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39 条记录 (耗时 0.046 秒)

    PACAP receptor protein, method for preparing said protein, and use thereof
    2.
    发明授权
    PACAP receptor protein, method for preparing said protein, and use thereof 失效
    PACAP受体蛋白质，所述蛋白质的制备方法及其用途

    公开(公告)号：US06399316B1

    公开(公告)日：2002-06-04

    申请号：US09201474

    申请日：1998-11-30

    申请人： Haruo Onda ,  Tetsuya Ohtaki ,  Yasushi Masuda ,  Chieko Kitada ,  Yoshihiro Ishibashi ,  Masaki Hosoya ,  Kazuhiro Ogi ,  Yasunori Miyamoto ,  Yugo Habata ,  Norio Shimamoto

    发明人： Haruo Onda ,  Tetsuya Ohtaki ,  Yasushi Masuda ,  Chieko Kitada ,  Yoshihiro Ishibashi ,  Masaki Hosoya ,  Kazuhiro Ogi ,  Yasunori Miyamoto ,  Yugo Habata ,  Norio Shimamoto

    IPC分类号： G01N3353

    CPC分类号： C07K14/72 ,  A61K38/00 ,  A61K48/00

    摘要： This invention discloses a PACAP receptor protein or a salt thereof, a DNA comprising a DNA fragment coding for the protein, a method for preparing the protein, antibody against the protein, and use of the protein, DNA, and antibodies. A PACAP receptor protein was purified from the bovine cerebrum. DNAs coding for PACAP receptor proteins were isolated from bovine, rat and human cDNA libraries, and their nucleotide sequences were determined. Further, amino acid sequences deduced from the nucleotide sequences were determined. The PACAP receptor proteins and the DNAs coding for the proteins of the present invention can be used for (1) acquisition of antibodies and antisera, (2) construction of expression systems of recombinant receptor proteins, (3) development of receptor binding assay systems using said expression systems and screening of potential compounds for drugs, (4) execution of drug design based on the comparison of ligands and receptors which are structurally similar to each other, (5) preparation of probes and PCR primers in gene diagnosis, and the like.

    摘要翻译： 本发明公开了一种PACAP受体蛋白或其盐，包含编码该蛋白质的DNA片段的DNA，该蛋白质的制备方法，针对该蛋白质的抗体以及该蛋白质，DNA及抗体的用途。 从牛大脑中纯化PACAP受体蛋白。 从牛，大鼠和人类cDNA文库中分离编码PACAP受体蛋白的DNA，测定其核苷酸序列。 此外，确定从核苷酸序列推导的氨基酸序列。 PACAP受体蛋白和编码本发明蛋白的DNA可用于（1）获得抗体和抗血清，（2）构建重组受体蛋白质的表达系统，（3）开发受体结合测定系统，使用 表达系统和药物潜在化合物的筛选，（4）基于结构相似的配体和受体的比较来执行药物设计，（5）基因诊断中探针和PCR引物的制备等 。

    DNA encoding PACAP receptor protein and method for preparing said protein
    3.
    发明授权
    DNA encoding PACAP receptor protein and method for preparing said protein 失效
    编码PACAP受体蛋白的DNA及其制备方法

    公开(公告)号：US5858787A

    公开(公告)日：1999-01-12

    申请号：US811897

    申请日：1997-03-05

    申请人： Haruo Onda ,  Masaki Hosoya ,  Kazuhiro Ogi ,  Yasunori Miyamoto ,  Yugo Habata

    发明人： Haruo Onda ,  Masaki Hosoya ,  Kazuhiro Ogi ,  Yasunori Miyamoto ,  Yugo Habata

    IPC分类号： A61K38/00 ,  C07K14/575 ,  C07K14/72 ,  C12N1/21 ,  C12N15/12 ,  C12P21/08 ,  C12N5/10 ,  C12N15/63

    CPC分类号： C07K14/57563 ,  C07K14/72 ,  A61K38/00

    摘要： This invention discloses a PACAP receptor protein or a salt thereof, a DNA comprising a DNA fragment coding for the protein, a method for preparing the protein, antibody against the protein and use of the protein, DNA and antibodies. A PACAP receptor protein was purified from the bovine cerebrum. DNAs coding for PACAP receptor proteins were isolated from bovine, rat and human cDNA libraries, and their nucleotide sequences were determined. The PACAP receptor proteins and the DNAs coding for the proteins of the present invention can be used for (1) acquisition of antibodies and antisera, (2) construction of expression systems of recombinant receptor proteins, (3) development of receptor binding assay systems using said expression systems and screening of potential compounds for drugs, (4) execution of drug design based on the comparison of ligands and receptors which are structurally similar to each other, (5) preparation of probes and PCR primers in gene diagnosis, and the like.

    摘要翻译： 本发明公开了一种PACAP受体蛋白质或其盐，包含编码该蛋白质的DNA片段的DNA，该蛋白质的制备方法，针对该蛋白质的抗体及该蛋白质，DNA及抗体的用途。 从牛大脑中纯化PACAP受体蛋白。 从牛，大鼠和人类cDNA文库中分离编码PACAP受体蛋白的DNA，测定其核苷酸序列。 PACAP受体蛋白和编码本发明蛋白的DNA可用于（1）获得抗体和抗血清，（2）构建重组受体蛋白质的表达系统，（3）开发受体结合测定系统，使用 表达系统和药物潜在化合物的筛选，（4）基于结构相似的配体和受体的比较进行药物设计，（5）基因诊断中探针和PCR引物的制备等 。

    Polypeptides their production and use
    5.
    发明授权
    Polypeptides their production and use 失效
    多肽的生产和使用

    公开(公告)号：US06228984B1

    公开(公告)日：2001-05-08

    申请号：US08776971

    申请日：1997-02-07

    申请人： Shuji Hinuma ,  Yugo Habata ,  Yuji Kawamata ,  Masaki Hosoya ,  Ryo Fujii ,  Shoji Fukusumi ,  Chieko Kitada

    发明人： Shuji Hinuma ,  Yugo Habata ,  Yuji Kawamata ,  Masaki Hosoya ,  Ryo Fujii ,  Shoji Fukusumi ,  Chieko Kitada

    IPC分类号： C07K1447

    CPC分类号： C07H21/04 ,  A61K38/00 ,  C07K14/575 ,  C07K14/705 ,  C07K14/72 ,  C07K16/28

    摘要： The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervous system function modulators, and pancreatic function modulators, and (2) development of recombinant receptor proteins and screening of pharmaceutical candidate compounds. In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.

    摘要翻译： 本发明涉及用于人垂体和小鼠胰腺衍生的G蛋白偶联受体蛋白质的配体多肽。 编码配体多肽的配体多肽或DNA可用于（1）开发药物如垂体功能调节剂，中枢神经系统功能调节剂和胰腺功能调节剂，以及（2）重组受体蛋白的发育和筛选 的药物候选化合物。 特别地，通过利用根据本发明的重组G蛋白偶联受体蛋白表达的受体结合测定系统，可以筛选对人类和其他温血动物特异性的G蛋白偶联受体的激动剂和拮抗剂， 获得的激动剂或拮抗剂可用作各种疾病的治疗和预防剂。

    Polypeptides, their production and use
    8.
    发明授权
    Polypeptides, their production and use 失效
    多肽，其生产和使用

    公开(公告)号：US06881545B1

    公开(公告)日：2005-04-19

    申请号：US09716147

    申请日：2000-11-17

    申请人： Shuji Hinuma ,  Yugo Habata ,  Yuji Kawamata ,  Masaki Hosoya ,  Ryo Fujii ,  Shoji Fukusumi ,  Chieko Kitada

    发明人： Shuji Hinuma ,  Yugo Habata ,  Yuji Kawamata ,  Masaki Hosoya ,  Ryo Fujii ,  Shoji Fukusumi ,  Chieko Kitada

    IPC分类号： C07K14/575 ,  C07K14/705 ,  G01N33/53 ,  C07K7/08 ,  C07K14/72

    CPC分类号： C07K14/705 ,  C07K14/575

    摘要： The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins.The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervious system function modulators, and pancreatic function modulators, and (2) development of receptor binding assay systems using the expression of recombinant receptor proteins and screening of pharmaceutical candidate compounds.In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.

    摘要翻译： 本发明涉及用于人垂体和小鼠胰腺衍生的G蛋白偶联受体蛋白质的配体多肽。 编码配体多肽的配体多肽或DNA可用于（1）开发药物，例如垂体功能调节剂，中枢神经系统功能调节剂和胰功能调节剂，以及（2）开发受体结合测定系统，其使用 重组受体蛋白的表达和药物候选化合物的筛选。 特别地，通过利用根据本发明的重组G蛋白偶联受体蛋白表达的受体结合测定系统，可以筛选对人类和其他温血动物特异性的G蛋白偶联受体的激动剂和拮抗剂， 获得的激动剂或拮抗剂可用作各种疾病的治疗和预防剂。