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4 条记录 (耗时 0.017 秒)

    Process for the preparation of 6-demethyl-6-deoxy-6-methylene-5-oxytetracyclin and the 11A-chloro-derivative thereof
    1.
    发明授权
    Process for the preparation of 6-demethyl-6-deoxy-6-methylene-5-oxytetracyclin and the 11A-chloro-derivative thereof 失效
    6-脱甲基-6-脱氧-6-亚甲基-5-氧四环素及其11A-氯衍生物的制备方法

    公开(公告)号：US4659515A

    公开(公告)日：1987-04-21

    申请号：US646574

    申请日：1984-08-31

    申请人： Gyorgy Lugosi ,  Maria Hima nee Toth ,  Maria Bakonyi ,  Sandor Szoke

    发明人： Gyorgy Lugosi ,  Maria Hima nee Toth ,  Maria Bakonyi ,  Sandor Szoke

    IPC分类号： C07C231/00 ,  C07C67/00 ,  C07C231/12 ,  C07C233/00 ,  C07C237/26 ,  C07C309/73 ,  C07C103/19

    CPC分类号： C07C237/26 ,  C07C233/00 ,  C07C309/73

    摘要： The invention relates to a new and improved process for the preparation of 6-demethyl-6-deoxy-6-methylene-5-oxytetracycline and the 11a-chloro derivative thereof by dehydrating 11a-chloro-5-oxytetracycline-6,12-hemiketal, which comprises treating 11a-chloro-5-oxytetracycline-6,12-hemiketal or an acid salt thereof with a dehydrating mixture formed by the reaction of chloro sulfonic acid and formic acid and isolating the 11a-chloro-6-demethyl-6-deoxy-6-methylene-5-oxytetracycline and salt thus obtained and optionally dehalogenating the same by reaction with a reducing agent.The advantage of the process of the present invention is that it is simple, economical and suitable for industrial scale manufacture and provides a pure product of high quality by excellent yields.

    摘要翻译： 本发明涉及一种通过使11a-氯-5-氧四环素-6,12-半缩酮脱水制备6-脱甲基-6-脱氧-6-亚甲基-5-土霉素及其11a-氯衍生物的新方法和改进方法 其包括用与氯磺酸和甲酸的反应形成的脱水混合物处理11a-氯-5-土霉素-6,12-半缩酮或其酸盐，并将11a-氯-6-去甲基-6- 脱氧-6-亚甲基-5-土霉素和盐，并通过与还原剂反应任选地使其脱卤。 本发明方法的优点在于它简单，经济，适用于工业规模的制造，并通过优异的成品率提供高品质的纯净产品。

    Aluminum alloys having a high reducing capacity and preparation thereof
    4.
    发明授权
    Aluminum alloys having a high reducing capacity and preparation thereof 失效
    具有高还原能力的铝合金及其制备

    公开(公告)号：US4273679A

    公开(公告)日：1981-06-16

    申请号：US44034

    申请日：1979-05-31

    申请人： Jeno Ghyczy ,  Sandor Szoke ,  Gyorgy Csermely

    发明人： Jeno Ghyczy ,  Sandor Szoke ,  Gyorgy Csermely

    IPC分类号： B01J23/06 ,  B01J23/34 ,  B01J23/38 ,  B01J23/72 ,  B01J23/745 ,  B01J37/30 ,  C07D231/46 ,  B01J21/04 ,  B01J23/44 ,  B01J23/74

    CPC分类号： C07D231/46

    摘要： This invention relates to a process for the preparation of aluminum alloys having a high reducing capacity for use in reductions in organic chemistry. According to this method a discontinuous heterodisperse superficial alloy is formed by subjecting an aluminum alloy prepared by a metallurgical process to superficial activation and/or treating aluminum with a salt of a metal having a greater normal electrode potential than that of aluminum; whereby the solution of said metal in a protic solvent is reacted with granular aluminum and/or an aluminum alloy. The catalyst prepared according to the invention is especially suitable for the reduction of a nitro or nitroso group into an amino group. The aluminum alloys having a high reducing capacity are also within the scope of the invention.

    摘要翻译： 本发明涉及一种制备具有高还原能力的铝合金的方法，用于有机化学的还原。 根据该方法，通过使用冶金工艺制备的铝合金对具有比铝铝合金的正常电极电位高的金属的盐进行表面活化和/或处理铝来形成不连续的异质分散表面合金; 由此所述金属在质子溶剂中的溶液与颗粒状铝和/或铝合金反应。 根据本发明制备的催化剂特别适用于将硝基或亚硝基还原成氨基。 具有高还原能力的铝合金也在本发明的范围内。