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公开(公告)号：US06448044B2
公开(公告)日：2002-09-10
申请号：US08832488
申请日：1997-04-03
申请人： Jian Ni , Haodong Li , Guo-Liang Yu , Reiner L. Gentz
发明人： Jian Ni , Haodong Li , Guo-Liang Yu , Reiner L. Gentz
IPC分类号： C12P2102
摘要： The invention relates to NKAF II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译： 本发明涉及NKAF II多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。
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公开(公告)号：US5919658A
公开(公告)日：1999-07-06
申请号：US832535
申请日：1997-04-03
申请人： Jian Ni , Haodong Li , Guo-Liang Yu , Reiner L. Gentz
发明人： Jian Ni , Haodong Li , Guo-Liang Yu , Reiner L. Gentz
CPC分类号： C07K14/8139 , A61K38/00 , C07K2319/00
摘要： The invention relates to cystatin F polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译： 本发明涉及半胱氨酸蛋白酶抑制剂F多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。
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公开(公告)号：US07309780B2
公开(公告)日：2007-12-18
申请号：US11378243
申请日：2006-03-20
申请人： Jian Ni , Haodong Li , Guo-Liang Yu , Reiner L. Gentz
发明人： Jian Ni , Haodong Li , Guo-Liang Yu , Reiner L. Gentz
摘要： The invention relates to NKAF II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译： 本发明涉及NKAF II多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。
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公开(公告)号：US06576745B1
公开(公告)日：2003-06-10
申请号：US09528436
申请日：2000-03-17
申请人： Haodong Li , Guo-Liang Yu , Reiner L. Gentz , Jian Ni
发明人： Haodong Li , Guo-Liang Yu , Reiner L. Gentz , Jian Ni
IPC分类号： C07K1600
CPC分类号： C07K14/8139 , A61K38/00 , C07K2319/00
摘要： The invention relates to Cystatin F polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译： 本发明涉及半胱氨酸蛋白酶抑制剂F多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。
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公开(公告)号：US06066617A
公开(公告)日：2000-05-23
申请号：US19485
申请日：1998-01-29
申请人： Haodong Li , Guo-Liang Yu , Reiner L. Gentz , Jian Ni
发明人： Haodong Li , Guo-Liang Yu , Reiner L. Gentz , Jian Ni
IPC分类号： G01N33/53 , A61K38/00 , A61P27/02 , A61P29/00 , A61P31/00 , A61P43/00 , C07K14/81 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12Q1/68 , C07K1/00
CPC分类号： C07K14/8139 , A61K38/00 , C07K2319/00
摘要： The invention relates to Cystatin F polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
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公开(公告)号：US07078482B2
公开(公告)日：2006-07-18
申请号：US10192611
申请日：2002-07-11
申请人： Jian Ni , Haodong Li , Guo-Liang Yu , Reiner L. Gentz
发明人： Jian Ni , Haodong Li , Guo-Liang Yu , Reiner L. Gentz
摘要： The invention relates to NKAF II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译： 本发明涉及NKAF II多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。
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公开(公告)号：US07708996B2
公开(公告)日：2010-05-04
申请号：US12046107
申请日：2008-03-11
申请人： Guo-Liang Yu , Jian Ni , Reiner L. Gentz , Patrick J. Dillon
发明人： Guo-Liang Yu , Jian Ni , Reiner L. Gentz , Patrick J. Dillon
IPC分类号： A61K39/395 , C07K16/18 , C07K16/28
CPC分类号： C07K14/4747 , A61K38/00 , A61K48/00 , C07K14/705 , C07K14/70578 , C07K16/2878 , C07K2317/21 , C12N2799/026
摘要： The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins that are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are antibodies and fragments thereof that bind to polypeptides of the invention. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.
摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新型死亡域含有受体（DR3和DR3-V1）蛋白。 特别地，提供编码人DR3和DR3-V1蛋白的分离的核酸分子。 还提供DR3和DR3-V1多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 还提供了结合本发明多肽的抗体及其片段。 本发明还涉及用于鉴定DR3和DR3-V1活性的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US07357927B2
公开(公告)日：2008-04-15
申请号：US10189189
申请日：2002-07-05
申请人： Guo-Liang Yu , Jian Ni , Reiner L. Gentz , Patrick J. Dillon
发明人： Guo-Liang Yu , Jian Ni , Reiner L. Gentz , Patrick J. Dillon
IPC分类号： A61K39/395 , A61K39/00 , C07K16/18 , C07K16/28
CPC分类号： C07K14/4747 , A61K38/00 , A61K48/00 , C07K14/705 , C07K14/70578 , C07K16/2878 , C07K2317/21 , C12N2799/026
摘要： The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins that are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are antibodies and fragments thereof that bind to polypeptides of the invention. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.
摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新型死亡域含有受体（DR3和DR3-V1）蛋白。 特别地，提供编码人DR3和DR3-V1蛋白的分离的核酸分子。 还提供DR3和DR3-V1多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 还提供了结合本发明多肽的抗体及其片段。 本发明还涉及用于鉴定DR3和DR3-V1活性的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US06951735B2
公开(公告)日：2005-10-04
申请号：US09314889
申请日：1999-05-19
申请人： Guo-Liang Yu , Jian Ni , Vishva Dixit , Reiner L. Gentz , Patrick J. Dillon
发明人： Guo-Liang Yu , Jian Ni , Vishva Dixit , Reiner L. Gentz , Patrick J. Dillon
IPC分类号： C12N15/09 , A61K38/00 , A61P29/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61P37/00 , A61P43/00 , C07H21/04 , C07K14/705 , C07K14/715 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/19 , C12R1/91 , C12N15/63
CPC分类号： C07K14/70578 , A61K38/00
摘要： The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.
摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新型死亡域含有受体（DR3和DR3-V1）蛋白。 特别地，提供编码人DR3和DR3-V1蛋白的分离的核酸分子。 还提供DR3和DR3-V1多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 本发明还涉及用于鉴定DR3和DR3-V1活性的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US06743625B2
公开(公告)日：2004-06-01
申请号：US09874138
申请日：2001-06-06
申请人： Jian Ni , Reiner L. Gentz , Guo-Liang Yu , Craig A. Rosen
发明人： Jian Ni , Reiner L. Gentz , Guo-Liang Yu , Craig A. Rosen
IPC分类号： C07K14705
CPC分类号： C07K14/7151 , A61K38/00 , A61K39/395 , C07K14/70578 , C07K2319/00 , C07K2319/30 , A61K2300/00
摘要： The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity.
摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族的成员的新的含有死亡域的受体-5（DR5）蛋白，现在已经显示结合TRAIL。 特别地，提供编码人DR5蛋白的分离的核酸分子。 还提供了DR5多肽，载体，宿主细胞以及用于制备它们的重组方法。 本发明还涉及用于鉴定DR5活性的拮抗剂和拮抗剂的筛选方法。
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