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    Composition, use and manufacture of bioactive glass
    1.
    发明申请
    Composition, use and manufacture of bioactive glass 审中-公开
    生物活性玻璃的组成，使用和制造

    公开(公告)号：US20060166807A1

    公开(公告)日：2006-07-27

    申请号：US10530043

    申请日：2003-10-02

    申请人： Heimo Ylanen ,  Antti Yli-Urpo ,  Mikko Hupa

    发明人： Heimo Ylanen ,  Antti Yli-Urpo ,  Mikko Hupa

    IPC分类号： C03C3/078

    CPC分类号： C03C4/0007 ,  A61L27/10 ,  A61L27/30 ,  C03C3/097 ,  C03C11/00 ,  C03C12/00 ,  C03C13/00 ,  C03C14/00

    摘要： A bioactive glass composition which contains SiO2, Na2O, CaO, K2O, MgO, P2O5 and B2O3. The amount of SiO2 is 51-56 wt-% of the starting oxides, Na2O is 7-9 wt-% of the starting oxides, CaO is 21-23 wt-% of the starting oxides, K2O is 10-12 wt-% of the starting oxides, MgO is 1-4 wt-% of the starting oxides, P2O5 is 0.5-1.5 wt-% of the starting oxides, B2O3 is 0-1 wt-% of the starting oxides, provided that the total amount of Na2O and K2O is 17-20 wt-% of the starting oxides. Also disclosed is the manufacture and use of the bioactive glass composition.

    摘要翻译： 含有SiO 2，Na 2 O，CaO，K 2 O，MgO，P 2 O 2的生物活性玻璃组合物 5 O 3和B 2 O 3 3。 SiO 2的量为起始氧化物的51-56重量％，Na 2 O 2为起始氧化物的7-9重量％，CaO为21重量％ 23重量％的起始氧化物，K 2 O 2为起始氧化物的10-12重量％，MgO为起始氧化物的1-4重量％，P < O 2 O 3为起始氧化物的0.5-1.5重量％，B 2 O 3 3为0-1重量％的0-1重量％ 起始氧化物，条件是Na 2 O 2和K 2 O 2的总量为起始氧化物的17-20重量％。 还公开了生物活性玻璃组合物的制造和使用。

    Biabsorbable implant having a varying characteristic
    3.
    发明申请
    Biabsorbable implant having a varying characteristic 审中-公开
    具有变化特性的可吸收植入物

    公开(公告)号：US20060280775A1

    公开(公告)日：2006-12-14

    申请号：US11451749

    申请日：2006-06-12

    申请人： Nureddin Ashammakhi ,  Pertti Tormala ,  Mikko Hupa ,  Heimo Ylanen

    发明人： Nureddin Ashammakhi ,  Pertti Tormala ,  Mikko Hupa ,  Heimo Ylanen

    IPC分类号： A61F2/06

    CPC分类号： A61L27/44 ,  A61L27/56 ,  A61L27/58

    摘要： A bioabsorbable implant or its part consists of a structure having a varying characteristic in at least in one direction defining a gradient corresponding this characteristic. The structure comprises bioabsorbable polymer and another substance within or next to said bioabsorbable polymer. The structure is constituted of a wound or folded blank (1) having a direction of variation (L) of a characteristic (Ch) which is at least one of the following: concentration of the other substance, species of the other substance, type of the bioabsorbable polymer, or porosity (size of openings in the blank), said structure having a winding axis or fold lines substantially perpendicular to said direction of variation (L). This results in said varying characteristic in the structure in said at least one direction defining the gradient and traversing superposed layers formed of sections of the blank (1) that are successive in said direction of variation (L).

    摘要翻译： 生物可吸收植入物或其部分由至少在一个方向上具有变化特性的结构限定对应于该特征的梯度组成。 所述结构包含生物可吸收聚合物和在所述生物可吸收聚合物内或之下的另一种物质。 该结构由具有以下至少之一的特征（Ch）的变化方向（L）的卷绕或折叠坯料（1）构成：另一种物质的浓度，另一种物质的种类， 生物可吸收聚合物或孔隙率（坯料中的开口尺寸），所述结构具有基本垂直于所述变化方向（L）的卷绕轴线或折线。 这导致在所述至少一个方向上的所述结构中的所述变化特征限定了梯度并且横穿由坯料（1）的在所述变化方向（L）上连续的部分形成的叠置层。

    Porous medical device and method for its manufacture
    4.
    发明申请
    Porous medical device and method for its manufacture 有权
    多孔医疗器械及其制造方法

    公开(公告)号：US20070141111A1

    公开(公告)日：2007-06-21

    申请号：US10568890

    申请日：2004-08-20

    申请人： Esa Suokas ,  Pertti Tormala ,  Nureddin Ashammakhi ,  Heimo Ylanen ,  Mikko Hupa

    发明人： Esa Suokas ,  Pertti Tormala ,  Nureddin Ashammakhi ,  Heimo Ylanen ,  Mikko Hupa

    IPC分类号： A61K48/00 ,  B32B27/04

    CPC分类号： B32B5/26 ,  A61F2/28 ,  A61F2/3094 ,  A61F2/30965 ,  A61F2002/2817 ,  A61F2002/30062 ,  A61F2002/30065 ,  A61F2002/30677 ,  A61F2002/30678 ,  A61F2002/30914 ,  A61F2002/30915 ,  A61F2002/30971 ,  A61F2210/0004 ,  A61F2210/0071 ,  A61F2310/00179 ,  A61F2310/00293 ,  A61L27/44 ,  A61L27/56 ,  A61L27/58 ,  B32B2255/02 ,  B32B2255/26 ,  B32B2262/105 ,  B32B2305/08 ,  B32B2556/00 ,  D02G3/448 ,  D04B1/14 ,  D04C1/06 ,  D10B2509/08 ,  Y10T442/2525

    摘要： Porous bioabsorbable, bioactive and load-bearing composite medical device structure includes a plurality of regular textile planar layers (1a, 1b . . . ) formed of continuous bioabsorbable polymer matrix and bioceramic fibers acting as reinforcements, both included in continuous fibrous elements (3) forming the textile layers. The layers are placed on top of each other to form a structure having two dimensions (x, y) at right angles to each other according to the two dimensions of the textile layer and a third dimension (z) perpendicular to them and resulting from the piling of the layers. A plurality of passages extend through the layers as a result of the openings (2) defined by portions of the continuous fibrous elements (3) extending substantially in the direction of the plane. The continuous fibrous elements (3) comprise both bioactive ceramic reinforcing fibers which form a reinforcing structure and a bioabsorbable polymer matrix material which forms a matrix which binds the layers together and also binds the portions of continuous fibers defining the openings together, thereby forming the passages and stiffening the structure. This bioactive and bioabsorbable composite structure is suitable to be used as a basic structure in medical devices, especially in osteochondral applications where the load-bearing properties of implant are required.

    摘要翻译： 多孔生物可吸收，生物活性和承载复合医疗装置结构包括由连续生物可吸收聚合物基质和作为增强剂的生物陶瓷纤维形成的多个规则的织物平面层（1a，1b ......），两者都包括在连续的纤维元素中 3）形成织物层。 这些层被放置在彼此的顶部上以根据织物层的两个尺寸和垂直于它们的第三尺寸（z）形成具有彼此成直角的两个尺寸（x，y）的结构，并由 堆积层。 由于由连续的纤维元件（3）的基本上沿平面方向延伸的部分限定的开口（2），多个通道延伸穿过层。 连续纤维元件（3）包括形成增强结构的生物活性陶瓷增强纤维和生物可吸收聚合物基质材料，其形成将层粘合在一起的基质，并且将限定开口的连续纤维的部分结合在一起，从而形成通道 并加强结构。 该生物活性和生物可吸收的复合结构适合用作医疗装置中的基本结构，特别是在需要植入物的承载性能的骨软骨应用中。