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1.发明申请Multivalent indole compounds and use thereof as phospholipase-A2 inhibitors 有权多价吲哚化合物及其作为磷脂酶A2抑制剂的用途公开(公告)号：US20070135385A1
公开(公告)日：2007-06-14
申请号：US11593177
申请日：2006-11-03
申请人： Han-Ting Chang , Dominique Charmot , Tomasz Glinka , Michael Cope , Elizabeth Goka , Jun Shao , Damien Cartigny , Shiah-yun Chen , Jerry Buysse
发明人： Han-Ting Chang , Dominique Charmot , Tomasz Glinka , Michael Cope , Elizabeth Goka , Jun Shao , Damien Cartigny , Shiah-yun Chen , Jerry Buysse
IPC分类号： A61K31/675 , A61K31/404 , C07D209/36
CPC分类号： C07D209/18 , C07D471/04 , C07D487/04
摘要： Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject.
摘要翻译： 公开了吲哚和吲哚相关化合物，组合物和方法。 本发明的化合物可用作磷脂酶抑制剂。 本发明的化合物和组合物可用于治疗动物受试者中磷脂酶相关病症，例如胰岛素相关，体重相关和/或胆固醇相关病症。
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2.发明申请Phospholipase inhibitors, including multi-valent phospholipase inhibitors, and use thereof, including as lumen-localized phospholipase inhibitors 审中-公开磷脂酶抑制剂，包括多价磷脂酶抑制剂及其用途，包括作为内腔定位的磷脂酶抑制剂公开(公告)号：US20070135383A1
公开(公告)日：2007-06-14
申请号：US11593176
申请日：2006-11-03
申请人： Han-Ting Chang , Dominque Charmot , Tomasz Glinka , Michael Cope , Elizabeth Goka , Jun Shao , Damien Cartigny , Shiah-yun Chen , Jerry Buysse
发明人： Han-Ting Chang , Dominque Charmot , Tomasz Glinka , Michael Cope , Elizabeth Goka , Jun Shao , Damien Cartigny , Shiah-yun Chen , Jerry Buysse
IPC分类号： A61K31/685 , A61K31/66 , A61K31/503 , A61K31/4745 , A61K31/405 , A61K31/365
CPC分类号： A61K31/404 , A61K9/0019 , A61K9/0095 , A61K31/41 , A61K31/66 , A61K47/10 , A61K47/20 , A61K47/55 , A61K47/58
摘要： The present invention provides methods and compositions for the treatment of phospholipase-related conditions. In particular, the invention provides a method of treating insulin-related, weight-related conditions and/or cholesterol-related conditions in an animal subject. The method generally involves the administration of a non-absorbed and/or effluxed phospholipase A2 inhibitor that is localized in a gastrointestinal lumen.
摘要翻译： 本发明提供了治疗磷脂酶相关病症的方法和组合物。 特别地，本发明提供了一种在动物受试者中治疗胰岛素相关，体重相关病症和/或胆固醇相关病症的方法。 该方法通常涉及施用定位在胃肠腔中的未吸收和/或流出的磷脂酶A2抑制剂。
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公开(公告)号：US20060099169A1
公开(公告)日：2006-05-11
申请号：US11249997
申请日：2005-10-13
申请人： Dominique Charmot , Jerry Buysse , Han Chang , Michael Cope , Tony Mong , Elizabeth Goka
发明人： Dominique Charmot , Jerry Buysse , Han Chang , Michael Cope , Tony Mong , Elizabeth Goka
IPC分类号： A61K31/785 , A61K31/74
CPC分类号： A61K47/50
摘要： Methods and compositions for the treatment of toxin-mediated diseases are provided herein. One aspect of the invention is oligosaccharide-based therapeutics that interact with toxins and methods of uses thereof. In one embodiment the oligosaccharide-based therapeutics of the invention comprise polymeric particles with attached oligosaccharide binding moieties. The compositions of the invention can be used in the treatment of toxin-mediated diseases such as antibiotic-associated diarrhea and pseudomembranous colitis, including Clostridium difficile associated diarrhea.
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公开(公告)号：US20060078534A1
公开(公告)日：2006-04-13
申请号：US10965688
申请日：2004-10-13
申请人： Dominique Charmot , Jerry Buysse , Han Chang , Tony Mong , Michael Cope , Elizabeth Goka
发明人： Dominique Charmot , Jerry Buysse , Han Chang , Tony Mong , Michael Cope , Elizabeth Goka
IPC分类号： A61K31/765 , C08G63/91
CPC分类号： A61K31/765 , A61K47/549 , A61K47/58 , A61K47/6927 , C08F293/005 , C08L2201/50
摘要： Methods and compositions for the treatment of toxin-mediated diseases are provided herein. One aspect of the invention is oligosaccharide-based therapeutics that interact with toxins and methods of uses thereof. In one embodiment the oligosaccharide-based therapeutics of the invention comprise polymeric particles with attached oligosaccharide binding moieties. The compositions of the invention can be used in the treatment of toxin-mediated diseases such as antibiotic-associated diarrhea and pseudomembranous colitis, including Clostridium difficile associated diarrhea.
摘要翻译： 本文提供了用于治疗毒素介导的疾病的方法和组合物。 本发明的一个方面是与毒素相互作用的基于寡糖的治疗剂及其使用方法。 在一个实施方案中，本发明的基于寡糖的治疗剂包含具有连接的寡糖结合部分的聚合物颗粒。 本发明的组合物可用于治疗毒素介导的疾病，例如抗生素相关性腹泻和假膜性结肠炎，包括艰难梭菌相关性腹泻。
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公开(公告)号：US07854924B2
公开(公告)日：2010-12-21
申请号：US10814527
申请日：2004-03-30
申请人： Robert Alpern , Jerry Buysse , Han Ting Chang , Dominique Charmot , Michael James Cope , John Fordtran , Gerrit Klaerner , Eric Connor , Mingjun Liu , Futian Liu , Jun Shao
发明人： Robert Alpern , Jerry Buysse , Han Ting Chang , Dominique Charmot , Michael James Cope , John Fordtran , Gerrit Klaerner , Eric Connor , Mingjun Liu , Futian Liu , Jun Shao
CPC分类号： A61K31/74
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
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公开(公告)号：US07488495B2
公开(公告)日：2009-02-10
申请号：US10965274
申请日：2004-10-13
申请人： Dominique Charmot , Han Ting Chang , Gerrit Klaerner , Michael James Cope , Mingjun Liu , Futian Liu , Jerry Buysse , Eric Connor , Tony Kwok-Kong Mong , Jun Shao , Deidre Madsen
发明人： Dominique Charmot , Han Ting Chang , Gerrit Klaerner , Michael James Cope , Mingjun Liu , Futian Liu , Jerry Buysse , Eric Connor , Tony Kwok-Kong Mong , Jun Shao , Deidre Madsen
CPC分类号： A61K31/74
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了包含钾结合聚合物及其药物组合物的组合物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗高钾血症，例如由肾衰竭引起的高钾血症和/或使用引起高钾血症的药物。
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公开(公告)号：US07776319B2
公开(公告)日：2010-08-17
申请号：US11095760
申请日：2005-03-30
申请人： Robert Alpern , Jerry Buysse , Han Ting Chang , Dominique Charmot , Michael James Cope , John Fordtran , Gerrit Klaerner , Eric Connor , Mingjun Liu , Futian Liu , Jun Shao
发明人： Robert Alpern , Jerry Buysse , Han Ting Chang , Dominique Charmot , Michael James Cope , John Fordtran , Gerrit Klaerner , Eric Connor , Mingjun Liu , Futian Liu , Jun Shao
IPC分类号： A61K31/74 , A61K31/765 , A61K31/785 , A61K9/14 , A61P3/12 , A61P9/12 , A61P13/12
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了包含钠结合聚合物及其药物组合物的组合物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗高血压，慢性心力衰竭，终末期肾病，肝硬化，慢性肾功能不全，流体过载或钠过载。
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公开(公告)号：US20070292385A1
公开(公告)日：2007-12-20
申请号：US11579251
申请日：2005-05-03
申请人： Dominique Charmot , Jerry Buysse , Han-Ting Chang , Michael Cope , David Hui
发明人： Dominique Charmot , Jerry Buysse , Han-Ting Chang , Michael Cope , David Hui
IPC分类号： A61K31/785 , A61P3/00
CPC分类号： A61K31/785 , A23L33/10 , A61K31/195 , A61K31/381 , A61K31/40 , A61K31/404 , A61K31/405 , A61K31/519 , A61K31/66 , A61K31/74
摘要： The present invention provides methods and compositions for the treatment of phospholipase-related conditions. In particular, the invention provides a method of treating insulin-related, weight-related conditions and/or cholesterol-related conditions in an animal subject. The method generally involves the administration of a non-absorbed and/or effluxed phospholipase A2 inhibitor that is localized in a gastrointestinal lumen.
摘要翻译： 本发明提供了治疗磷脂酶相关病症的方法和组合物。 特别地，本发明提供了一种在动物受试者中治疗胰岛素相关，体重相关病症和/或胆固醇相关病症的方法。 该方法通常涉及施用定位在胃肠腔中的未吸收和/或流出的磷脂酶A2抑制剂。
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9.发明申请Treatment Of Diet-Related Conditions Using Phospholipase-A2 Inhibitors Comprising Indoles And Related Compounds 审中-公开使用包含吲哚和相关化合物的磷脂酶A2抑制剂治疗饮食相关病症公开(公告)号：US20080021049A1
公开(公告)日：2008-01-24
申请号：US11579253
申请日：2005-05-03
申请人： Jerry Buysse , Dominique Charmot , Han-Ting Chang , Michael Cope , David Hui
发明人： Jerry Buysse , Dominique Charmot , Han-Ting Chang , Michael Cope , David Hui
IPC分类号： A61K31/404 , A61K31/195 , A61K31/381 , A61P3/00 , A61K31/519 , A61K31/40
CPC分类号： A61K31/785 , A23L33/10 , A61K31/195 , A61K31/381 , A61K31/40 , A61K31/404 , A61K31/405 , A61K31/519 , A61K31/66 , A61K31/74
摘要： The present invention provides methods and compositions for the treatment of phospholipase-related conditions. In particular, the invention provides a method of treating insulin-related, weight-related conditions and/or cholesterol-related conditions in an animal subject. The method generally involves the administration of a phospholipase A2 inhibitor having comprising a substituted organic compound having a fused five-member ring and six-member ring, such as indole-containing compounds.
摘要翻译： 本发明提供了治疗磷脂酶相关病症的方法和组合物。 特别地，本发明提供了一种在动物受试者中治疗胰岛素相关，体重相关病症和/或胆固醇相关病症的方法。 该方法通常包括施用含有具有稠合的五元环和六元环的取代的有机化合物的磷脂酶A2抑制剂，例如含吲哚的化合物。
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10.发明申请Treatment Of Hypercholesterolemia, Hypertriglyceridemia And Cardiovascular-Related Conditions Using Phospholipase-A2 Inhibitors 审中-公开使用磷脂酶A2抑制剂治疗高胆固醇血症，高甘油三酯血症和心血管相关病症公开(公告)号：US20080051447A1
公开(公告)日：2008-02-28
申请号：US11579252
申请日：2005-05-03
申请人： Dominique Charmot , Jerry Buysse , Han-Ting Chang , Michacl Cope , David Hui
发明人： Dominique Charmot , Jerry Buysse , Han-Ting Chang , Michacl Cope , David Hui
IPC分类号： A61K31/404 , A23L1/00 , A61P3/00 , A61K31/015
CPC分类号： A61K31/015 , A23V2002/00 , A61K31/404 , A23V2200/328
摘要： The present invention provides methods and compositions for the treatment of phospholipase-related conditions. In particular, the invention provides a method of treating insulin-related, weight-related conditions and/or cholesterol-related conditions in an animal subject. The method generally involves the administration of a non-absorbed and/or effluxed phospholipase A2 inhibitor that is localized in a gastrointestinal lumen.
摘要翻译： 本发明提供了治疗磷脂酶相关病症的方法和组合物。 特别地，本发明提供了一种在动物受试者中治疗胰岛素相关，体重相关病症和/或胆固醇相关病症的方法。 该方法通常涉及施用定位在胃肠腔中的未吸收和/或流出的磷脂酶A2抑制剂。
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