摘要:
The present invention relates to novel hIL-4 mutant proteins, to processes for preparing them, and to their use as medicaments, in particular in overshooting, falsely regulated immune reactions and autoimmune diseases.
摘要:
An automobile mirror device comprises a mirror mounted in a carrier which is connected by a universal joint to a base. A threaded spindle, driven by an electric motor, engages a split nut held by a spring steel stirrup pivotally connected to the carrier. When the mirror is tilted by rotation of the spindle to either of its end positions, the thread will disengage the nut by forcing apart the parts of the nut.
摘要:
The design of antagonists of 4-helix bundle cytokine specific receptors, mimetic peptides that are able to act as such antagonists and their use as pharmaceutical agents is disclosed.
摘要:
The invention concerns the intercistronic DNA sequence of the atp operon of Escherichia coli for the subunit c of the ATP synthase, a DNA structure and an expression vector which are characterized by the said intercistronic DNA sequence, and a process for the production of proteins using the same. The DNA sequence enhances the rate of synthesis of the proteins.
摘要:
The present invention is related to a mutein of a bone morphogenetic protein, whereby the mutein comprises an amino acid substitution compared to the wildtype of the bone morphogenetic protein at the amino acid position corresponding to amino acid position 51 of human BMP-2.
摘要:
The present invention is related to a mutein of a bone morphogenetic protein, whereby the mutein comprises an amino acid substitution compared to the wildtype of the bone morphogenetic protein at the amino acid position corresponding to amino acid position 51 of human BMP-2.
摘要:
The present invention provides a freeze-dried preparation obtained by dissolving an active type human bone morphogenetic protein-2 homodimer added with an alanine residue to the N-terminus in a strong acid solution and freeze-drying the solution, a production method of the preparation, and a kit for regeneration and treatment of bone, which contains the preparation.
摘要:
The invention pertains to polypeptide variants with increased heparin-binding ability. Increased heparin-binding ability is achieved by addition, insertion, and/or substitution of an amino acid sequence X1X2X3X4X5X6 (SEQ ID NO. 1 or NO.2). Polypeptide variants according to the invention are particularly suited for stimulation of chondrogenesis, osteogenesis, and wound healing. The invention also pertains to amino acid molecules that encode said polypeptide variants, host cells containing said nucleic acid molecules, and processes for producing the polypeptide variants.
摘要翻译:本发明涉及具有增加的肝素结合能力的多肽变体。 增加的肝素结合能力是通过氨基酸序列X 1 X 2 X 3 X X的加入,插入和/或取代来实现的, 5×X 6(SEQ ID NO.1或NO.2)。 根据本发明的多肽变体特别适用于刺激软骨形成,成骨和伤口愈合。 本发明还涉及编码所述多肽变体的氨基酸分子,含有所述核酸分子的宿主细胞,以及产生多肽变体的方法。
摘要:
The invention relates to therapeutic agents which are antagonists or partial agonists of human interleukin 4, or contain these antagonists or partial agonists, to mutant hIL-4 proteins and to processes for their preparation.