公开(公告)号：US20070232774A1

公开(公告)日：2007-10-04

申请号：US11277956

申请日：2006-03-30

申请人： Guohua Xiu ,  Tong Sun ,  Jan Lens ,  Sunil Ashtekar ,  Mahesh Malusare ,  Gurram Kishan ,  Pushpa Narayanan

发明人： Guohua Xiu ,  Tong Sun ,  Jan Lens ,  Sunil Ashtekar ,  Mahesh Malusare ,  Gurram Kishan ,  Pushpa Narayanan

IPC分类号： C08G61/02 ,  C07C39/10

CPC分类号： C07C37/685 ,  C07C37/72 ,  C07C37/82 ,  C08G64/04 ,  C07C39/08

摘要： A process comprising the steps of dissolving a dihydric phenol in a solvent to form a solution A; contacting the solution A with a zeolite; filtering the zeolite to form a solution B; adding an anti-solvent to the solution B to form a solution C; and distilling the solution C; wherein the dihydric phenol is represented by Formula (I): wherein R is a hydrogen atom or an aliphatic functionality having 1 to 6 carbon atoms and n is an integer having a value 1 to 4.

摘要翻译： 一种方法，包括将二元酚溶解在溶剂中以形成溶液A的步骤; 使溶液A与沸石接触; 过滤沸石以形成溶液B; 向溶液B中加入抗溶剂以形成溶液C; 并蒸馏溶液C; 其中所述二元酚由式（I）表示：其中R是氢原子或具有1至6个碳原子的脂族官能团，n是具有1至4的整数。

公开(公告)号：US07528210B2

公开(公告)日：2009-05-05

申请号：US11277956

申请日：2006-03-30

申请人： Guohua Xiu ,  Tong Sun ,  Jan Plen Lens ,  Sunil Ashtekar ,  Mahesh Malusare ,  Gurram Kishan ,  Pushpa Narayanan

发明人： Guohua Xiu ,  Tong Sun ,  Jan Plen Lens ,  Sunil Ashtekar ,  Mahesh Malusare ,  Gurram Kishan ,  Pushpa Narayanan

IPC分类号： C08G63/00 ,  C08G63/02

CPC分类号： C07C37/685 ,  C07C37/72 ,  C07C37/82 ,  C08G64/04 ,  C07C39/08

摘要： A process comprising the steps of dissolving a dihydric phenol in a solvent to form a solution A; contacting the solution A with a zeolite; filtering the zeolite to form a solution B; adding an anti-solvent to the solution B to form a solution C; and distilling the solution C; wherein the dihydric phenol is represented by Formula (I): wherein R is a hydrogen atom or an aliphatic functionality having 1 to 6 carbon atoms and n is an integer having a value 1 to 4.

摘要翻译： 一种方法，包括将二元酚溶解在溶剂中以形成溶液A的步骤; 使溶液A与沸石接触; 过滤沸石以形成溶液B; 向溶液B中加入抗溶剂以形成溶液C; 并蒸馏溶液C; 其中二元酚由式（I）表示：其中R是氢原子或具有1至6个碳原子的脂族官能团，n是1至4的整数。

公开(公告)号：US07884220B2

公开(公告)日：2011-02-08

申请号：US11687943

申请日：2007-03-19

申请人： Zhongqi Xu ,  Guohua Xiu ,  Tong Sun ,  Jingwu Yang

发明人： Zhongqi Xu ,  Guohua Xiu ,  Tong Sun ,  Jingwu Yang

IPC分类号： C07D209/44

CPC分类号： C07D209/46

摘要： A method for decoloring 2-phenyl-3,3-bis(4-hydroxyphenyl)phthalimidine (“p,p-PPPBP”) is disclosed. The method comprises contacting a liquid solution containing p,p-PPPBP and the common impurities o,p-PPPBP and aminophenone with activated carbon fibers. The activated carbon fibers adsorb the impurities, resulting in a purified solution of p,p-PPPBP. The activated carbon fibers can then be regenerated, such as with a methanol solution having a highly basic pH.

摘要翻译： 公开了2-苯基-3,3-双（4-羟苯基）苯并二氮吡啶（“p，p-PPPBP”）脱色方法。 该方法包括将含有p，p-PPPBP和常见杂质o，p-PPPBP和氨基苯酚的液体溶液与活性碳纤维接触。 活性炭纤维吸附杂质，得到p，p-PPPBP的纯化溶液。 然后可以再生活性炭纤维，例如用具有高碱性pH的甲醇溶液。

公开(公告)号：US20080234496A1

公开(公告)日：2008-09-25

申请号：US11687943

申请日：2007-03-19

申请人： Zhongqi Xu ,  Guohua Xiu ,  Tong Sun ,  Jingwu Yang

发明人： Zhongqi Xu ,  Guohua Xiu ,  Tong Sun ,  Jingwu Yang

IPC分类号： C07D209/32

CPC分类号： C07D209/46

摘要： A method for decoloring 2-phenyl-3,3-bis(4-hydroxyphenyl)phthalimidine (“p,p-PPPBP”) is disclosed. The method comprises contacting a liquid solution containing p,p-PPPBP and the common impurities o,p-PPPBP and aminophenone with activated carbon fibers. The activated carbon fibers adsorb the impurities, resulting in a purified solution of p,p-PPPBP. The activated carbon fibers can then be regenerated, such as with a methanol solution having a highly basic pH.

摘要翻译： 公开了2-苯基-3,3-双（4-羟苯基）苯并二氮吡啶（“p，p-PPPBP”）脱色方法。 该方法包括将含有p，p-PPPBP和常见杂质o，p-PPPBP和氨基苯酚的液体溶液与活性碳纤维接触。 活性炭纤维吸附杂质，得到p，p-PPPBP的纯化溶液。 然后可以再生活性炭纤维，例如用具有高碱性pH的甲醇溶液。

公开(公告)号：US09792087B2

公开(公告)日：2017-10-17

申请号：US13452701

申请日：2012-04-20

申请人： Yuanbin Guo ,  Tong Sun ,  Weizhong Chen

发明人： Yuanbin Guo ,  Tong Sun ,  Weizhong Chen

IPC分类号： G06F7/483

CPC分类号： G06F7/483

摘要： An embodiment of a system and method for performing a numerical operation on input data in a hybrid floating-point format includes representing input data as a sign bit, exponent bits, and mantissa bits. The exponent bits are represented as an unsigned integer including an exponent bias, and a signed numerical value of zero is represented as a first reserved combination of the mantissa bits and the exponent bits. Each of all other combinations of the mantissa bits and the exponent bits represents a real finite non-zero number. The mantissa bits are operated on with a “one” bit before a radix point for the all other combinations of the mantissa bits and the exponent bits.

公开(公告)号：US09274750B2

公开(公告)日：2016-03-01

申请号：US13452690

申请日：2012-04-20

申请人： Tong Sun ,  Weizhong Chen ,  Zhikun Cheng ,  Yuanbin Guo

发明人： Tong Sun ,  Weizhong Chen ,  Zhikun Cheng ,  Yuanbin Guo

IPC分类号： G06F7/48 ,  G06F7/483 ,  G06F7/544

CPC分类号： G06F7/4806 ,  G06F7/483 ,  G06F7/5443

摘要： An embodiment of a method and a related apparatus for digital computation of a floating point complex multiply-add is provided. The method includes receiving an input addend, a first product, and a second product. The input addend, the first product and the second product each respectively has a mantissa and an exponent. The method includes shifting the mantissas of the two with smaller exponents of the input addend, the first product, and the second product to align together with the mantissa of the one with largest exponent of the input addend, the first product and the second product, and adding the aligned input addend, the aligned first product and the aligned second product.

摘要翻译： 提供了一种用于浮点复数乘法的数字计算的方法和相关装置的实施例。 该方法包括接收输入加数，第一产品和第二产品。 输入加法，第一产品和第二产品分别具有尾数和指数。 该方法包括以输入加数，第一乘积和第二乘积的较小指数移动两者的尾数，使其与输入加法器，第一乘积和第二乘积的最大指数的尾数对齐， 并添加对齐的输入加数，对齐的第一个产品和对齐的第二个产品。

公开(公告)号：US08954431B2

公开(公告)日：2015-02-10

申请号：US13156568

申请日：2011-06-09

申请人： Akiko Okazaki ,  Joshua Mateo ,  Edward Werner ,  Robert Hendricks ,  Alexandra Woodbury ,  Tong Sun ,  Gregory Cameron

发明人： Akiko Okazaki ,  Joshua Mateo ,  Edward Werner ,  Robert Hendricks ,  Alexandra Woodbury ,  Tong Sun ,  Gregory Cameron

IPC分类号： G06F7/00 ,  G06F3/0488 ,  G06F3/0481 ,  G10L15/26

CPC分类号： G06F3/0488 ,  G06F3/04815 ,  G10L15/26

摘要： Methods and a system are disclosed for a collaborate brainstorming interface that defines a collaboration session with a three dimensional holographic mind map. An intelligent agent guides a collaboration session that is structured by the interface. The intelligent agent detects key words, work flow steps and user interactions in the session to initiate searches that are filtered using artificial intelligence. The results are presented to developers interacting through the interface.

摘要翻译： 公开了一种协作头脑风暴界面的方法和系统，该界面定义了与三维全息思维导图的协作会话。 智能代理指导由界面构成的协作会话。 智能代理检测会话中的关键词，工作流步骤和用户交互，以启动使用人工智能过滤的搜索。 结果提供给开发人员通过界面进行交互。

公开(公告)号：US20130282778A1

公开(公告)日：2013-10-24

申请号：US13452690

申请日：2012-04-20

申请人： Tong Sun ,  Weizhong Chen ,  Zhikun Cheng ,  Yuanbin Guo

发明人： Tong Sun ,  Weizhong Chen ,  Zhikun Cheng ,  Yuanbin Guo

IPC分类号： G06F7/483 ,  G06F17/10 ,  G06F7/499 ,  G06F5/01

CPC分类号： G06F7/4806 ,  G06F7/483 ,  G06F7/5443

摘要： An embodiment of a method and a related apparatus for digital computation of a floating point complex multiply-add is provided. The method includes receiving an input addend, a first product, and a second product. The input addend, the first product and the second product each respectively has a mantissa and an exponent. The method includes shifting the mantissas of the two with smaller exponents of the input addend, the first product, and the second product to align together with the mantissa of the one with largest exponent of the input addend, the first product and the second product, and adding the aligned input addend, the aligned first product and the aligned second product.

摘要翻译： 提供了一种用于浮点复数乘法的数字计算的方法和相关装置的实施例。 该方法包括接收输入加数，第一产品和第二产品。 输入加法，第一产品和第二产品分别具有尾数和指数。 该方法包括以输入加数，第一乘积和第二乘积的较小指数移动两者的尾数，使其与输入加法器，第一乘积和第二乘积的最大指数的尾数对齐， 并添加对齐的输入加数，对齐的第一个产品和对齐的第二个产品。

公开(公告)号：US08440404B2

公开(公告)日：2013-05-14

申请号：US11071864

申请日：2005-03-03

申请人： Vladimir L. Makarov ,  Emmanuel Kamberov ,  Tong Sun ,  Jonathon H. Pinter ,  Brendan J. Tarrier ,  Eric E. Bruening ,  Takao Kurihara ,  Tim Tesmer ,  Joseph M'Mwirichia

发明人： Vladimir L. Makarov ,  Emmanuel Kamberov ,  Tong Sun ,  Jonathon H. Pinter ,  Brendan J. Tarrier ,  Eric E. Bruening ,  Takao Kurihara ,  Tim Tesmer ,  Joseph M'Mwirichia

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C12Q1/6869 ,  C12N15/1072 ,  C12Q1/6827 ,  C12Q1/6855 ,  C12Q2525/301 ,  C12Q2525/191 ,  C12Q2521/331 ,  C12Q2523/125

摘要： The present invention regards a variety of methods and compositions for obtaining epigenetic information, such as DNA methylation patterns, through the preparation, amplification and analysis of Methylome libraries. In particular, the method employs preparation of a DNA molecule by digesting the DNA molecule with at least one methylation-sensitive restriction enzyme; incorporating a nucleic acid molecule into at least some of the digested DNA molecules by either (1) incorporating at least one primer from a plurality of primers that have a 5′ constant sequence and a 3′ variable sequence, wherein the primers are substantially non-self-complementary and substantially non-complementary to other primers in the plurality; or (2) incorporating an oligonucleotide having an inverted repeat and a loop under conditions wherein the oligonucleotide becomes blunt-end ligated to one strand of the digested DNA molecule, followed by polymerization from a 3′ hydroxyl group present in a nick in the oligonucleotide-linked molecule; and amplifying one or more of the DNA molecules.

摘要翻译： 本发明涉及通过Methylome文库的制备，扩增和分析来获得表观遗传信息的各种方法和组合物，例如DNA甲基化模式。 特别地，该方法通过用至少一种甲基化敏感性限制酶消化DNA分子来制备DNA分子; 通过（1）从具有5'恒定序列和3'可变序列的多个引物掺入至少一个引物，将核酸分子掺入到至少一些消化的DNA分子中，其中所述引物基本上不含 与多个中的其它引物互补且基本上不互补; 或者（2）在其中寡核苷酸变得钝端连接到消化的DNA分子的一条链上，然后从存在于寡聚核苷酸的切口中的3'羟基聚合的条件下，引入具有反向重复和环的寡核苷酸， 连接分子 并扩增一个或多个DNA分子。

公开(公告)号：US20130116330A1

公开(公告)日：2013-05-09

申请号：US13646931

申请日：2012-10-08

申请人： Tong Sun ,  Kurt Nielsen ,  Shawn Watson ,  Rolf Hilfiker

发明人： Tong Sun ,  Kurt Nielsen ,  Shawn Watson ,  Rolf Hilfiker

IPC分类号： C07C233/32

CPC分类号： C07C233/32 ,  C07C2603/34

摘要： Disclosed are new colchicine solid-state forms, methods of preparing the solid-state forms, as well as formulations prepared therefrom and uses thereof.