Automobile mirror
    2.
    发明授权
    Automobile mirror 失效
    汽车镜

    公开(公告)号:US4089233A

    公开(公告)日:1978-05-16

    申请号:US715928

    申请日:1976-08-19

    申请人: Walter Sebald

    发明人: Walter Sebald

    IPC分类号: B60R1/072 F16H25/20 F16H1/18

    摘要: An automobile mirror device comprises a mirror mounted in a carrier which is connected by a universal joint to a base. A threaded spindle, driven by an electric motor, engages a split nut held by a spring steel stirrup pivotally connected to the carrier. When the mirror is tilted by rotation of the spindle to either of its end positions, the thread will disengage the nut by forcing apart the parts of the nut.

    摘要翻译: 汽车镜装置包括安装在通过万向接头连接到基座的托架中的反射镜。 由电动马达驱动的螺纹主轴接合由枢转地连接到托架的弹簧钢筋箍固定的分裂螺母。 当镜子通过主轴转动到其任何一个端部位置而使镜子倾斜时,通过强制将螺母的部分分开,螺纹将脱离螺母。

    Mutein of a bone morphogenetic protein and use thereof
    5.
    发明授权
    Mutein of a bone morphogenetic protein and use thereof 失效
    骨形态发生蛋白的突变蛋白及其用途

    公开(公告)号:US07786080B2

    公开(公告)日:2010-08-31

    申请号:US10591482

    申请日:2005-03-04

    IPC分类号: A61K38/18 C07K14/51

    CPC分类号: C07K14/51 A61K38/00

    摘要: The present invention is related to a mutein of a bone morphogenetic protein, whereby the mutein comprises an amino acid substitution compared to the wildtype of the bone morphogenetic protein at the amino acid position corresponding to amino acid position 51 of human BMP-2.

    摘要翻译: 本发明涉及骨形态发生蛋白的突变蛋白,其中与对应于人BMP-2的氨基酸位置51的氨基酸位置处的骨形态发生蛋白的野生型相比,突变蛋白包含氨基酸取代。

    FREEZE-DRIED RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2 PREPARATION
    7.
    发明申请
    FREEZE-DRIED RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2 PREPARATION 审中-公开
    冷冻干燥重组人骨骼形态蛋白-2制备

    公开(公告)号:US20140148387A1

    公开(公告)日:2014-05-29

    申请号:US13819934

    申请日:2010-09-01

    IPC分类号: A61K38/18

    CPC分类号: A61K38/1875 A61K9/19

    摘要: The present invention provides a freeze-dried preparation obtained by dissolving an active type human bone morphogenetic protein-2 homodimer added with an alanine residue to the N-terminus in a strong acid solution and freeze-drying the solution, a production method of the preparation, and a kit for regeneration and treatment of bone, which contains the preparation.

    摘要翻译: 本发明提供一种通过在强酸溶液中将添加有丙氨酸残基的活性型人骨形态发生蛋白-2同二聚体溶解在N-末端并冷冻干燥该溶液而获得的冷冻干燥制剂,该制备方法 ,以及用于骨的再生和治疗的试剂盒,其包含制剂。

    Polypeptide variants with increased heparin-binding capacity
    8.
    发明授权
    Polypeptide variants with increased heparin-binding capacity 失效
    具有增加肝素结合能力的多肽变体

    公开(公告)号:US07253254B1

    公开(公告)日:2007-08-07

    申请号:US09913467

    申请日:2000-01-27

    申请人: Walter Sebald

    发明人: Walter Sebald

    摘要: The invention pertains to polypeptide variants with increased heparin-binding ability. Increased heparin-binding ability is achieved by addition, insertion, and/or substitution of an amino acid sequence X1X2X3X4X5X6 (SEQ ID NO. 1 or NO.2). Polypeptide variants according to the invention are particularly suited for stimulation of chondrogenesis, osteogenesis, and wound healing. The invention also pertains to amino acid molecules that encode said polypeptide variants, host cells containing said nucleic acid molecules, and processes for producing the polypeptide variants.

    摘要翻译: 本发明涉及具有增加的肝素结合能力的多肽变体。 增加的肝素结合能力是通过氨基酸序列X 1 X 2 X 3 X X的加入,插入和/或取代来实现的, 5×X 6(SEQ ID NO.1或NO.2)。 根据本发明的多肽变体特别适用于刺激软骨形成,成骨和伤口愈合。 本发明还涉及编码所述多肽变体的氨基酸分子,含有所述核酸分子的宿主细胞,以及产生多肽变体的方法。