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公开(公告)号：US20140336374A1
公开(公告)日：2014-11-13
申请号：US14445137
申请日：2014-07-29
申请人： Heiner EBEL , Sara FRATTINI , Riccardo GIOVANNINI , Christoph HOENKE , Thomas TRIESELMANN , Patrick TIELMANN
发明人： Heiner EBEL , Sara FRATTINI , Riccardo GIOVANNINI , Christoph HOENKE , Thomas TRIESELMANN , Patrick TIELMANN
IPC分类号： C07D498/10 , C07D405/14 , C07D401/06 , C07D403/06 , C07D451/02 , C07D471/10 , C07D417/14 , C07D413/14 , C07D471/04 , C07D491/052 , C07D401/14 , C07D403/14
CPC分类号： C07D498/10 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/553 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D407/14 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/10 , C07D491/052 , Y02A50/385 , Y02A50/409 , Y02A50/411
摘要： The present invention relates to a process for the production of novel antagonists for CCR2 (CC chemokine receptor 2) and intermediates thereof.
摘要翻译： 本发明涉及生产CCR2（CC趋化因子受体2）的新型拮抗剂及其中间体的方法。
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2.发明申请CYCLIC PYRIMIDIN-4-CARBOXAMIDES AS CCR2 RECEPTOR ANTAGONISTS FOR TREATMENT OF INFLAMMATION, ASTHMA AND COPD 有权CYPIC PYRIMIDIN-4-CARBOXAMIDES作为CCR2受体拮抗剂用于治疗炎症，哮喘和COPD公开(公告)号：US20130324517A1
公开(公告)日：2013-12-05
申请号：US13949696
申请日：2013-07-24
申请人： Heiner EBEL , Sara FRATTINI , Riccardo GIOVANNINI , Christoph HOENKE , Thomas TRIESELMANN , Patrick TIELMANN , Stefan SCHEUERER , Silke HOBBIE , Frank BUETTNER
发明人： Heiner EBEL , Sara FRATTINI , Riccardo GIOVANNINI , Christoph HOENKE , Thomas TRIESELMANN , Patrick TIELMANN , Stefan SCHEUERER , Silke HOBBIE , Frank BUETTNER
IPC分类号： A61K31/506 , C07D405/14 , C07D403/14 , C07D471/10 , C07D403/06 , A61K31/5377 , A61K31/55 , A61K31/553 , A61K31/551 , C07D401/06 , C07D417/14 , C07D471/04 , C07D498/10 , C07D451/02 , C07D413/14 , C07D491/052 , C07D401/14
CPC分类号： C07D498/10 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/553 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D407/14 , C07D413/14 , C07D417/14 , C07D451/02 , C07D471/04 , C07D471/10 , C07D491/052 , Y02A50/385 , Y02A50/409 , Y02A50/411
摘要： The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD.
摘要翻译： 本发明涉及CCR2（CC趋化因子受体2）的新型拮抗剂及其用于治疗疾病，特别是肺疾病如哮喘和COPD的药物的用途。
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公开(公告)号：US20140235661A1
公开(公告)日：2014-08-21
申请号：US14260552
申请日：2014-04-24
申请人： Heiner EBEL , Sara FRATTINI , Kai GERLACH , Riccardo GIOVANNINI , Christoph HOENKE , Rocco MAZZAFERRO , Marco SANTAGOSTINO , Stefan SCHEUERER , Christofer TAUTERMANN , Thomas TRIESELMANN
发明人： Heiner EBEL , Sara FRATTINI , Kai GERLACH , Riccardo GIOVANNINI , Christoph HOENKE , Rocco MAZZAFERRO , Marco SANTAGOSTINO , Stefan SCHEUERER , Christofer TAUTERMANN , Thomas TRIESELMANN
IPC分类号： C07D491/107 , C07D405/14
CPC分类号： C07D491/107 , C07D405/14
摘要： The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD.
摘要翻译： 本发明涉及CCR2（CC趋化因子受体2）的新型拮抗剂及其用于治疗疾病，特别是肺疾病如哮喘和COPD的药物的用途。
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4.发明申请公开(公告)号：US20120053197A1
公开(公告)日：2012-03-01
申请号：US13029690
申请日：2011-02-17
申请人： Holger WAGNER , Daniela BERTA , Klaus FUCHS , Riccardo GIOVANNINI , Dieter Wolfgang HAMPRECHT , Ingo KONETZKI , Ruediger STREICHER , Thomas TRIESELMANN
发明人： Holger WAGNER , Daniela BERTA , Klaus FUCHS , Riccardo GIOVANNINI , Dieter Wolfgang HAMPRECHT , Ingo KONETZKI , Ruediger STREICHER , Thomas TRIESELMANN
IPC分类号： A61K31/4355 , C07D491/20 , A61P3/00 , C07D215/56 , A61P9/00 , C07D491/107
CPC分类号： C07D491/04 , A61K31/506 , C07D215/56 , C07D491/20
摘要： The present invention relates to compounds defined by formula I wherein the variables R1-R8 are defined as in the description, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of cholesterol ester transfer protein (CETP) and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme.
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5.发明申请TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION 有权三环吡啶衍生物，含有这些化合物的药物，其使用及其制备方法公开(公告)号：US20120046304A1
公开(公告)日：2012-02-23
申请号：US13029697
申请日：2011-02-17
申请人： Holger WAGNER , Daniela BERTA , Klaus FUCHS , Riccardo GIOVANNINI , Dieter Wolfgang HAMPRECHT , Ingo KONETZKI , Ruediger STREICHER , Thomas TRIESELMANN
发明人： Holger WAGNER , Daniela BERTA , Klaus FUCHS , Riccardo GIOVANNINI , Dieter Wolfgang HAMPRECHT , Ingo KONETZKI , Ruediger STREICHER , Thomas TRIESELMANN
IPC分类号： A61K31/506 , A61K31/4355 , C07D491/20 , C07D215/56 , A61P3/00 , A61P9/10 , A61P3/06 , C07D491/048 , A61P9/00
CPC分类号： C07D491/04 , A61K31/506 , C07D215/56 , C07D491/20
摘要： The present invention relates to compounds defined by formula I wherein the variables R1-R8 are defined as in the description, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of cholesterol ester transfer protein (CETP) and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme.
摘要翻译： 本发明涉及由式I定义的化合物，其中变量R1-R8如描述中所定义，具有有价值的药理学活性。 特别地，化合物是胆固醇酯转移蛋白（CETP）的抑制剂，因此适用于治疗和预防可受该酶抑制影响的疾病。
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![Furo[3,4-c]quinoline derivatives, medicaments containing such compounds, their use and process for their preparation](/abs-image/US/2013/08/15/US20130210850A1/abs.jpg.150x150.jpg)
公开(公告)号：US20130210850A1
公开(公告)日：2013-08-15
申请号：US13586977
申请日：2012-08-16
IPC分类号： C07D491/20 , A61K45/06 , A61K31/4747
CPC分类号： C07D491/20 , A61K31/4747 , A61K45/06
摘要： The present invention relates to compounds defined by formula I wherein the variables R1-R8 are defined as in the description, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of cholesterol ester transfer protein (CETP) and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this protein.
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