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公开(公告)号：US3681331A
公开(公告)日：1972-08-01
申请号：US3681331D
申请日：1970-04-02
Applicant: HOFFMANN LA ROCHE
Inventor： LEIMGRUBER WILLY , WEIGELE MANFRED
IPC: C07D241/52 , C07D87/40
CPC classification number: C07D241/52
Abstract: 6-Substituted derivatives of 1-phenazinol 5,10-dioxide which possess broad spectrum anti-microbial activity are disclosed.
Abstract translation: 公开了6-取代的具有广谱抗微生物活性的1-苯并菲醇5,10-二氧化物的衍生物。
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公开(公告)号：US3917632A
公开(公告)日：1975-11-04
申请号：US43591874
申请日：1974-01-23
Applicant: HOFFMANN LA ROCHE
Inventor： LEIMGRUBER WILLY , WEIGELE MANFRED
IPC: C07D261/14
CPC classification number: C07C255/00
Abstract: A process for preparing 5-aminoisoxazole by reacting an 3disubstituted-aminoacrylonitrile and an acid addition salt of hydroxylamine.
Abstract translation: 通过3-二取代 - 氨基丙烯腈和羟胺的酸加成盐反应制备5-氨基异恶唑的方法。
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3.发明授权Nuclear substituted derivatives of 1-hydroxy-6-methoxyphenazine 5,10-dioxide 失效1-羟基-6-甲氧基苯胺5,10-二氧化物的核取代衍生物
公开(公告)号：US3700679A
公开(公告)日：1972-10-24
申请号：US4455570
申请日：1970-06-08
Applicant: HOFFMANN LA ROCHE
Inventor： LEIMGRUBER WILLY , WEIGELE MANFRED
IPC: C07D241/52 , C07D51/80
CPC classification number: C07D241/52 , A01N43/60
Abstract: Nuclear substituted derivatives of 1-hydroxy-6-methoxyphenazine 5,10-dioxide which possess broad spectrum antimicrobial activity are disclosed.
Abstract translation: 公开了具有广谱抗菌活性的1-羟基-6-甲氧基吩嗪5,10-二氧化物的核取代衍生物。
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公开(公告)号：US3871825A
公开(公告)日：1975-03-18
申请号：US44761074
申请日：1974-03-04
Applicant: HOFFMANN LA ROCHE
Inventor： LEIMGBURGER WILLY , WEIGELE MANFRED
IPC: C07C45/74 , C07C49/683 , C07C49/697 , C07C49/753 , C07C49/755 , C07C65/40 , C07C229/38 , C07D303/32 , C07D311/76 , C07D317/60 , C07D493/10 , G01N31/22 , G01N33/48 , G01N33/52 , G01N33/68 , G01N33/16
CPC classification number: C07D493/10 , C07C45/74 , C07C49/683 , C07C49/697 , C07C49/753 , C07C49/755 , C07C65/40 , C07C229/38 , C07D303/32 , C07D311/76 , C07D317/60 , G01N31/22 , G01N33/48 , G01N33/52 , G01N33/6809 , Y10T436/173845
Abstract: A novel class of reagents react with primary amine-containing compounds, preferably polypeptides and amino acids to form highly fluorescent products. This reaction serves as a basis for a rapid and highly sensitive assay method for primary amine-containing compounds.
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5.发明授权Organometallic derivatives of 6-lower alkoxy 1-phenazinol 5,10-dioxide 失效6位低碱性1-PHENAZINOL 5,10-二氧化物的有机衍生物
公开(公告)号：US3586674A
公开(公告)日：1971-06-22
申请号：US3586674D
申请日：1969-04-08
Applicant: HOFFMANN LA ROCHE
Inventor： LEIMGRUBER WILLY , MAESTRONE GIAN PAOLO , MITROVIC MILAN , WEIGELE MANFRED
IPC: C07D241/52 , C07D51/80
CPC classification number: C07D241/52 , Y10S514/924
Abstract: COPPER DERIVATIVES OF 6-LOWER ALKOXY-1-PHENAZINOL 5,10DIOXIDE PREPARED BY TREATING A 6-LOWER ALKOXY-1-PHENAZINOL 5,10-DIOXIDE WITH A COPPER SALT POSSESS BROAD SPECTRUM ANTI-MICROBIAL ACTIVITY.
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Patent Agency Ranking
公开(公告)号：US3542848A
公开(公告)日：1970-11-24
申请号：US3542848D
申请日：1968-04-09
Applicant: HOFFMANN LA ROCHE
Inventor： LEIMGRUBER WILLY , WEIGELE MANFRED
IPC: C07C255/30 , C07C121/42
CPC classification number: C07C255/00
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公开(公告)号：US3530130A
公开(公告)日：1970-09-22
申请号：US3530130D
申请日：1967-09-14
Applicant: HOFFMANN LA ROCHE
Inventor： LEIMGRUBER WILLY , WEIGELE MANFRED
IPC: C07D241/52 , C07D51/80
CPC classification number: C07D241/52
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8.发明授权4-Lower alkyl or aryl substituted-spiro{8 furan-2(3H),1{40 -phthalan{9 -3,3{40 -diones as fluorometric reagents 失效4-低级烷基或芳基取代 - 螺（8）呋喃-2（3H），1 {40-酞（9-3,3
公开(公告)号：US3917646A
公开(公告)日：1975-11-04
申请号：US44771174
申请日：1974-03-04
Applicant: HOFFMANN LA ROCHE
Inventor： LEIMGRUBER WILLY , WEIGELE MANFRED
IPC: C07C45/74 , C07C49/683 , C07C49/697 , C07C49/753 , C07C49/755 , C07C65/40 , C07C229/38 , C07D303/32 , C07D311/76 , C07D317/60 , C07D493/10 , G01N31/22 , G01N33/48 , G01N33/52 , G01N33/68 , C07D209/18 , C07D307/88 , C07D317/50
CPC classification number: C07D493/10 , C07C45/74 , C07C49/683 , C07C49/697 , C07C49/753 , C07C49/755 , C07C65/40 , C07C229/38 , C07D303/32 , C07D311/76 , C07D317/60 , G01N31/22 , G01N33/48 , G01N33/52 , G01N33/6809
Abstract: A novel class of reagents react with primary amine-containing compounds, preferably polypeptides and amino acids, to form highly fluorescent products. This reaction serves as a basis for a rapid and highly sensitive assay method for primary aminecontaining compounds.
Abstract translation: 一类新的试剂与含伯胺的化合物，优选多肽和氨基酸反应，形成高度荧光的产物。 该反应作为用于含伯胺化合物的快速和高灵敏度测定方法的基础。
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9.发明授权
公开(公告)号：US3901888A
公开(公告)日：1975-08-26
申请号：US41373573
申请日：1973-11-07
Applicant: HOFFMANN LA ROCHE
Inventor： LEIMGRUBER WILLY , WEIGELE MANFRED
IPC: C07D239/42
CPC classification number: C07C255/00
Abstract: This invention is directed to a process for the preparation of 4-amino-2-methylpyrimidine 5-carboxamide from 2-cyano-3-di-(lower alkyl)amino acrolein. The 4-amino-2-methylpyrimidine 5carboxamide is a known compound which is a valuable intermediate in the synthesis of thiamine.
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公开(公告)号：US3900511A
公开(公告)日：1975-08-19
申请号：US48066074
申请日：1974-06-19
Applicant: HOFFMANN LA ROCHE
Inventor： LEIMGRUBER WILLY , WEIGELE MANFRED
IPC: C07C120/00 , C07C121/20
CPC classification number: C07C255/00
Abstract: This invention is directed to a process for the preparation of aminomethylene malononitrile from dialkyl aminoacylonitrile including intermediates therein. Aminomethylene malononitrile is a known compound which is a valuable intermediate in the synthesis of thiamine.
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