利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

73 条记录 (耗时 0.057 秒)

    Phenylpiperazine derivatives and their acid addition salts
    1.
    发明授权
    Phenylpiperazine derivatives and their acid addition salts 失效
    苯基哌嗪衍生物及其酸加成盐

    公开(公告)号：US4716161A

    公开(公告)日：1987-12-29

    申请号：US719456

    申请日：1985-04-03

    申请人： Harukazu Fukami ,  Ryoji Kikumoto ,  Kenichiro Nakao ,  Issei Nitta ,  Shinya Inoue

    发明人： Harukazu Fukami ,  Ryoji Kikumoto ,  Kenichiro Nakao ,  Issei Nitta ,  Shinya Inoue

    IPC分类号： C07D239/96 ,  C07D285/32 ,  C07D491/04 ,  C07D491/056 ,  C07D513/04 ,  A61K31/54 ,  C07D417/06

    CPC分类号： C07D491/04 ,  C07D239/96 ,  C07D285/32 ,  C07D513/04

    摘要： A phenylpiperazine derivative according to the present invention has the following general formula [I]: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are independently hydrogen or alkoxy group having 1 to 3 carbon atoms, orR.sup.1 and R.sup.2 or R.sup.2 and R.sup.3 together with carbon atoms to which they are attached form --O(CH.sub.2).sub.m O-- wherein m is an integer of 1 to 3, oreither R.sup.1 or R.sup.2 is amine residue selected from the group consisting of --NH.sub.2 , --NHSO.sub.2 CH.sub.3, --NHCOCH.sub.3 and --NHCONH.sub.2 and the other is hydrogen or alkoxy group of 1 to 3 carbon atoms and R.sup.3 is hydrogen;R.sup.4 and R.sup.5 are independently hydrogen or alkyl group of 1 to 3 carbon atoms;Y is --CO-- or --SO.sub.2 -- provided that at least one of R.sup.1 and R.sup.2 is not hydrogen when Y is --CO--; andn is an integer of 2 to 4.An acid addition salt of the phenylpiperazine derivative having the general formula [I] is included in the present invention. The phenylpiperazine derivative as well as its acid addition salt according to the present invention have the ability to reduce the blood pressure.

    摘要翻译： 根据本发明的苯基哌嗪衍生物具有以下通式[I]：其中R 1，R 2和R 3独立地是氢或具有1至3个碳原子的烷氧基，或者R 1和R 2或R 2和R 3 与其连接的碳原子一起形成-O（CH 2）m O-，其中m是1至3的整数，或者R 1或R 2是选自-NH 2，-NHSO 2 CH 3，-NHCOCH 3和 -NHCONH 2，另一个是1或3个碳原子的氢或烷氧基，R 3是氢; R4和R5独立地是氢或1〜3个碳原子的烷基; Y是-CO-或-SO 2 - ，条件是当Y是-CO-时，R 1和R 2中的至少一个不是氢; n为2〜4的整数。本发明包括具有通式[I]的苯基哌嗪衍生物的酸加成盐。 根据本发明的苯基哌嗪衍生物及其酸加成盐具有降低血压的能力。

    Piperazine derivatives and their acid addition salts
    2.
    发明授权
    Piperazine derivatives and their acid addition salts 失效
    哌嗪衍生物及其酸加成盐

    公开(公告)号：US4613598A

    公开(公告)日：1986-09-23

    申请号：US708641

    申请日：1985-03-06

    申请人： Harukazu Fukami ,  Shinya Inoue ,  Issei Nitta ,  Kenichiro Nakao ,  Ryoji Kikumoto

    发明人： Harukazu Fukami ,  Shinya Inoue ,  Issei Nitta ,  Kenichiro Nakao ,  Ryoji Kikumoto

    IPC分类号： C07D213/74 ,  C07D265/36 ,  C07D267/14 ,  C07D279/16 ,  C07D295/084 ,  C07D295/108 ,  C07D417/12 ,  A61K31/55 ,  C07D417/10

    CPC分类号： C07D295/108 ,  C07D213/74 ,  C07D265/36 ,  C07D267/14 ,  C07D279/16 ,  C07D295/092 ,  C07D417/12

    摘要： A piperazine derivative according to the present invention has the following general formula [I]: ##STR1## wherein R.sup.1 is --OH, --OR.sup.3, --SR.sup.3, --SOR.sup.3 or --SO.sub.2 R.sup.3 wherein R.sup.3 is alkyl group having 1 to 3 carbon atoms;R.sup.2 is --SO.sub.2 NH.sub.2, --SO.sub.2 NHR.sup.4, --SO.sub.2 NR.sup.4 R.sup.5, --COOH, --COOR.sup.4, --CONH.sub.2, --CONHR.sup.4, --CONR.sup.4 R.sup.5, --NHCONH.sub.2, --NHCSNH.sub.2, --NHCONHR.sup.4, --NHCOR.sup.4 or --NHSO.sub.2 R.sup.4 wherein R.sup.4 and R.sup.5 are independently alkyl group having 1 to 3 carbon atoms; orR.sup.1 and R.sup.2 together with carbon atoms to which they are attached form ##STR2## Z is --CO-- or --CH(OH)--; Ar is pyridyl or substituted or unsubstituted phenyl; andn is an integer of 3 to 5.An acid addition salt of the piperazine derivative having the above formula [I] is included in the present invention. The piperazine derivative as well as its acid addition salt according to the present invention have the ability to reduce the blood pressure.

    摘要翻译： 根据本发明的哌嗪衍生物具有以下通式[I]：其中R 1是-OH，-OR 3，-SR 3，-SOR 3或-SO 2 R 3，其中R 3是具有1至3个碳原子的烷基 原子 R2是-SO2NH2，-SO2NHR4，-SO2NR4R5，-COOH，-COOR4，-CONH2，-CONHR4，-CONR4R5，-NHCONH2，-NHCSNH2，-NHCONHR4，-NHCOR4或-NHSO2R4，其中R4和R5独立地为具有1 至3个碳原子; 或R 1和R 2与它们所连接的碳原子一起形成Z是-CO-或-CH（OH） - ; Ar为吡啶基或取代或未取代的苯基; n为3〜5的整数。上述式[I]的哌嗪衍生物的酸加成盐包括在本发明中。 根据本发明的哌嗪衍生物及其酸加成盐具有降低血压的能力。