公开(公告)号：US11713330B2

公开(公告)日：2023-08-01

申请号：US16848239

申请日：2020-04-14

申请人： HelixBind, Inc.

发明人： Alon Singer ,  David Steinmiller ,  Nadish Goyal ,  Jork Nolling

IPC分类号： C07F9/141 ,  C12Q1/6844 ,  C12Q1/6888

CPC分类号： C07F9/1411 ,  C12Q1/6844 ,  C12Q1/6888 ,  C12Q2523/10 ,  C12Q2527/119 ,  C12Q2527/137

摘要： The present disclosure generally relates to the field of ultrasensitive microbial pathogen detection and identification utilizing genomic sequence recognition.

公开(公告)号：US20170218434A1

公开(公告)日：2017-08-03

申请号：US15488204

申请日：2017-04-14

申请人： HELIXBIND

发明人： Alon Singer

IPC分类号： C12Q1/68

CPC分类号： C12Q1/689 ,  C12Q1/6816 ,  C12Q1/6883 ,  C12Q1/6895 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2525/107 ,  C12Q2537/143 ,  C12Q2565/519 ,  C12Q2565/625

摘要： The present disclosure provides for compositions of γPNA probes. Additionally, the present disclosure provide for methods and kits using γPNA probes for the diagnosis of sepsis.

公开(公告)号：US11975320B2

公开(公告)日：2024-05-07

申请号：US16898883

申请日：2020-06-11

申请人： HelixBind, Inc.

发明人： Alon Singer ,  Ranjit Prakash

IPC分类号： B01L3/00 ,  B01D63/08 ,  B01D69/02 ,  B01D71/34 ,  B01L7/00 ,  C12Q1/686

CPC分类号： B01L3/502 ,  B01D71/34 ,  B01L3/5027 ,  C12Q1/686 ,  B01D63/088 ,  B01D69/02 ,  B01D2325/20 ,  B01D2325/38 ,  B01L7/52 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/16 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/166 ,  B01L2300/1827 ,  B01L2400/0487 ,  B01L2400/049 ,  B01L2400/06

摘要： Fluidic devices and related methods are generally provided. The fluidic devices described herein may be useful, for example, for diagnostic purposes (e.g., detection of the presence of one or more disease causing bacteria in a patient sample). Unlike certain existing fluidic devices for diagnostic purposes, the fluidic devices and methods described herein may be useful for detecting the presence of numerous disease causing bacteria in a patient sample substantially simultaneously (e.g., in parallel). In some embodiments, the fluidic devices and methods described herein provide highly sensitive detection of microbes in relatively large fluidic samples (e.g., between 0.5 mL and about 5 mL), as compared to certain existing fluidic detection (e.g., microfluidic) devices and methods. In an exemplary embodiment, increased detection sensitivity of microbial pathogens present in a patient sample (e.g., blood) is performed by selectively removing human nucleic acid prior to sensitive detection of microbial infection. In some embodiments, the fluidic device allows for the identification of microbial pathogens directly from unprocessed blood without having to conduct blood culturing processes.

公开(公告)号：US20200331938A1

公开(公告)日：2020-10-22

申请号：US16848239

申请日：2020-04-14

申请人： HelixBind, Inc.

发明人： Alon Singer ,  David Steinmiller ,  Nadish Goyal ,  Jork Nolling

IPC分类号： C07F9/141 ,  C12Q1/6844 ,  C12Q1/6888

摘要： The present disclosure generally relates to the field of ultrasensitive microbial pathogen detection and identification utilizing genomic sequence recognition.

公开(公告)号：US20150099657A1

公开(公告)日：2015-04-09

申请号：US14402028

申请日：2013-05-17

申请人： HELIXBIND

发明人： Alon Singer

IPC分类号： C12Q1/68

CPC分类号： C12Q1/689 ,  C12Q1/6816 ,  C12Q1/6883 ,  C12Q1/6895 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2525/107 ,  C12Q2537/143 ,  C12Q2565/519 ,  C12Q2565/625

摘要： The present disclosure provides for composition of γPNA probes. Additionally, the present disclosure provide for methods and kits using γPNA probes for the prognosis of sepsis. In some embodiments, wherein the γPNA capture probes and γPNA reporter probes comprise one or more functional moiety selected from the group consisting of: a binding molecule, a spacer group, a linker group, a hydrophobicity-changing group, a charge-inducing group, and a structural charge-inducing group.

摘要翻译： 本公开提供了γPNA探针的组成。 另外，本公开提供了使用γPNA探针用于败血症预后的方法和试剂盒。 在一些实施方案中，其中γPNA捕获探针和γPNA报道探针包含一个或多个选自以下的功能部分：结合分子，间隔基团，连接基团，疏水性变化基团，电荷诱导基团， 和结构电荷诱导组。

公开(公告)号：US20240238776A1

公开(公告)日：2024-07-18

申请号：US18616649

申请日：2024-03-26

申请人： HelixBind, Inc.

发明人： Alon Singer ,  Ranjit Prakash

IPC分类号： B01L3/00 ,  B01D63/08 ,  B01D69/02 ,  B01D71/34 ,  B01L7/00 ,  C12Q1/686

CPC分类号： B01L3/502 ,  B01D71/34 ,  B01L3/5027 ,  C12Q1/686 ,  B01D63/088 ,  B01D69/02 ,  B01D2325/20 ,  B01D2325/38 ,  B01L7/52 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/16 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/166 ,  B01L2300/1827 ,  B01L2400/0487 ,  B01L2400/049 ,  B01L2400/06

摘要： Fluidic devices and related methods are generally provided. The fluidic devices described herein may be useful, for example, for diagnostic purposes (e.g., detection of the presence of one or more disease causing bacteria in a patient sample). Unlike certain existing fluidic devices for diagnostic purposes, the fluidic devices and methods described herein may be useful for detecting the presence of numerous disease causing bacteria in a patient sample substantially simultaneously (e.g., in parallel). In some embodiments, the fluidic devices and methods described herein provide highly sensitive detection of microbes in relatively large fluidic samples (e.g., between 0.5 mL and about 5 mL), as compared to certain existing fluidic detection (e.g., microfluidic) devices and methods. In an exemplary embodiment, increased detection sensitivity of microbial pathogens present in a patient sample (e.g., blood) is performed by selectively removing human nucleic acid prior to sensitive detection of microbial infection. In some embodiments, the fluidic device allows for the identification of microbial pathogens directly from unprocessed blood without having to conduct blood culturing processes.

公开(公告)号：US20240025929A1

公开(公告)日：2024-01-25

申请号：US18351061

申请日：2023-07-12

申请人： HelixBind, Inc.

发明人： Alon Singer ,  David Steinmiller ,  Nadish Goyal ,  Jork Nolling

IPC分类号： C07F9/141 ,  C12Q1/6844 ,  C12Q1/6888

CPC分类号： C07F9/1411 ,  C12Q1/6844 ,  C12Q1/6888 ,  C12Q2527/137 ,  C12Q2523/10 ,  C12Q2527/119

摘要： The present disclosure generally relates to the field of ultrasensitive microbial pathogen detection and identification utilizing genomic sequence recognition.

公开(公告)号：US11590507B2

公开(公告)日：2023-02-28

申请号：US17183897

申请日：2021-02-24

申请人： HelixBind, Inc.

发明人： Alon Singer ,  Ranjit Prakash ,  David Steinmiller

IPC分类号： B01L3/00

摘要： Fluidic systems and reagent carriers suitable for storing reagents in a desirable manner are generally provided. In some embodiments, a reagent carrier stores a liquid film comprising a solid reagent and/or stores different reagents in different locations. In some embodiments, a fluidic system comprises a reagent carrier constrained such that it comprises an elongated axis positioned within 30° of a vertical axis of the fluidic reservoir.

公开(公告)号：US20210017581A1

公开(公告)日：2021-01-21

申请号：US16499515

申请日：2018-04-02

申请人： HelixBind, Inc.

发明人： Alon Singer ,  Ranjit Prakash ,  Jork Nolling

IPC分类号： C12Q1/689 ,  C12Q1/6895

摘要： The present disclosure generally relates to the field of microbial pathogen detection and identification utilizing genomic sequence recognition.

公开(公告)号：US11840721B2

公开(公告)日：2023-12-12

申请号：US16499515

申请日：2018-04-02

申请人： HelixBind, Inc.

发明人： Alon Singer ,  Ranjit Prakash ,  Jork Nolling

IPC分类号： C12Q1/68 ,  C12Q1/689 ,  C12Q1/6895

CPC分类号： C12Q1/689 ,  C12Q1/6895

摘要： The present disclosure generally relates to the field of microbial pathogen detection and identification utilizing genomic sequence recognition.