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    PROCESS FOR PREPARING A SUBSTRATE COATED WITH A BIOMOLECULE
    3.
    发明申请
    PROCESS FOR PREPARING A SUBSTRATE COATED WITH A BIOMOLECULE 有权
    制备用生物分子涂覆的基材的方法

    公开(公告)号：US20080241349A1

    公开(公告)日：2008-10-02

    申请号：US12061212

    申请日：2008-04-02

    申请人： Patrick Cahalan ,  Linda Cahalan ,  Greg Johnson ,  Mark Gartner

    发明人： Patrick Cahalan ,  Linda Cahalan ,  Greg Johnson ,  Mark Gartner

    IPC分类号： B05D3/04

    CPC分类号： A61L31/10 ,  A61M1/1698 ,  C08L83/04

    摘要： Processes are provided for preparing a substrate coated with a biomolecule, comprising: a) providing a substrate; b) coating the substrate with a polysiloxane, typically by exposing the substrate to a reactive gas containing siloxane functional groups and to plasma energy to yield a plasma-deposited polysiloxane surface on the substrate; c) rendering the polysiloxane surface amino functional; and d) contacting the amino-functional polysiloxane surface with a biomolecule under conditions effective to attach the biomolecule to the substrate. The coated substrate may be a medical device that demonstrates an ability to maintain gas permeability when in contact with blood or blood components, compared to a substantially identical medical device that has not been coated with a biomolecule using this process.

    摘要翻译： 提供了制备涂覆有生物分子的底物的方法，包括：a）提供底物; b）用聚硅氧烷涂覆基材，通常通过将基材暴露于含有硅氧烷官能团的反应性气体和等离子体能量，以在基材上产生等离子体沉积的聚硅氧烷表面; c）使聚硅氧烷表面具有氨基功能; 和d）在有效地将生物分子附着到底物的条件下，使氨基官能聚硅氧烷表面与生物分子接触。 涂覆的基底可以是与使用该方法未用生物分子涂覆的基本相同的医疗装置相比，其表现出与血液或血液成分接触时保持透气性的能力的医疗装置。

    Blood oxygenator with spacers
    4.
    发明申请
    Blood oxygenator with spacers 审中-公开
    血液充氧器与垫片

    公开(公告)号：US20050042131A1

    公开(公告)日：2005-02-24

    申请号：US10919080

    申请日：2004-08-16

    申请人： Mark Gartner

    发明人： Mark Gartner

    IPC分类号： A61M1/16 ,  A61M1/14

    CPC分类号： A61M1/1698

    摘要： An apparatus and method related to mass transfer and fluid pump devices. The apparatus generally includes a housing that defines an interior cavity, a diffuser positioned in the interior cavity of the housing, the diffuser comprising porous elements arranged in discrete layers, a diffusion area that is defined by a pre-determined distance between the discrete layers of porous elements. A fluid is accelerated through each diffuser layer and is then de-accelerated in the diffusion area.

    摘要翻译： 与传质和流体泵装置相关的装置和方法。 该装置通常包括限定内腔的壳体，位于壳体的内腔中的扩散器，扩散器包括以离散层布置的多孔元件，扩散区域由离散层之间的预定距离 多孔元素。 流体通过每个扩散层加速，然后在扩散区域中被去加速。

    Surface Treated Polymeric Synthetic Hernia Mesh Prosthesis, Surface Treated Sutures and Staples and Methods of Manufacturing the Same
    7.
    发明申请
    Surface Treated Polymeric Synthetic Hernia Mesh Prosthesis, Surface Treated Sutures and Staples and Methods of Manufacturing the Same 审中-公开
    表面处理聚合物合成疝网假体，表面处理缝线和钉子及其制造方法

    公开(公告)号：US20130110137A1

    公开(公告)日：2013-05-02

    申请号：US13632197

    申请日：2012-10-01

    申请人： Enrico Nicolo ,  Linda Cahalan ,  Greg Johnson ,  Mark Gartner ,  Patrick Cahalan ,  Brian J Fill ,  Ali HUSSAIN ,  Jeffrey W. Speakman

    发明人： Enrico Nicolo ,  Linda Cahalan ,  Greg Johnson ,  Mark Gartner ,  Patrick Cahalan ,  Brian J Fill ,  Ali HUSSAIN ,  Jeffrey W. Speakman

    IPC分类号： A61L27/24 ,  A61L27/22

    CPC分类号： A61L27/24 ,  A61L27/227 ,  A61L31/048 ,  A61L31/10 ,  A61L33/0029 ,  A61L2400/18 ,  A61M1/1698 ,  C08L83/04 ,  C08L23/12

    摘要： A variety of polymeric synthetic hernia mesh prosthesis with surface treatment on at least one tissue-facing surface to control tissue adhesion are disclosed including heparin surface treatment which provides heparin present in an amount to yield heparin bioactivity of at least one of i) an ATIII binding of at least 2 pmol/cm2, and ii) a thrombin deactivation of at least 0.2 IU/cm2; an acrylic surface treatment for coupling thereto of a heparin surface treatment, a collagen surface treatment or both; and an amino-functional polysiloxane surface treatment for coupling thereto of a heparin surface treatment. The synthetic hernia mesh may be formed of monofilament or multifilament polypropylene or polyester, and may be formed as a multi-layer prosthesis with an outer layer formed of a polymeric synthetic hernia mesh with surface treatment to control tissue adhesion coupled to one or more polymeric synthetic hernia meshes without such surface treatments.

    摘要翻译： 公开了在至少一个面向组织的表面上进行表面处理以控制组织粘附的各种聚合合成疝网假体，其包括肝素表面处理，其提供一定量的肝素以产生以下至少一种的肝素生物活性：i）ATIII结合 至少2pmol / cm 2，和ii）至少0.2IU / cm 2的凝血酶失活; 用于与肝素表面处理，胶原表面处理或两者结合的丙烯酸表面处理; 和用于与肝素表面处理偶联的氨基官能聚硅氧烷表面处理。 合成疝网可以由单丝或多丝聚丙烯或聚酯形成，并且可以形成为具有由聚合物合成疝网形成的外层的多层假体，其具有表面处理以控制与一种或多种聚合物合成 没有这种表面处理的疝气网眼。

    Process for preparing a substrate coated with a biomolecule
    8.
    发明授权
    Process for preparing a substrate coated with a biomolecule 有权
    制备涂有生物分子的基材的方法

    公开(公告)号：US08114465B2

    公开(公告)日：2012-02-14

    申请号：US12061212

    申请日：2008-04-02

    申请人： Patrick Cahalan ,  Linda Cahalan ,  Greg Johnson ,  Mark Gartner

    发明人： Patrick Cahalan ,  Linda Cahalan ,  Greg Johnson ,  Mark Gartner

    IPC分类号： B05D3/04

    CPC分类号： A61L31/10 ,  A61M1/1698 ,  C08L83/04

    摘要： Processes are provided for preparing a substrate coated with a biomolecule, comprising: a) providing a substrate; b) coating the substrate with a polysiloxane, typically by exposing the substrate to a reactive gas containing siloxane functional groups and to plasma energy to yield a plasma-deposited polysiloxane surface on the substrate; c) rendering the polysiloxane surface amino functional; and d) contacting the amino-functional polysiloxane surface with a biomolecule under conditions effective to attach the biomolecule to the substrate. The coated substrate may be a medical device that demonstrates an ability to maintain gas permeability when in contact with blood or blood components, compared to a substantially identical medical device that has not been coated with a biomolecule using this process.

    摘要翻译： 提供了制备涂覆有生物分子的底物的方法，包括：a）提供底物; b）用聚硅氧烷涂覆基材，通常通过将基材暴露于含有硅氧烷官能团的反应性气体和等离子体能量，以在基材上产生等离子体沉积的聚硅氧烷表面; c）使聚硅氧烷表面具有氨基功能; 和d）在有效地将生物分子附着到底物的条件下，使氨基官能聚硅氧烷表面与生物分子接触。 涂覆的基底可以是与使用该方法未用生物分子涂覆的基本相同的医疗装置相比，其表现出与血液或血液成分接触时保持透气性的能力的医疗装置。

    Method of treating the surface of a medical device with a biomolecule
    10.
    发明授权
    Method of treating the surface of a medical device with a biomolecule 有权
    用生物分子处理医疗器械表面的方法

    公开(公告)号：US08343567B2

    公开(公告)日：2013-01-01

    申请号：US13345813

    申请日：2012-01-09

    申请人： Patrick Cahalan ,  Linda Cahalan ,  Greg Johnson ,  Mark Gartner

    发明人： Patrick Cahalan ,  Linda Cahalan ,  Greg Johnson ,  Mark Gartner

    IPC分类号： B05D3/04

    CPC分类号： A61L31/10 ,  A61M1/1698 ,  C08L83/04

    摘要： A method of treating the surface of a medical device with a biomolecule comprising the steps of: providing a polyolefin substrate forming a medical device; cleaning the polyolefin substrate; exposing the polyolefin substrate to a reactive gas containing acrylic acid and to plasma energy to yield a plasma-deposited polyacrylic acid coating on the polyolefin substrate; and attaching a biomolecule, such as heparin, to the polyolefin substrate following formation of the plasma-deposited polyacrylic acid coating on the polyolefin substrate.

    摘要翻译： 一种用生物分子处理医疗装置的表面的方法，包括以下步骤：提供形成医疗装置的聚烯烃基材; 清洗聚烯烃基材; 将聚烯烃基材暴露于含有丙烯酸的反应性气体和等离子体能量，以在聚烯烃基材上产生等离子体沉积的聚丙烯酸涂层; 以及在聚烯烃基材上形成等离子体沉积的聚丙烯酸涂层之后，将生物分子如肝素附着到聚烯烃基材上。