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39 条记录 (耗时 0.034 秒)

    Stable oxpenem-3-carboxylic acids as beta-lactamase inhibitors
    1.
    发明授权
    Stable oxpenem-3-carboxylic acids as beta-lactamase inhibitors 失效
    稳定的氧化烯-3-羧酸作为β-乳酸酶抑制剂

    公开(公告)号：US5108747A

    公开(公告)日：1992-04-28

    申请号：US413404

    申请日：1989-09-27

    申请人： Hans-Rudolf Pfaendler ,  Karl G. Metzger ,  Rainer Endermann ,  Ingo Haller ,  Hanno Wild ,  Wolfgang Hartiwg

    发明人： Hans-Rudolf Pfaendler ,  Karl G. Metzger ,  Rainer Endermann ,  Ingo Haller ,  Hanno Wild ,  Wolfgang Hartiwg

    IPC分类号： A61K31/42 ,  A61P31/04 ,  C07D503/00

    CPC分类号： A61K31/70 ,  C07D503/00

    摘要： A pharmaceutical preparation comprising an antibiotic, a pharmaceutical excipient therefor, and in addition an oxapenem-3-carboxylic acid of the formula ##STR1## or a pharmaceutically acceptable salt, ester or amide in which R.sup.1 and R.sup.2 each independently is hydrogen or a pharmaceutically acceptable group having 1 to 10 carbon atoms which is connected with the balance of the molecule via carbon-carbon single bonds, and in whichR.sup.3, R.sup.4 and R.sup.5 each independently is a pharmaceutically acceptable group having 1 to 10 carbon atoms which is connected with the balance of the molecule via carbon-carbon single bonds.

    摘要翻译： 一种药物制剂，其包含抗生素，其药用赋形剂，另外还包含式IMA的oxapenem-3-羧酸或其药学上可接受的盐，酯或酰胺，其中R 1和R 2各自独立地为氢或药学上可接受的 具有1至10个碳原子的基团，其经由碳 - 碳单键与分子的余量连接，并且其中R 3，R 4和R 5各自独立地为具有1-10个碳原子的药学上可接受的基团，其与天平连接 的分子通过碳 - 碳单键。

    Antibacterial 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
    6.
    发明授权
    Antibacterial 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids 失效
    抗菌8-氰基-1-环丙基-1,4-二氢-4-氧代-3-喹啉羧酸

    公开(公告)号：US5190955A

    公开(公告)日：1993-03-02

    申请号：US645751

    申请日：1991-01-25

    申请人： Michael Schriewer ,  Klaus Grohe ,  Uwe Petersen ,  Ingo Haller ,  Karl G. Metzger ,  Rainer Endermann ,  Hans-Joachim Zeiler

    发明人： Michael Schriewer ,  Klaus Grohe ,  Uwe Petersen ,  Ingo Haller ,  Karl G. Metzger ,  Rainer Endermann ,  Hans-Joachim Zeiler

    IPC分类号： C07D215/56 ,  C07D401/04 ,  C07D487/08

    CPC分类号： C07D215/56 ,  C07D401/04 ,  C07D487/08

    摘要： Antibacterial 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxlyic acid derivatives of the formula ##STR1## in which Y represents a carboxyl group, a nitrile group, an ester group --COOR.sup.1 or an acid amide group --CONR.sup.2 R.sup.3,X.sup.1 represents hydrogen nitro, alkyl or halogenX.sup.4 can be hydrogen or halogen, or alkyl,R.sup.4 and R.sup.5, together with the nitrogen atom to which they are bonded, form a 5- or 6-membered heterocyclic ring which can additionally contain the atoms or groups --O--, --S--, --SO--, --SO.sub.2 --, ##STR2## as ring members or the group ##STR3## can also represent a ring system of the structure ##STR4## which can optionally be substituted on the ring carbons by methyl and pharmaceutically usable hydrates, salts or esters thereof.These compounds have a high antibacterial activity and are therefore suitable as active compounds for human and veterinary medicine.

    摘要翻译： 其中Y表示羧基，腈基，酯基-COOR1或酸的式“IMAGE”的抗菌8-氰基-1-环丙基-1,4-二氢-4-氧代-3-喹啉代羧酸衍生物 酰胺基-CONR2R3，X1表示氢硝基，烷基或卤素X4可以是氢或卤素，或烷基，R4和R5与它们所键合的氮原子一起形成5-或6-元杂环，其可以 还包含原子或基团-O + 13，-S + 13，-SO-，-SO 2 - ，作为环成员或组也可以表示结构的环系统