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    Sitagliptin intermediates, preparation methods and uses thereof
    5.
    发明授权
    Sitagliptin intermediates, preparation methods and uses thereof 有权
    西他列汀中间体，其制备方法和用途

    公开(公告)号：US08471057B2

    公开(公告)日：2013-06-25

    申请号：US13497874

    申请日：2010-09-25

    申请人： Guoliang Zhu ,  Jian Zhang ,  Lijun Yang ,  Qingdan Yao ,  Jie Ying

    发明人： Guoliang Zhu ,  Jian Zhang ,  Lijun Yang ,  Qingdan Yao ,  Jie Ying

    IPC分类号： C07C69/035

    CPC分类号： C07C229/34

    摘要： The present invention relates to Sitagliptin intermediate and preparation method and use thereof. The method comprises reacting compound of formula (II) and trifluorobromobenzene with a Grignard reagent by a Grignard reaction to obtain a compound of formula (I). Compound of formula (I) is a new intermediate compound for the synthesis of Sitagliptin. Compound of formula (I) can be easily used for preparing another important intermediate compound of formula (V) for the synthesis of Sitagliptin. The structures of the compounds mentioned above are as the following:

    摘要翻译： 本发明涉及西他列汀中间体及其制备方法和用途。 该方法包括通过格利雅反应使式（II）化合物与三氟溴苯与格氏试剂反应，得到式（I）化合物。 式（I）的化合物是用于合并西格列汀的新的中间体化合物。 式（I）的化合物可以容易地用于制备用于合并西格列汀的另一种重要的式（V）中间体化合物。 上述化合物的结构如下：

    Method for differentiating rat hepatic stem cells to insulin-producing cells
    6.
    发明授权
    Method for differentiating rat hepatic stem cells to insulin-producing cells 失效
    将大鼠肝干细胞分化为胰岛素生成细胞的方法

    公开(公告)号：US07029915B2

    公开(公告)日：2006-04-18

    申请号：US10373124

    申请日：2003-02-24

    申请人： Lijun Yang

    发明人： Lijun Yang

    IPC分类号： C12N5/02 ,  C12N5/00 ,  C12N5/06

    CPC分类号： C12N5/0676 ,  A61K35/12 ,  C12N2500/34

    摘要： Highly purified hepatic stem cells are trans-differentiated into pancreatic endocrine hormone-producing cells by culturing them in vitro in a medium containing high levels of glucose. These trans-differentiated cells express insulin, glucagon, and pancreatic polypeptide, but not hepatocyte protein Hep-par. When stimulated with glucose, these cells synthesize and secrete insulin, a response enhanced by nicotinamide. Transplantation of these trans-differentiated cells into a hyperglycemic animal normalizes blood sugar levels in the animal.

    摘要翻译： 通过在含有高水平葡萄糖的培养基中体外培养将高纯度肝干细胞转化成胰腺内分泌激素产生细胞。 这些转分化细胞表达胰岛素，胰高血糖素和胰多肽，但不表达肝细胞蛋白Hep-par。 当用葡萄糖刺激时，这些细胞合成和分泌胰岛素，这是由烟酰胺增强的反应。 将这些转分化细胞移植到高血糖动物中使动物的血糖水平正常化。

    ELECTRODE CATALYST FOR MEMBRANE ELECTRODE OF FUEL CELL AND ITS METHOD OF PREPARATION AND FUEL CELL MEMBRANE ELECTRODE
    7.
    发明申请
    ELECTRODE CATALYST FOR MEMBRANE ELECTRODE OF FUEL CELL AND ITS METHOD OF PREPARATION AND FUEL CELL MEMBRANE ELECTRODE 审中-公开
    燃料电池用电极用电极催化剂及其制备方法和燃料电池电极

    公开(公告)号：US20120107719A1

    公开(公告)日：2012-05-03

    申请号：US13379693

    申请日：2010-03-30

    申请人： Shijun Liao ,  Huaping Zhu ,  Leimin Xu ,  Huaneng Su ,  Lijun Yang ,  Yanni Wu ,  Zhenxing Liang

    发明人： Shijun Liao ,  Huaping Zhu ,  Leimin Xu ,  Huaneng Su ,  Lijun Yang ,  Yanni Wu ,  Zhenxing Liang

    IPC分类号： H01M4/92 ,  B05D3/02 ,  B05D5/12 ,  H01M4/90 ,  H01M8/10

    CPC分类号： H01M4/8803 ,  H01M4/8828 ,  H01M4/9075 ,  H01M4/9083 ,  H01M4/92

    摘要： This invention discloses an electrocatalyst for membrane electrode assembly, and its preparation method, as well as a fuel cell membrane electrode assembly. An electrocatalyst for fuel cell application, it is featured that the electrocatalyst is prepared by supporting precious metal (10-60 wt %) on a composite carrier which is prepared by depositing water-containing substance (0.3-10 wt %) on carbon material; Using the catalyst invented by this invention as anode catalyst, an fuel cell membrane electrode assembly with excellent non-humidification performance can be prepared by normal procedures. No need to construct a water retention layer, no need to add water retention material in proton exchange membrane, it avoids the possible problems caused by adding water attention material into proton exchange membrane or inserting a water retention layer. The approach suggested by this invention is a simple and effective approach to realize non-humidification membrane electrode assembly.

    摘要翻译： 本发明公开了一种用于膜电极组件的电极催化剂及其制备方法以及燃料电池膜电极组件。 一种用于燃料电池应用的电催化剂，其特征在于通过在通过在碳材料上沉积含水物质（0.3-10重量％）制备的复合载体上支持贵金属（10-60重量％）来制备电催化剂; 使用本发明发明的催化剂作为阳极催化剂，可以通过常规方法制备具有优异的非加湿性能的燃料电池膜电极组件。 不需要构建保水层，不需要在质子交换膜中加入保水材料，避免了将注水材料加入质子交换膜或插入保水层引起的可能问题。 本发明提出的方法是实现非加湿膜电极组件的简单有效的方法。

    DYE-SENSITIZED SOLAR CELL BASED ON INDIRECT CHARGE TRANSFER
    9.
    发明申请
    DYE-SENSITIZED SOLAR CELL BASED ON INDIRECT CHARGE TRANSFER 有权
    基于间接充电转移的透明太阳能电池

    公开(公告)号：US20130298981A1

    公开(公告)日：2013-11-14

    申请号：US13470370

    申请日：2012-05-14

    申请人： Wallace Woon-fong Leung ,  Lijun Yang

    发明人： Wallace Woon-fong Leung ,  Lijun Yang

    IPC分类号： H01L31/0224 ,  H01L31/18 ,  H01L51/44 ,  B82Y99/00 ,  B82Y40/00

    CPC分类号： H01G9/2059 ,  B82Y30/00 ,  B82Y40/00 ,  H01G9/2063 ,  H01L31/18 ,  H01L51/0078 ,  H01L51/0086 ,  Y02E10/542 ,  Y02P70/521

    摘要： A dye-sensitized solar cell that includes an electrode having a semiconductor nanoparticle layer dispersed on a transparent conductive substrate, a plurality of semiconductor nanofibers dispersed on the nanoparticle layer, a first light absorption material is attached to the plurality of semiconductor nanofibers in which the first light absorption material having a first light absorption bandwidth, and a second light absorption material deposited on the light absorption material of the plurality of semiconductor nanofibers, the second light absorption material having a second light absorption bandwidth complementary to the first light absorption bandwidth, a counter electrode includes a metal-coated transparent conductive substrate, and an electrolyte in contact with the near-infrared light absorption material and the counter electrode.

    摘要翻译： 一种染料敏化太阳能电池，其包括分散在透明导电性基板上的半导体纳米粒子层的电极，分散在纳米粒子层上的多个半导体纳米纤维，第一吸光材料附着在多个半导体纳米纤维上， 具有第一光吸收带宽的光吸收材料和沉积在多个半导体纳米纤维的光吸收材料上的第二光吸收材料，第二光吸收材料具有与第一光吸收带宽互补的第二光吸收带宽， 电极包括金属涂覆的透明导电基板和与近红外光吸收材料和对电极接触的电解质。