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    PHOSPHOLIPID MICELLAR AND LIPOSOMAL COMPOSITIONS AND USES THEREOF
    2.
    发明申请
    PHOSPHOLIPID MICELLAR AND LIPOSOMAL COMPOSITIONS AND USES THEREOF 审中-公开
    磷脂细胞和脂质组合物及其用途

    公开(公告)号：US20110256213A1

    公开(公告)日：2011-10-20

    申请号：US13124605

    申请日：2009-10-15

    申请人： Hayat Onyuksel ,  Israel Rubinstein

    发明人： Hayat Onyuksel ,  Israel Rubinstein

    IPC分类号： A61K9/127 ,  C12N5/071 ,  A61K38/26 ,  A61K38/22 ,  A61P37/00 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P33/00 ,  A61K38/12 ,  A61K31/216

    CPC分类号： A61K38/26 ,  A61K9/0014 ,  A61K9/0048 ,  A61K9/107 ,  A61K9/19 ,  A61K31/00 ,  A61K31/395 ,  A61K45/06 ,  A61K47/24 ,  A61K47/6911

    摘要： The invention generally relates to compositions and methods for the reduction or neutralization of toxins associated with a bacterial, mycobacterial, fungal, viral, or protozoal agent. More particularly, the invention is directed to sterically stabilized phospholipid micellar and liposomal compositions, which interact with the toxins to decrease or neutralize their toxicity. Additionally, the invention includes the use of sterically stabilized phospholipid micellar compositions comprising one or more water-insoluble antibiotic, antifungal, antiviral, antiprotozoal, or anti-inflammatory agent(s), wherein the micellar or liposomal composition inhibits the formation of aggregates. The invention further includes the use of sterically stabilized micelle and liposomal compositions to deliver compounds to the site of action, and in some cases targets the compound to the site of action, for the treatment of inflammation and infection. The invention includes the use of combinations of such micellar and liposomal compositions to improve the effectiveness of treatment.

    摘要翻译： 本发明一般涉及用于还原或中和与细菌，分枝杆菌，真菌，病毒或原生动物相关的毒素的组合物和方法。 更具体地，本发明涉及空间稳定的磷脂胶束和脂质体组合物，其与毒素相互作用以降低或中和其毒性。 此外，本发明包括使用包含一种或多种水不溶性抗生素，抗真菌，抗病毒，抗原虫或抗炎剂的空间稳定化的磷脂胶束组合物，其中胶束或脂质体组合物抑制聚集体的形成。 本发明还包括使用空间稳定的胶束和脂质体组合物将化合物递送到作用部位，并且在一些情况下将化合物靶向作用部位，用于治疗炎症和感染。 本发明包括使用这种胶束和脂质体组合物的组合来改善治疗的有效性。

    HYDROPHILIC POLYMER-CONJUGATED LIPIDS FOR PEPTIDE AND PROTEIN FOLDING DISORDERS
    3.
    发明申请
    HYDROPHILIC POLYMER-CONJUGATED LIPIDS FOR PEPTIDE AND PROTEIN FOLDING DISORDERS 审中-公开
    用于肽和蛋白折叠病的亲水性聚合物脂肪

    公开(公告)号：US20100062969A1

    公开(公告)日：2010-03-11

    申请号：US12296238

    申请日：2007-04-06

    申请人： Hayat Onyuksel ,  Israel Rubinstein

    发明人： Hayat Onyuksel ,  Israel Rubinstein

    IPC分类号： A61K38/00 ,  A61K31/685

    CPC分类号： A61K47/6907 ,  A61K47/544 ,  A61K47/60

    摘要： The present invention provides a method of correcting peptide or protein misfolding, which can be used to treat peptide and protein disorder in a mammalian subject. The method comprises administering to the mammalian subject, preferably a human subject, an effective amount of a composition comprising sterically stabilized simple micelles (SSM) of a hydrophilic polymer-conjugated lipid or sterically stabilized mixed micelles (SSMM) of a hydrophilic polymer-conjugated lipid and a water-insoluble lipid. The composition may further comprise a biologically active compound, such as but not limited to vasoactive intestinal peptide (VIP), associated with the SSM or SSMM.

    摘要翻译： 本发明提供了一种校正肽或蛋白质错误折叠的方法，其可用于治疗哺乳动物受试者中的肽和蛋白质紊乱。 该方法包括向哺乳动物受试者，优选人受试者施用有效量的包含亲水性聚合物共轭脂质的亲水性聚合物共轭脂质或空间稳定的混合胶束（SSMM）的空间稳定的简单胶束（SSM）的组合物 和水不溶性脂质。 组合物还可包含与SSM或SSMM相关的生物活性化合物，例如但不限于血管活性肠肽（VIP）。