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公开(公告)号：US5247935A
公开(公告)日：1993-09-28
申请号：US854040
申请日：1992-03-19
IPC分类号： A61B17/22 , A61B19/00 , A61N7/02 , G01R33/48 , G01R33/561
CPC分类号： G01R33/4804 , A61B17/2256 , A61B2090/374 , A61N7/02 , G01R33/56308
摘要： A magnetic resonance surgery system facilitates performance of surgery with a focussed ultrasound transducer that selectively destroys tissue in a region within a subject. The focussed ultrasound transducer dissipates ultrasonic energy at a focal point within the region of tissue to be destroyed. A number of hydraulic positioners position the focal point under the control of a surgeon. A magnetic resonance imaging system employing a temperature sensitive pulse sequence creates an image of the tissue and the region being heated to allow the surgeon to adjust the position of the ultrasonic transducer so as to direct ultrasonic energy to the appropriate location.
摘要翻译： 磁共振手术系统有助于利用选择性地破坏受试者内的区域中的组织的聚焦超声换能器进行手术。 聚焦超声波换能器在被破坏的组织区域内的焦点处消散超声波能量。 一些液压定位器将焦点定位在外科医生的控制之下。 使用温度敏感脉冲序列的磁共振成像系统产生组织的图像和被加热的区域，以允许外科医生调节超声换能器的位置，以便将超声波能量引导到适当的位置。
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2.发明授权
公开(公告)号：US5526814A
公开(公告)日：1996-06-18
申请号：US443229
申请日：1995-05-17
申请人： Harvey E. Cline , Ronald D. Watkins
发明人： Harvey E. Cline , Ronald D. Watkins
CPC分类号： A61N7/02 , A61B17/2256 , A61B34/70 , A61B18/00 , A61B2090/101 , A61B2090/374 , A61B90/36
摘要： An automatically positioned focussed energy transducer system facilitates medical procedures by allowing a physician to interactively view the position the focal point of a focussed energy transducer superimposed upon a medical image and computer generated model of internal structures of a patient. A tracking device tracks the position and orientation of the ultrasound transducer. A medical imaging system creates an image of internal structures of the patient near the location of the energy transducer. A general purpose computer either receives a model of internal structures constructed in advance, or employs a medical imaging device to create the model. The general purpose computer displays selected surfaces of the model in an orientation and view which coincides with the medical image acquired. A superposition device receives the position and orientation of the ultrasound transducer from the tracking device and superimposes a symbol on the images corresponding to the position of the energy transducer relative to the patient. The physician then selects an internal structure to be destroyed which the general purpose computer determines the locations which the focal point must scan in order to destroy the structure. An actuator, coupled to the general purpose computer causes the focal point of the energy transducer to scan these locations which the physician adjusts the intensity of energy provided to the focal point by an input device.
摘要翻译： 自动定位的聚焦能量换能器系统通过允许医师交互地观察叠加在医学图像上的聚焦能量换能器的焦点和计算机产生的患者内部结构模型的位置来促进医疗过程。 跟踪装置跟踪超声换能器的位置和方位。 医疗成像系统在能量传感器的位置附近创建患者的内部结构的图像。 通用计算机可以接收预先构建的内部结构的模型，或者使用医学成像装置来创建模型。 通用计算机以与所获取的医学图像重合的取向和视图来显示模型的所选表面。 叠加装置从跟踪装置接收超声换能器的位置和方向，并将符号叠加在与能量换能器相对于患者的位置相对应的图像上。 然后，医师选择要销毁的内部结构，通用计算机确定焦点必须扫描的位置以破坏结构。 耦合到通用计算机的致动器使得能量换能器的焦点扫描这些位置，医师通过输入装置调节提供给焦点的能量的强度。
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3.发明授权Magnetic resonance guided ultrasound therapy system with inclined track to move transducers in a small vertical space 失效具有倾斜轨道的磁共振引导超声治疗系统在小的垂直空间中移动传感器
公开(公告)号：US5275165A
公开(公告)日：1994-01-04
申请号：US972331
申请日：1992-11-06
CPC分类号： A61N7/02 , A61B2017/00911 , A61B2090/374
摘要： A magnetic resonance (MR) surgery system facilitates surgery with a focussed ultrasound transducer that selectively destroys tissue in a region within a subject. The focussed energy transducer dissipates energy at a focal point within the region of tissue to be destroyed. A non-magnetic positioning device having a vertical dimension small enough to fit easily within the bore of an MR magnet moves an energy transducer in a limited vertical space. The positioning device employs a plurality of hydraulic positioners and an inclined plane to position the ultrasound focal point under the control of an operator. An MR imaging system employing a temperature sensitive pulse sequence creates an image of the tissue and the region being heated to allow the operator to adjust the position of the ultrasonic transducer so as to direct ultrasonic energy to the appropriate location.
摘要翻译： 磁共振（MR）手术系统利用选择性地破坏受试者内的区域中的组织的聚焦超声换能器促进手术。 聚焦能量传感器在要破坏的组织区域内的焦点处消耗能量。 具有小到足以容易地配合在MR磁体的孔内的垂直尺寸的非磁性定位装置在有限的垂直空间中移动能量换能器。 定位装置采用多个液压定位器和倾斜平面，以在操作者的控制下定位超声焦点。 使用温度敏感脉冲序列的MR成像系统产生组织的图像和被加热的区域，以允许操作者调整超声波换能器的位置，以将超声能量引导到适当的位置。
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4.发明授权Thermal imaging of fat and muscle using a simultaneous phase and magnitude double echo sequence 有权使用同时相位和幅度双回声序列对脂肪和肌肉进行热成像公开(公告)号：US06618608B1
公开(公告)日：2003-09-09
申请号：US09696624
申请日：2000-10-24
申请人： Ronald D. Watkins , Harvey E. Cline
发明人： Ronald D. Watkins , Harvey E. Cline
IPC分类号： A61B505
CPC分类号： G01R33/4804 , A61B2090/374 , A61N7/02 , G01R33/4828
摘要： A method for magnetic resonance imaging includes applying a first two echo gradient echo sequence to a tissue region, the first two echo sequence generating a first echo and a subsequent second echo. A second two echo gradient echo sequence is applied after heating the tissue region, the second two echo sequence generating a third echo and a subsequent fourth echo. A magnitude difference between the third echo and the first echo is measured and correlated to a temperature shift for fat tissue, and a phase difference between the fourth echo and the second echo is measured and correlated to a temperature shift for water-based tissue. A thermal image is generated of the tissue region based upon the temperature shift for both fat and water-based tissue.
摘要翻译： 一种用于磁共振成像的方法包括将第一个两个回波梯度回波序列应用于组织区域，所述前两个回波序列产生第一回波和随后的第二回波。 在加热组织区域之后应用第二个两个回波梯度回波序列，第二个两个回波序列产生第三回波和随后的第四回波。 测量第三回波和第一回波之间的幅度差并与脂肪组织的温度偏移相关，并且测量第四回波和第二回波之间的相位差并与水基组织的温度偏移相关。 基于脂肪和水基组织的温度变化，产生组织区域的热图像。
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公开(公告)号：US5368032A
公开(公告)日：1994-11-29
申请号：US149485
申请日：1993-11-09
申请人： Harvey E. Cline , Ronald D. Watkins
发明人： Harvey E. Cline , Ronald D. Watkins
CPC分类号： G01R33/4804 , A61B34/20 , A61N7/02 , G01R33/285 , A61B2034/107 , A61B2034/2055 , A61B2034/2063 , A61B2090/365 , A61B2090/374
摘要： A manually positioned focussed energy transducer system facilitates medical procedures by allowing a physician to manually position the focal point of the focussed energy transducer to a selected tissue. The focal point of the focussed energy transducer is the location which tissue is destroyed when the energy transducer is activated. A tracking device tracks the position and orientation of the ultrasound transducer. An MR imaging system creates an image of internal structures of the patient near the location of the energy transducer. A superposition device receives the position and orientation of the ultrasound transducer from the tracking device and superimposes a symbol on the image corresponding to the position of the energy transducer relative to the patient. This allows the physician to adjust the position of the energy transducer to the appropriate location without the need for energizing the energy transducer.
摘要翻译： 手动定位的聚焦能量换能器系统通过允许医师将聚焦的能量换能器的焦点手动定位到所选择的组织来促进医疗过程。 聚焦能量传感器的焦点是当能量传感器被激活时组织被破坏的位置。 跟踪装置跟踪超声换能器的位置和方位。 MR成像系统在能量传感器的位置附近创建患者的内部结构的图像。 叠加装置从跟踪装置接收超声波换能器的位置和方向，并将符号叠加在对应于能量换能器相对于患者的位置的图像上。 这允许医师将能量换能器的位置调整到适当的位置，而不需要为能量换能器通电。
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6.发明授权Method and apparatus for three-dimensional ultrasound imaging by projecting filtered pixel data 失效通过投影滤波像素数据进行三维超声成像的方法和装置
公开(公告)号：US5779641A
公开(公告)日：1998-07-14
申请号：US852773
申请日：1997-05-07
CPC分类号： G01S15/8993 , A61B8/06 , A61B8/13 , A61B8/483 , G01S7/5206 , G01S7/52071 , Y10S128/916
摘要： A method and an apparatus for three-dimensional imaging of ultrasound data by reducing speckle artifact data before the acquired data from a volume of interest is projected onto an image plane. An ultrasound scanner collects B-mode or color flow mode images in a cine memory, i.e., for a multiplicity of slices. The data from a respective region of interest for each slice is sent to a master controller, such data forming a volume of interest. The master controller performs an algorithm that iteratively projects the pixel data in the volume of interest onto a plurality of rotated image planes using a ray-casting technique. Prior to projection, the master controller smooths the speckle contained in the pixel data filtering using a convolution filter having a nine-point kernel. Convolution filtering of image data is carried out by defining a desired area of the image, such as an area represented by an array of pixels, by weighting each of the pixels in the array with a respective weighting coefficient, and then by summing the weighted pixels to produce a filtered pixel value which is substituted for the central pixel in the array. The filtered pixel data forms a new data volume which is then projected onto each successive image plane.
摘要翻译： 在从感兴趣的体积获取的数据被投影到图像平面之前，通过减少散斑伪影数据来对超声数据进行三维成像的方法和装置。 超声波扫描仪在电影存储器中收集B模式或彩色流模式图像，即多个切片。 来自每个切片的相关感兴趣区域的数据被发送到主控制器，这样的数据形成感兴趣的体积。 主控制器执行一种算法，其使用光线投射技术将感兴趣的体积中的像素数据迭代地投影到多个旋转的图像平面上。 在投影之前，主控制器使用具有九点内核的卷积滤波器平滑像素数据滤波中包含的斑点。 图像数据的卷积滤波通过利用各自的加权系数对阵列中的每个像素进行加权来定义图像的期望区域，例如由像素阵列表示的区域，然后通过将加权像素相加 以产生被替换为阵列中的中心像素的滤波像素值。 经滤波的像素数据形成新的数据量，然后将其投影到每个连续的图像平面上。
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7.发明授权Apparatus and methods for magnetic resonance (MR) imaging of cavities using fluids polarized at low temperatures 失效使用在低温下极化的流体对空腔进行磁共振（MR）成像的装置和方法
公开(公告)号：US5617859A
公开(公告)日：1997-04-08
申请号：US537574
申请日：1995-10-02
IPC分类号： A61B5/055
CPC分类号： A61B5/055
摘要： A magnetic resonance (MR) active invasive device system employs a small, high-field polarizing magnet, and a large magnetic resonance (MR) imaging magnet for the purpose of generating MR images of selected body cavities. A subject is positioned in a large low-field MR imaging magnet. A substance, intended to be used as a contrast agent is first cooled, and then passed through the small high-field polarizing magnet where it becomes highly polarized. The substance is then heated to physiologic temperatures, vaporized, and introduced into the subject through a transfer conduit as a vapor. Radiofrequency (RF) pulses and magnetic field gradients are then applied to the patient as in conventional MR imaging. Since the vapor is highly polarized, it can be imaged even though it has a much lower density than the surrounding tissue.
摘要翻译： 磁共振（MR）有源侵入性装置系统采用小型高场极化磁体和大型磁共振（MR）成像磁体，用于产生选定体腔的MR图像。 受试者位于大型低场MR成像磁体中。 首先将要用作造影剂的物质冷却，然后通过小型高场极化磁体，在其中高度极化。 然后将物质加热至生理温度，蒸发，并通过作为蒸气的转移导管引入受试者。 然后将射频（RF）脉冲和磁场梯度应用于患者，如在常规MR成像中。 由于蒸气是高度极化的，所以即使其具有比周围组织低得多的密度，也可以成像。
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公开(公告)号：US5514962A
公开(公告)日：1996-05-07
申请号：US203079
申请日：1994-02-28
CPC分类号： G01R33/54 , G01R33/543 , G01R33/546
摘要： Three-dimensional (3D) image data is acquired from a subject with a medical imaging device and stored. The stored 3D image data is processed by a model workstation to segment the model into discrete structures and produce a segmented computer graphic model. An operator interacts with the model workstation to cause it to display desired structures of the the segmented model in a desired view and orientation. The operator also selects a position and orientation of a cutting plane passing through the segmented model. Once selected, the position and orientation information is provided to a pulse sequencer of a magnetic resonance (MR) imaging system. The pulse sequencer controls an RF transmitter and gradient amplifiers to cause an MR image of the subject at an imaging plane, corresponding to the cutting plane of the model workstation, to be acquired. This allows fast, accurate image plane selection, which may be selected by an operator who is simultaneously performing a medical procedure on the subject, aid in the procedure.
摘要翻译： 利用医学成像装置从受检者获取三维（3D）图像数据并存储。 存储的3D图像数据由模型工作站处理以将模型分割成离散结构并产生分段计算机图形模型。 操作者与模型工作站进行交互，使其以期望的视图和方向显示分段模型的所需结构。 操作员还选择通过分段模型的切割平面的位置和方向。 一旦选择，位置和取向信息被提供给磁共振（MR）成像系统的脉冲序列器。 脉冲序列发生器控制RF发射器和梯度放大器，以便在对应于模型工作站的切割平面的成像平面处引起被摄体的MR图像。 这允许快速，准确的图像平面选择，其可以由同时对主体执行医疗程序的操作者选择，辅助该过程。
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9.发明授权
公开(公告)号：US5368031A
公开(公告)日：1994-11-29
申请号：US125520
申请日：1993-09-24
申请人： Harvey E. Cline , Thomas R. Anthony
发明人： Harvey E. Cline , Thomas R. Anthony
IPC分类号： A61B17/00 , A61B18/22 , A61B19/00 , A61N7/02 , G01R33/48 , G01R33/561 , G01R33/563 , A61B5/055
CPC分类号： G01R33/4804 , A61B18/22 , A61N7/02 , A61B2017/00154 , A61B2090/374 , G01R33/561 , G01R33/56341
摘要： Surgery is performed with pulsed heat means that selectively destroys tissue in a region within a patient. The size of the region destroyed is dependent upon the frequency of the pulses of the pulsed heat means and thermal conductivity of the tissue of the patient. The pulsed heat means can be a coherent optical source that is guided by laser fiber to the tissue to be destroyed. In another embodiment the pulsed heat means is a focussed ultrasound transducer that dissipates ultrasonic energy at a focal point within the region of tissue to be destroyed. A magnetic resonance imaging system employing a temperature sensitive pulse sequence creates an image of the tissue and the region being heated to allow a surgeon to alter the position of the pulsed heat means or vary the pulse frequency.
摘要翻译： 使用脉冲加热手段进行手术，其选择性地破坏患者内的区域中的组织。 破坏的区域的大小取决于脉冲加热装置的脉冲频率和患者组织的热导率。 脉冲加热装置可以是由激光纤维引导到要破坏的组织的相干光源。 在另一个实施例中，脉冲加热装置是聚焦的超声换能器，其在要破坏的组织区域内的焦点处散发超声波能量。 使用温度敏感脉冲序列的磁共振成像系统产生组织的图像和被加热的区域，以允许外科医生改变脉冲加热装置的位置或改变脉冲频率。
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公开(公告)号：US5365927A
公开(公告)日：1994-11-22
申请号：US146345
申请日：1993-11-02
申请人： Peter B. Roemer , Samuel M. Blumenfeld , Kirby G. Vosburgh , Harvey E. Cline , William D. Barber , William E. Lorensen , Richard L. St. Peters , John F. Schenck , Charles L. Dumoulin , Robert D. Darrow , Christopher J. Hardy
发明人： Peter B. Roemer , Samuel M. Blumenfeld , Kirby G. Vosburgh , Harvey E. Cline , William D. Barber , William E. Lorensen , Richard L. St. Peters , John F. Schenck , Charles L. Dumoulin , Robert D. Darrow , Christopher J. Hardy
IPC分类号： G01R33/48 , A61B5/055 , G01R33/28 , G01R33/38 , G01R33/385 , G01R33/54 , G01R33/563
CPC分类号： G01R33/385 , G01R33/3806 , G01R33/285 , G01R33/4804 , G01R33/543 , G01R33/563
摘要： A magnetic resonance (MR) imaging system for use in a medical procedure employs an open main magnet allowing access to a portion of a patient within an imaging volume, for producing a main magnetic field over the imaging volume; a set of open gradient coils which provide magnetic fields gradients over the imaging volume without restricting access to the imaging volume; a radiofrequency coil set for transmitting RF energy into the imaging volume to nutate nuclear spins within the imaging volume and receive an MR response signal from the nuclear spins; and a pointing device for indicating the position and orientation of a plane in which an image is to be acquired; an image control means for operating power supplies for the gradient coils and the RF coils to acquire an MR signal from the desired imaging plane; and a computation unit for constructing an image of the desired imaging plane. The MR imaging system is intended to operate to provide images to a physician during medical procedures to guide the physician in his procedures.
摘要翻译： 用于医疗过程的磁共振（MR）成像系统采用打开的主磁体，其允许进入成像体积内的患者的一部分，用于在成像体积上产生主磁场; 一组开放的梯度线圈，其在成像体积上提供磁场梯度，而不限制对成像体积的访问; 射频线圈组，用于将RF能量传输到成像体积中，以在成像体积内盘旋核自旋，并从核自旋接收MR响应信号; 以及指示装置，用于指示要获取图像的平面的位置和方位; 图像控制装置，用于操作梯度线圈和RF线圈的电源，以从期望的成像平面获取MR信号; 以及用于构造所需成像平面的图像的计算单元。 MR成像系统旨在在医疗程序期间向医生提供图像以在他的程序中指导医师。
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