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    Biocompatible polymeric compositions for use in making anterior chamber intraocular lenses
    1.
    发明申请
    Biocompatible polymeric compositions for use in making anterior chamber intraocular lenses 有权
    用于制造前房人工晶状体的生物相容性聚合物组合物

    公开(公告)号：US20060004163A1

    公开(公告)日：2006-01-05

    申请号：US11219021

    申请日：2005-09-01

    申请人： Harish Makker ,  Michael Lowery ,  Can Hu

    发明人： Harish Makker ,  Michael Lowery ,  Can Hu

    IPC分类号： A61F2/14

    CPC分类号： A61L27/26 ,  A61L2430/16 ,  C08F220/18

    摘要： Biocompatible polymers useful for making anterior chamber intraocular lenses (AC-IOL) are provided. The biocompatible polymers are generally composed of one or more acrylate monomers, crosslinked with at least one diacrylate ester and may include one or more additional components such as ultraviolet light and/or blue-violate light absorbing dyes. The AC-IOLs made using the biocompatible polymers disclosed herein are suitable for placement in phakic or aphakic eyes and are intended for refractive correction including myopia, hyperopia, presbyopia and astigmatisms.

    摘要翻译： 提供了可用于制备前房人工晶状体（AC-IOL）的生物相容性聚合物。 生物相容性聚合物通常由一种或多种丙烯酸酯单体组成，与至少一种二丙烯酸酯交联，并且可以包括一种或多种另外的组分，例如紫外线和/或蓝色的光吸收染料。 使用本文公开的生物相容性聚合物制备的AC-IOL适于放置在晶状体或无晶状体眼睛中，并且用于屈光矫正，包括近视，远视，老花眼和散光。

    Intraocular lens insertion plunger with low stimulus soft tip
    2.
    发明申请
    Intraocular lens insertion plunger with low stimulus soft tip 审中-公开
    眼内透镜插入柱塞，低刺激软尖

    公开(公告)号：US20070005135A1

    公开(公告)日：2007-01-04

    申请号：US11173337

    申请日：2005-07-01

    申请人： Harish Makker ,  Can Hu ,  Michael Lowery

    发明人： Harish Makker ,  Can Hu ,  Michael Lowery

    IPC分类号： A61F2/16

    CPC分类号： A61F2/1678 ,  A61F2/167

    摘要： An intraocular lens (IOL) insertion apparatus for implanting IOLs through smaller incisions. The insertion apparatus includes an insertion cartridge that receives the IOL and cooperates with a handpiece. The cartridge includes a longitudinal lumen from a loading chamber to an open distal mouth that gradually narrows in dimension. A push rod having an extremely soft tip thereon urges the IOL through the cartridge and from the open distal mouth. The soft tip is made of low-stimulus material having a minimum ultimate elongation of 400%. Because of the extremely soft material of the tip, the outside diameter of the open distal mouth can be reduced to no more than 2.0 mm, enabling passage through incisions of 2.2 mm or less. The soft tip may be a thermoplastic elastomer having a relatively high elongation and relatively low modulus at elongations of 100-300%.

    摘要翻译： 一种用于通过较小切口植入IOL的人工晶状体（IOL）插入装置。 插入装置包括容纳IOL并与手持件配合的插入盒。 药筒包括从装载室到开口的远端口的纵向腔，其逐渐变窄。 具有非常软的尖端的推杆通过药筒和从开放的远端口引导IOL。 软尖端由具有最小极限伸长率为400％的低刺激材料制成。 由于尖端的材料非常柔软，所以开放式远端口的外径可以减小到不超过2.0mm，能够穿过2.2mm以下的切口。 软末端可以是在100-300％的伸长率下具有相对高的伸长率和相对低的模量的热塑性弹性体。

    Lubricious, biocompatible coatings for medical devices
    3.
    发明申请
    Lubricious, biocompatible coatings for medical devices 审中-公开
    适用于医疗器械的生物相容性涂层

    公开(公告)号：US20050147735A1

    公开(公告)日：2005-07-07

    申请号：US11021869

    申请日：2004-12-22

    申请人： Michael Lowery ,  Harish Makker ,  Can Hu

    发明人： Michael Lowery ,  Harish Makker ,  Can Hu

    IPC分类号： A61F2/16 ,  A61F9/00 ,  A61L27/34 ,  A61L27/44 ,  A61L29/12 ,  A61L31/10 ,  A61L31/12 ,  B05D3/00

    CPC分类号： A61L27/34 ,  A61F2/1662 ,  A61L31/10 ,  A61L2400/10 ,  C08L39/06

    摘要： A lubricous coating composition and methods for using same are provided. Specifically, a composition suitable for providing hydrophobic polymer surfaces with lubricious coatings is described wherein a polyolefin surface is reiteratively treated with hydrophilic polymer solutions and cross-linking solutions. Methods for reiterative coating polymer surfaces are also provided including methods wherein the hydrophobic polymer surface is pretreated using plasma energy.

    摘要翻译： 提供了一种润滑涂料组合物及其使用方法。 具体而言，描述了适用于提供具有光滑涂层的疏水性聚合物表面的组合物，其中聚合物表面用亲水聚合物溶液和交联溶液反复进行处理。 还提供了重复涂布聚合物表面的方法，包括其中使用等离子体能预处理疏水性聚合物表面的方法。

    Medical devices having soft, flexible lubricious coatings
    4.
    发明申请
    Medical devices having soft, flexible lubricious coatings 有权
    具有软，柔性润滑涂层的医疗设备

    公开(公告)号：US20060229635A1

    公开(公告)日：2006-10-12

    申请号：US11104321

    申请日：2005-04-11

    申请人： Can Hu ,  Michael Lowery ,  Harish Makker

    发明人： Can Hu ,  Michael Lowery ,  Harish Makker

    IPC分类号： A61F9/00

    CPC分类号： A61F2/1675 ,  A61L27/34 ,  C08G18/0823 ,  C08G18/833 ,  C08L39/06 ,  C09D175/04 ,  Y10T428/31536 ,  Y10T428/31551 ,  Y10T428/31663 ,  C08L5/08 ,  C08L2666/04

    摘要： Soft, flexible highly lubricious coatings for polymeric IOL insertion cartridges that allow IOLs to be easily inserted through small bore cartridges suitable for use with small (less than 3 mm) incisions are provided. These lubricious coatings allow IOLs to be inserted into the eye of a patient without the risk of lens damage or transfer of lubricants to the lens surface during implantation. Specifically, polymeric coatings comprising a matrix polymer having an equivalent weight greater than 5000 g/eq are used to form interpenetrating networks (IPN) on the surface of hydrophobic structural polymers. The IPNs thus formed entrap highly lubricious hydrophilic compounds within the IPN using multi-functional cross linkers.

    摘要翻译： 提供用于聚合物IOL插入盒的柔软，柔性高润滑性涂层，其允许IOL容易地插入适于与小（小于3mm）切口一起使用的小孔筒。 这些光滑涂层允许IOL插入患者的眼睛，而不会在植入期间发生晶状体损伤或将润滑剂转移到镜片表面。 具体地说，使用包含当量大于5000g / eq的基质聚合物的聚合物涂层在疏水结构聚合物的表面上形成互穿网络（IPN）。 因此，IPNs使用多功能交联剂在IPN内捕获高度润滑的亲水性化合物。

    Intraocular lens materials suitable for insertion through a small bore cartridge
    5.
    发明申请
    Intraocular lens materials suitable for insertion through a small bore cartridge 有权
    适合通过小孔筒插入的人工晶状体材料

    公开(公告)号：US20050143751A1

    公开(公告)日：2005-06-30

    申请号：US11027876

    申请日：2004-12-29

    申请人： Harish Makker ,  Michael Lowery ,  Can Hu

    发明人： Harish Makker ,  Michael Lowery ,  Can Hu

    IPC分类号： A61L27/16 ,  G02B1/04 ,  A61F9/00

    CPC分类号： G02B1/043 ,  C08L33/12 ,  C08L33/10

    摘要： A polymer material useful for manufacturing an intraocular lens (IOL) suitable for insertion through an IOL inserter barrel having an inner diameter of less than 3 mm is provided. Specifically, acrylic-silicone hybrids having a tensile strength of approximately 100 psi to 400 psi and a percent elongation at break of between 50% and 400% are disclosed.

    摘要翻译： 提供了一种用于制造适于通过内径小于3mm的IOL插入筒插入的眼内透镜（IOL）的聚合物材料。 具体地，公开了具有约100psi至400psi的拉伸强度和50％至400％的断裂伸长率的丙烯酸 - 硅氧烷杂化物。

    IOL insertion apparatus and methods for making and using same
    6.
    发明申请
    IOL insertion apparatus and methods for making and using same 有权
    IOL插入装置及其制造和使用方法

    公开(公告)号：US20050221041A1

    公开(公告)日：2005-10-06

    申请号：US11146983

    申请日：2005-06-07

    申请人： Harish Makker ,  Can Hu ,  Michael Lowery

    发明人： Harish Makker ,  Can Hu ,  Michael Lowery

    IPC分类号： A61F2/16 ,  B32B1/08

    CPC分类号： A61F2/1664 ,  A61F2/167 ,  A61F2/1675 ,  A61F2/1678 ,  Y10T428/1393

    摘要： Apparatus, and methods of making and using apparatus, for inserting intraocular lenses (IOLs) are disclosed. The apparatus includes a hollow tube having an interior wall defining a hollow space through which an intraocular lens may be passed from the open space into an eye. A lubricity enhancing component is covalently bonded to the hollow tube at the interior wall in an amount effective to facilitate the passage of the intraocular lens through the hollow space. The lubricity enhancing component includes a substituent component effective to reduce hydrolysis of said lubricity enhancing component relative to an identical lubricity enhancing component without the substituent component.

    摘要翻译： 公开了用于插入眼内透镜（IOL）的装置和制造和使用装置的方法。 该装置包括具有限定中空空间的内壁的中空管，眼内透镜可以通过该中空空间从开放空间传入眼睛。 润滑性增强组分以有效促进眼内透镜通过中空空间的量在内壁处共价结合到中空管。 润滑性增强组分包括相对于没有取代基组分的相同润滑性增强组分有效减少所述润滑性增强组分的水解的取代基组分。

    IOL INSERTION APPARATUS AND METHODS FOR MAKING AND USING SAME
    7.
    发明申请
    IOL INSERTION APPARATUS AND METHODS FOR MAKING AND USING SAME 有权
    IOL插入装置及其制造和使用方法

    公开(公告)号：US20100129523A1

    公开(公告)日：2010-05-27

    申请号：US12622554

    申请日：2009-11-20

    申请人： Harish Makker ,  Can Hu ,  Michael D. Lowery

    发明人： Harish Makker ,  Can Hu ,  Michael D. Lowery

    IPC分类号： B05D3/02

    CPC分类号： A61F2/1664 ,  A61F2/167 ,  A61F2/1675 ,  A61F2/1678 ,  Y10T428/1393

    摘要： Apparatus, and methods of making and using apparatus, for inserting intraocular lenses (IOLs) are disclosed. The apparatus includes a hollow tube having an interior wall defining a hollow space through which an intraocular lens may be passed from the open space into an eye. A lubricity enhancing component is covalently bonded to the hollow tube at the interior wall in an amount effective to facilitate the passage of the intraocular lens through the hollow space. The lubricity enhancing component includes a substituent component effective to reduce hydrolysis of said lubricity enhancing component relative to an identical lubricity enhancing component without the substituent component.

    摘要翻译： 公开了用于插入眼内透镜（IOL）的装置和制造和使用装置的方法。 该装置包括具有限定中空空间的内壁的中空管，眼内透镜可以通过该中空空间从开放空间传入眼睛。 润滑性增强组分以有效促进眼内透镜通过中空空间的量在内壁处共价结合到中空管。 润滑性增强组分包括相对于没有取代基组分的相同润滑性增强组分有效减少所述润滑性增强组分的水解的取代基组分。

    IOL insertion apparatus and methods for making and using same
    8.
    发明授权
    IOL insertion apparatus and methods for making and using same 有权
    IOL插入装置及其制造和使用方法

    公开(公告)号：US08956684B2

    公开(公告)日：2015-02-17

    申请号：US12622554

    申请日：2009-11-20

    申请人： Harish Makker ,  Can Hu ,  Michael D. Lowery

    发明人： Harish Makker ,  Can Hu ,  Michael D. Lowery

    IPC分类号： B05D3/02 ,  B05D3/06 ,  C08J7/18 ,  B29C71/02 ,  A61F9/00 ,  A61F2/16

    CPC分类号： A61F2/1664 ,  A61F2/167 ,  A61F2/1675 ,  A61F2/1678 ,  Y10T428/1393

    摘要： Apparatus, and methods of making and using apparatus, for inserting intraocular lenses (IOLs) are disclosed. The apparatus includes a hollow tube having an interior wall defining a hollow space through which an intraocular lens may be passed from the open space into an eye. A lubricity enhancing component is covalently bonded to the hollow tube at the interior wall in an amount effective to facilitate the passage of the intraocular lens through the hollow space. The lubricity enhancing component includes a substituent component effective to reduce hydrolysis of said lubricity enhancing component relative to an identical lubricity enhancing component without the substituent component.

    摘要翻译： 公开了用于插入眼内透镜（IOL）的装置和制造和使用装置的方法。 该装置包括具有限定中空空间的内壁的中空管，眼内透镜可以通过该中空空间从开放空间传入眼睛。 润滑性增强组分以有效促进眼内透镜通过中空空间的量在内壁处共价结合到中空管。 润滑性增强组分包括相对于没有取代基组分的相同润滑性增强组分有效减少所述润滑性增强组分的水解的取代基组分。

    Biocompatible polymeric compositions for use in making posterior chamber intraocular lenses
    9.
    发明申请
    Biocompatible polymeric compositions for use in making posterior chamber intraocular lenses 审中-公开
    用于制备后房人工晶状体的生物相容性聚合物组合物

    公开(公告)号：US20060135642A1

    公开(公告)日：2006-06-22

    申请号：US11281085

    申请日：2005-11-17

    申请人： Harish Makker ,  Massoud Ghazizadeh ,  Michael Lowery

    发明人： Harish Makker ,  Massoud Ghazizadeh ,  Michael Lowery

    IPC分类号： A61L24/00 ,  A61F2/16

    CPC分类号： A61L27/14 ,  A61F2/16 ,  A61L27/16 ,  A61L27/26 ,  A61L2430/16 ,  C08F220/18 ,  C08F220/28 ,  C08F222/1006 ,  C08L2312/00 ,  C08L33/08 ,  C08L33/10

    摘要： Biocompatible polymers useful for making intraocular lenses are provided. The biocompatible polymers are generally composed of one or more acrylate monomers, crosslinked with at least one diacrylate ester and may include one or more additional components such as ultraviolet light and/or blue-violet light absorbing dyes. The posterior chamber IOLs made using the biocompatible polymers disclosed herein are suitable for placement in phakic or aphakic eyes and are intended for refractive correction including myopia, hyperopia, presbyopia, astigmatisms and for implantation after removal of the natural crystalline lens as warranted by medical conditions such as cataracts.

    摘要翻译： 提供了可用于制造眼内透镜的生物相容性聚合物。 生物相容性聚合物通常由一种或多种丙烯酸酯单体组成，与至少一种二丙烯酸酯交联，并且可以包括一种或多种另外的组分，例如紫外光和/或蓝紫色光吸收染料。 使用本文公开的生物相容性聚合物制备的后室IOL适合于放置在晶状体或无晶状体眼中，并且用于屈光矫正，包括近视，远视，老花眼，散光，以及在除去天然晶状体之后，由医疗条件 作为白内障。