-
公开(公告)号：US20110086889A1
公开(公告)日：2011-04-14
申请号：US12996840
申请日：2009-06-10
申请人： Hamed Aissaoui , Christoph Boss , Christine Brotschi , John Gatfield , Ralf Koberstein , Romain Siegrist , Thierry Sifferlen , Jodi Williams
发明人： Hamed Aissaoui , Christoph Boss , Christine Brotschi , John Gatfield , Ralf Koberstein , Romain Siegrist , Thierry Sifferlen , Jodi Williams
IPC分类号： A61K31/4439 , C07D403/12 , A61K31/41 , C07D401/14 , A61P3/00 , A61P25/00
CPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14
摘要： The invention relates to tetrazole compounds of formula (I) wherein X, Y, Z, R1, R2 and R3 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.
摘要翻译： 本发明涉及式（I）的四唑化合物，其中X，Y，Z，R 1，R 2和R 3如说明书所述; 和其药学上可接受的盐，以及这些化合物的用途用作药物，特别是作为食欲素受体拮抗剂。
-
公开(公告)号：US20110212968A1
公开(公告)日：2011-09-01
申请号：US13124233
申请日：2009-10-13
申请人： Hamed Aissaoui , Christoph Boss , Christine Brotschi , Ralf Koberstein , Romain Siegrist , Thierry Sifferlen , Daniel Trachsel , Jodi T. Williams
发明人： Hamed Aissaoui , Christoph Boss , Christine Brotschi , Ralf Koberstein , Romain Siegrist , Thierry Sifferlen , Daniel Trachsel , Jodi T. Williams
IPC分类号： A61K31/502 , A61K31/4965 , A61K31/437 , A61K31/44 , A61K31/4192 , A61K31/426 , A61K31/421 , C07D237/28 , C07D241/18 , C07D471/04 , C07D213/81 , C07D285/06 , C07D277/28 , C07D263/34 , A61P25/32 , A61P25/20 , A61P25/30 , A61P25/22 , A61P25/00 , A61P25/28
CPC分类号： C07D277/30 , C07D213/63 , C07D235/04 , C07D237/28 , C07D239/34 , C07D241/18 , C07D263/36 , C07D285/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12 , C07D417/14
摘要： The invention relates to novel phenethylamide derivatives and their wherein A, B, R1, R2 and R3 are as described in the application, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.
摘要翻译： 本发明涉及新的苯乙酰胺衍生物，其中A，B，R 1，R 2和R 3如本申请中所述，以及这些化合物或这些化合物的药学上可接受的盐作为药物，特别是食欲素受体 拮抗剂
-
![THIAZOLIDIN-4-ONE AND [1,3]-THIAZINAN-4-ONE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS](/abs-image/US/2012/04/12/US20120088759A1/abs.jpg.150x150.jpg)
3.发明申请THIAZOLIDIN-4-ONE AND [1,3]-THIAZINAN-4-ONE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS 审中-公开噻吗啉-4-酮和[1,3] - 噻嗪-4-酮化合物作为OREXIN受体拮抗剂公开(公告)号：US20120088759A1
公开(公告)日：2012-04-12
申请号：US13319774
申请日：2010-05-11
申请人： Hamed Aissaoui , Christoph Boss , Christine Brotschi , Markus Gude , John Gatfield , Romain Siegrist , Thierry Sifferlen , Jodi T. Williams
发明人： Hamed Aissaoui , Christoph Boss , Christine Brotschi , Markus Gude , John Gatfield , Romain Siegrist , Thierry Sifferlen , Jodi T. Williams
IPC分类号： A61K31/54 , C07D277/34 , C07D417/12 , A61K31/506 , A61K31/4439 , A61K31/426 , A61K31/498 , A61P25/22 , A61P25/00 , C07D417/10 , C07D417/04 , C07D279/06 , A61K31/501 , A61K31/427 , A61K31/4709 , A61K31/541 , A61P25/20 , A61P25/18 , C07D277/14
CPC分类号： C07D277/14 , C07D417/04
摘要： The present invention relates to thiazolidin-4-one and [1,3]-thiazinan-4-one compounds of formula (I) wherein X, Y, R3 and R4 are as described in the description, or pharmaceutically acceptable salts thereof, for the prevention or treatment of diseases related to the orexin system. The present invention also relates to novel thiazolidin-4-one compounds of formula (II) and their use as pharmaceuticals, pharmaceutical compositions containing one or more compounds of formula (II), and especially their use as orexin receptor antagonists.
摘要翻译： 本发明涉及式（I）的噻唑烷-4-酮和[1,3]噻嗪-4-酮化合物，其中X，Y，R 3和R 4如说明书中所述或其药学上可接受的盐，用于 预防或治疗与食欲素系统有关的疾病。 本发明还涉及式（II）的新型噻唑烷-4-酮化合物及其作为药物的用途，含有一种或多种式（II）化合物的药物组合物，特别是其作为食欲素受体拮抗剂的用途。
-
公开(公告)号：US20120101111A1
公开(公告)日：2012-04-26
申请号：US13319780
申请日：2010-05-11
申请人： Hamed Aissaoui , Christoph Boss , Christine Brotschi , Markus Gude , Romain Siegrist , Thierry Sifferlen , Jodi T. Williams
发明人： Hamed Aissaoui , Christoph Boss , Christine Brotschi , Markus Gude , Romain Siegrist , Thierry Sifferlen , Jodi T. Williams
IPC分类号： A61K31/497 , A61K31/428 , A61K31/421 , C07D417/02 , A61P25/28 , C07D413/02 , A61P25/30 , A61P25/00 , A61P25/20 , A61P25/18 , A61K31/4439 , C07D263/18
CPC分类号： C07D263/18 , C07D263/56 , C07D413/06 , C07D413/10 , C07D417/06 , C07D417/10
摘要： The present invention relates to oxazolidinone derivatives of formula (I) wherein Y, R3 and R4 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as orexin receptor antagonists.
摘要翻译： 本发明涉及式（I）的恶唑烷酮衍生物，其中Y，R 3和R 4如本说明书所述，其制备方法，其药学上可接受的盐及其作为药物的用途，含有一种或多种化合物 式（I），特别是它们作为食欲素受体拮抗剂的用途。
-
公开(公告)号：US08329706B2
公开(公告)日：2012-12-11
申请号：US13319780
申请日：2010-05-11
申请人： Hamed Aissaoui , Christoph Boss , Christine Brotschi , Markus Gude , Romain Siegrist , Thierry Sifferlen , Jodi T Williams
发明人： Hamed Aissaoui , Christoph Boss , Christine Brotschi , Markus Gude , Romain Siegrist , Thierry Sifferlen , Jodi T Williams
IPC分类号： A61K31/497 , A61K31/4439 , A61K31/428 , A61K31/421 , C07D413/02 , C07D417/02 , C07D263/18
CPC分类号： C07D263/18 , C07D263/56 , C07D413/06 , C07D413/10 , C07D417/06 , C07D417/10
摘要： The present invention relates to oxazolidinone derivatives of formula (I) wherein Y, R3 and R4 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as orexin receptor antagonists.
摘要翻译： 本发明涉及式（I）的恶唑烷酮衍生物，其中Y，R 3和R 4如本说明书所述，其制备方法，其药学上可接受的盐及其作为药物的用途，含有一种或多种化合物 式（I），特别是它们作为食欲素受体拮抗剂的用途。
-
![5,6,7,8-TETRAHYDRO-IMIDAZO[1,5-A]PYRAZINE COMPOUNDS](/abs-image/US/2011/05/05/US20110105514A1/abs.jpg.150x150.jpg)
公开(公告)号：US20110105514A1
公开(公告)日：2011-05-05
申请号：US13000201
申请日：2009-06-24
IPC分类号： A61K31/4985 , C07D487/04 , A61P25/00 , A61P25/30
CPC分类号： C07D487/04
摘要： The invention relates to 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives of formula (I) wherein R1, R2, R3, and R4 are as described n the description, to salts, especially pharmaceutically acceptable salts thereof, and to the use of such compounds as medicaments; especially as orexin receptor antagonists.
摘要翻译： 本发明涉及式（I）的5,6,7,8-四氢 - 咪唑并[1,5-a]吡嗪衍生物，其中R 1，R 2，R 3和R 4如在描述中所述， 可接受的盐，以及这些化合物作为药物的用途; 特别是作为食欲素受体拮抗剂。
-
公开(公告)号：US20110105491A1
公开(公告)日：2011-05-05
申请号：US13002365
申请日：2009-07-07
申请人： Hamed Aissaoui , Christoph Boss , Julien Hazemann , Ralf Koberstein , Romain Siegrist , Thierry Sifferlen
发明人： Hamed Aissaoui , Christoph Boss , Julien Hazemann , Ralf Koberstein , Romain Siegrist , Thierry Sifferlen
IPC分类号： A61K31/538 , C07D417/14 , C07D513/04 , C07D471/04 , C07D417/10 , A61K31/427 , A61K31/429 , A61K31/437 , A61K31/4245 , A61K31/433 , A61K31/498 , A61K31/4439 , A61K31/4375 , A61K31/497 , A61P25/20 , A61P25/30 , A61P25/00 , A61P25/18 , A61P25/32
CPC分类号： C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
摘要： The invention relates to thiazolidine derivatives of the formula (I) wherein A, B, and R1 are as described in the description, to salts, especially pharmaceutically acceptable salts, of such compounds and to their use as medicaments, especially as orexin receptor antagonists.
摘要翻译： 本发明涉及式（I）的噻唑烷衍生物，其中A，B和R 1如描述中所述，这些化合物的盐，特别是药学上可接受的盐，以及它们作为药物，特别是作为食欲素受体拮抗剂的用途。
-
8.发明授权公开(公告)号：US08003654B2
公开(公告)日：2011-08-23
申请号：US12296842
申请日：2007-04-10
申请人： Hamed Aissaoui , Christoph Boss , Markus Gude , Ralf Koberstein , Thierry Sifferlen , Cornelia Zumbrunn Acklin
发明人： Hamed Aissaoui , Christoph Boss , Markus Gude , Ralf Koberstein , Thierry Sifferlen , Cornelia Zumbrunn Acklin
IPC分类号： A61K31/4965
CPC分类号： C07C311/29 , C07C2601/02 , C07D213/40 , C07D213/61 , C07D213/64 , C07D231/12 , C07D231/16 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D275/02 , C07D275/04 , C07D277/28 , C07D285/12 , C07D417/12
摘要： The invention relates to novel sulfonamide compounds of the formula (I) and their use as orexin receptor antagonists.
摘要翻译： 本发明涉及式（I）的新型磺酰胺化合物及其作为食欲素受体拮抗剂的用途。
-
公开(公告)号：US20100222328A1
公开(公告)日：2010-09-02
申请号：US12600160
申请日：2008-05-13
IPC分类号： A61K31/55 , A61K31/495 , A61K31/445 , C07D417/14 , C07D495/04
CPC分类号： C07D417/06 , C07D417/14
摘要： The invention relates to selected 2-cyclopropyl-thiazole derivatives of the formula (I) wherein B, Y and R1 are as described in the description; to salts and especially pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.
摘要翻译： 本发明涉及式（I）的选择的2-环丙基 - 噻唑衍生物，其中B，Y和R 1如描述中所述; 盐，特别是其药学上可接受的盐，以及这些化合物的用途用作药物，特别是作为食欲素受体拮抗剂。
-
![TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES](/abs-image/US/2010/08/12/US20100204285A1/abs.jpg.150x150.jpg)
10.发明申请公开(公告)号：US20100204285A1
公开(公告)日：2010-08-12
申请号：US12670809
申请日：2008-07-25
申请人： Hamed Aissaoui , Christoph Boss , Markus Gude , Ralf Koberstein , David Lehman , Thierry Sifferlen , Daniel Trachsel
发明人： Hamed Aissaoui , Christoph Boss , Markus Gude , Ralf Koberstein , David Lehman , Thierry Sifferlen , Daniel Trachsel
IPC分类号： A61K31/427 , C07D209/52 , C07D277/04 , A61K31/40 , A61P25/18
CPC分类号： C07D209/52 , C07D405/12 , C07D417/14 , C07D513/04
摘要： The invention relates to novel trans-3-aza-bicyclo[3.1.0]hexane derivatives of formula (I), wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.
摘要翻译： 本发明涉及式（I）的新型反式-3-氮杂 - 双环[3.1.0]己烷衍生物，其中A，B，n和R 1如说明书所述，以及这些化合物的用途，或 这些化合物的药学上可接受的盐，作为药物，特别是作为食欲素受体拮抗剂。
-
-
-
-
-
-
-
-
-
搜索结果
68 条记录 (耗时 0.038 秒)
