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公开(公告)号：US06348175B1
公开(公告)日：2002-02-19
申请号：US09412483
申请日：1999-10-05
IPC分类号： A61M114
CPC分类号： B01F7/00758 , A61M1/1698 , A61M1/262 , A61M2206/14 , B01D63/02 , B01D63/043 , B01D63/16 , B01D65/08 , B01D2313/20 , B01D2321/2041 , B01D2321/2083 , Y10S261/28
摘要： A blood membrane oxygenator having a housing defining a blood flow path, a rotor hub in the form of a double lumen shaft, and a plurality of distributor disks each having a plurality of hollow fibers which extend across the housing blood flow path. The plurality of distributor disks rotate within the housing to mix the blood resulting in three-dimensional mixing, disruption of the blood boundary layer and efficient blood oxygenation.
摘要翻译： 具有限定血液流动通道的壳体的血液膜氧合器，双腔轴心形式的转子轮毂，以及多个分配器盘，每个分配盘具有跨过壳体血液流路延伸的多个中空纤维。 多个分配器盘在壳体内旋转以混合血液，导致三维混合，血液边界层破裂和有效的血氧合。
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公开(公告)号：US6106776A
公开(公告)日：2000-08-22
申请号：US837048
申请日：1997-04-11
IPC分类号： A61M1/16 , A61M1/22 , A61M1/26 , B01D63/02 , B01D63/04 , B01D63/16 , B01D65/08 , B01F7/00 , A61M1/14
CPC分类号： B01F7/00758 , A61M1/262 , B01D63/02 , B01D63/043 , B01D63/16 , B01D65/08 , A61M1/1698 , A61M2206/14 , B01D2313/20 , B01D2321/2041 , B01D2321/2083 , Y10S261/28
摘要： A blood membrane oxygenator has a housing defining a blood flow path, a rotor hub in the form of a double lumen shaft, and a plurality of distributor disks each having a plurality of hollow fibers which extend across the housing blood flow path. The plurality of distributor disks rotate within the housing to mix the blood resulting in three-dimensional mixing, disruption of the blood boundary layer and efficient blood oxygenation.
摘要翻译： 血液膜氧合器具有限定血流路径的壳体，双腔轴心形式的转子轮毂，以及多个分配盘，每个分配盘具有跨过壳体血液流路延伸的多个中空纤维。 多个分配器盘在壳体内旋转以混合血液，导致三维混合，血液边界层破裂和有效的血氧合。
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3.发明授权Membrane apparatus with enhanced mass transfer, heat transfer and pumping capabilities via active mixing 失效膜装置通过主动混合具有增强的传质，传热和泵送能力公开(公告)号：US06723284B1
公开(公告)日：2004-04-20
申请号：US09707040
申请日：2000-11-06
IPC分类号： A61M114
CPC分类号： B01F7/00758 , A61M1/1006 , A61M1/101 , A61M1/1012 , A61M1/1029 , A61M1/1629 , A61M1/1698 , A61M1/26 , A61M1/262 , A61M1/267 , A61M2206/14 , B01D63/026 , B01D63/043 , B01D63/16 , B01D65/08 , B01D2313/38 , B01D2321/2066 , B01D2321/2083 , Y10S128/03 , Y10S165/357
摘要： A combination mass transfer and pump apparatus, which in a single step actively mixes a first mass and a second mass and simultaneously pumps one of the first mass and the second mass through the apparatus. The combination mass transfer and pump apparatus substantially comprises a housing and at least one distributor element having a plurality of selectively fluid-permeable membrane elements wherein the at least one distributor element is agitated within the second mass such that the first mass diffuses across the selectively fluid-permeable membrane elements, mixing with the second mass, and in the same step the second mass is pumped through the housing.
摘要翻译： 组合质量传递和泵装置，其在单步中主动混合第一质量块和第二质量块，同时通过装置泵送第一质量块和第二质量块中的一种。 组合质量传递和泵装置基本上包括壳体和至少一个具有多个选择性流体可渗透膜元件的分配器元件，其中至少一个分配器元件在第二质量块内被搅动，使得第一质量块扩散穿过选择性流体 不渗透膜元件，与第二质量块混合，并且在相同步骤中，第二质量泵送通过壳体。
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4.发明授权Membrane apparatus with enhanced mass transfer, heat transfer and pumping capabilities via active mixing 失效膜装置通过主动混合具有增强的传质，传热和泵送能力公开(公告)号：US07122151B2
公开(公告)日：2006-10-17
申请号：US10827400
申请日：2004-04-19
CPC分类号： B01F7/00758 , A61M1/1006 , A61M1/101 , A61M1/1012 , A61M1/1029 , A61M1/1629 , A61M1/1698 , A61M1/26 , A61M1/262 , A61M1/267 , A61M2206/14 , B01D63/026 , B01D63/043 , B01D63/16 , B01D65/08 , B01D2313/38 , B01D2321/2066 , B01D2321/2083 , Y10S128/03 , Y10S165/357
摘要： A combination mass transfer and pump apparatus, which in a single step actively mixes a first mass and a second mass and simultaneously pumps one of the first mass and the second mass through the apparatus. The combination mass transfer and pump apparatus substantially comprises a housing and at least one distributor element having a plurality of selectively fluid-permeable membrane elements wherein the at least one distributor element is agitated within the second mass such that the first mass diffuses across the selectively fluid-permeable membrane elements, mixing with the second mass, and in the same step the second mass is pumped through the housing.
摘要翻译： 组合质量传递和泵装置，其在单步中主动混合第一质量块和第二质量块，同时通过装置泵送第一质量块和第二质量块中的一种。 组合质量传递和泵装置基本上包括壳体和至少一个具有多个选择性流体可渗透膜元件的分配器元件，其中至少一个分配器元件在第二质量块内被搅动，使得第一质量块扩散穿过选择性流体 不渗透膜元件，与第二质量块混合，并且在相同步骤中，第二质量泵送通过壳体。
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5.发明授权Membrane apparatus with enhanced mass transfer, heat transfer and pumping capabilities via active mixing 有权膜装置通过主动混合具有增强的传质，传热和泵送能力公开(公告)号：US06217826B1
公开(公告)日：2001-04-17
申请号：US09157815
申请日：1998-09-21
IPC分类号： A61M114
CPC分类号： B01F7/00758 , A61M1/1006 , A61M1/101 , A61M1/1025 , A61M1/1086 , A61M1/1629 , A61M1/1698 , A61M1/26 , A61M1/262 , A61M1/267 , A61M2205/33 , A61M2205/3303 , A61M2206/14 , B01D63/02 , B01D63/026 , B01D63/043 , B01D63/16 , B01D65/08 , B01D2313/243 , B01D2313/38 , B01D2321/2041 , B01D2321/2066 , B01D2321/2083
摘要： A combination mass transfer and pump apparatus, which in a single step actively mixes a first mass and a second mass and simultaneously pumps one of the first mass and the second mass through the apparatus. The combination mass transfer and pump apparatus substantially comprises a housing and at least one distributor element having a plurality of selectively fluid-permeable membrane elements wherein the at least one distributor element is agitated within the second mass such that the first mass diffuses across the selectively fluid-permeable membrane elements, mixing with the second mass, and in the same step the second mass is pumped through the housing.
摘要翻译： 组合质量传递和泵装置，其在单步中主动混合第一质量块和第二质量块，同时通过装置泵送第一质量块和第二质量块中的一种。 组合质量传递和泵装置基本上包括壳体和至少一个具有多个选择性流体可渗透膜元件的分配器元件，其中至少一个分配器元件在第二质量块内被搅动，使得第一质量块扩散穿过选择性流体 不渗透膜元件，与第二质量块混合，并且在相同步骤中，第二质量泵送通过壳体。
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公开(公告)号：US5501663A
公开(公告)日：1996-03-26
申请号：US87487
申请日：1993-07-02
CPC分类号： A61M1/1678 , A61M1/1698 , A61M1/26 , Y10S128/03 , Y10S261/28
摘要： An intravenous fiber membrane oxygenator is disclosed in several embodiments wherein the fibers either run at a transverse angle relative to the longitudinal axis of the oxygenator and/or are of a reduced length to optimize the gas transfer efficiency of the oxygenator. Various helical or spiral wraps of fibers are disclosed. One embodiment utilizes two sets of longitudinally extending fibers wherein the oxygen gas is moved in opposite directions from a central location of the oxygenator.
摘要翻译： 在几个实施方案中公开了静脉内纤维膜氧合器，其中纤维相对于氧合器的纵向轴线以横向角度运行和/或具有减小的长度以优化氧合器的气体转移效率。 公开了各种螺旋或螺旋形的纤维卷。 一个实施例使用两组纵向延伸纤维，其中氧气从氧合器的中心位置沿相反方向移动。
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公开(公告)号：US5312589A
公开(公告)日：1994-05-17
申请号：US019400
申请日：1993-03-04
CPC分类号： A61M1/1698 , A61M1/1625 , A61M1/1629 , B01D63/043 , B01D2313/14 , B01D2319/06
摘要： A gas transfer apparatus readily adapted for oxygenating blood includes a housing with a hollow internal chamber having a fiber mat consisting of two sets of intermingled hollow fibers with one set of fibers having micropores formed in the walls thereof and the other set having solid liquid impermeable walls. The housing for the apparatus is designed such that the blood being processed passes substantially uniformly across the entire cross section of the fiber mat whereby a treating gas such as oxygen being directed through the microporous fibers can be diffused into the oxygen deficient blood while excess CO.sub.2 in the blood can cross diffuse into the interior of the fiber and be removed from the apparatus. Simultaneously with the cross diffusion of gas between the microporous fibers and the blood, a thermal conducting fluid such as water is passed through the solid walled fibers to maintain or regulate the temperature of the blood in the apparatus. The microporous and solid walled fibers may be woven in layers which are laminated to form a predetermined mat thickness separated by layers with only parallel fibers of a single set in each layer.
摘要翻译： 容易适用于血液充氧的气体输送装置包括具有中空内室的壳体，该壳体具有由两组混合中空纤维组成的纤维垫，一组纤维在其壁中形成有微孔，另一组具有固体液体不可渗透壁 。 设备的外壳被设计成使得被处理的血液基本均匀地穿过纤维垫的整个横截面，由此通过微孔纤维引导的氧气等处理气体可以扩散到缺氧血液中，而过量的CO 2 血液可以扩散到纤维的内部并从装置中取出。 与微孔纤维和血液之间的气体的交叉扩散同时，诸如水的导热流体通过固体壁纤维，以维持或调节装置中血液的温度。 微孔和固体壁纤维可以以层压编织形成预定的垫厚度，每层仅具有单组的平行纤维，层间隔开。
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公开(公告)号：US4964984A
公开(公告)日：1990-10-23
申请号：US366645
申请日：1989-06-14
申请人： Gary D. Reeder , Michael J. Janicki
发明人： Gary D. Reeder , Michael J. Janicki
CPC分类号： B01D36/001 , A61M1/3627 , B01D19/0031 , B01D27/005 , B01D29/114
摘要： A blood filter device for separating gas bubbles from a flow of blood includes a filter medium in a lower body portion of the device through which the blood must flow before being directed through an outlet tube. An upper cap sealed to the top of the lower body portion includes a blood inlet tube into which a conical dispersion plate is projected so as to decrease the rate of flow of the blood. The rate of flow further decreases as it enters a debubbling chamber in the cap. A top wall of the cap defines a sloped and arched channel around the inlet tube adapted to direct released gas toward a vent tube at the uppermost extent of the sloped top wall.
摘要翻译： 用于从血液流中分离气泡的血液过滤装置包括在装置的下部主体部分中的过滤介质，在穿过出口管之前血液必须通过该过滤介质流动。 密封到下主体部分的顶部的上盖包括血液入口管，其中突出有锥形分散板，以降低血液的流速。 当进入盖中的脱泡室时，流速进一步降低。 盖的顶壁限定了入口管周围的倾斜和拱形通道，其适于将排放的气体引向倾斜顶壁的最上部的通风管。
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公开(公告)号：US4668214A
公开(公告)日：1987-05-26
申请号：US872015
申请日：1986-06-09
申请人： Gary D. Reeder
发明人： Gary D. Reeder
CPC分类号： B04B5/0442 , A61M1/3621 , A61M1/3692 , A61M1/3693 , A61M1/3696 , B04B2005/0464
摘要： A method of cleaning red blood cells which have been separated from undesirable components of blood in a centrifugal separating chamber includes the steps of pulsating a washing solution through the red blood cells in an alternating high flow rate/low flow rate sequence so as to alternately agitate the red cells for optimal cleaning and stabilize the red cells to prevent a flushing of the cells from the separation chamber.
摘要翻译： 在离心分离室中分离出与血液不良成分分离的红细胞的方法包括以交替高流量/低流量顺序使洗涤溶液以红细胞脉动的步骤，以交替地搅动 红细胞用于最佳清洁并稳定红细胞以防止细胞从分离室中冲洗。
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公开(公告)号：US5876667A
公开(公告)日：1999-03-02
申请号：US584275
申请日：1996-01-11
申请人： Robert F. Gremel , Sean D. Plunkett , Henry W. Palermo , Gary D. Reeder , Peter Z. Kubisa , Peter J. Hier
发明人： Robert F. Gremel , Sean D. Plunkett , Henry W. Palermo , Gary D. Reeder , Peter Z. Kubisa , Peter J. Hier
CPC分类号： F28F21/062 , B01D19/0031 , F28F2260/02
摘要： Micro-conduit with enhanced wetting characteristics for use in providing a blood heat exchanger apparatus with improved heat exchange capability. The micro-conduit comprises a plurality of elongated fibers, which may be made of a hydrophobic material such as polypropylene or polyethylene. Each fiber is open at two opposing ends, and has an inner surface between the open ends. The inner surface is coated with a wetting agent, such as phosphatidyl choline or another ampiphilic material with a hydrophilic end and a hydrophobic end. The fibers may have a shape and size that without presence of the wetting agent, would otherwise substantially impair free passage of water. The micro-conduit may be provided as a heat exchanger micro-conduit wrapping material, wherein micro-conduit fibers are attached to a thin flexible interconnect, such as woven netting, to maintain the fibers at predetermined spacings in substantially parallel alignment with each other. The wrapping material is wrapped about an elongated spindle to provide a generally cylindrical heat exchange core. Opposing first and second seals are created by applying potting compound between fibers proximate the spindle's first end and proximate the spindle's second end. After ends of the fibers are trimmed and sealed, a shell is placed around the core.
摘要翻译： 具有增强的润湿特性的微导管，用于提供具有改善的热交换能力的血液热交换器装置。 微导管包括多个细长纤维，其可以由诸如聚丙烯或聚乙烯的疏水材料制成。 每个纤维在两个相对的端部开口，并且在开口端之间具有内表面。 内表面涂覆有润湿剂，例如磷脂酰胆碱或具有亲水末端和疏水末端的另一个极性材料。 纤维可以具有不存在润湿剂的形状和尺寸，否则将显着损害水的自由通过。 微导管可以作为热交换器微管道包裹材料提供，其中微导管纤维附接到薄的柔性互连（例如编织网），以将纤维保持在彼此基本平行对准的预定间隔。 包裹材料围绕细长的主轴缠绕以提供大致圆柱形的热交换芯。 相反的第一和第二密封通过在靠近主轴的第一端并且靠近主轴的第二端的纤维之间施加灌封复合物来产生。 在纤维末端被修剪和密封之后，将壳放置在芯周围。
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