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公开(公告)号：US10224195B2
公开(公告)日：2019-03-05
申请号：US15571568
申请日：2016-08-26
发明人： Yasuhide Naito , Masahiro Kotani , Takayuki Ohmura
摘要： A surface-assisted laser desorption/ionization method according to an aspect includes: a first process of preparing a sample support having a substrate in which a plurality of through-holes passing from one surface thereof to the other surface thereof are provided and a conductive layer that covers at least the one surface; a second process of placing a sample on a sample stage and arranging the sample support on the sample such that the other surface faces the sample; and a third process of applying a laser beam to the one surface and ionizing the sample moved from the other surface side to the one surface side via the through-holes due to a capillary phenomenon.
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公开(公告)号：US11139155B2
公开(公告)日：2021-10-05
申请号：US16762971
申请日：2018-10-05
发明人： Yasuhide Naito , Takayuki Ohmura , Masahiro Kotani
摘要： A laser desorption/ionization method, includes: a first step of preparing a sample support body including a substrate on which a plurality of through holes opening to a first surface and a second surface facing each other are formed, and a conductive layer provided on at least the first surface; a second step of introducing a sample and a solvent having refractoriness in a vacuum into the plurality of through holes; and a third step of ionizing a component of the sample by irradiating the first surface with laser beam while applying a voltage to the conductive layer.
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公开(公告)号：US11031228B2
公开(公告)日：2021-06-08
申请号：US16489753
申请日：2018-03-01
发明人： Yasuhide Naito , Masahiro Kotani , Takayuki Ohmura
摘要： A mass spectrometry device according to one aspect of the invention includes: a sample stage on which a sample is placed and on which a sample support having a substrate, in which a plurality of through-holes passing from one surface thereof to the other surface thereof are provided, and a conductive layer, which covers at least a portion of the one surface which is not provided with the through-holes, is placed such that the other surface faces the sample; a laser beam application unit that controls application of a laser beam such that the laser beam is applied to an imaging target region on the one surface; and a detector that detects the sample ionized by the application of the laser beam in a state where a positional relation of the sample in the imaging target region is maintained.
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4.发明授权公开(公告)号：US11442039B2
公开(公告)日：2022-09-13
申请号：US16967266
申请日：2019-01-08
发明人： Yasuhide Naito , Takayuki Ohmura , Masahiro Kotani
IPC分类号： G01N27/62
摘要： Provided is a sample support body that includes: a substrate having a first surface and a second surface opposite to each other; and a conductive layer provided on at least the first surface. A plurality of through-holes, which open to the second surface and a third surface of the conductive layer which is located on a side opposite to the substrate, are formed in the substrate and the conductive layer. At least one of the second surface and the third surface is subjected to surface treatment for providing a difference in an affinity with water between a surface close to the second surface and a surface close to the third surface.
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公开(公告)号：US11335546B2
公开(公告)日：2022-05-17
申请号：US16762517
申请日：2018-10-05
发明人： Yasuhide Naito , Takayuki Ohmura , Masahiro Kotani
摘要： A laser desorption/ionization method, includes: a first step of preparing a sample support body including a substrate on which a plurality of through holes opening to a first surface and a second surface facing each other are formed, a conductive layer provided on at least the first surface, and a solvent provided in the plurality of through holes with refractoriness in a vacuum; a second step of mounting a sample on a mounting surface of a mounting portion, and of disposing the sample support body on the sample such that the second surface is in contact with the sample; and a third step of ionizing a component of the sample that is mixed with the solvent and is moved to the first surface side from the second surface side through the through hole by irradiating the first surface with laser beam while applying a voltage to the conductive layer.
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公开(公告)号：US11170985B2
公开(公告)日：2021-11-09
申请号：US16864919
申请日：2020-05-01
发明人： Yasuhide Naito , Masahiro Kotani , Takayuki Ohmura
摘要： A surface-assisted laser desorption/ionization method according to an aspect includes: a first process of preparing a sample support (2) having a substrate (21) in which a plurality of through-holes (S) passing from one surface (21a) thereof to the other surface (21b) thereof are provided and a conductive layer (23) that covers at least the one surface (21a); a second process of placing a sample (10) on a sample stage (1) and arranging the sample support (2) on the sample (10) such that the other surface (21b) faces the sample (10); and a third process of applying a laser beam (L) to the one surface (21a) and ionizing the sample (10) moved from the other surface (21b) side to the one surface (21a) side via the through-holes (S) due to a capillary phenomenon.
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公开(公告)号：US11961728B2
公开(公告)日：2024-04-16
申请号：US18117632
申请日：2023-03-06
发明人： Yasuhide Naito , Masahiro Kotani , Takayuki Ohmura
CPC分类号： H01J49/0418 , G01N1/2806 , G01N1/2813 , G01N27/623 , G01N33/6851 , H01J49/164 , H01J49/26
摘要： A surface-assisted laser desorption/ionization method according to an aspect includes: a first process of preparing a sample support (2) having a substrate (21) in which a plurality of through-holes (S) passing from one surface (21a) thereof to the other surface (21b) thereof are provided and a conductive layer (23) that covers at least the one surface (21a); a second process of placing a sample (10) on a sample stage (1) and arranging the sample support (2) on the sample (10) such that the other surface (21b) faces the sample (10); and a third process of applying a laser beam (L) to the one surface (21a) and ionizing the sample (10) moved from the other surface (21b) side to the one surface (21a) side via the through-holes (S) due to a capillary phenomenon.
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公开(公告)号：US11101122B2
公开(公告)日：2021-08-24
申请号：US16647261
申请日：2018-08-06
发明人： Yasuhide Naito , Masahiro Kotani , Takayuki Ohmura
摘要： A laser desorption/ionization method, includes: a first step of preparing a sample support body including a substrate on which plurality of through holes opening to a first surface and a second surface facing each other are formed, and a conductive layer provided on at least the first surface; a second step of mounting a sample on a mounting surface of a mounting portion, and of disposing the sample support body on the sample such that the second surface is in contact with the sample; a third step of introducing a matrix solution into the plurality of through holes; and a fourth step of ionizing a component of the sample that is mixed with the matrix solution and is moved to the first surface side from the second surface side through the through hole by irradiating the first surface with laser light while a voltage is applied to the conductive layer.
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公开(公告)号：US11127577B2
公开(公告)日：2021-09-21
申请号：US16647493
申请日：2018-08-03
发明人： Yasuhide Naito , Takayuki Ohmura , Masahiro Kotani
摘要： A laser desorption/ionization method includes a first process of preparing a sample support body. The sample support body includes a substrate, an ionization substrate, and a support that supports the ionization substrate with respect to the substrate such that a first surface of the ionization substrate is separated from the substrate. A plurality of through-holes are formed at least in measurement regions of the ionization substrate. A conductive layer is provided on peripheral edges of the through-holes at least on the second surface. Further, the laser desorption/ionization method includes a second process of dropping the sample on the measurement regions of the ionization substrate, and a third process of, after the sample has infiltrated into the ionization substrate, ionizing components of the sample by applying a laser beam to the second surface while applying a voltage to the conductive layer.
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10.发明授权公开(公告)号：US10679835B2
公开(公告)日：2020-06-09
申请号：US16238250
申请日：2019-01-02
发明人： Yasuhide Naito , Masahiro Kotani , Takayuki Ohmura
摘要： A surface-assisted laser desorption/ionization method according to an aspect includes: a first process of preparing a sample support (2) having a substrate (21) in which a plurality of through-holes (S) passing from one surface (21a) thereof to the other surface (21b) thereof are provided and a conductive layer (23) that covers at least the one surface (21a); a second process of placing a sample (10) on a sample stage (1) and arranging the sample support (2) on the sample (10) such that the other surface (21b) faces the sample (10); and a third process of applying a laser beam (L) to the one surface (21a) and ionizing the sample (10) moved from the other surface (21b) side to the one surface (21a) side via the through-holes (S) due to a capillary phenomenon.
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