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公开(公告)号：US20160186123A1
公开(公告)日：2016-06-30
申请号：US14909277
申请日：2014-08-01
Applicant: HITACHI, LTD.
Inventor： Masaru NANBA , Ryouichi HAGA , Sei MURAKAMI , Haruo SUZUKI
Abstract: A cell culture apparatus is provided which can continuously and accurately measure turbidity of a cell culture solution and culture a cell, without inserting a turbidity sensor from outside into a sterile bag. The cell culture apparatus includes: a flexible and transparent sterile bag that is installed at a prescribed position in the cell culture apparatus and in which a cell contained in a cell culture solution is cultured; and a turbidity sensor that includes a light emitter which emits light to the cell culture solution in the sterile bag via a portion of the sterile bag, a light receiver which receives the light transmitted through the cell culture solution via another portion of the sterile bag, and that is configured to place the light emitter, the portion of the sterile bag, another portion of the sterile bag, and the light receiver, optically on a same straight line.
Abstract translation: 提供一种细胞培养装置，其可以连续且准确地测量细胞培养液的浊度并培养细胞，而不将浊度传感器从外部插入无菌袋中。 细胞培养装置包括：柔性透明的无菌袋，其安装在细胞培养装置的规定位置，培养细胞培养液中所含的细胞; 以及浊度传感器，其包括经由所述无菌袋的一部分向所述无菌袋中的细胞培养溶液发光的发光体，所述光接收器经由所述无菌袋的另一部分接收透过所述细胞培养溶液的光， 并且被配置为将光发射器，无菌袋的一部分，无菌袋的另一部分和光接收器光学地放置在相同的直线上。
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公开(公告)号：US20160136543A1
公开(公告)日：2016-05-19
申请号：US14897844
申请日：2014-06-19
Applicant: HITACHI, LTD.
Inventor： Keisuke SHIBUYA , Yasuhiko TADA , Takeyuki KONDO , Sei MURAKAMI
CPC classification number: B01D15/22 , B01D15/08 , B01D15/1821 , B01D15/1885 , B01D15/20 , C07K1/22 , G01N2030/8813
Abstract: An object of the present invention is to separate a material to be separated at a low cost and constant accuracy when the material to be separated is separated from a mobile phase containing the material to be separated through the passing of the mobile phase through a stationary phase, even if the mobile phase has a large volume. A separation device characterized in that a separation column provided with a stationary phase having a volume capable of processing the entire volume of a mobile phase containing a material to be separated is provided, the separation column is replaceable, and the usage count of the stationary phase reaches a lifetime count through the processing of one batch.
Abstract translation: 本发明的目的是当待分离的材料通过流动相通过固定相与含有待分离材料的流动相分离时，以低成本和恒定的精度将待分离的材料分离 ，即使流动相具有较大的体积。 一种分离装置，其特征在于，设置有具有能够处理含有待分离材料的流动相的整个体积的体积的固定相的分离塔，所述分离塔是可更换的，并且所述固定相的使用计数 通过一批处理达到终身计数。
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公开(公告)号：US20180223233A1
公开(公告)日：2018-08-09
申请号：US15749609
申请日：2016-07-01
Applicant: HITACHI, LTD. , FUJIMORI KOGYO CO., LTD.
Inventor： Masaru NANBA , Takashi ANDOU , Yui SUGITA , Sei MURAKAMI , Hiroyuki MATSUDA
CPC classification number: C12M1/06 , C12M1/007 , C12M1/02 , C12M3/00 , C12M23/14 , C12M23/26 , C12M23/48 , C12M27/20
Abstract: A single-use cell culturing apparatus and a culturing bag are provided, each of which can improve efficiency of stirring a culture solution and further reduce a possibility of leakage of the culture solution. The single-use cell culturing apparatus of the present invention includes a housing that accommodates the culturing bag which is flexible and can seal the culture solution inside thereof. The housing has, on an inner surface thereof, a curved convex-shaped protrusion provided at a portion of a contact face at which the housing is in contact with the culturing bag. The culturing bag of the present invention is accommodated in the housing of the single-use cell culturing apparatus; is flexible; and can seal the culture solution inside thereof. The culturing bag includes a concave portion having a shape corresponding to the curved convex protrusion disposed on a part of the housing.
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