13973979
申请日:2013-08-22
申请人: Haizhou Sun , Xiaoming Xu , Ming Zhou , Susan Harran , Gunnar James Hanson , Lai Wang
发明人: Haizhou Sun , Xiaoming Xu , Ming Zhou , Susan Harran , Gunnar James Hanson , Lai Wang
CPC分类号: A61K38/08 , A61K38/00 , A61K38/06 , A61K38/191 , C07D207/16 , C07D401/14 , C07D403/14 , C07D413/14 , C07K5/06026 , C07K5/0806 , C07K7/02 , C07K14/4747 , Y02A50/401 , Y02A50/411 , Y02A50/414
摘要: The invention provides small molecule mimics of the Smac peptide that are dimers or dimer-like compounds having two binding domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.
摘要翻译: 本发明提供Smac肽的小分子模拟物,其是具有通过连接体连接的两个结合结构域的二聚体或二聚体样化合物。 这些化合物可用于促进凋亡。 本发明包括包含这些化合物的药物组合物和使用它们来治疗包括癌症和自身免疫疾病的病症的方法。
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公开(公告)号:US20120270841A1
公开(公告)日:2012-10-25
申请号:US13447259
申请日:2012-04-15
申请人: Qi Wei , Ming Zhou , Xiaoming Xu , Charles Caldwell , Susan Harran , Lai Wang
发明人: Qi Wei , Ming Zhou , Xiaoming Xu , Charles Caldwell , Susan Harran , Lai Wang
IPC分类号: A61K31/424 , A61K31/4245 , C07D519/00 , A61K31/437 , C07D498/04 , C07D498/20 , C07F9/6561 , A61K31/675 , A61P35/00 , C07D498/22 , A61K31/427
CPC分类号: C07D498/06 , C07D491/04 , C07D498/08 , C07D498/20 , C07D498/22 , C07D519/00 , C07F9/6561
摘要: Diazonamide analogs having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders, and related pharmaceutical compositions are provided.
摘要翻译: 提供了具有抗有丝分裂活性的二氮嗪类似物,其可用于治疗癌症和其它增殖性疾病,以及相关的药物组合物。
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公开(公告)号:US08592469B2
公开(公告)日:2013-11-26
申请号:US13447259
申请日:2012-04-15
申请人: Qi Wei , Ming Zhou , Xiaoming Xu , Charles Caldwell , Susan Harran , Lai Wang
发明人: Qi Wei , Ming Zhou , Xiaoming Xu , Charles Caldwell , Susan Harran , Lai Wang
CPC分类号: C07D498/06 , C07D491/04 , C07D498/08 , C07D498/20 , C07D498/22 , C07D519/00 , C07F9/6561
摘要: Diazonamide analogs having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders, and related pharmaceutical compositions are provided.
摘要翻译: 提供了具有抗有丝分裂活性的二氮嗪类似物,其可用于治疗癌症和其它增殖性疾病,以及相关的药物组合物。
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公开(公告)号:US20160068536A1
公开(公告)日:2016-03-10
申请号:US14782936
申请日:2014-04-08
申请人: Xiaoming XU , Stephen A. COSTIN
发明人: Xiaoming Xu , Stephen Costin
IPC分类号: C07D487/08 , A61K6/00 , C07C229/14
CPC分类号: C07D487/08 , A61K6/0047 , C07C229/14 , A61K6/083 , C08L33/10
摘要: Antimicrobial compounds are provided that are polymerizable. The compounds include monomers with antimicrobial properties. The compounds have cross-linking properties and are hydrolytically stable. The compounds may be utilized in dental and/or medical applications, including dental composites, dentures, bonding agents, sealants, resins and medical devices.
摘要翻译: 提供可聚合的抗微生物化合物。 这些化合物包括具有抗微生物性质的单体。 该化合物具有交联性能并且具有水解稳定性。 这些化合物可以用于牙科和/或医学应用,包括牙科复合材料,义齿,粘合剂,密封剂,树脂和医疗装置。
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公开(公告)号:US20120264939A1
公开(公告)日:2012-10-18
申请号:US13483624
申请日:2012-05-30
IPC分类号: C07F7/00 , C07C229/30 , C07D401/12 , C07D207/46
CPC分类号: C07C69/734 , C07C233/49 , C07C237/22 , C07D207/46 , C07D213/69 , C07D401/12 , C07F7/003
摘要: Chelating monomers and fluoride-releasing compositions are disclosed that may be incorporated into dental composite restorative materials, dental bonding agents or other dental materials, to produce materials with high fluoride release rates, and high fluoride recharge capability. Such dental restorative materials may help reduce the level of dental caries in patients, particularly the level of caries occurring on the margins of the restorative materials.
摘要翻译: 公开了螯合单体和氟化物释放组合物,其可以并入牙齿复合材料修复材料,牙科粘合剂或其他牙科材料中,以产生具有高氟释放速率的材料和高氟化物补给能力。 这种牙齿修复材料可以帮助减少患者的龋齿水平,特别是在修复材料的边缘发生的龋齿水平。
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公开(公告)号:US10392394B2
公开(公告)日:2019-08-27
申请号:US15886591
申请日:2018-02-01
申请人: Xiaoming Xu
发明人: Xiaoming Xu
IPC分类号: A61K6/083 , C07C229/14 , C08L33/02 , C07D487/08 , A61K6/00 , C08F26/02
摘要: Antimicrobial compounds are provided that are polymerizable. The compounds include monomers with antimicrobial properties. The compounds have cross-linking properties. The compounds may be utilized in dental and/or medical applications, including dental composites, dentures, bonding agents, sealants, resins and medical devices.
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公开(公告)号:US20140306027A1
公开(公告)日:2014-10-16
申请号:US14240927
申请日:2012-08-24
申请人: Xiaoming Xu , Yongjun Zhou , Jianwei Wu , Yunxin Ding
发明人: Xiaoming Xu , Yongjun Zhou , Jianwei Wu , Yunxin Ding
IPC分类号: C23C16/455
CPC分类号: C23C16/45572 , C23C16/45565
摘要: The present invention intends to provide a shower of a large diameter MOCVD reactor, and the difficulty for manufacturing the shower does not obviously increase when its size increases. The shower of a large diameter MOCVD reactor of the present invention comprises III group chamber, V group chamber and a cooling water chamber, and it is characterized in that, III group chamber, V group chamber and cooling water chamber are all separated as N chambers, wherein N is a natural number greater than or equal to 2 and each chamber is an individual unity.
摘要翻译: 本发明旨在提供大直径MOCVD反应器的淋浴,并且当其尺寸增加时,用于制造淋浴器的难度不会明显增加。 本发明的大直径MOCVD反应器的淋浴器包括III组室,V组室和冷却水室,其特征在于,III组室,V组室和冷却水室均分离为N室 其中N是大于或等于2的自然数,并且每个室是个体单位。
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公开(公告)号:US20180155353A1
公开(公告)日:2018-06-07
申请号:US15886591
申请日:2018-02-01
申请人: Xiaoming Xu , Stephen Costin
发明人: Xiaoming Xu , Stephen Costin
IPC分类号: C07D487/08 , A61K6/00 , C07C229/14 , A61K6/083 , C08L33/10
CPC分类号: C07D487/08 , A61K6/0047 , C07C229/14 , A61K6/083 , C08L33/10
摘要: Antimicrobial compounds are provided that are polymerizable. The compounds include monomers with antimicrobial properties. The compounds have cross-linking properties. The compounds may be utilized in dental and/or medical applications, including dental composites, dentures, bonding agents, sealants, resins and medical devices.
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