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公开(公告)号：US09851356B2
公开(公告)日：2017-12-26
申请号：US14239449
申请日：2012-09-13
申请人： Haruo Sugiyama , Yusuke Oji , Kiyonori Katsuragi , Hideaki Tanaka , Shinji Sogo , Yoshihiro Goto , Yasukazu Ohmoto , Husako Iwata
发明人： Haruo Sugiyama , Yusuke Oji , Kiyonori Katsuragi , Hideaki Tanaka , Shinji Sogo , Yoshihiro Goto , Yasukazu Ohmoto , Husako Iwata
IPC分类号： G01N33/53 , G01N33/574 , C07K14/82 , A61K39/00
CPC分类号： G01N33/574 , A61K39/0011 , C07K14/82 , G01N33/57407 , G01N33/57419 , G01N33/57426 , G01N33/57488 , G01N33/6854
摘要： Provided is an invention relating to a method for measuring an anti-WT1 antibody in a sample allowing measurement and evaluation of the anti-WT1 antibody with higher accuracy and to use of the method. The method for measuring an anti-WT1 antibody in a sample includes using a polypeptide having antigenicity to the anti-WT1 antibody selected from a polypeptide comprising the amino acid sequence of positions 294-449 in SEQ ID NO: 1, a partial polypeptide of the polypeptide, and a polypeptide including an amino acid sequence having deletion, substitution, or addition of one to several amino acids in the amino acid sequence constituting each of these polypeptides and/or a polypeptide having antigenicity to the anti-WT1 antibody selected from a polypeptide comprising the amino acid sequence of positions 181-324 in SEQ ID NO: 1, a partial polypeptide of the polypeptide, and a polypeptide including an amino acid sequence having deletion, substitution, or addition of one to several amino acids in the amino acid sequence constituting each of these polypeptides.
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公开(公告)号：US20140227799A1
公开(公告)日：2014-08-14
申请号：US14239449
申请日：2012-09-13
申请人： Haruo Sugiyama , Yusuke Oji , Kiyonori Katsuragi , Hideaki Tanaka , Shinji Sogo , Yoshihiro Goto , Yasukazu Ohmoto , Husako Iwata
发明人： Haruo Sugiyama , Yusuke Oji , Kiyonori Katsuragi , Hideaki Tanaka , Shinji Sogo , Yoshihiro Goto , Yasukazu Ohmoto , Husako Iwata
IPC分类号： G01N33/574
CPC分类号： G01N33/574 , A61K39/0011 , C07K14/82 , G01N33/57407 , G01N33/57419 , G01N33/57426 , G01N33/57488 , G01N33/6854
摘要： Provided is an invention relating to a method for measuring an anti-WT1 antibody in a sample allowing measurement and evaluation of the anti-WT1 antibody with higher accuracy and to use of the method. The method for measuring an anti-WT1 antibody in a sample includes using a polypeptide having antigenicity to the anti-WT1 antibody selected from a polypeptide comprising the amino acid sequence of positions 294-449 in SEQ ID NO: 1, a partial polypeptide of the polypeptide, and a polypeptide including an amino acid sequence having deletion, substitution, or addition of one to several amino acids in the amino acid sequence constituting each of these polypeptides and/or a polypeptide having antigenicity to the anti-WT1 antibody selected from a polypeptide comprising the amino acid sequence of positions 181-324 in SEQ ID NO: 1, a partial polypeptide of the polypeptide, and a polypeptide including an amino acid sequence having deletion, substitution, or addition of one to several amino acids in the amino acid sequence constituting each of these polypeptides.
摘要翻译： 本发明涉及一种测定样品中抗WT1抗体的方法，该方法允许以更高的精度测量和评价抗WT1抗体并使用该方法。 用于测量样品中抗WT1抗体的方法包括使用对抗WT1抗体具有抗原性的多肽，所述抗WT1抗体选自包含SEQ ID NO：1中294-449位氨基酸序列的多肽， 多肽和包含在构成每个这些多肽的氨基酸序列中具有1至数个氨基酸的缺失，取代或添加的氨基酸序列的多肽和/或对抗WT1抗体具有抗原性的多肽，所述抗WT1抗体选自多肽 包括SEQ ID NO：1中的位置181-324的氨基酸序列，多肽的部分多肽，以及包含在氨基酸序列中具有1至数个氨基酸的缺失，取代或添加的氨基酸序列的多肽 构成这些多肽中的每一种。
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公开(公告)号：US20110281284A1
公开(公告)日：2011-11-17
申请号：US12673346
申请日：2008-08-07
申请人： Hideji Nakamura , Youichi Yabuuchi , Yasukazu Ohmoto , Toyoki Mori , Masahiro Muraguchi , Keiko Oga , Fusako Iwata , Kaori Murata
发明人： Hideji Nakamura , Youichi Yabuuchi , Yasukazu Ohmoto , Toyoki Mori , Masahiro Muraguchi , Keiko Oga , Fusako Iwata , Kaori Murata
IPC分类号： G01N33/566 , C07K16/22 , C07K14/475
CPC分类号： G01N33/57438 , C07K14/4748 , C07K16/22 , C07K2317/56
摘要： According to the present invention, HDGF in the blood of patients with chronic liver disease is measured to diagnose whether the patients have liver cancer. A measurement kit for the diagnosis is also provided.
摘要翻译： 根据本发明，测量慢性肝病患者血液中的HDGF，以诊断患者是否患有肝癌。 还提供了用于诊断的测量套件。
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4.发明申请Smooth muscle growth inhibitory composition, diagnostic method for arteriosclerosis, and kit therefor 有权平滑肌生长抑制成分，动脉硬化诊断方法及其用途公开(公告)号：US20050163779A1
公开(公告)日：2005-07-28
申请号：US11097334
申请日：2005-04-04
申请人： Yuji Matsuzawa , Yasukazu Ohmoto
发明人： Yuji Matsuzawa , Yasukazu Ohmoto
IPC分类号： A61K38/00 , A61K38/17 , A61K38/22 , C07K14/575 , C07K16/18 , C07K16/26 , C12P21/08 , G01N33/50 , G01N33/68 , A61K39/395 , C07H21/04 , C07K16/22 , C12N5/06 , G01N33/53
CPC分类号： C07K14/5759 , A61K38/00 , C07K16/18 , C07K16/26 , G01N33/5091 , G01N33/6893 , G01N2333/4704 , G01N2800/323 , Y10S530/809
摘要： The invention provides not only a smooth muscle growth inhibitory composition and a composition for inhibiting expression of adhesion molecules in vascular endothelial cells, each comprising the adipose tissue-specific secretory factor apM1 as an active ingredient, but also a method for diagnosis of arteriosclerosis which comprises assaying apM1 in a sample, an antibody against apM1, and a diagnostic kit for arteriosclerosis which comprises the antibody as an active component, all of which contribute to the elucidation of obesity-related genes and corresponding expression products which are useful for the etiologic exploration and establishment of therapeutic modalities for various obesity-related diseases, particularly arteriosclerosis inclusive of angina pectoris and myocardial infarction. By utilizing the information thus obtained, therapeutic and diagnostic methods for various diseases can be established.
摘要翻译： 本发明不仅提供平滑肌生长抑制组合物和用于抑制血管内皮细胞中粘附分子表达的组合物，其各自包含脂肪组织特异性分泌因子apM1作为活性成分，而且还提供了一种用于诊断动脉硬化的方法，其包括 测定样品中的apM1，针对apM1的抗体和用于动脉硬化的诊断试剂盒，其包含作为活性成分的抗体，所有这些都有助于阐明肥胖相关基因和相应的表达产物，其可用于病因学探查和 建立各种肥胖相关疾病，特别是包括心绞痛和心肌梗死的动脉硬化的治疗方式。 通过利用所获得的信息，可以建立各种疾病的治疗和诊断方法。
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公开(公告)号：US20150104811A1
公开(公告)日：2015-04-16
申请号：US14238050
申请日：2012-08-10
申请人： Sei Sasaki , Yasukazu Ohmoto , Toyoki Mori , Fusako Iwata , Masahiro Muraguchi
发明人： Sei Sasaki , Yasukazu Ohmoto , Toyoki Mori , Fusako Iwata , Masahiro Muraguchi
CPC分类号： G01N33/5306 , G01N1/42 , G01N33/6872
摘要： The present invention provides a method for pretreatment of a biological sample in the immunoassay of a protein contained in the biological sample. The method includes the steps of: (1) freezing the biological sample at a temperature higher than −80° C., in particular at −70° C. or higher; (2) thawing the frozen biological sample; and (3) solubilizing the biological sample using a surfactant.
摘要翻译： 本发明提供了在生物样品中包含的蛋白质的免疫测定中预处理生物样品的方法。 该方法包括以下步骤：（1）在高于-80℃，特别是-70℃或更高的温度下冷冻生物样品; （2）解冻冷冻生物样品; 和（3）使用表面活性剂增溶生物样品。
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公开(公告)号：US20110218146A1
公开(公告)日：2011-09-08
申请号：US13060422
申请日：2009-08-27
IPC分类号： A61K38/22 , C07K14/575 , A61P11/00
CPC分类号： A61K38/22 , A61K38/2264 , C07K14/575 , C07K14/785
摘要： The present invention provides an agent for inhibiting alveolar airspace enlargement containing adiponectin or an agent for inhibiting alveolar wall destruction containing adiponectin. The pulmonary disease therapeutic agents of the present invention are highly safe drugs that possess an excellent effect of decreasing the deterioration of the pulmonary function, such as airflow limitation, and exhibit an extremely high effect of treating pulmonary disease accompanied by irreversible deterioration in pulmonary function, with fewer adverse side effects such as nausea, vomiting and gastric acid secretion.
摘要翻译： 本发明提供了抑制含有脂连蛋白的肺泡空腔增大剂或抑制含有脂联素的肺泡壁破坏剂的药剂。 本发明的肺部疾病治疗剂是具有降低肺功能恶化如气流受限的优异效果的高度安全的药物，并且具有极高的治疗伴随肺功能不可逆性恶化的肺部疾病的效果， 副作用较少，如恶心，呕吐和胃酸分泌。
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7.发明授权Human tumor necrosis factor .alpha.specific monoclonal antibody and method for detecting human tumor necrosis factor .alpha. 失效人肿瘤坏死因子α特异性单克隆抗体及其检测人肿瘤坏死因子α的方法
公开(公告)号：US5360716A
公开(公告)日：1994-11-01
申请号：US22428
申请日：1993-02-16
申请人： Yasukazu Ohmoto , Tsutomu Nishida , Keiko Mizuno , Satoru Nakai
发明人： Yasukazu Ohmoto , Tsutomu Nishida , Keiko Mizuno , Satoru Nakai
CPC分类号： C07K16/241 , C07K14/525 , G01N33/6863 , A61K38/00
摘要： Monoclonal antibodies exhibiting specificity for human TNF-.alpha. are disclosed. The antibodies are useful for immunological purification and for measurement of said human TNF-.alpha. in immunoassays.
摘要翻译： 公开了对人TNF-α显示特异性的单克隆抗体。 该抗体可用于免疫纯化和免疫测定中所述人TNF-α的测定。
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8.发明授权Smooth muscle growth inhibitory composition, diagnostic method for arteriosclerosis, and kit therefor 有权平滑肌生长抑制成分，动脉硬化诊断方法及其用途公开(公告)号：US07285275B2
公开(公告)日：2007-10-23
申请号：US11097334
申请日：2005-04-04
申请人： Yuji Matsuzawa , Yasukazu Ohmoto
发明人： Yuji Matsuzawa , Yasukazu Ohmoto
CPC分类号： C07K14/5759 , A61K38/00 , C07K16/18 , C07K16/26 , G01N33/5091 , G01N33/6893 , G01N2333/4704 , G01N2800/323 , Y10S530/809
摘要： The invention provides not only a smooth muscle growth inhibitory composition and a composition for inhibiting expression of adhesion molecules in vascular endothelial cells, each comprising the adipose tissue-specific secretory factor apM1 as an active ingredient, but also a method for diagnosis of arteriosclerosis which comprises assaying apM1 in a sample, an antibody against apM1, and a diagnostic kit for arteriosclerosis which comprises the antibody as an active component, all of which contribute to the elucidation of obesity-related genes and corresponding expression products which are useful for the etiologic exploration and establishment of therapeutic modalities for various obesity-related diseases, particularly arteriosclerosis inclusive of angina pectoris and myocardial infarction. By utilizing the information thus obtained, therapeutic and diagnostic methods for various diseases can be established.
摘要翻译： 本发明不仅提供平滑肌生长抑制组合物和用于抑制血管内皮细胞中粘附分子表达的组合物，其各自包含脂肪组织特异性分泌因子apM1作为活性成分，而且还提供了一种用于诊断动脉硬化的方法，其包括 测定样品中的apM1，针对apM1的抗体和用于动脉硬化的诊断试剂盒，其包含作为活性成分的抗体，所有这些都有助于阐明肥胖相关基因和相应的表达产物，其可用于病因学探查和 建立各种肥胖相关疾病，特别是包括心绞痛和心肌梗死的动脉硬化的治疗方式。 通过利用所获得的信息，可以建立各种疾病的治疗和诊断方法。
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9.发明授权Smooth muscle growth inhibitory composition, diagnostic method for arteriosclerosis, and kit therefor 有权平滑肌生长抑制成分，动脉硬化诊断方法及其用途公开(公告)号：US06461821B1
公开(公告)日：2002-10-08
申请号：US09530423
申请日：2000-05-01
申请人： Yuji Matsuzawa , Yasukazu Ohmoto
发明人： Yuji Matsuzawa , Yasukazu Ohmoto
IPC分类号： G01N3353
CPC分类号： C07K14/5759 , A61K38/00 , C07K16/18 , C07K16/26 , G01N33/5091 , G01N33/6893 , G01N2333/4704 , G01N2800/323 , Y10S530/809
摘要： The invention provides not only a smooth muscle growth inhibitory composition and a composition for inhibiting expression of adhesion molecules in vascular endothelial cells, each comprising the adipose tissue-specific secretory factor apM1 as an active ingredient, but also a method for diagnosis of arteriosclerosis which comprises assaying apM1 in a sample, an antibody against apM1, and a diagnostic kit for arteriosclerosis which comprises the antibody as an active component, all of which contribute to the elucidation of obesity-related genes and corresponding expression products which are useful for the etiologic exploration and establishment of therapeutic modalities for various obesity-related diseases, particularly arteriosclerosis inclusive of angina pectoris and myocardial infarction. By utilizing the information thus obtained, therapeutic and diagnostic methods for various diseases can be established.
摘要翻译： 本发明不仅提供平滑肌生长抑制组合物和用于抑制血管内皮细胞中粘附分子表达的组合物，其各自包含脂肪组织特异性分泌因子apM1作为活性成分，而且还提供了一种用于诊断动脉硬化的方法，其包括 测定样品中的apM1，针对apM1的抗体和用于动脉硬化的诊断试剂盒，其包含作为活性成分的抗体，所有这些都有助于阐明肥胖相关基因和相应的表达产物，其可用于病因学探查和 建立各种肥胖相关疾病，特别是包括心绞痛和心肌梗死的动脉硬化的治疗方式。 通过利用所获得的信息，可以建立各种疾病的治疗和诊断方法。
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10.发明授权Human interferon-related peptides, antigens, antibodies and process for preparing the same 失效人类干扰素相关肽，抗原，抗体及其制备方法
公开(公告)号：US4474754A
公开(公告)日：1984-10-02
申请号：US363505
申请日：1982-03-30
申请人： Fumio Shimizu , Yasukazu Ohmoto , Kenichi Imagawa
发明人： Fumio Shimizu , Yasukazu Ohmoto , Kenichi Imagawa
IPC分类号： A61K39/44 , C07K5/06 , C07K5/083 , C07K5/103 , C07K14/555 , C07K16/24 , A61K39/395 , A61K45/02
CPC分类号： C07K16/249 , A61K39/44 , C07K14/555 , C07K5/06043 , C07K5/081 , C07K5/1005 , Y10S530/806 , Y10S530/807 , Y10S930/142 , Y10S930/28
摘要： Human interferons related peptides and derivatives thereof, antigens, antibodies prepared therefrom, immobilized antibodies to be used for affinity chromatography, and novel method for assaying human interferons by using said affinity chromatography.
摘要翻译： 人干扰素相关肽及其衍生物，抗原，由其制备的抗体，用于亲和层析的固定化抗体，以及通过使用所述亲和层析分析人类干扰素的新方法。
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