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公开(公告)号：US07041789B2
公开(公告)日：2006-05-09
申请号：US10487634
申请日：2002-08-22
申请人： Shuji Hinuma , Hiromi Yoshida , Yugo Habata , Masaki Hosoya , Chieko Kitada
发明人： Shuji Hinuma , Hiromi Yoshida , Yugo Habata , Masaki Hosoya , Chieko Kitada
摘要： The RFRP-3 peptide of the present invention which is an agent for promoting prolactin secretion is useful as a prophylactic and/or therapeutic agent for various diseases associated with prolactin secretion, such as hypoovarianism, seminal vesicle hypoplasia, menopausal syndrome and hypothyroidism.
摘要翻译： 作为促进催乳素分泌的药剂的本发明的RFRP-3肽可用作与催乳素分泌有关的各种疾病的预防和/或治疗剂，例如低血浆病，精囊发育不全，绝经综合征和甲状腺机能减退。
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公开(公告)号：US20060035332A1
公开(公告)日：2006-02-16
申请号：US11223294
申请日：2005-09-09
申请人： Shuji Hinuma , Hiromi Yoshida , Yugo Habata , Masaki Hosoya , Chieko Kitada
发明人： Shuji Hinuma , Hiromi Yoshida , Yugo Habata , Masaki Hosoya , Chieko Kitada
IPC分类号： C07K14/705 , C07H21/04 , C12P21/06
摘要： The RFRP-3 peptide of the present invention which is an agent for promoting prolactin secretion is useful as a prophylactic and/or therapeutic agent for various diseases associated with prolactin secretion, such as hypoovarianism, seminal vesicle hypoplasia, menopausal syndrome and hypothyroidism.
摘要翻译： 作为促进催乳素分泌的药剂的本发明的RFRP-3肽可用作与催乳素分泌相关的各种疾病的预防和/或治疗剂，例如低血浆病，精囊发育不全，绝经期综合征和甲状腺机能减退。
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公开(公告)号：US07217808B2
公开(公告)日：2007-05-15
申请号：US11223294
申请日：2005-09-09
申请人： Shuji Hinuma , Hiromi Yoshida , Yugo Habata , Masaki Hosoya , Chieko Kitada
发明人： Shuji Hinuma , Hiromi Yoshida , Yugo Habata , Masaki Hosoya , Chieko Kitada
摘要： The RFRP-3 peptide of the present invention which is an agent for promoting prolactin secretion is useful as a prophylactic and/or therapeutic agent for various diseases associated with prolactin secretion, such as hypoovarianism, seminal vesicle hypoplasia, menopausal syndrome and hypothyroidism.
摘要翻译： 作为促进催乳素分泌的药剂的本发明的RFRP-3肽可用作与催乳素分泌相关的各种疾病的预防和/或治疗剂，例如低血浆病，精囊发育不全，绝经期综合征和甲状腺机能减退。
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公开(公告)号：US06492324B1
公开(公告)日：2002-12-10
申请号：US09255518
申请日：1999-02-22
申请人： Shuji Hinuma , Kazuhiko Tatemoto , Masaki Hosoya , Yugo Habata , Ryo Fujii , Chieko Kitada
发明人： Shuji Hinuma , Kazuhiko Tatemoto , Masaki Hosoya , Yugo Habata , Ryo Fujii , Chieko Kitada
IPC分类号： C07K400
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00 , C07K14/4702
摘要： This invention relates to a novel polypeptide involving in the modulation of central nervous system function, circulatory function, immune function, gastrointestinal function, metabolic function, reproductive function, etc., it can be used as a drug for treating or preventing a variety of diseases, e.g. HIV infection or AIDS (acquired immune deficiency syndrome) or the like.
摘要翻译： 本发明涉及一种涉及调节中枢神经系统功能，循环功能，免疫功能，胃肠功能，代谢功能，生殖功能等的新型多肽，可用作治疗或预防各种疾病的药物 ，例如 艾滋病毒感染或艾滋病（获得性免疫缺陷综合征）等。
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公开(公告)号：US06228984B1
公开(公告)日：2001-05-08
申请号：US08776971
申请日：1997-02-07
申请人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
发明人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
IPC分类号： C07K1447
CPC分类号： C07H21/04 , A61K38/00 , C07K14/575 , C07K14/705 , C07K14/72 , C07K16/28
摘要： The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervous system function modulators, and pancreatic function modulators, and (2) development of recombinant receptor proteins and screening of pharmaceutical candidate compounds. In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.
摘要翻译： 本发明涉及用于人垂体和小鼠胰腺衍生的G蛋白偶联受体蛋白质的配体多肽。 编码配体多肽的配体多肽或DNA可用于（1）开发药物如垂体功能调节剂，中枢神经系统功能调节剂和胰腺功能调节剂，以及（2）重组受体蛋白的发育和筛选 的药物候选化合物。 特别地，通过利用根据本发明的重组G蛋白偶联受体蛋白表达的受体结合测定系统，可以筛选对人类和其他温血动物特异性的G蛋白偶联受体的激动剂和拮抗剂， 获得的激动剂或拮抗剂可用作各种疾病的治疗和预防剂。
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公开(公告)号：US07799533B2
公开(公告)日：2010-09-21
申请号：US12166444
申请日：2008-07-02
申请人： Shuji Hinuma , Kazuhiko Tatemoto , Masaki Hosoya , Yugo Habata , Ryo Fujii , Chieko Kitada
发明人： Shuji Hinuma , Kazuhiko Tatemoto , Masaki Hosoya , Yugo Habata , Ryo Fujii , Chieko Kitada
IPC分类号： G01N33/566 , C07K14/705
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00 , C07K14/4702
摘要： This invention relates to a novel polypeptide involving in the modulation of central nervous system function, circulatory function, immune function, gastrointestinal function, metabolic function, reproductive function, etc., it can be used as a drug for treating or preventing a variety of diseases, e.g. HIV infection or AIDS (acquired immune deficiency syndrome) or the like.
摘要翻译： 本发明涉及一种涉及调节中枢神经系统功能，循环功能，免疫功能，胃肠功能，代谢功能，生殖功能等的新型多肽，可用作治疗或预防各种疾病的药物 ，例如 艾滋病毒感染或艾滋病（获得性免疫缺陷综合征）等。
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公开(公告)号：US07410776B2
公开(公告)日：2008-08-12
申请号：US10184722
申请日：2002-06-27
申请人： Shuji Hinuma , Kazuhiko Tatemoto , Masaki Hosoya , Yugo Habata , Ryo Fujii , Chieko Kitada
发明人： Shuji Hinuma , Kazuhiko Tatemoto , Masaki Hosoya , Yugo Habata , Ryo Fujii , Chieko Kitada
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00 , C07K14/4702
摘要： This invention relates to a novel polypeptide involving in the modulation of central nervous system function, circulatory function, immune function, gastrointestinal function, metabolic function, reproductive function, etc., it can be used as a drug for treating or preventing a variety of diseases, e.g. HIV infection or AIDS (acquired immune deficiency syndrome) or the like.
摘要翻译： 本发明涉及一种涉及调节中枢神经系统功能，循环功能，免疫功能，胃肠功能，代谢功能，生殖功能等的新型多肽，可用作治疗或预防各种疾病的药物 ，例如 艾滋病毒感染或艾滋病（获得性免疫缺陷综合征）等。
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公开(公告)号：US06794491B1
公开(公告)日：2004-09-21
申请号：US09576290
申请日：2000-05-23
申请人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
发明人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
IPC分类号： C07K14475
CPC分类号： C07H21/04 , A61K38/00 , C07K14/575 , C07K14/705 , C07K14/72 , C07K16/28
摘要： The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervious system function modulators, and pancreatic function modulators, and (2) development of receptor binding assay systems using the expression of recombinant receptor proteins and screening of pharmaceutical candidate compounds. In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.
摘要翻译： 本发明涉及用于人垂体和小鼠胰腺衍生的G蛋白偶联受体蛋白质的配体多肽。配体多肽或编码配体多肽的DNA可用于（1）开发诸如垂体的药物 功能调节剂，中枢神经系统功能调节剂和胰腺功能调节剂，以及（2）使用重组受体蛋白质的表达和药物候选化合物的筛选开发受体结合测定系统。特别地，通过受体结合测定系统利用表达 根据本发明的重组G蛋白偶联受体蛋白质，可以筛选对人类和其他温血动物特异性的G蛋白偶联受体的激动剂和拮抗剂，并且所获得的激动剂或拮抗剂可用作治疗和预防 各种疾病的代理
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公开(公告)号：US20090075334A1
公开(公告)日：2009-03-19
申请号：US12166444
申请日：2008-07-02
申请人： Shuji Hinuma , Kazuhiko Tatemoto , Masaki Hosoya , Yugo Habata , Ryo Fujii , Chieko Kitada
发明人： Shuji Hinuma , Kazuhiko Tatemoto , Masaki Hosoya , Yugo Habata , Ryo Fujii , Chieko Kitada
IPC分类号： C12P21/02 , C07K7/08 , C07K14/47 , C07K7/06 , C07K5/10 , G01N33/68 , C07K16/18 , C07H21/04 , C12N15/63 , C12N1/21
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00 , C07K14/4702
摘要： This invention relates to a novel polypeptide involving in the modulation of central nervous system function, circulatory function, immune function, gastrointestinal function, metabolic function, reproductive function, etc., it can be used as a drug for treating or preventing a variety of diseases, e.g. HIV infection or AIDS (acquired immune deficiency syndrome) or the like.
摘要翻译： 本发明涉及一种涉及调节中枢神经系统功能，循环功能，免疫功能，胃肠功能，代谢功能，生殖功能等的新型多肽，可用作治疗或预防各种疾病的药物 ，例如 艾滋病毒感染或艾滋病（获得性免疫缺陷综合征）等。
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公开(公告)号：US20050170461A1
公开(公告)日：2005-08-04
申请号：US11054211
申请日：2005-02-08
申请人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
发明人： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
IPC分类号： A61K38/00 , C07H21/04 , C07K14/575 , C07K14/705 , C07K14/72 , C07K16/28 , C12N1/21 , C12N15/12
CPC分类号： C07H21/04 , A61K38/00 , C07K14/575 , C07K14/705 , C07K14/72 , C07K16/28
摘要： The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervious system function modulators, and pancreatic function modulators, and (2) development of receptor binding assay systems using the expression of recombinant receptor proteins and screening of pharmaceutical candidate compounds. In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.
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