公开(公告)号：US5972810A

公开(公告)日：1999-10-26

申请号：US826169

申请日：1997-03-27

申请人： Hans-Joachim Gabrisch ,  Marteen De Zwart ,  Markus Rudin

发明人： Hans-Joachim Gabrisch ,  Marteen De Zwart ,  Markus Rudin

IPC分类号： B29B15/12 ,  B29C70/08 ,  B32B5/28 ,  D06N7/06 ,  B32B5/16

CPC分类号： B29C70/08 ,  B29B15/122 ,  B32B5/28 ,  Y10T428/24116 ,  Y10T428/251 ,  Y10T442/2008 ,  Y10T442/2082 ,  Y10T442/2475 ,  Y10T442/2738 ,  Y10T442/2902 ,  Y10T442/2951 ,  Y10T442/2967 ,  Y10T442/2984 ,  Y10T442/2992 ,  Y10T442/3301 ,  Y10T442/659

摘要： There are described a self-adhesive prepreg on the basis of a resin-impregnated fibrous supporting material carrying on at least one surface a layer with an increased ratio of resin to supporting material, and the use thereof for the production of sandwich structures.

摘要翻译： 描述了一种基于树脂浸渍的纤维支撑材料的基于树脂浸渍的纤维支撑材料的自粘性预浸料，并且其在至少一个表面上具有树脂与支撑材料的比例增加的层以及其用于生产夹层结构的用途。

公开(公告)号：US20090117120A1

公开(公告)日：2009-05-07

申请号：US12157664

申请日：2008-06-11

申请人： Jan Grimm ,  Roger Nitsch ,  Marlen Knobloch ,  Uwe Konietzko ,  Markus Rudin ,  Thomas Muggler ,  Felicitas Kranz

发明人： Jan Grimm ,  Roger Nitsch ,  Marlen Knobloch ,  Uwe Konietzko ,  Markus Rudin ,  Thomas Muggler ,  Felicitas Kranz

IPC分类号： A61K39/395 ,  A01K67/027 ,  C12N15/85 ,  A61P25/28 ,  C12N15/12 ,  A61B10/00

CPC分类号： C07K14/4711 ,  A01K67/0275 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/0312 ,  A61K39/0007 ,  C07K14/47 ,  C12N15/8509 ,  C12N2830/008 ,  C12N2830/85

摘要： Provided is a novel APP (amyloid precursor protein) transgenic non-human animal modeling in vivo the pathophysiological effects and effects on cognitive behavior of early intraneuronal and extracellular brain parenchymal amyloid-β (Aβ) deposition and cerebral amyloid angiopathy associated with brain microhemorrhages and reduced vasoreactivity and blood flow. Furthermore, methods of screening for therapeutic or diagnostic agents useful in the treatment or diagnosis of Alzheimer's disease, in particular for improving blood flow to the brain are provided as well as the corresponding therapeutic methods.

摘要翻译： 提供了一种新型的APP（淀粉样蛋白前体蛋白）转基因非人动物模型，体内对脑微量出血相关的早期神经元和细胞外脑实质淀粉样蛋白β（Abeta）沉积和脑淀粉样变性血管病的认知行为的病理生理作用和影响减少 血管活性和血流量。 此外，提供了可用于治疗或诊断阿尔茨海默氏病，特别是用于改善对脑的血流量的治疗或诊断剂的筛选方法以及相应的治疗方法。

公开(公告)号：US09746419B2

公开(公告)日：2017-08-29

申请号：US12662815

申请日：2010-05-05

申请人： Florian Stuker ,  Katerina Dikaiou ,  Christof Baltes ,  Markus Rudin

发明人： Florian Stuker ,  Katerina Dikaiou ,  Christof Baltes ,  Markus Rudin

IPC分类号： A61B5/05 ,  G01N21/64 ,  A61B5/00 ,  G01N21/47

CPC分类号： G01N21/6456 ,  A61B5/0035 ,  A61B5/0042 ,  A61B5/0073 ,  A61B5/0077 ,  A61B2503/40 ,  G01N21/4795

摘要： A dual modality imaging apparatus, comprising a magnetic resonance imaging (=MRI) system and a fluorescence molecular tomography (=FMT) system, for investigating a sample (42) located at a sample position (10), wherein the MRI system comprises a magnet (9) with a room temperature bore (8), with the sample position (10) located within the bore (8), and wherein the FMT system comprises means for directing a light beam (12, 17; 30) towards the sample position (10), and a position-sensitive detector (37) for collecting fluorescence light from the sample (42), is characterized in that the position-sensitive detector (37) is located within the bore (8), wherein at least part of the sample (42) is imaged onto the position-sensitive detector (37), and that the means for directing the light beam (12, 17; 30) comprise a focusing device for focusing the light beam (12, 17; 30) into a focal spot (41) on the sample (42), and a scanning device for scanning the focal spot (41) on the sample (42). The apparatus is simple in design and versatile in application, and in particular imposes less limitations on the maximum number of source/detector pairs during FMT imaging, thus allowing a better FMT image resolution.

公开(公告)号：US08022268B2

公开(公告)日：2011-09-20

申请号：US12157664

申请日：2008-06-11

申请人： Jan Grimm ,  Roger Nitsch ,  Marlen Knobloch ,  Uwe Konietzko ,  Markus Rudin ,  Thomas Müggler ,  Felicitas Kranz

发明人： Jan Grimm ,  Roger Nitsch ,  Marlen Knobloch ,  Uwe Konietzko ,  Markus Rudin ,  Thomas Müggler ,  Felicitas Kranz

IPC分类号： A01K67/027 ,  A01K67/00 ,  A01K67/033

CPC分类号： C07K14/4711 ,  A01K67/0275 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/0312 ,  A61K39/0007 ,  C07K14/47 ,  C12N15/8509 ,  C12N2830/008 ,  C12N2830/85

摘要： Provided is a novel APP (amyloid precursor protein) transgenic non-human animal modeling in vivo the pathophysiological effects and effects on cognitive behavior of early intraneuronal and extracellular brain parenchymal amyloid-β (Aβ) deposition and cerebral amyloid angiopathy associated with brain microhemorrhages and reduced vasoreactivity and blood flow. Furthermore, methods of screening for therapeutic or diagnostic agents useful in the treatment or diagnosis of Alzheimer's disease, in particular for improving blood flow to the brain are provided as well as the corresponding therapeutic methods.

摘要翻译： 提供了一种新型APP（淀粉样蛋白前体蛋白）转基因非人动物体内模型，对早期神经元和细胞外脑实质淀粉样蛋白的认知行为的病理生理作用和影响。 （A＆BGR）沉积和与脑微出血相关的脑淀粉样血管病变，并减少血管反应性和血流量。 此外，提供了可用于治疗或诊断阿尔茨海默氏病，特别是用于改善对脑的血流量的治疗或诊断剂的筛选方法以及相应的治疗方法。

公开(公告)号：US20100292563A1

公开(公告)日：2010-11-18

申请号：US12662815

申请日：2010-05-05

申请人： Florian Stuker ,  Katerina Dikaiou ,  Christof Baltes ,  Markus Rudin

发明人： Florian Stuker ,  Katerina Dikaiou ,  Christof Baltes ,  Markus Rudin

IPC分类号： A61B5/05 ,  A61B6/00

CPC分类号： G01N21/6456 ,  A61B5/0035 ,  A61B5/0042 ,  A61B5/0073 ,  A61B5/0077 ,  A61B2503/40 ,  G01N21/4795

摘要： A dual modality imaging apparatus, comprising a magnetic resonance imaging (=MRI) system and a fluorescence molecular tomography (=FMT) system, for investigating a sample (42) located at a sample position (10), wherein the MRI system comprises a magnet (9) with a room temperature bore (8), with the sample position (10) located within the bore (8), and wherein the FMT system comprises means for directing a light beam (12, 17; 30) towards the sample position (10), and a position-sensitive detector (37) for collecting fluorescence light from the sample (42), is characterized in that the position-sensitive detector (37) is located within the bore (8), wherein at least part of the sample (42) is imaged onto the position-sensitive detector (37), and that the means for directing the light beam (12, 17; 30) comprise a focusing device for focusing the light beam (12, 17; 30) into a focal spot (41) on the sample (42), and a scanning device for scanning the focal spot (41) on the sample (42). The apparatus is simple in design and versatile in application, and in particular imposes less limitations on the maximum number of source/detector pairs during FMT imaging, thus allowing a better FMT image resolution.

摘要翻译： 一种双模式成像设备，包括用于调查位于样本位置（10）的样本（42）的磁共振成像（= MRI）系统和荧光分子断层摄影（= FMT）系统，其中所述MRI系统包括磁体 （9）具有室温孔（8），其中样品位置（10）位于孔（8）内，并且其中FMT系统包括用于将光束（12,17; 30）引向样品位置的装置 （10）和用于从样品（42）收集荧光的位置敏感检测器（37）的特征在于位置敏感检测器（37）位于孔（8）内，其中至少部分 样品（42）被成像到位置敏感检测器（37）上，并且用于引导光束（12,17; 30）的装置包括聚焦装置，用于将光束（12,17; 30）聚焦到 样品（42）上的焦点（41）和用于扫描样品（42）上的焦点（41）的扫描装置。 该设备设计简单，应用广泛，特别是在FMT成像期间对源/检测器对的最大数量的限制较少，因此允许更好的FMT图像分辨率。