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    Method of recovering ethylene oxide
    3.
    发明授权
    Method of recovering ethylene oxide 失效
    回收环氧乙烷的方法

    公开(公告)号：US4028070A

    公开(公告)日：1977-06-07

    申请号：US638841

    申请日：1975-12-08

    申请人： Jiro Uchii ,  Masatsugu Kodo ,  Tsunehiko Soga ,  Yutaka Morimoto

    发明人： Jiro Uchii ,  Masatsugu Kodo ,  Tsunehiko Soga ,  Yutaka Morimoto

    IPC分类号： B01D19/00 ,  B01D19/04

    CPC分类号： B01D19/0005 ,  B01D19/0409

    摘要： A method of recovering ethylene oxide from the reaction product gas that is obtained by the catalytic vapor phase oxidation of ethylene with molecular oxygen over a silver-containing catalyst, which comprises conducting the reaction product gas to an absorption column maintained at a pressure in the range of 2 - 40 kg/cm.sup.2, countercurrently contacting reaction product gas with an aqueous absorbent in the absorption column to dissolve ethylene oxide in the aqueous absorbent to form an aqueous ethylene oxide solution, conducting the thus formed aqueous solution to a stripping column, stripping and recovering ethylene oxide from aqueous ethylene oxide solution at the stripping column, and thereafter recycling the remaining aqueous solution which is obtained after stripping ethylene oxide to the absorption column to be again used as the aqueous absorbent; characterized by using as the aqueous absorbent one containing ethylene glycol in the range of 0.1 - 40% by weight and a defoaming agent in the range of 0.5 - 1000 ppm and having a pH in the range of 3 - 12.

    摘要翻译： 从通过在含银催化剂上分子氧的乙烯的催化气相氧化获得的反应产物气体中回收环氧乙烷的方法，其包括将反应产物气体导入保持在该范围内的压力的吸收塔 2-40kg / cm 2，将反应产物气体与吸收塔中的含水吸收剂逆流接触以溶解含水吸收剂中的环氧乙烷以形成环氧乙烷水溶液，将由此形成的水溶液导入汽提塔，汽提和 在汽提塔处从环氧乙烷水溶液中回收环氧乙烷，然后将汽提环氧乙烷后得到的剩余水溶液再循环到吸收塔，再次用作水性吸收剂; 其特征在于使用含有0.1-40重量％的乙二醇和0.5-1000ppm范围内的消泡剂并且pH在3-12范围内的含水吸收剂。

    Pentacyclic compound
    5.
    发明授权
    Pentacyclic compound 有权
    五环化合物

    公开(公告)号：US06545151B2

    公开(公告)日：2003-04-08

    申请号：US09759378

    申请日：2001-01-16

    申请人： Hirofumi Terasawa ,  Tsunehiko Soga ,  Takashi Ishiyama

    发明人： Hirofumi Terasawa ,  Tsunehiko Soga ,  Takashi Ishiyama

    IPC分类号： C07D49308

    CPC分类号： C07D493/08 ,  C07D305/14

    摘要： The present invention relates to a novel taxol derivative having an antitumor-activity which is represented by formula (1). [In the formula (I), R1: a phenyl group, R2: an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group or an alkoxyl group, R3: a hydrogen atom, a hydroxyl group, a halogen atom, an alkoxyl group, a group —O—R31, an acyloxy group or a group —O—CO—R31 (in which R31: an alkylamino group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group or a heterocyclic group), R4 and R5: a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, an aryl group or a heterocyclic group, Z1: a hydrogen atom, a hydroxyl group, a halogen atom or an alkyl group, Z2: a hydrogen atom, a hydroxyl group, a halogen atom or an alkyl group, Z3: an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group or a heterocyclic group].

    摘要翻译： 本发明涉及由式（1）表示的具有抗肿瘤活性的新型紫杉醇衍生物[式（I）中，R 1为苯基，R 2为烷基，烯基，炔基 ，环烷基或烷氧基，R3：氢原子，羟基，卤素原子，烷氧基，-O-R31基，酰氧基或-O-CO-R31基（其中R31 ：烷基氨基，烯基，炔基，环烷基，芳基或杂环基），R4和R5：氢原子，烷基，烯基，炔基，芳基或 杂环基，Z 1：氢原子，羟基，卤原子或烷基，Z 2：氢原子，羟基，卤素原子或烷基，Z 3：烷基，烯基， 炔基，环烷基，芳基或杂环基]。

    Amino sugar derivatives
    6.
    发明授权
    Amino sugar derivatives 失效
    氨基糖衍生物

    公开(公告)号：US5432267A

    公开(公告)日：1995-07-11

    申请号：US40987

    申请日：1993-03-31

    申请人： Tsuneo Kusama ,  Tsunehiko Soga ,  Akiko Tohgo

    发明人： Tsuneo Kusama ,  Tsunehiko Soga ,  Akiko Tohgo

    IPC分类号： C07H15/04 ,  C07H5/04 ,  C07H11/04 ,  C07H13/02

    CPC分类号： C07H15/04

    摘要： A compound represented by formula (I): ##STR1## wherein R.sup.1 represents --CO--Z.sup.1 --N(Z.sup.11)--CO--Z.sup.2 --H or --CO--Z.sup.3 --H, wherein Z.sup.1, Z.sup.2, and Z.sup.3 each represent an alkylene group having from 1 to 20 carbon atoms, a phenylene group, or a combination thereof, and Z.sup.11 represents a hydrogen atom, an alkyl group having from 1 to 20 carbon atoms which may be substituted with a phenyl group, a phenyl group which may be substituted with an alkyl group having from 1 to 20 carbon atoms, or an alkylene group having from 1 to 20 carbon atoms which may contain therein a phenylene group; R.sup.2 represents --CO--Z.sup.4 --N(Z.sup.12)--CO--Z.sup.5 --H, --CO--Z.sup.6 --H or a hydrogen atom, wherein Z.sup.4, Z.sup.5, and Z.sup.6 each have the same meaning as Z.sup.1, and Z.sup.12 has the same meaning as Z.sup.11 ; Q.sup.1 and Q.sup.2 each represent a carboxyl group or a phosphonoxy group; Q.sup.3 represents a hydrogen atom, a carboxyl group or a phosphonoxy group; m represents 0 or an integer of from 1 to 20; n represents 0 or an integer of from 1 to 20; Y.sup.1 represents an alkylene group having from 1 to 10 carbon atoms which may contain one or more substituents selected from --OCOR.sup.11 and --NHCOR.sup.12, wherein R.sup.11 represents --Z.sup.13 or --Z.sup.7 --N (Z.sup.14)--CO--Z.sup.8 --H (wherein Z.sup.7 and Z.sup.8 each have the same meaning as Z.sup.1, and Z.sup.13 and Z.sup.14 each have the same meaning as Z.sup.11) and R.sup.12 represents --Z.sup.15 or --Z.sup.9 --N(Z.sup.16)--CO--Z.sup.10 --H (wherein Z.sup.9 and Z.sup.10 each have the same meaning as Z.sup.1, and Z.sup.15 and Z.sup.16 each have the same meaning as Z.sup.11), and a salt thereof. The compound inhibits TNF derivation by endotoxin and is therefore useful for the treatment of multiorganic insufficiencies.

    摘要翻译： 由式（I）表示的化合物：其中Z 1，Z 2和Z 3各自表示具有1至20个碳原子的亚烷基，亚苯基或其组合，和 Z 11表示氢原子，可以被苯基取代的碳原子数1〜20的烷基，可以被碳原子数1〜20的烷基取代的苯基或具有碳原子数1〜20的亚烷基 可含有亚苯基的1至20个碳原子; R2表示-CO-Z4-N（Z12）-CO-Z5-H，-CO-Z6-H或氢原子，其中Z4，Z5和Z6各自与Z1相同，Z12具有相同的含义 如Z11; Q1和Q2各自表示羧基或膦酰氧基; Q3表示氢原子，羧基或膦氧基; m表示0或1〜20的整数， n表示0或1〜20的整数， Y1表示可含有一个或多个选自-OCOR 11和-NHCOR 12的取代基的具有1至10个碳原子的亚烷基，其中R11表示-Z13或-Z7-N（Z14）-CO-Z8-H（其中Z7和 Z 8各自具有与Z1相同的含义，Z 13和Z 14各自具有与Z 11相同的含义，R 12表示-Z 15或-Z 9 -N（Z 16）-CO-Z 10 -H（其中Z 9和Z 10各自具有相同的含义 Z1，Z15和Z16各自具有与Z11相同的含义）及其盐。 该化合物通过内毒素抑制TNF衍生，因此可用于治疗多机能不足。

    Deacetoxytaxol derivatives
    7.
    发明授权
    Deacetoxytaxol derivatives 失效
    脱乙酰氧基紫杉醇衍生物

    公开(公告)号：US5767296A

    公开(公告)日：1998-06-16

    申请号：US750374

    申请日：1996-12-06

    申请人： Hirofumi Terasawa ,  Tsunehiko Soga ,  Kiyoshi Nakayama

    发明人： Hirofumi Terasawa ,  Tsunehiko Soga ,  Kiyoshi Nakayama

    IPC分类号： C07D305/14 ,  C07D407/12

    CPC分类号： C07D407/12 ,  C07D305/14

    摘要： A novel taxol derivative having the formula (I), in which the 10-position is modified to have a carbon-carbon bond, is disclosed. The taxol derivative of the present invention has an antitumor activity. ##STR1##

    摘要翻译： PCT No.PCT / JP95 / 01163 Sec。 371日期1996年12月6日第 102（e）日期1996年12月6日PCT Filed 1995年6月9日PCT公布。 第WO95 / 33740号公报 1995年12月14日，公开了具有式（I）的新型紫杉醇衍生物，其中10位被改性为具有碳 - 碳键。 本发明的紫杉酚衍生物具有抗肿瘤活性。 （一）

    2-Deoxy-2-aminoglucopyranoside derivatives
    8.
    发明授权
    2-Deoxy-2-aminoglucopyranoside derivatives 失效
    2-脱氧-2-氨基吡喃糖苷衍生物

    公开(公告)号：US5134230A

    公开(公告)日：1992-07-28

    申请号：US614417

    申请日：1991-01-18

    申请人： Tsuneo Kusama ,  Tsunehiko Soga ,  Tetsuo Shiba

    发明人： Tsuneo Kusama ,  Tsunehiko Soga ,  Tetsuo Shiba

    IPC分类号： C07H13/06 ,  C07H15/04

    CPC分类号： C07H13/06 ,  C07H15/04

    摘要： A disaccharide compound represented by formula (I): ##STR1## wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are as defined in the specification and a salt thereof are disclosed. The compound exhibits excellent antitumor activity and low toxicity and is useful as an antitumor agent.

    摘要翻译： 由式（I）表示的二糖化合物：其中R，R 1，R 2，R 3，R 4和R 5如本说明书中所定义，及其盐。 该化合物具有优异的抗肿瘤活性和低毒性，可用作抗肿瘤剂。

    Pentacyclic Compound
    10.
    发明授权
    Pentacyclic Compound 失效
    五环化合物

    公开(公告)号：US06646123B2

    公开(公告)日：2003-11-11

    申请号：US10126653

    申请日：2002-04-22

    申请人： Hirofumi Terasawa ,  Tsunehiko Soga ,  Takashi Ishiyama

    发明人： Hirofumi Terasawa ,  Tsunehiko Soga ,  Takashi Ishiyama

    IPC分类号： C07D49308

    CPC分类号： C07D493/08 ,  C07D305/14

    摘要： The present invention relates to a novel taxol derivative having an antitumor activity which is represented by formula (1). [In the formula (I), R1: a phenyl group, R2: an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group or an alkoxyl group, R3: a hydrogen atom, a hydroxyl group, a halogen atom, an alkoxyl group, a group —O—R311 an acyloxy group or a group —O—CO—R31, (in which R31: an alkylamino group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group or a heterocyclic group), R4 and R5: a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, an aryl group or a heterocyclic group, Z1: a hydrogen atom, a hydroxyl group, a halogen atom or an alkyl group, Z2: a hydrogen atom, a hydroxyl group, a halogen atom or an alkyl group, Z3: an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group or a heterocyclic group].

    摘要翻译： 本发明涉及由式（1）表示的具有抗肿瘤活性的新型紫杉醇衍生物[在式（I）中，R 1：苯基，R 2：烷基，烯基 基团，炔基，环烷基或烷氧基，R 3：氢原子，羟基，卤素原子，烷氧基，基团-OR 31，酰氧基或基团， O-CO-R 31（其中R 31：烷基氨基，烯基，炔基，环烷基，芳基或杂环基），R 4和R 5 >：氢原子，烷基，烯基，炔基，芳基或杂环基，Z 1：氢原子，羟基，卤素原子或烷基，Z 2 >：氢原子，羟基，卤素原子或烷基，Z 3：烷基，烯基，炔基，环烷基，芳基或杂环基]。