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13 条记录 (耗时 0.03 秒)

    Composition for inhibiting tumor cell proliferation
    3.
    发明授权
    Composition for inhibiting tumor cell proliferation 有权
    用于抑制肿瘤细胞增殖的组合物

    公开(公告)号：US09034317B2

    公开(公告)日：2015-05-19

    申请号：US13522741

    申请日：2011-02-10

    申请人： Alex Karlsson-Parra ,  Bengt Andersson ,  AnnaCarin Wallgren

    发明人： Alex Karlsson-Parra ,  Bengt Andersson ,  AnnaCarin Wallgren

    IPC分类号： A01N63/00 ,  C12N5/071 ,  C12N5/0784

    CPC分类号： C12N5/0639

    摘要： This invention pertains to cancer immunotherapy, by providing a proinflammatory dendritic cell (DC), which has been stimulated to maturation ex vivo by specific treatment, a method for such treatment and a composition comprising the proinflammatory DC. The DC may be used as a cell based immunotherapy for inhibiting tumor cell proliferation.

    摘要翻译： 本发明涉及癌症免疫治疗，其通过提供通过特异性治疗离体培养成熟的促炎树突细胞（DC），这种治疗方法和包含促炎症DC的组合物。 DC可以用作基于细胞的免疫治疗来抑制肿瘤细胞增殖。

    Method and composition for producing a cellular allogeneic vaccine
    4.
    发明授权
    Method and composition for producing a cellular allogeneic vaccine 有权
    用于产生细胞同种异体疫苗的方法和组合物

    公开(公告)号：US08673296B2

    公开(公告)日：2014-03-18

    申请号：US11603819

    申请日：2006-11-24

    申请人： Alex Karlsson-Parra ,  AnnaCarin Wallgren ,  Bengt Andersson

    发明人： Alex Karlsson-Parra ,  AnnaCarin Wallgren ,  Bengt Andersson

    IPC分类号： A01N63/00 ,  A61K45/00 ,  A61K47/00

    CPC分类号： A61K39/0011 ,  A61K2039/5154 ,  C12N5/0645 ,  C12N2501/599 ,  C12N2501/70 ,  Y02A50/472

    摘要： The present invention relates to a method for the production of a cellular allogeneic vaccine, which is based upon an allogeneic APC, comprising the following steps: isolation of an APC from a subject or providing an APC already established and/or isolated from a myeloid leukemia cell line, and modifying the APC with an antigen using any of the following methods: pulsing, transfection, infection or fusion; treatment using an agent capable of removing sialic acid on cell surfaces; and optionally culturing the APC in a suitable medium, an allogeneic vaccine obtainable by the above method, a composition comprising said vaccine and a pharmaceutically acceptable carrier and therapeutic use of said vaccine or said composition.

    摘要翻译： 本发明涉及一种用于产生基于同种异体APC的细胞同种异体疫苗的方法，其包括以下步骤：从受试者中分离APC或提供已经建立和/或从骨髓性白血病分离的APC 细胞系，并使用任何以下方法用抗原修饰APC：脉冲，转染，感染或融合; 使用能够除去细胞表面上的唾液酸的试剂进行处理; 并任选地在合适的培养基中培养APC，通过上述方法获得的同种异体疫苗，包含所述疫苗和药学上可接受的载体的组合物以及所述疫苗或所述组合物的治疗用途。

    Method and composition for producing a cellular allogeneic vaccine
    5.
    发明申请
    Method and composition for producing a cellular allogeneic vaccine 有权
    用于产生细胞同种异体疫苗的方法和组合物

    公开(公告)号：US20070134219A1

    公开(公告)日：2007-06-14

    申请号：US11603819

    申请日：2006-11-24

    申请人： Alex Karlsson-Parra ,  AnnaCarin Wallgren ,  Bengt Andersson

    发明人： Alex Karlsson-Parra ,  AnnaCarin Wallgren ,  Bengt Andersson

    IPC分类号： A61K48/00 ,  A61K39/00

    CPC分类号： A61K39/0011 ,  A61K2039/5154 ,  C12N5/0645 ,  C12N2501/599 ,  C12N2501/70 ,  Y02A50/472

    摘要： The present invention relates to a method for the production of a cellular allogeneic vaccine, which is based upon an allogeneic APC, comprising the following steps: isolation of an APC from a subject or providing an APC already established and/or isolated from a myeloid leukemia cell line, and modifying the APC with an antigen using any of the following methods: pulsing, transfection, infection or fusion; treatment using an agent capable of removing sialic acid on cell surfaces; and optionally culturing the APC in a suitable medium, an allogeneic vaccine obtainable by the above method, a composition comprising said vaccine and a pharmaceutically acceptable carrier and therapeutic use of said vaccine or said composition.

    摘要翻译： 本发明涉及一种用于产生基于同种异体APC的细胞同种异体疫苗的方法，其包括以下步骤：从受试者中分离APC或提供已经建立和/或从骨髓性白血病分离的APC 细胞系，并使用任何以下方法用抗原修饰APC：脉冲，转染，感染或融合; 使用能够除去细胞表面上的唾液酸的试剂进行处理; 并任选地在合适的培养基中培养APC，通过上述方法获得的同种异体疫苗，包含所述疫苗和药学上可接受的载体的组合物以及所述疫苗或所述组合物的治疗用途。